ライフサイエンスコーパス: asymmetric

1 he parental contributions to ZGA were highly asymmetric.

2 In the present work, a new asymmetric 2,2'-spirobis[chromene] intermediate possessi

3 rds a symmetric [2]catenane (SC.7PF6) and an asymmetric [2]catenane (AC.7PF6) on reaction of the 1:1

4 The first asymmetric [3+1]-cycloaddition was successfully achieved

5 s significant potential, a general catalytic asymmetric [4+2]-cycloaddition of simple and electronica

6 rom Corynebacterium glutamicum recognizes an asymmetric 5'-GCCGC-3' site and cleaves the DNA 7 and 6/

7 TmrAB can be regarded as a model system for asymmetric ABC exporters in general, and for TAP in part

8 .23) and COLQ (collagen-like tail subunit of asymmetric acetylcholinesterase; rs7609897-T: P=1.5 x 10

9 turning while walking backward might reflect asymmetric activation of the left and right MDNs.

10 synthesized and tested as organocatalysts in asymmetric aldol additions.

11 ps, which are catalytically competent toward asymmetric aldol reactions, were selected as the catalyt

12 e trans-2,6-disubstituted dihydropyran ring, asymmetric alpha-aminoxylation reaction, and Still-Genna

13 Asymmetric alpha-carotene, a provitamin A carotenoid, is

14 Asymmetric alternating biasing forces can cause the defe

15 Development of the asymmetric amniotic sac-with the embryonic disc and amni

16 FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with co

17 demonstrated that chromosome positioning is asymmetric and proportional to cell size.

18 ant increases in urea, arginine, citrulline, asymmetric and symmetric dimethylarginine, alongside dec

19 similar DNA affinities, indicating that both asymmetric and symmetric liganded states activate DNA in

20 localized excitonic states are dominated by asymmetric and symmetric modes of the acetylene groups o

21 appeared at presynaptic plasmalemma, making asymmetric and symmetric synapses.

22 sion of normally symmetric cell divisions to asymmetric and vice versa during development, which affe

23 hick nanowires (t = 40 nm) with both single (asymmetric) and double (symmetric) notches, showing how

24 These robust asymmetric anion-accelerated amino-Cope enabled cascades

25 This asymmetric APKR of allenyl acetates is a rare example of

26 A catalytic asymmetric approach was also studied preliminarily, and

27 We observe an asymmetric, approximately bell-shaped, relationship betw

28 -symmetric ligands catalyzed effectively the asymmetric arylation of N-tosylaldimines to (S)-diarylam

29 anocene-mediated radical cyclization for the asymmetric assembly of the "AB" ring and the constructio

30 rated and their effectiveness in a catalytic asymmetric aziridination was evaluated.

31 a slower but more accurate response with the asymmetric barrier.

32 Asymmetric bi- and triantennary glycans could be obtaine

33 The asymmetric binding is consistent with the experimentally

34 Finally, asymmetric binding patterns of anesthetic to the channel

35 This was accomplished by engineering an asymmetric, biodegradable triblock copolymer molecule co

36 Furthermore, we observe asymmetric BMP-SMAD signaling concurrent with PASE devel

37 Flatfish have the most extreme asymmetric body morphology of vertebrates.

38 We report here an asymmetric boronate addition to sulfonyl hydrazones cata

39 We show that asymmetric branching can be incorporated into the WBE mo

40 ical examination was remarkable for slightly asymmetric breath sounds, which appeared to be diminishe

41 This mechanism appears unprecedented in asymmetric catalysis.

42 R) and SCARECROW (SCR), cooperatively direct asymmetric cell division and the patterning of root cell

43 Asymmetric cell division is the primary mechanism to gen

44 erstood, and the upstream signal to initiate asymmetric cell division is unknown.

45 x and maintaining cell size asymmetry during asymmetric cell division of Drosophila neuroblasts (NBs)

46 ouple spindle orientation to polarity during asymmetric cell division of Drosophila neuroblasts.

47 ontrol changes in actomyosin dynamics during asymmetric cell division remain unclear.

48 nnected with processes including cell cycle, asymmetric cell division, apoptosis and actomyosin-regul

49 Asymmetric cell division, creating sibling cells with di

50 developmental disorders involving defective asymmetric cell division.

