ライフサイエンスコーパス: astrovirus

1 MAbs) were produced against serotype 1 human astrovirus.

2 to have potent neutralizing activity against astrovirus.

3 o those observed after infection with intact astrovirus.

4 bute to the adaptive immune response against astrovirus.

5 nt of vaccines and antiviral drugs targeting astrovirus.

6 n microscopy reconstruction image of a human astrovirus.

7 ghly divergent from all previously described astroviruses.

8 sid protein, a property apparently unique to astroviruses.

9 mary site of infection and pathogenicity for astroviruses.

10 he molecular surfaces of immature and mature astroviruses.

11 that drive the cross-species transmission of astroviruses.

12 man and avian spikes, and studies with human astrovirus 1 (HAstV-1) suggest a minor role in infection

13 t a visit, 26% (78/305) were associated with astrovirus; 17% (78/452) of astrovirus infections were a

14 e report the crystal structure of the turkey astrovirus 2 (TAstV-2) capsid surface spike domain, dete

15 4.5-5.0), Campylobacter spp (3.5%, 0.4-6.3), astrovirus (2.7%, 2.2-3.1), and Cryptosporidium spp (2.0

16 (5.4%, 2.1-7.8), rotavirus (4.9%, 4.4-5.2), astrovirus (4.2%, 3.5-4.7), and Shigella spp (4.0%, 3.6-

17 arrhea outbreaks were more likely to contain astrovirus (40/476) than were samples not associated wit

18 Of infants with astrovirus, 70% shed at multiple visits over a period of

19 In this report, we show that astrovirus activates ERK1/2 early in infection independe

20 fants and 268 older siblings were tested for astrovirus, adenovirus 40/41, rotavirus and Salmonella,

21 previously determined low-resolution maps of astrovirus allowed us to characterize the molecular surf

22 The genomes of a previously uncharacterized astrovirus and picobirnaviruses were also partially or f

23 Astroviruses and bocaviruses showed the highest prevalen

24 genomes of multiple novel species of porcine astroviruses and bocaviruses were generated and phylogen

25 ther nonenveloped positive-stranded viruses (astroviruses and human noroviruses) and with flavivirus

26 The nonenveloped astroviruses and noroviruses similarly showed high frequ

27 Rotavirus, astrovirus, and adenovirus were more common among cases

28 yptosporidiosis, and giardiasis), rotavirus, astrovirus, and enterotoxigenic Escherichia coli (ETEC).

29 xamined for the presence of norovirus (NoV), astrovirus, and rotavirus (RV) by reverse transcriptase

30 Adenovirus, astrovirus, and sapovirus infections were detected in 22

31 x assay to detect norovirus (types 1 and 2), astrovirus, and sapovirus.

32 ses, parechoviruses, rotaviruses, cosavirus, astroviruses, and hepatitis B virus.

33 most diarrheagenic Escherichia coli strains, astroviruses, and sapoviruses.

34 rty stool samples from 26 patients contained astrovirus antigen, while rotavirus was found in 34 samp

35 onal pathogens were identified in six of the astrovirus antigen-positive stool samples.

36 To better understand astrovirus antigenic structure and the basis of protecti

37 centers (CCCs) and determined the infecting astrovirus antigenic types by reverse transcriptase-poly

38 Astroviruses are a leading cause of infantile viral gast

39 Astroviruses are a leading cause of viral diarrhea in yo

40 Human astroviruses are a major cause of pediatric diarrhea, ye

41 a leading cause of pediatric diarrhea, human astroviruses are among the least characterized enteric R

42 pism and neuropathogenesis of VA1.IMPORTANCE Astroviruses are an emerging cause of central nervous sy

43 Astroviruses are important agents of pediatric gastroent

44 Astroviruses are known to cause enteric disease in sever

45 Human astroviruses are nonenveloped, positive-sense single-str

46 Astroviruses are nonenveloped, positive-sense single-str

47 Human astroviruses are recognized as a leading cause of viral

48 Astroviruses are single-stranded, plus-sense RNA viruses

49 Astroviruses are small, nonenveloped, single-stranded RN

50 This study examines the importance of astroviruses as a cause of acute diarrhea in hospitalize

51 Clinical studies have established astroviruses as the second leading cause of viral diarrh

52 ne as well as small-molecule drugs targeting astrovirus assembly/maturation.

53 ne as well as small-molecule drugs targeting astrovirus assembly/maturation.

