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1 MAbs) were produced against serotype 1 human astrovirus.
2 to have potent neutralizing activity against astrovirus.
3 o those observed after infection with intact astrovirus.
4 bute to the adaptive immune response against astrovirus.
5 nt of vaccines and antiviral drugs targeting astrovirus.
6 n microscopy reconstruction image of a human astrovirus.
7 ghly divergent from all previously described astroviruses.
8 sid protein, a property apparently unique to astroviruses.
9 mary site of infection and pathogenicity for astroviruses.
10 he molecular surfaces of immature and mature astroviruses.
11 that drive the cross-species transmission of astroviruses.
12 man and avian spikes, and studies with human astrovirus 1 (HAstV-1) suggest a minor role in infection
13 t a visit, 26% (78/305) were associated with astrovirus; 17% (78/452) of astrovirus infections were a
14 e report the crystal structure of the turkey astrovirus 2 (TAstV-2) capsid surface spike domain, dete
15 4.5-5.0), Campylobacter spp (3.5%, 0.4-6.3), astrovirus (2.7%, 2.2-3.1), and Cryptosporidium spp (2.0
16 (5.4%, 2.1-7.8), rotavirus (4.9%, 4.4-5.2), astrovirus (4.2%, 3.5-4.7), and Shigella spp (4.0%, 3.6-
17 arrhea outbreaks were more likely to contain astrovirus (40/476) than were samples not associated wit
20 fants and 268 older siblings were tested for astrovirus, adenovirus 40/41, rotavirus and Salmonella,
21 previously determined low-resolution maps of astrovirus allowed us to characterize the molecular surf
22 The genomes of a previously uncharacterized astrovirus and picobirnaviruses were also partially or f
24 genomes of multiple novel species of porcine astroviruses and bocaviruses were generated and phylogen
25 ther nonenveloped positive-stranded viruses (astroviruses and human noroviruses) and with flavivirus
28 yptosporidiosis, and giardiasis), rotavirus, astrovirus, and enterotoxigenic Escherichia coli (ETEC).
29 xamined for the presence of norovirus (NoV), astrovirus, and rotavirus (RV) by reverse transcriptase
34 rty stool samples from 26 patients contained astrovirus antigen, while rotavirus was found in 34 samp
37 centers (CCCs) and determined the infecting astrovirus antigenic types by reverse transcriptase-poly
41 a leading cause of pediatric diarrhea, human astroviruses are among the least characterized enteric R
42 pism and neuropathogenesis of VA1.IMPORTANCE Astroviruses are an emerging cause of central nervous sy
55 Hepatitis E virus (HEV), rotavirus (RV), and astrovirus (AstV) are important pathogens that transmit
57 eminested PCR assays were used to screen for astroviruses (AsV), noroviruses (NoV), and rotaviruses (
59 d neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO cla
60 review summarizes these remarkable facets of astrovirus biology, highlighting critical steps toward i
63 lizing but reacted to all seven serotypes of astrovirus by enzyme-linked immunosorbentassay (ELISA) a
64 m analysis pipeline, we identified two novel astroviruses capable of infecting research mice, murine
65 logy modeling and produced a complete, T = 3 astrovirus capsid model with features remarkably similar
66 ires extensive proteolytic processing of the astrovirus capsid protein (CP) both inside and outside t
67 Taken together, these data suggest that the astrovirus capsid protein VP29 may be important in viral
70 y, we investigated the structure of an avian astrovirus capsid spike and compared it to a previously
71 distant structural similarities to the human astrovirus capsid spike and other viral capsid spikes.