51 ing the CD70/CD27 interaction by mAb induced asymmetric cell divisions and differentiation in AML bla

52 Asymmetric cell divisions are required for cellular dive

53 cell-cycle kinetics and a premature shift to asymmetric cell divisions impairing progenitor cell pool

54 a decrease in the frequency of symmetric and asymmetric cell divisions producing daughter cells capab

55 mmetric increase in interareal influences or asymmetric changes in directed influences among brain ar

56 nt GJ-forming proteins, creating molecularly asymmetric channels that are correlated with functional

57 ept of electrical energy generation based on asymmetric chemical doping of single-walled carbon nanot

58 we study the mechanism of internalization of asymmetric, chemically stabilized, cholesterol-modified

59 We suggest that asymmetric clearance of pluripotency regulators may repr

60 Finally, using an in vivo asymmetric cleavage assay, we show that despite containi

61 pends on spatial distance and on nonspatial, asymmetric clustering.

62 The striking feature of this system is its asymmetric coexpression patterns, which suggest side-spe

63 001) facet of wurtzite CdSe cores, producing asymmetric compressive shells that create built-in biaxi

64 ere, we address the molecular basis for this asymmetric conduction by investigating the structure and

65 These results indicate that asymmetric conduction in WT M2 is due to W41 inhibition

66 r the majority of peptides, demonstrating an asymmetric configuration of the two subunits.

67 ing wild-type and mutant subunits in various asymmetric configurations, we revealed a linear relation

68 active state is closed in a highly strained asymmetric conformation.

69 The model shows how asymmetric connectivity could enhance the representation

70 These observations suggest that asymmetric connectivity in the vestibular system facilit

71 tures of central neural populations, such as asymmetric connectivity, to the computations the populat

72 s the door to a new area of research for the asymmetric construction of these skeletons for which ena

73 It also reveals asymmetric contacts such as enhancer-promoter contacts t

74 rein we describe an iterative application of asymmetric copper catalysis towards the synthesis of six

75 ations into two groups: patients with highly asymmetric cortical dysplasia caused by the common p.E17

76 Asymmetric cryo-electron microscopy reconstruction of th

77 ergy propagation in nonlinear materials with asymmetric crystalline structures and topological proper

78 ting in vacuum, can show characteristic Fano asymmetric curves when coupled in arrays.

79 e aim of highlighting their applicability in asymmetric cycloadditions for the assembly of complex mo

80 -bipyridinium radical cation (DB(*+)) and an asymmetric cyclophane bisradical dication (DAPQT(2(*+)))

81 Key features include the first catalytic asymmetric cyclopropanation of allene, mediated by the d

82 that the directed motion is a result of the asymmetric damping due to the size difference in the fil

83 Furthermore, we show unreported asymmetric deletions and large insertions of middle repe

84 o construct the polyol chain, a Ti-catalyzed asymmetric Diels-Alder reaction to generate the cis-deca

85 urotransmitter release, and calcium-mediated asymmetric differentiation of the AWC olfactory neuron p

86 a levels of arginine, citrulline, ornithine, asymmetric dimethylarginine (ADMA), symmetric dimethylar

87 plasma levels of l-arginine, arginase-1, and asymmetric dimethylarginine were measured at serial time

88 s of high-sensitivity C-reactive protein and asymmetric dimethylarginine).

89 Decompartmentalized hemoglobin, arginase 1, asymmetric dimethylarginine, and adenine nucleotides are

90 This asymmetric distribution depended on Ydj1 farnesylation a

91 APK activity and this is correlated with the asymmetric distribution of activated p38MAPK.

92 There was asymmetric distribution of growth of EFW: a slightly wid

93 investigated, the specific problem caused by asymmetric division at the transcription level has not y

94 ation of apical-basal determinants, ensuring asymmetric division into daughter cells of different fat

95 tipotent progenitors, and suggesting that an asymmetric division is involved in the acquisition of go

96 Whereas physical asymmetric division mechanisms and cell fate consequence

97 protein that has a pivotal role in directing asymmetric division of mammalian stem cells to sustain t

98 d ARF activity cell-autonomously control the asymmetric division of the first ground tissue cells.