54 Of 179 children with diarrhea, 36 (20%) had astrovirus-associated diarrhea.

55 Hepatitis E virus (HEV), rotavirus (RV), and astrovirus (AstV) are important pathogens that transmit

56 Astrovirus (AstV) infections are among the most common c

57 eminested PCR assays were used to screen for astroviruses (AsV), noroviruses (NoV), and rotaviruses (

58 A novel astrovirus (casa astrovirus) basal to those infecting mammals and birds,

59 d neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO cla

60 review summarizes these remarkable facets of astrovirus biology, highlighting critical steps toward i

61 To understand astrovirus biology, it is essential to understand factor

62 Adenovirus, Aichi virus, Anellovirus, Astrovirus, Bocavirus, Enterovirus, Parechovirus, Picobi

63 lizing but reacted to all seven serotypes of astrovirus by enzyme-linked immunosorbentassay (ELISA) a

64 m analysis pipeline, we identified two novel astroviruses capable of infecting research mice, murine

65 logy modeling and produced a complete, T = 3 astrovirus capsid model with features remarkably similar

66 ires extensive proteolytic processing of the astrovirus capsid protein (CP) both inside and outside t

67 Taken together, these data suggest that the astrovirus capsid protein VP29 may be important in viral

68 Pulse-chase experiments showed that the astrovirus capsid protein was initially translated as an

69 e high-resolution structures of the two main astrovirus capsid proteins.

70 y, we investigated the structure of an avian astrovirus capsid spike and compared it to a previously

71 distant structural similarities to the human astrovirus capsid spike and other viral capsid spikes.

72 d compared it to a previously reported human astrovirus capsid spike structure.

73 f astroviruses, including the ability of the astrovirus capsid to act as an enterotoxin, disrupting t

74 the nature of proteolytic processing of the astrovirus capsid, we infected Caco-2 cells with a high

75 A novel astrovirus (casa astrovirus) basal to those infecting ma

76 endent diarrhea; however, the means by which astroviruses cause diarrhea remain unknown.

77 Unlike other human astrovirus cell culture systems, which require addition

78 Astrovirus contains three open reading frames (ORF) on i

79 HAstV requires proteolytic processing of the astrovirus CP both inside and outside the host cell, res

80 This study describes the epidemiology of astrovirus diarrhea among a population-based cohort of 3

81 Because we observed 38% of the incidence of astrovirus diarrhea to occur in infants aged <6 months,

82 In determining whether astrovirus diarrhea was associated with a reduced incide

83 The overall incidence rate of astrovirus diarrhea was the same as that of rotavirus di

84 mune response is not the primary mediator of astrovirus diarrhea.

85 The age-specific incidence rates of astrovirus diarrheal episodes per person-year were 0.38

86 we report the crystal structure of the human astrovirus dimeric surface spike determined to 1.8-A res

87 All tested negative for astroviruses, enteroviruses, Group A rotaviruses, Sappor

88 of sequence reads, consisted of kobuviruses, astroviruses, enteroviruses, sapoviruses, sapeloviruses,

89 Astrovirus, for which only rehydration therapy is requir

90 Different regions of the human astrovirus frameshift signal were cloned into the rhesus

91 An outbreak of astrovirus gastroenteritis occurred in the Primary Immun

92 w curtain of a patient who was admitted with astrovirus gastroenteritis.

93 ecombination events have occurred across the astrovirus genome.

94 genome sequence of newly identified porcine astrovirus genotype 3 (PAstV3) strain US-MO123 was deter

95 An astrovirus genotype 3 strain was identified in both envi

96 1; mamastrovirus 9) is a recently discovered astrovirus genotype that is divergent from the classic h

97 and birds, potentially representing a third astrovirus genus, was partially characterized.

98 K1(a), which was highly divergent from human astrovirus (HAstV 1-8) genotypes, but closely related to

99 This study assessed the role of human astrovirus (HAstV) in outbreaks and sporadic cases of di

100 Human astrovirus (HAstV) is a leading cause of viral diarrhea

101 Human astrovirus (HAstV) is a significant cause of acute diarr

102 articles of Human adenovirus C (HAdV), Human astrovirus (HAstV), and group A Rotavirus (RV-A) were es

