ライフサイエンスコーパス: asymmetric synthesis

1 of their use in both kinetic resolution and asymmetric synthesis.

2 important role in the development of modern asymmetric synthesis.

3 re compounds despite many recent advances in asymmetric synthesis.

4 als, nonlinear optics, chirality studies and asymmetric synthesis.

5 arious topics of conformational analysis and asymmetric synthesis.

6 sis is now recognized as the third pillar of asymmetric synthesis.

7 s ranging from plasmonic sensors to absolute asymmetric synthesis.

8 another fundamentally important strategy for asymmetric synthesis.

9 ater examination of such archaeal enzymes in asymmetric synthesis.

10 the development of ligands and catalysts for asymmetric synthesis.

11 genic centers in amphidinolide W were set by asymmetric synthesis.

12 porated as chiral auxiliaries and ligands in asymmetric synthesis.

13 established them as an important target for asymmetric synthesis.

14 oselective manner are attractive methods for asymmetric synthesis.

15 al pool" of potential starting materials for asymmetric synthesis.

16 as however precluded their widespread use in asymmetric synthesis.

17 nalized alpha-amino acids based on catalytic asymmetric synthesis.

18 atives are widely used as organocatalysts in asymmetric synthesis.

19 The R- and S-enantiomers were prepared by asymmetric synthesis.

20 l boronic esters are useful intermediates in asymmetric synthesis.

21 of 1-alkenes is high enough to be useful for asymmetric synthesis.

22 ctive peptides as well as chiral inducers in asymmetric synthesis.

23 s chiral, making them attractive targets for asymmetric synthesis.

24 significant gap in the methods for catalytic asymmetric synthesis.

25 and is of general interest in the context of asymmetric synthesis.

26 on of prochiral olefins is a key reaction in asymmetric synthesis.

27 on metals has been proven to be effective in asymmetric synthesis.

28 ent to a Merrifield-Cl resin and its use for asymmetric synthesis.

29 tuted pyran derivatives, we have carried out asymmetric synthesis and biological characterization of

30 y increase the enantiomeric excess of direct asymmetric synthesis and catalysis.

31 The asymmetric synthesis and evaluation of the two diastereo

32 with potential application in fields such as asymmetric synthesis and organic electronics.

33 We have previously described the asymmetric synthesis and revision of the relative config

34 ase from this Sulfolobus hyperthermophile to asymmetric synthesis and the first example of a DYRKR wi

35 Chiral organometallic reagents are useful in asymmetric synthesis, and configurational stability of t

36 e analogues of Cyclophostin were obtained by asymmetric synthesis, and their absolute configurations

37 ate ligands, prepared in enantiopure form by asymmetric synthesis, and their circular dichroic and ot

38 s are among the most sought after targets in asymmetric synthesis, and therefore, their chemical char

39 e to chiral N-acylhydrazones of interest for asymmetric synthesis applications.

40 ligands could enable their modification for asymmetric synthesis, as demonstrated in this study.

41 es, respectively, are important compounds in asymmetric synthesis, crop protection and medicinal chem

42 Despite many advances in asymmetric synthesis, developing general and practical s

43 ber of excellent synthetic methods for their asymmetric synthesis, few effective enzymatic tools exis

44 An asymmetric synthesis for the preparation of nonracemic a

45 Asymmetric synthesis, in which chiral organocatalysts or

46 Asymmetric synthesis is carried out using (-)-sparteine-

47 pha-haloalkyl)boronic esters as reagents for asymmetric synthesis is reviewed.

48 ailability in an optically pure form through asymmetric synthesis is urgently needed.

49 of the most useful and versatile methods for asymmetric synthesis known in organometallic chemistry.

50 ed by total synthesis, using efficient novel asymmetric synthesis methods for the preparation of two

51 chemistry has been demonstrated in a concise asymmetric synthesis of (+)-beta-cuparenone.

52 l 26, the key aminocyclitol component for an asymmetric synthesis of (+)-carbapentostatin.

53 Complete details of an asymmetric synthesis of (+)-isatisine A (1) are describe

54 al cations was demonstrated by completing an asymmetric synthesis of (+)-nemorensic acid.

55 ds of this type, demonstrated with a concise asymmetric synthesis of (+)-roseophilin (3).