99 line and is first detected shortly after the asymmetric division that segregates the germ cell lineag

100 Following asymmetric division, the mother cell engulfs the forespo

101 riction of developmental potential following asymmetric division.

102 s determines the fate of daughter cells upon asymmetric division.

103 e Arabidopsis leaf epidermis [5], polarized, asymmetric divisions of stomatal stem cells (meristemoid

104 establishing polarity in CE cells, and that asymmetric divisions resulting from CE polarity are requ

105 ole of non-muscle myosin II (nmy-2) in these asymmetric divisions.

106 The asymmetric droplet interface bilayer method may be gener

107 gative dielectrophoresis (nDEP), followed by asymmetric droplet splitting using a Y-shaped junction,

108 Due to the highly asymmetric durations of infectiousness between males and

109 Non-escalation was highest in RHP asymmetric dyads of the second contest, irrespective of

110 using dual-resonator concept to obtain large asymmetric elastic wave transmission in multiple low fre

111 wavelength aperture is originally coupled to asymmetric electrodes, which activate the thermo-electri

112 muscle contraction waves are associated with asymmetric embryo rolling, unveiling a new chirality mar

113 eparation of products typically accessed via asymmetric enolate methodologies.

114 Clearly, due to the asymmetric environment, with metal on one side and a die

115 egans embryo elongation, a process driven by asymmetric epidermal cell shape changes.

116 Common to most cell types is the asymmetric establishment and regulation of cortical NuMA

117 he cascade reaction and an initial catalytic asymmetric example that generates a carbon stereocenter

118 tation proxy data, to demonstrate that while asymmetric extratropical forcings (icesheets, freshwater

119 Our device is inspired by an asymmetric Fabry-Perot resonator, with pixels comprising

120 s of bioactive TGF-beta1 are associated with asymmetric fate choice in vitro in single HSPCs via p38M

121 f a time-dependent potential with repeating, asymmetric features.

122 These asymmetric fitness outcomes suggest conflicts between pa

123 eous extract of yacon are investigated using asymmetric flow field-flow fractionation (AF4) coupled t

124 Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a signaling cascade

125 reo-, and regioselectivity through catalytic asymmetric fluoroenolate alkylation with allylic acetate

126 re challenging as the plasma response can be asymmetric for positrons and electrons.

127 ompressibility, density differences, and the asymmetric freezing dynamics with inward solidification

128 urs only in a narrow frequency band, and the asymmetric frequencies are always within ultrasound rang

129 dent force generation, protein clustering by asymmetric friction, and entropic expansion forces will

130 ion angles, while in MoS2 both symmetric and asymmetric GBs show a gradual dependence on mismatch ang

131 ) Omega mum for 21 degrees mismatch in tilt (asymmetric) GBs.

132 s dissolving through a "recovery cascade" of asymmetric gene flow from South to North between neighbo

133 the present, (b) divergence with potentially asymmetric gene flow until some point in the past and in

134 e scenarios: (a) divergence with potentially asymmetric gene flow until the present, (b) divergence w

135 and distribution gaps correlated with highly asymmetric gene-flow that was inefficient in maintaining

136 An accelerative asymmetric gold catalysis is achieved for the first time

137 ric and cognate sites on the GPCR, and (iii) asymmetric GPCR dimers.

138 e flow asymmetry by showing that many of the asymmetric growth patterns observed experimentally can b

139 orphogenesis requires differential and often asymmetric growth.

140 "Symmetric" and "asymmetric" growth together correlated with greater freq

141 This study shows that asymmetric H-FIRE waveforms can be used to create ablati

142 , LT as low as 536 V/cm were found for 2 mus asymmetric H-FIRE waveforms.

143 A mild, asymmetric Heck-Matsuda reaction of five-, six- and seve

144 e that 5-HT2 receptors can form functionally asymmetric heterodimers in vitro and in vivo that must b

145 Comparing the effects of asymmetric histone tail point mutants with those of symm

146 tructure of the leptospiral PerR revealed an asymmetric homodimer, with one monomer displaying comple

147 ecause of the complementary action of CI and asymmetric hybrid incompatibilities.

148 stimulated the development of heterogeneous asymmetric hydrogenation catalysis.