103 We identified an astrovirus, HAstV-VA1/HMO-C-UK1(a), which was highly div

104 Human astroviruses (HAstVs) are a leading cause of viral diarr

105 Human astroviruses (HAstVs) are a major cause of gastroenterit

106 Human astroviruses (HAstVs) are nonenveloped, positive-sense,

107 Human astroviruses (HAstVs) belong to a family of nonenveloped

108 diverse loop conformations.IMPORTANCE Human astroviruses (HAstVs) infect nearly every person in the

109 Human astroviruses (HAstVs) infect nearly every person in the

110 Human astroviruses (HAstVs) were detected in 23 stool samples

111 However, only human astroviruses have been well characterized at the nucleot

112 transmission zones determine the prevailing astrovirus host and virus diversity, which in turn sugge

113 functional studies provide new insights into astrovirus host cell entry, species specificity, and evo

114 d astrovirus VA1/HMO-C is the most prevalent astrovirus in cases of human encephalitis.

115 suggestive of a diverse population of murine astroviruses in research mice.

116 genotypes, but closely related to VA1/HMO-C astroviruses, including one recovered from a case of fat

117 e discovered several important properties of astroviruses, including the ability of the astrovirus ca

118 Here, we demonstrate that astrovirus increases barrier permeability in a Caco-2 ce

119 Very little is known about the mechanisms of astrovirus-induced diarrhea.

120 to the lack of inflammation associated with astrovirus-induced gastroenteritis.

121 Together, these results demonstrate that astrovirus-induced permeability occurs independently of

122 del, we investigated the mechanisms by which astrovirus induces diarrhea and the role of both the ada

123 Astroviruses infect a wide range of hosts, affecting bot

124 teric viruses, the current dogma states that astroviruses infect in a species-specific manner; howeve

125 Astrovirus-infected animals were analyzed for changes in

126 led astrovirus proteins from supernatants of astrovirus-infected cells showed that all three neutrali

127 However, astrovirus-infected children had a lower median age, les

128 The symptoms of astrovirus-infected children were similar to those of ch

129 Studies of astrovirus-infected humans and turkeys have demonstrated

130 Only diarrhea was associated with astrovirus infection (odds ratio, 1.4; 95% confidence in

131 V STL permits the study of the mechanisms of astrovirus infection and host-pathogen interactions in a

132 Here we show that type I interferon limits astrovirus infection and preserves barrier permeability

133 Astrovirus infection in a variety of species results in

134 e many viral infections, but its role during astrovirus infection is unknown.

135 Community-acquired astrovirus infection occurred in 6.8% of patients, and n

136 Astrovirus infection was pathogenic and associated with

137 Symptomatic and asymptomatic astrovirus infection was prospectively determined in a 3

138 The point prevalence of astrovirus infection was significantly higher among infa

139 ll line, BHK, which is largely refractory to astrovirus infection, was found to support efficient gro

140 ibe the potential role of innate immunity in astrovirus infection.

141 okine transforming growth factor beta during astrovirus infection.

142 intrinsic epithelial cell responses against astrovirus infection.

143 e currently no vaccines available to prevent astrovirus infection; however, antibodies developed by h

144 associated with astrovirus; 17% (78/452) of astrovirus infections were associated with diarrhea and

145 Half of the astrovirus infections were nosocomial.

146 Astrovirus infections were significantly more common tha

147 Astrovirus is one of the major causes of infant and chil

148 nd predicted amino acid sequence of a turkey astrovirus isolated from poults with an emerging enteric

149 Despite the prevalence of astroviruses, little is known at the molecular level abo

150 ype that is divergent from the classic human astroviruses (mamastrovirus 1).

151 t into the molecular mechanisms that lead to astrovirus maturation and infectivity.

152 found similar results in vivo using a murine astrovirus (MuAstV) model, providing new evidence that v

153 s capable of infecting research mice, murine astrovirus (MuAstV) STL1 and STL2.

154 campylobacter) and viral (adenovirus 40/41, astrovirus, nonpolio enteroviruses, and rotavirus) infec

155 lytica, Giardia lamblia, adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus

156 eropathogens, including viruses (adenovirus, astrovirus, norovirus GII, rotavirus, and sapovirus), ba

157 io, and Yersinia (by culture), adenoviruses, astroviruses, noroviruses, rotavirus, and Shiga toxin-pr

158 re positive-strand RNA viruses (Aichi virus, astrovirus, or salivirus/klassevirus) suspected of being

159 entified in a highly conserved region of the astrovirus ORF2 product.