56 An efficient and practical asymmetric synthesis of (+)-trans-3-hydroxymethyl-4-(3-f

57 The asymmetric synthesis of (-)-(R)-pyrrolam A was achieved

58 ed in 8 steps and 18% overall yield, and the asymmetric synthesis of (-)-(R,R)-hopromine was achieved

59 The asymmetric synthesis of (-)-(S,S)-homaline was achieved

60 The asymmetric synthesis of (-)-7-epicylindrospermopsin defi

61 he morphine alkaloids has been applied in an asymmetric synthesis of (-)-dihydrocodeinone.

62 A concise asymmetric synthesis of (-)-halenaquinone is described.

63 In addition, the first asymmetric synthesis of (-)-marcfortine C is described.

64 The asymmetric synthesis of (-)-N-methylwelwitindolinone B i

65 Described is the first catalytic, asymmetric synthesis of (-)-podophyllotoxin and its C(2)

66 The application of this method to a concise asymmetric synthesis of (-)-tylophorine is also discusse

67 The asymmetric synthesis of (2R,3R)-3-methyl-3-hydroxypipeco

68 overy project, we needed to develop a robust asymmetric synthesis of (2S,5S)-5-substituted-azepane-2-

69 nal alkynes to aldehydes, allowing the first asymmetric synthesis of (3R,4E,16E,18R)-icosa-4,16-diene

70 A novel and practical asymmetric synthesis of (5S)-(acetamidomethyl)-2-oxazoli

71 Furthermore, the asymmetric synthesis of (P)-2 through a dynamic thermody

72 An improved asymmetric synthesis of (S)-(+)-2,4,6-trimethylphenylsul

73 We describe an original asymmetric synthesis of (S)-alpha-methylDOPA proceeding

74 Via this method, an asymmetric synthesis of (S)-cathinone hydrochloride (er

75 An asymmetric synthesis of (S)-gamma-fluoroleucine ethyl es

76 The key step for the asymmetric synthesis of (S,E)-3-(tert-butyldimethylsilyl

77 this methodology is exemplified in a concise asymmetric synthesis of (S,S)-3-deoxy-3-fluorosafingol.

78 ationally stable at low temperature, and the asymmetric synthesis of 1,1-disubstituted tetrahydroisoq

79 An efficient asymmetric synthesis of 1,2,3-trisubstituted cyclopentan

80 In this context, the asymmetric synthesis of 1,2-diamines through amination o

81 The first asymmetric synthesis of 1,2-dioxolane-3-acetic acids is

82 An efficient asymmetric synthesis of 11-beta-HSD inhibitor 1 has been

83 viability of this approach for the catalytic asymmetric synthesis of 2,3-dihydrobenzofurans and indan

84 A novel and convenient one-pot asymmetric synthesis of 2- and 2,3-disubstituted tetrahy

85 alkaloid-mediated Neber reaction allows the asymmetric synthesis of 2-(tetrazol-5-yl)-2H-azirines.

86 olution has been studied as a method for the asymmetric synthesis of 2-substituted pyrrolidines.

87 bromoaryl ketones has been developed for the asymmetric synthesis of 3-methyleneindanes bearing a ter

88 We describe herein the total asymmetric synthesis of 3-methylphosphonate, 3-(monofluo

89 Our work has opened a new route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabic

90 ly enantio- and diastereoselective catalytic asymmetric synthesis of a beta-lactam.

91 odology was successfully implemented for the asymmetric synthesis of a C7-C17 fragment of swinholide

92 The development of the first asymmetric synthesis of a chiral anthraquinone dimer is

93 formylation were utilized for the practical asymmetric synthesis of a chiral quaternary FLAP inhibit

94 Key transformations include an asymmetric synthesis of a chiral tertiary alcohol via Sh

95 A short, asymmetric synthesis of a cyclic N-acyl O-amino phenol d

96 This work has culminated in the asymmetric synthesis of a dimer bearing the complete car

97 An eight step, asymmetric synthesis of a dimeric thiaspirane nuphar alk

98 Described herein is the asymmetric synthesis of a functionalized, trioxadecalin

99 of these reactions will allow the catalytic asymmetric synthesis of a great variety of functional ch