149 inchona-modified Pt and Pd catalysts for the asymmetric hydrogenation of activated C horizontal lineO

150 count the early breakthroughs concerning the asymmetric hydrogenation of largely unfunctionalized ole

151 The catalytic asymmetric hydrogenation of trisubstituted enol esters u

152 of killing between the strains to be highly asymmetric, i.e., one strain kills another at a much hig

153 nt in both DLB and PCA, although it was more asymmetric in PCA.

154 Our data suggest that an asymmetric increase in cortical tension promotes filamen

155 The mechanism and sources of asymmetric induction in Nazarov reactions reported by Ti

156 nd can be scaled up without compromising the asymmetric induction.

157 While this asymmetric inheritance maintains the efficacy of purifyi

158 Strikingly, MEK1 appeared to control the asymmetric inheritance of Ventx2 protein following cell

159 ega mum for 14 degrees mismatch in Class-II (asymmetric) interfaces.

160 ents to opposite cells ends, where they form asymmetric intracellular complexes that couple cell-cell

161 Finally, we describe asymmetric introgression events occurring among common b

162 of their low field ion mobility, while field asymmetric ion mobility spectrometers (FAIMS) separate t

163 e mechanism and origin of stereoinduction in asymmetric iron-catalyzed C(sp(2))-C(sp(3)) cross-coupli

164 ells, symmetric Li/garnet/Li (LGL) cells and asymmetric Li/garnet/carbon-nanotubes (LGC), are fabrica

165 erichia coli, the outer membrane is a unique asymmetric lipid bilayer with lipopolysaccharide in the

166 Little attention has been given to how the asymmetric lipid distribution of the plasma membrane mig

167 iation of DLC1 with NEDD9 is crucial for its asymmetric localization and differential RHOA activity.

168 Strikingly, this asymmetric localization cannot be explained by the distr

169 ssion, we uncovered that maintenance of Mira asymmetric localization requires interaction with the co

170 r coils are controlled separately to form an asymmetric magnetic field to change the direction of las

171 in-5-ones have been used as electrophiles in asymmetric Mannich reactions with pyrazolones.

172 ing the role of life-history differences and asymmetric mating on competitive outcomes.

173 These structurally well-defined, asymmetric membranes facilitate control over membrane fl

174 Asymmetric mesoporous silica nanoparticles (MSNs) with c

175 concatone H were assembled through catalytic asymmetric methodologies: Krische allylation, cross-meta

176 Whereas numerous asymmetric methods for formation of quaternary carbon st

177 om 2005 that cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.

178 ally in a confined space that is coated with asymmetric micro-patterns.

179 provided in vivo evidence in support of the asymmetric mode of replication.

180 ric trithiols (CD2), and (iii) the periphery-asymmetric monothiols (DB2), in which B functionality is

181 How left-right patterning drives asymmetric morphogenesis is unclear.

182 Asymmetric multilayers of non-magnetic heavy metals with

183 o prepare any bi-, tri-, and tetra-antennary asymmetric N-glycan from a single precursor.

184 r than that of PSS sites, accounting for the asymmetric nature of multilayer growth.

185 iary rootlets of photoreceptors and identify asymmetric NE aggregates of Nesprin1alpha and Sun2 that

186 iber's Law can still be attained within many asymmetric networks.

187 An asymmetric Ni-catalyzed reductive cross-coupling has bee

188 An asymmetric Ni-catalyzed reductive cross-coupling of (het

189 Catalytic, asymmetric Ni/Cr-mediated coupling was used for three C-

190 2 Ni(III) ](2+) complex and the decay of the asymmetric [Ni(III) (mu-O)2 Co(III) ](2+) core through a

191 hat, in PD, M1 beta oscillations have sharp, asymmetric, nonsinusoidal features, specifically asymmet

192 The ability to generate asymmetric nucleosomes in vivo and in vitro provides a p

193 ve site conformations in each monomer of the asymmetric obligate homo-dimer.

194 ially in the three protomers, generating two asymmetric oligomer intermediates according to the schem

195 on rotators and waveguide devices supporting asymmetric optical power transmission.