73 f astroviruses, including the ability of the astrovirus capsid to act as an enterotoxin, disrupting t
74 the nature of proteolytic processing of the astrovirus capsid, we infected Caco-2 cells with a high
79 HAstV requires proteolytic processing of the astrovirus CP both inside and outside the host cell, res
80 This study describes the epidemiology of astrovirus diarrhea among a population-based cohort of 3
81 Because we observed 38% of the incidence of astrovirus diarrhea to occur in infants aged <6 months,
86 we report the crystal structure of the human astrovirus dimeric surface spike determined to 1.8-A res
88 of sequence reads, consisted of kobuviruses, astroviruses, enteroviruses, sapoviruses, sapeloviruses,
94 genome sequence of newly identified porcine astrovirus genotype 3 (PAstV3) strain US-MO123 was deter
96 1; mamastrovirus 9) is a recently discovered astrovirus genotype that is divergent from the classic h
98 K1(a), which was highly divergent from human astrovirus (HAstV 1-8) genotypes, but closely related to
102 articles of Human adenovirus C (HAdV), Human astrovirus (HAstV), and group A Rotavirus (RV-A) were es
108 diverse loop conformations.IMPORTANCE Human astroviruses (HAstVs) infect nearly every person in the
112 transmission zones determine the prevailing astrovirus host and virus diversity, which in turn sugge
113 functional studies provide new insights into astrovirus host cell entry, species specificity, and evo
116 genotypes, but closely related to VA1/HMO-C astroviruses, including one recovered from a case of fat
117 e discovered several important properties of astroviruses, including the ability of the astrovirus ca
121 Together, these results demonstrate that astrovirus-induced permeability occurs independently of
122 del, we investigated the mechanisms by which astrovirus induces diarrhea and the role of both the ada
124 teric viruses, the current dogma states that astroviruses infect in a species-specific manner; howeve
126 led astrovirus proteins from supernatants of astrovirus-infected cells showed that all three neutrali
131 V STL permits the study of the mechanisms of astrovirus infection and host-pathogen interactions in a
132 Here we show that type I interferon limits astrovirus infection and preserves barrier permeability
139 ll line, BHK, which is largely refractory to astrovirus infection, was found to support efficient gro
143 e currently no vaccines available to prevent astrovirus infection; however, antibodies developed by h
144 associated with astrovirus; 17% (78/452) of astrovirus infections were associated with diarrhea and
148 nd predicted amino acid sequence of a turkey astrovirus isolated from poults with an emerging enteric
152 found similar results in vivo using a murine astrovirus (MuAstV) model, providing new evidence that v
154 campylobacter) and viral (adenovirus 40/41, astrovirus, nonpolio enteroviruses, and rotavirus) infec
155 lytica, Giardia lamblia, adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus
156 eropathogens, including viruses (adenovirus, astrovirus, norovirus GII, rotavirus, and sapovirus), ba
157 io, and Yersinia (by culture), adenoviruses, astroviruses, noroviruses, rotavirus, and Shiga toxin-pr
158 re positive-strand RNA viruses (Aichi virus, astrovirus, or salivirus/klassevirus) suspected of being
161 s known at the molecular level about how the astrovirus particle assembles and is converted into an i
162 that appeared quite similar to trypsin-grown astrovirus particles by negatively stained electron micr
163 e able to prevent attachment of radiolabeled astrovirus particles to human Caco 2 intestinal cell mon
164 s phenomenon, along with the pathogenesis of astroviruses, particularly in those strains that can cau
168 ens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruse
172 ies suggest that NO is important in limiting astrovirus replication and are the first, to our knowled
177 d by electron microscopy and were tested for astrovirus, rotavirus, and enteric adenovirus by EIA.
178 ted with other enteric viruses (Aichi virus, astrovirus, salvirus/klassevirus); however, none could b
180 ber 2009 were tested for enteric adenovirus, astrovirus, sapovirus, parechovirus, bocavirus, and aich
181 ctivated virus or purified recombinant human astrovirus serotype 1 capsid in the form of virus-like p
182 terminally deleted forms of ORF1a from human astrovirus serotype 1 were expressed in BHK cells, and n
183 co-2 cells that had been infected with human astrovirus serotype 1, confirming the presence of the cl
185 mechanism by which several strains of human astrovirus serotype 2 (HAstV-2) are resistant to the pot
188 c, another (7C2) neutralized all seven human astrovirus serotypes, while the third (3B2) neutralized
190 portant impact on future characterization of astrovirus structure and function, and will likely have
192 Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infe
199 analysis demonstrated that this virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all
201 al nervous system infections in mammals, and astrovirus VA1/HMO-C is the most prevalent astrovirus in
202 occur in infants aged <6 months, a candidate astrovirus vaccine would have to confer immunity very ea
203 eted with each other for binding to purified astrovirus virions, suggesting that their epitopes were
213 g MAbs were used to select antigenic variant astroviruses, which were then studied in neutralization
214 ted Caco-2 cells with a high multiplicity of astrovirus without trypsin in the presence of 5 to 10% f
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