100 A practical asymmetric synthesis of a highly substituted N-acylpyrro

101 ing hydroxyl group direction facilitated the asymmetric synthesis of a key chiral quinone monoepoxide

102 This approach was used to develop the first asymmetric synthesis of a key intermediate in the synthe

103 A practical asymmetric synthesis of a novel aminopiperidine-fused im

104 The total asymmetric synthesis of a novel hybrid lipid possessing

105 An efficient asymmetric synthesis of a selective estrogen receptor mo

106 The catalytic asymmetric synthesis of a series of tertiary alpha-aryl

107 The asymmetric synthesis of a series of these compounds inco

108 e have developed a one-pot procedure for the asymmetric synthesis of a synthetically challenging clas

109 The method has been applied to the asymmetric synthesis of a triarylmethane-based anti-canc

110 amine reagent that has enabled the reliable asymmetric synthesis of a very broad range of different

111 and general route has been developed for the asymmetric synthesis of a wide family of 3-methyl-3,4-di

112 ock chemical isobutyric acid has enabled the asymmetric synthesis of a wide variety of polyketides.

113 o the successful development of an efficient asymmetric synthesis of A-240610.0, 1.

114 An asymmetric synthesis of alkaloid (-)-205B, a tricyclic m

115 This Review summarizes strategies for the asymmetric synthesis of alkyl boronic esters, from the s

116 The catalytic asymmetric synthesis of alkyl fluorides, particularly al

117 rategy has been used to rapidly complete the asymmetric synthesis of alliacol A.

118 The first asymmetric synthesis of alpha,alpha-disubstituted allyli

119 A new method for the asymmetric synthesis of alpha-alkyl-alpha,beta-dihydroxy

120 Allylating agents were explored for the asymmetric synthesis of alpha-allyl-alpha-aryl alpha-ami

121 An efficient asymmetric synthesis of alpha-amino allylsilane derivati

122 A general and efficient new method for the asymmetric synthesis of alpha-amino boronate esters has

123 The stereocontrolled asymmetric synthesis of alpha-hydroxy-beta-amino acids h

124 ughput screening of chiral catalysts for the asymmetric synthesis of alpha-hydroxycarboxylic acids.

125 inatorial search of chiral catalysts for the asymmetric synthesis of alpha-hydroxycarboxylic acids.

126 e and extensively used intermediates for the asymmetric synthesis of amines.

127 Three steps are commonly applied to the asymmetric synthesis of amines: (i) condensation of tBS

128 A general, asymmetric synthesis of amino acid derivatives is report

129 Zr-C bonds of zirconaaziridines leads to the asymmetric synthesis of amino acid methyl esters.

130 A concise asymmetric synthesis of an 11beta-HSD-1 inhibitor has be

131 ts are directly utilized in a very efficient asymmetric synthesis of an antiviral carbocyclic nucleos

132 This represents the only example of an asymmetric synthesis of an organic urea via C-H activati

133 26 incorporating the backbone ester was the asymmetric synthesis of an orthogonally protected l-thre

134 26 incorporating the backbone ester was the asymmetric synthesis of an orthogonally protected L-thre

135 An asymmetric synthesis of anti-aldol segments via a nonald

136 -nor stemmadenine natural product, the first asymmetric synthesis of any member of this natural produ

137 Complete details of an asymmetric synthesis of apicularen (1) are described.

138 ed by the sulfoxides may be exploited in the asymmetric synthesis of atropisomers, including the liga

139 An asymmetric synthesis of aza analogues of the ABC ring sy

140 ure sulfinimines, has been developed for the asymmetric synthesis of aziridine 2-phosphonates.

141 A highly divergent de novo asymmetric synthesis of benzyl alpha-6-deoxyaltropyranos

142 lt effects on conformational equilibria, (7) asymmetric synthesis of beta-amino acids, and (8) asymme

143 -lactones is presented as a generally useful asymmetric synthesis of beta-disubstituted carboxylic ac

144 ort practical methodology for the catalytic, asymmetric synthesis of beta-lactams resulting from the

145 This process was applied to the catalytic asymmetric synthesis of beta-lactams, to yield pure prod

146 The asymmetric synthesis of beta-phenyl-substituted cysteine

147 es of enone sugars as reactive dienophile in asymmetric synthesis of bicyclic adduct through Diels-Al

148 A general method is described for asymmetric synthesis of both syn- and anti-1,3-amino alc

149 A general organocatalytic strategy for asymmetric synthesis of both syn/anti-1,3-diamines has b

150 While the developed asymmetric synthesis of C10 substituted anthrones is ant

151 tion, which makes this method useful for the asymmetric synthesis of chiral beta-amino ketones.