196 rromagnetic Co surface can interact with the asymmetric orbital on an organometal halide perovskite s

197 duced by removal of the thyroid gland caused asymmetric organ growth, increased pancreatic beta cell

198 c environment, which is composed of a large, asymmetric organic cation and inorganic (or organic) ani

199 Proper execution of asymmetric organogenesis is critical to health, making f

200 The full historical period of asymmetric oxidation catalysis (1970 to the present day)

201 ew of catalyst systems capable of conducting asymmetric oxygenative transformations of organic molecu

202 Asymmetric particles can exhibit unique properties.

203 However, reported synthesis methods for asymmetric particles hinder their application because th

204 the potential to produce large quantities of asymmetric particles.

205 Asymmetric partitioning is an essential component of man

206 glial determination in progenitors involves asymmetric partitioning of EGFR and TRalpha1, expression

207 We propose an asymmetric pathway for coupling active transpososome ass

208 thyroidism in the sheep fetus resulted in an asymmetric pattern of organ growth, pancreatic beta cell

209 nlikely, particularly in regions with strong asymmetric patterns of dispersal connectivity.

210 audate nucleus than PCA, and PCA showed more asymmetric patterns of hypometabolism than DLB.

211 PlpA and MglA localize into opposite asymmetric patterns.

212 reading of the calix[5]arene wheels with the asymmetric pentylbenzylammonium axle 2c(+) led to the to

213 nent of ZIKV transmission behaves akin to an asymmetric percolation process on the network of sexual

214 ar (Ursus arctos middendorffi), responded to asymmetric phenological shifts between its primary troph

215 of benzoic acid/thiourea co-catalysis in the asymmetric Pictet-Spengler reaction is reported.

216 at retinoic acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid

217 Asymmetric pigmented follicular openings by dermoscopy c

218 This asymmetric plasticity uncovers important insights into a

219 Asymmetric positioning of the mitotic spindle is a funda

220 erogradely labeled endings in the DCN formed asymmetric postsynaptic densities, a feature of excitato

221 that choreograph the assembly of the highly asymmetric pre- and postsynaptic structures are still po

222 For significant asymmetric presentation (so called unilateral KC), the f

223 pounds that are difficult to obtain by other asymmetric procedures.

224 development of a flow chemistry process for asymmetric propargylation using allene gas as a reagent

225 imer traces by combining interface exchange, asymmetric Protein A binding, and the scFv x Fab format.

226 e ambiguous mechanism of the decarboxylative asymmetric protonation was conducted.

227 t in the palladium-catalyzed decarboxylative asymmetric protonation.

228 nism, is an efficient organocatalyst for the asymmetric reaction of homophthalic anhydride with imine

229 d achieving up to >99:1 dr selectivity, this asymmetric reaction was successfully applied to produce

230 ing molecular details for different modes of asymmetric recognition of Env trimer and a binding model

231 catalyzed by chiral biphenols, results in an asymmetric reductive transposition of the in situ genera

232 These asymmetric responses pose a tractable challenge to proce

233 Asymmetric rose-shaped gold particles were fabricated as

234 The asymmetric ruthenium-catalyzed reductive amination emplo

235 ntials produced a large potentiation with an asymmetric seconds-long time course.

236 -1 has considerably reduced affinity for the asymmetric sequence (meZRE2).

237 iginally reported to recognize two different asymmetric sequences: 5'-GACCGA-3' and 5'-CACCCA-3'.

238 Predictions from the three-state model imply asymmetric sequential binding of the terminal domains.

239 ficial for some forms of chemotaxis, but why asymmetric shape is so prevalent when a symmetric shape

240 Arterial spin labeling and asymmetric spin echo sequences measured CBF and OEF, res

241 polymerization of astral microtubules during asymmetric spindle positioning has remained elusive.

242 rotubule depolymerization causes exaggerated asymmetric spindle positioning.

243 ical subdomain of the ER that is involved in asymmetric spindle positioning.

244 omes rapidly and stably restricted following asymmetric stem cell division is unclear.

245 um and a shorter vibrational lifetime of the asymmetric stretch mode compared to the IL phase.

246 alous at these wavelengths due to the nearby asymmetric-stretch rovibrational band of atmospheric car

247 vertheless arrange themselves into a largely asymmetric structure made of hexamers and pentamers.

