ライフサイエンスコーパス: at least two

1 Eligible patients had at least two 4-6 HLA-identical UCBs with >3 x 10(7) nucl

2 The protocol, comprising at least two 5-day courses of Ara-C (1 g/m(2) per day) p

3 esting that PRORP1 catalysis is optimal with at least two active site metal ions, consistent with the

4 Here, we show that sNASP contains at least two additional histone interaction sites that,

5 rimary target muscle group [PTMG]), and into at least two additional muscle groups from the elbow, wr

6 Productive budding events required at least two additional Vps4 hexamers.

7 ated the presence of PLTX, hydroxy-PLTX and, at least, two additional compounds with PLTX-like profil

8 All patients treated with at least two adjacent NDIs or SDIs according to availabl

9 our experiments have revealed that there are at least two alleles in this initial locus, both of whic

10 ted short term desensitized nAChRs that have at least two alpha4 subunits but not those with only one

11 es indicate that 100% of human genes produce at least two alternative mRNA isoforms.

12 When at least two analytes were elevated, the odds ratio for

13 In vitro, both require at least two and prefer three or more unpaired 5'-termin

14 In contrast, mutation of at least two arginines was necessary to reduce depurinat

15 at least one asthma exacerbation and 21% had at least two, as compared with 47% and 24%, respectively

16 ion and quality assessment were conducted by at least two authors.

17 support of recent theoretical calculations, at least two Bi-related traps were revealed and associat

18 This suggests that there are at least two binding events when LcrG binds to LcrV.

19 ponse element (E2RE), a region that contains at least two binding sites for cellular factors; one of

20 c interactions were instead observed between at least two BODIPY chromophores along the edges of the

21 lyses when elevated BP was defined as having at least two BP readings of >140/90 mmHg or those with e

22 onounced cancer suppressing activity towards at least two cancer cells, breast cancer MDA-MB-231 and

23 In at least two cases we found first-generation recombinant

24 llenged: new studies indicate that, instead, at least two cells that lack the dendrites characteristi

25 Thus, at least two classes of antidepressants accumulate in li

26 fast radio burst, suggesting that there are at least two classes of bursts.

27 The neuropil contains at least two classes of tangential elements, one connect

28 Overall, our data shows that HDA6 has at least two clearly separable activities in different g

29 86% of tumors across 12 cancer types had at least two clones.

30 alkylperoxide that liberates acetophenone by at least two competitive processes, one of which involve

31 Fifteen (42%) patients with at least two complete obstruction sites defined by DISE

32 Functional assessment confirmed at least two compounds as potent KOR antagonists, while

33 nctions as an ensemble of molecules sampling at least two conformational states.

34 ically switch back and forth (blink) between at least two conformations with different heights.

35 on Naming Test Short Form) once per day over at least two consecutive days using novel test forms eac

36 ined evidence for 'trans SD-MMEJ,' involving at least two consecutive rounds of microhomology anneali

37 variants of S. aureus that lack esaD encode at least two copies of EsaG-like proteins, most probably

38 turreted reoviruses of known structures have at least two copies of the clamp protein per asymmetric

39 ve site by a complicated mechanism involving at least two covalent intermediates at a catalytic lysin

40 ction in patients (aged >/=18 years) who had at least two creatinine, thyrotropin, calcium, glycated

41 inase-associated pancreatitis was defined by at least two criteria: abdominal pain, pancreatic enzyme

42 ious lines of systemic therapy consisting of at least two cycles of a chemotherapy-containing regimen

43 tructural changes are likely associated with at least two differences between and .

44 We also observed at least two different bound FRET states that may repres

45 dly had associations with frost tolerance in at least two different environments with two different s

46 tations suggested that these antibodies bind at least two different epitopes on the stalk region.

47 Using at least two different experimental types for the calibr

48 n enhances the RAD51 recombinase activity by at least two different mechanisms, modifies the RAD51 nu

49 Therefore, at least two different molecular mechanisms govern the p

50 nd clones selected for their reactivity with at least two different oligomeric conformers from Alzhei

51 h a history of a systemic reaction involving at least two different organ systems.

52 adation of nitrated compounds by sulfides by at least two different pathways: reduction involving ele

53 nd that little phosphorylation occurs unless at least two different PDEs are concurrently inhibited i

54 n, L1Cy5-7OTD might be able to bind to GQ in at least two different primary orientations and occasion

55 ngle VPS13 orthologue, which is required for at least two different processes: protein sorting to the

56 pecifically enriched by co-purification with at least two different small regulatory RNAs (sRNAs), Ry

57 n these data, we propose that E6AP exists in at least two different states, an active and a less acti

58 ticipants with 240678 HCC cases who received at least two different strategies were retrieved in this

59 n total nine different receptor pentamers in at least two different ways and expressed them in Xenopu

60 hin 40 miles of each other were processed in at least two different wineries.

61 synthetic approaches to compounds containing at least two directly bonded phosphorus atoms in differe

62 mGBPs reside in at least two discrete subcellular reservoirs and attack

63 Surprisingly however, at least two disease variants, one of which represents t

64 species within the Caryophyllales suggested at least two distinct [Na]shoot phenotypes within this o

65 show that DNA damage induces the assembly of at least two distinct activation platforms for caspase-2

66 f the PO genome was estimated to derive from at least two distinct ancestral pools.

67 all other nonpolyploid eukaryotes, there are at least two distinct and functional SUMO E2 conjugases

68 t the retina of axolotl salamanders contains at least two distinct classes of DS ganglion cells.