152 P-OAc](2) is a broadly useful method for the asymmetric synthesis of chiral branched allylic esters.

153 In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline a

154 reaction will open new possibilities in the asymmetric synthesis of chiral peroxides.

155 makes this method practically useful for the asymmetric synthesis of chiral propargyl amines.

156 The asymmetric synthesis of cis-7-methoxycalamenene 1 has be

157 A chiral Koga amine-controlled asymmetric synthesis of cis-gamma-lactones through a for

158 e elaboration of these structures toward the asymmetric synthesis of complex aminocyclopentitols and

159 ent transformations as shown in an efficient asymmetric synthesis of coniine.

160 A full account of our efforts toward an asymmetric synthesis of crisamicin A are presented.

161 amides are valuable building blocks for the asymmetric synthesis of cyclic beta-amino acid derivativ

162 reb amides, valuable building blocks for the asymmetric synthesis of cyclic beta-amino acids derivati

163 A general and efficient asymmetric synthesis of cyclic indoline aminals was deve

164 ne ([(11)C] L-Met), we developed an enhanced asymmetric synthesis of D-[methyl-(11)C]methionine ([(11

165 An asymmetric synthesis of d-ribo-phytosphingosine (1) was

166 t one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidi

167 An efficient asymmetric synthesis of dipyridyl TRPV3 antagonist 1 is

168 In addition, a new synthetic scheme for the asymmetric synthesis of disubstituted cis-(6-benzhydryl-

169 The asymmetric synthesis of dragmacidin D (1) was completed

170 We have accomplished an asymmetric synthesis of each enantiomer of 4,4-difluorog

171 A new and general method for asymmetric synthesis of either enantiomer of 2-substitut

172 le three-component Strecker reaction for the asymmetric synthesis of enantiopure alpha-arylglycines h

173 The asymmetric synthesis of ent-ketorfanol from simple and c

174 In asymmetric synthesis of fluorinated compounds, significa

175 th the use of this novel chiral complex, the asymmetric synthesis of Fmoc-Gla(O(t)Bu)(2)-OH was compl

176 The asymmetric synthesis of functionalized nitrocyclopropane

177 using the recovered sulfoximine (+)-1j in an asymmetric synthesis of FXa inhibitor F.

178 A new and practical method for the asymmetric synthesis of gamma-amino acids from beta,gamm

179 The first direct catalytic asymmetric synthesis of gamma-amino ketones was realized

180 e report that RA95.5-8 variants catalyze the asymmetric synthesis of gamma-nitroketones via two alter

181 An asymmetric synthesis of gem-difluoromethylenated dihydro

182 An asymmetric synthesis of gem-difluoromethylenated linear

183 Alternatively, a convenient asymmetric synthesis of gem-difluoromethylenated linear

184 nt strategy has been developed for the rapid asymmetric synthesis of gem-dimethyl and spirocyclopropy

185 herein are one-pot methods for the catalytic asymmetric synthesis of halocyclopropyl alcohols with up

186 s the centerpiece process for the successful asymmetric synthesis of hamigerans A (2), B (3), and E (

187 ese redox-neutral transformations enable the asymmetric synthesis of highly substituted polycyclic ri

188 In budding yeast, the asymmetric synthesis of HO 1 (ASH1) pre-mRNP originates

189 Ash1 (for asymmetric synthesis of HO) was first uncovered in genet

190 This mutation defines the ASH1 gene (asymmetric synthesis of HO).

191 A catalytic asymmetric synthesis of imidazolines with a fully substi

192 ur knowledge, this work represents the first asymmetric synthesis of L-alpha-vinyl analogues of m-tyr

193 nulation reaction were extended to the first asymmetric synthesis of L-isotryptophan 38 and L-benz[f]