248 Our results reveal how the asymmetric structure of TREK-2 allows it to distinguish

249 ins, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypepti

250 We provide evidence showing asymmetric subgenome domestication for directional selec

251 Transparent solid-state, asymmetric supercapacitors (72% transmittance) based on

252 Asymmetric supercapacitors (ASCs) assembled using two di

253 This asymmetric suppression may be a key component of the per

254 e peripheral dissection, irregular incision, asymmetric suture position and tension, inadequate corre

255 Here we report a rhodium-catalysed asymmetric Suzuki-Miyaura reaction with important partne

256 First, the density of asymmetric synapses does not differ between frontal and

257 m a small fraction (M1: 12%; S1: 17%) of all asymmetric synapses in L4 of both areas.

258 H and SR were preferentially associated with asymmetric synapses rather than symmetric synapses.

259 The asymmetric syntheses of all eight tetraponerine alkaloid

260 We describe efficient asymmetric syntheses of four photoswitchable Delta(9)-te

261 In this context, the asymmetric synthesis of 1,2-diamines through amination o

262 Our work has opened a new route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabic

263 ock chemical isobutyric acid has enabled the asymmetric synthesis of a wide variety of polyketides.

264 This Review summarizes strategies for the asymmetric synthesis of alkyl boronic esters, from the s

265 While the developed asymmetric synthesis of C10 substituted anthrones is ant

266 ne ([(11)C] L-Met), we developed an enhanced asymmetric synthesis of D-[methyl-(11)C]methionine ([(11

267 e report that RA95.5-8 variants catalyze the asymmetric synthesis of gamma-nitroketones via two alter

268 A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecul

269 nvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative tra

270 The control of asymmetric synthesis tools represents a major challenge,

271 Asymmetric synthesis, in which chiral organocatalysts or

272 d chiral ligands and organocatalysts used in asymmetric synthesis, which have been published within t

273 of their use in both kinetic resolution and asymmetric synthesis.

274 on of prochiral olefins is a key reaction in asymmetric synthesis.

275 important role in the development of modern asymmetric synthesis.

276 s chiral, making them attractive targets for asymmetric synthesis.

277 cks should be tolerated, the consequences of asymmetric technical attribution capabilities, and when

278 ogy is demonstrated by the preparation of an asymmetric tetra-antennary N-glycan found in human breas

279 This novel field asymmetric time of flight ion mobility spectrometer (FAT

280 The first asymmetric total synthesis of the putative structure of

281 repared, characterized, and evaluated in the asymmetric transfer hydrogenation (ATH) of a wide range

282 cyclopentenone product in a dynamic kinetic asymmetric transformation (DyKAT).

283 Asymmetric transformations with these intermediates, a c

284 mic kinetic resolutions, and dynamic kinetic asymmetric transformations.

285 ed chiral N-heterocyclic carbene ligands for asymmetric transition-metal catalysis' by Daniel Janssen

286 Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that

287 However, asymmetric transmission performance in existing devices

288 by kicking out an electron, resulting in an asymmetric trion photoluminescence (PL) peak with a long

289 trithiol of the core (C3), (ii) the interior-asymmetric trithiols (CD2), and (iii) the periphery-asym

290 tion, and two tetramers were observed in the asymmetric unit.

291 crystals of GCRho have only a monomer in an asymmetric unit.

292 some-to-hexasome transition is guided by the asymmetric unwrapping of the DNA.

293 , length-dependent neuropathies (n = 1), and asymmetric vasculitic neuropathy (n = 1).

294 Synthetic highlights include a catalytic and asymmetric vinylogous Mukaiyama reaction and a stereospe

295 The effect of damping on the asymmetric wave transmission is further discussed.

296 inherent advantage of differential or field asymmetric waveform IMS (FAIMS) based on the derivative

297 Full scan field asymmetric waveform ion mobility spectrometry (FAIMS) co

298 The combination of field asymmetric waveform ion mobility spectrometry with liqui

299 Ts for symmetric waveforms and 33% lower for asymmetric waveforms indicating that waveform symmetry c

300 ous carbon-organosilica Janus particles with asymmetric wettability are synthesized through a one-ste