160 Eight astrovirus outbreaks occurred in 6 CCCs.

161 s known at the molecular level about how the astrovirus particle assembles and is converted into an i

162 that appeared quite similar to trypsin-grown astrovirus particles by negatively stained electron micr

163 e able to prevent attachment of radiolabeled astrovirus particles to human Caco 2 intestinal cell mon

164 s phenomenon, along with the pathogenesis of astroviruses, particularly in those strains that can cau

165 seful small-animal model with which to study astrovirus pathogenesis and immunity.

166 The mechanisms of astrovirus pathogenesis are largely unknown, in part due

167 Our understanding of astrovirus pathogenesis trails behind our knowledge of i

168 ens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruse

169 Mapping conserved residues onto the astrovirus projection domain revealed a putative recepto

170 Immunoprecipitation of radiolabeled astrovirus proteins from supernatants of astrovirus-infe

171 Most (80%) of the astroviruses recovered were of serotype 1.

172 ies suggest that NO is important in limiting astrovirus replication and are the first, to our knowled

173 irus-induced type I IFNs may protect against astrovirus replication and pathogenesis in vivo.

174 characterized a new mouse model for studying astrovirus replication and pathogenesis.

175 g children, the cellular factors involved in astrovirus replication are not well defined.

176 rated, for the first time, that NO inhibited astrovirus replication.

177 d by electron microscopy and were tested for astrovirus, rotavirus, and enteric adenovirus by EIA.

178 ted with other enteric viruses (Aichi virus, astrovirus, salvirus/klassevirus); however, none could b

179 Adenovirus, astrovirus, sapovirus, parechovirus, bocavirus, and aich

180 ber 2009 were tested for enteric adenovirus, astrovirus, sapovirus, parechovirus, bocavirus, and aich

181 ctivated virus or purified recombinant human astrovirus serotype 1 capsid in the form of virus-like p

182 terminally deleted forms of ORF1a from human astrovirus serotype 1 were expressed in BHK cells, and n

183 co-2 cells that had been infected with human astrovirus serotype 1, confirming the presence of the cl

184 tructed a genome-length cDNA clone for human astrovirus serotype 1.

185 mechanism by which several strains of human astrovirus serotype 2 (HAstV-2) are resistant to the pot

186 amino acids [aa] 71 to 415 of VP90) of human astrovirus serotype 8 at a 2.15-A resolution.

187 e crystal structure of VP90(71-415) of human astrovirus serotype 8.

188 c, another (7C2) neutralized all seven human astrovirus serotypes, while the third (3B2) neutralized

189 l similarity of the crystal structure of the astrovirus spike domain with the HEV P-domain.

190 portant impact on future characterization of astrovirus structure and function, and will likely have

191 s the genomic sequences of nine novel turkey astrovirus (TAstV) type 2-like clinical isolates.

192 Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infe

193 Here we show that human astrovirus type 1 (HAstV-1) infection induces type I int

194 cases occurred from March through June, and astrovirus type 1 was the most common.

195 aptive and innate immune responses to turkey astrovirus type-2 (TAstV-2) infection.

196 enomic-length data set available for any one astrovirus type.

197 Adenovirus (type 41), astrovirus (types 1, 2, 3, 4, and 8), sapovirus (genogro

198 Our studies provide the first evidence that astroviruses undergo viral RNA-dependent assembly.

199 analysis demonstrated that this virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all

200 Astrovirus VA1/HMO-C (VA1; mamastrovirus 9) is a recentl

201 al nervous system infections in mammals, and astrovirus VA1/HMO-C is the most prevalent astrovirus in

202 occur in infants aged <6 months, a candidate astrovirus vaccine would have to confer immunity very ea

203 eted with each other for binding to purified astrovirus virions, suggesting that their epitopes were

204 (vTF7-3), were transfected with the various astrovirus-VP4 constructs.

205 Astrovirus was a significant cause of diarrhea outbreaks

206 Astrovirus was detected in 164 infants (61%) and 20 sibl

207 Astrovirus was identified throughout the year, peaked in

208 In this population, astrovirus was the most common enteric pathogen isolated

209 An enzyme immunoassay for astrovirus was used to screen 357 stool samples from 267

210 Astroviruses were detected in four environmental swabs a

211 ple sequences with limited identity to known astroviruses were identified.

212 Astroviruses were second only to rotaviruses as etiologi

213 g MAbs were used to select antigenic variant astroviruses, which were then studied in neutralization

214 ted Caco-2 cells with a high multiplicity of astrovirus without trypsin in the presence of 5 to 10% f