194 Complete details of an asymmetric synthesis of leucascandrolide A (1) are descr

195 otocol was illustrated with a concise formal asymmetric synthesis of marine alkaloid pseudodistomin B

196 Herein we describe the first asymmetric synthesis of methylenetetrahydrofurans utiliz

197 A practical asymmetric synthesis of N-tert-butyl disubstituted pyrro

198 alization process that has been used for the asymmetric synthesis of natural products and pharmaceuti

199 ew and concise routes were developed for the asymmetric synthesis of nitrogen-heterocycles such as py

200 The first asymmetric synthesis of novel, potent photoreactive gamm

201 A straightforward, two-step asymmetric synthesis of octahydroindoles has been develo

202 A new approach toward the asymmetric synthesis of optically active trifluoromethyl

203 oped that is based on a novel method for the asymmetric synthesis of organofluorine compounds, by eno

204 pplied without modification to the catalytic asymmetric synthesis of other families of fluorinated or

205 ow Merck) jointly developed a chemoenzymatic asymmetric synthesis of P2 where the net reaction was an

206 A program directed toward an asymmetric synthesis of pestalotiopsin A is described.

207 We report a catalytic asymmetric synthesis of piperidines through [4 + 2] cycl

208 employed as a platform to develop a concise asymmetric synthesis of platensimycin.

209 The asymmetric synthesis of polycyclic compounds from optica

210 This is a very efficient method for the asymmetric synthesis of polycyclic compounds.

211 sent a simple and robust methodology for the asymmetric synthesis of pyranose derivatives with talo-

212 coupling process has been developed for the asymmetric synthesis of QUINAP and its derivatives in hi

213 re (-40 or -60 degrees C), which enables the asymmetric synthesis of racemization-prone alpha-arylket

214 A full account of an asymmetric synthesis of reblastatin (1) and the first to

215 This methodology was applied to the asymmetric synthesis of rivastigmine and the formal synt

216 duction and a chiral (salen)Ti(IV) catalyzed asymmetric synthesis of silyl cyanohydrins proved effica

217 The first examples of catalytic asymmetric synthesis of spirocyclic structures by enanti

218 has been developed and applied to the total asymmetric synthesis of steroids 19-hydroxysarmentogenin

219 A general asymmetric synthesis of substituted cycloalkyl[b]indoles

220 l provide a synthetic entry into the de novo asymmetric synthesis of such structures.

221 s has been designed and demonstrated for the asymmetric synthesis of sulfinamides using quinine as au

222 lopentenones are important precursors in the asymmetric synthesis of target chiral molecules.

223 A one-pot method for the asymmetric synthesis of tert-butanesulfinyl-protected am

224 A short, asymmetric synthesis of the 1,2,9,9a-tetrahydrocycloprop

225 An asymmetric synthesis of the 1-alkyloxy analog of the thi

226 [reaction: see text] The asymmetric synthesis of the 2,3,6-trisubstituted piperid

227 ey features of the synthetic approach are an asymmetric synthesis of the 2-alkynyl piperazine core vi

228 The total asymmetric synthesis of the 5-methylenephosphonate (MP)

229 An asymmetric synthesis of the aminocyclopentitol pseudosug

230 The asymmetric synthesis of the antibacterial natural produc

231 An asymmetric synthesis of the antibiotic (+)-negamycin (1)

232 ns into cell cycle checkpoint inhibitors, an asymmetric synthesis of the antimitotic natural product,

233 n of a 1,1-diaryl olefin enables a four-step asymmetric synthesis of the C2-symmetric phenylethyl imi

234 The asymmetric synthesis of the core structure of leucoscept

235 An asymmetric synthesis of the cytotoxic natural product, (

236 We report the asymmetric synthesis of the gamma-amino acid (1R,2R)-2-a

237 nes or trienes and was used in the catalytic asymmetric synthesis of the gamma-secretase modulator JN

238 n deracemization reactions for the efficient asymmetric synthesis of the generic active pharmaceutica

239 new method enables the general and efficient asymmetric synthesis of the important class of alpha-bra

240 We report the first asymmetric synthesis of the individual enantiomers of me

241 successful synthetic strategy are a concise asymmetric synthesis of the key building block (3R,4E)-3

242 The asymmetric synthesis of the macrolide antibiotics (+)-ru

243 An asymmetric synthesis of the major metabolite of the calc

244 First asymmetric synthesis of the marine natural product (-)-g

245 new reaction is illustrated in the catalytic asymmetric synthesis of the Martinelline alkaloids chrom

246 ey benzofuran intermediate enabled the first asymmetric synthesis of the natural enantiomer of maoecr

247 is methodology has been demonstrated for the asymmetric synthesis of the natural product 2-deoxy-D-ri

248 An asymmetric synthesis of the paralytic shellfish poison (

249 This paper describes an asymmetric synthesis of the potent substance P receptor

250 A highly convergent asymmetric synthesis of the protein phosphatase inhibito

251 An asymmetric synthesis of the quinone epoxide dimer (+)-to

252 , ultimately leading to the completion of an asymmetric synthesis of the target compound with a high

253 A concise total asymmetric synthesis of the tetrahydronaphthyridine alka

254 A divergent asymmetric synthesis of the titled iminosugars has been

255 ication has long been considered to occur by asymmetric synthesis of the two strands, starting at the

256 l assignment of this molecule, including the asymmetric synthesis of the unique beta-hydroxy acid moi

257 ights of the synthesis include an efficient, asymmetric synthesis of the western hemisphere; the ster

258 lkaloids, one that is readily adapted to the asymmetric synthesis of these compounds.

259 nd we have successfully developed a scalable asymmetric synthesis of these derivatives that starts wi

260 A new asymmetric synthesis of these marine sponge metabolites

261 and represents valuable methodology for the asymmetric synthesis of this important heterocyclic ring

262 to a range of bioactive compounds; however, asymmetric synthesis of this motif is complicated due to

263 A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecul

264 We report an efficient strategy for the asymmetric synthesis of trifluoromethyl-substituted cycl

265 titutes a unique, convergent approach to the asymmetric synthesis of valuable carbonyl compounds from

266 Asymmetric synthesis of value-added targets and other re

267 The diastereoselective asymmetric synthesis of vicinal all-carbon-atom quaterna

268 A novel synthetic strategy toward the asymmetric synthesis of vicinal diols bearing a tertiary

269 We present an asymmetric synthesis of wickerol A (1) that is based on

270 tions of chiral oxazolidinone auxiliaries in asymmetric synthesis operate through a common set of ste

271 of enantioenriched helicenes, either from an asymmetric synthesis or from a chiral separation.

272 Alternatives to asymmetric synthesis or kinetic resolution include dynam

273 very useful rhodium carboxylate catalyst for asymmetric synthesis, Rh(2)(DOSP)(4), shows slightly slo

274 eta-(1-->3)-glucans have been accessed by an asymmetric synthesis route featuring an iterative double

275 ate-stage epimerization, not a failure of an asymmetric synthesis step, caused the formation of minor

276 effort has been directed towards developing asymmetric synthesis strategies that yield product molec

277 l)-4-hydoxyindole, 3, were prepared using an asymmetric synthesis that employed (+)- or (-)-proline.

278 nvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative tra

279 fford a solid-supported chiral auxiliary for asymmetric synthesis that takes approximately 7 d to pre

280 Despite recent advances of asymmetric synthesis, the preparation of enantiomericall

281 rison to the most widely used auxiliaries in asymmetric synthesis, the simplicity and practicality of

282 ments and extends our bioorganic approach to asymmetric synthesis to a versatile synthon class.

283 The control of asymmetric synthesis tools represents a major challenge,

284 ed for the first time in this report, and by asymmetric synthesis using a method formally demonstrate

285 ere obtained through a powerful and flexible asymmetric synthesis using pseudoephedrine as a chiral a

286 including chemical and enzymatic resolution, asymmetric synthesis via Pauson-Khand reaction, Nazarov

287 An asymmetric synthesis was developed for the production of

288 ional C4 secondary methyl building blocks in asymmetric synthesis, we have developed a mole-scale, tw

289 d chiral ligands and organocatalysts used in asymmetric synthesis, which have been published within t

290 ations of these intermediates as partners in asymmetric synthesis will be discussed including methods

291 box for chiral amine synthesis as they allow asymmetric synthesis with quantitative yields and high e

292 Asymmetric synthesis yielded 18 (IC(50) = 226 +/- 10 nM)