69 iochemical analyses reveal that Baf200 forms at least two distinct complexes.

70 experiments, which revealed the presence of at least two distinct conformations.

71 Digit loss occurred three times through at least two distinct developmental mechanisms, and elon

72 onstrate that Khatyrka must have experienced at least two distinct events: first, an event as early a

73 ly efficacious and safe treatment option for at least two distinct forms of the presently non-treatab

74 d SHROOM3 is normal in the mutants, CFL1 has at least two distinct functions in the apical and basal

75 ted that physicians could be classified into at least two distinct groups.

76 erall, our findings suggest the existence of at least two distinct heteromeric VRACs in astroglial ce

77 esicles in rodent neurons are recycled using at least two distinct mechanisms.

78 RAD18 governs at least two distinct mechanisms: translesion synthesis

79 Our findings indicate that at least two distinct modes of intraperitoneal spread op

80 in ARM, suggesting that the process involves at least two distinct molecular pathways.

81 show that the basal forebrain (BF) contains at least two distinct neural-coding strategies to suppor

82 stability of the Hsc70-client complex using at least two distinct protein-protein contacts, providin

83 At least two distinct rate constants for rotations about

84 with the only exception of hematite, present at least two distinct reactive pools with significantly

85 Sleep in flies thus appears to involve at least two distinct stages: increased oscillatory acti

86 mans, pluripotent stem cells (PSCs) exist in at least two distinct states of pluripotency, known as t

87 de 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both

88 indicate that Tasmanian devils have spawned at least two distinct transmissible cancer lineages and

89 thma, rhinoconjunctivitis and eczema suggest at least two distinct trends.

90 We find that Hfq has at least two distinct ways in which it interacts with sR

91 Finally, the lmFG contributed to at least two distinguishable stages of word processing,

92 s at least two SDs below population norms or at least two domains at least 1.5 SDs below norms.

93 nt in 3 copies, and showed that it contained at least two dosage-sensitive loci.

94 outbreak, 98.1% of the students had received at least two doses of MMR vaccine.

95 MC neurons inhibit neuronal activity through at least two effectors with distinct levels of receptor

96 e to lithium or any of the comparator drugs, at least two eGFR values available in the observation pe

97 The toxin contains at least two enzymatic domains: an effector glucosyltran

98 We found that there are at least two evolutionarily distinct mechanisms that com

99 a clinical diagnosis of asthma, a history of at least two exacerbations in the previous year that req

100 itation, symptoms of chronic bronchitis, and at least two exacerbations in the previous year.

101 severe eosinophilic asthma and a history of at least two exacerbations requiring treatment in the pr

102 diagnosis of asthma for at least 1 year and at least two exacerbations while on high-dosage inhaled

103 investigational therapies (19 [70%] received at least two experimental interventions).

104 suggests a molecular repeat unit comprising at least two extended beta-strands, separated by a turn

105 s to identify admixture into the steppe from at least two external sources.

106 aregiver should be present at all times, and at least two family caregivers should be trained specifi

107 We reveal the presence of at least two fibroblast lineages in murine dorsal skin.

108 Anti-C2Cat recognizes active cPKCs at least two-fold better than inactive kinase in ELISA a

109 after the onset of septic shock, defined as at least two-fold increase from baseline serum creatinin

110 These results are ascribed to at least two-fold increase in the concentrations of flav

111 incident cardiometabolic multimorbidity (ie, at least two from: type 2 diabetes, coronary heart disea

112 rdiometabolic multimorbidity (ie, developing at least two from: type 2 diabetes, coronary heart disea

113 tions, we find that a bundle operates within at least two functional regimes.

114 rmore, Atypical CR-expressing cells comprise at least two functionally distinct subpopulations based

115 These data imply that at least two gene regulatory networks act to coordinate

116 , whereas defence priming was maintained for at least two generations.

117 in bovines with respiratory disease and that at least two genetic and antigenically distinct clades c

118 At least two genetic loci affect the rate of Abeta-relat

119 Fully attenuated viruses required at least two genome segments from BTV8H, including Seg2

120 Of the 70 chemicals with at least two GL studies, 18 (26%) had discordant outcome

121 same genetic mutation, due to inhibition of at least two H3K36 methyltransferases, MMSET and SETD2,

122 ations suggests that each individual carries at least two heterozygous premature stop alleles that co

123 ongicarpus, allorecognition is controlled by at least two highly polymorphic allorecognition genes, A

124 a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regu

125 rthermore, we show that molecules containing at least two hydroxyl groups can be converted into metha

126 ia meningitides, and previous treatment with at least two immunosuppressive therapies or one immunosu

127 es have shown that motor learning results in at least two important neurophysiological changes: modul

128 aryotic phylogeny makes it a unique model in at least two important ways: as a representative of the

129 ncers that were associated with melanoma, in at least two independent analyses, included breast, pros

130 howed that 35% of genes with a cis eQTL have at least two independent cis eQTLs; for several genes up

131 Thus, there are at least two independent cleavage events that regulate T

132 entry of ADPriboDB is annotated manually by at least two independent curators from the literature be

133 SPPL3 associates with STIM1 through at least two independent domains, the transmembrane regi

134 eolar fate is a robust process controlled by at least two independent extrinsic signalling inputs.

135 These findings indicate that at least two independent mechanisms to overcome Slit-Rob

136 O version 2 (v2) framework, and ESMO-MCBS by at least two independent reviewers.

137 We demonstrate at least two independent rewiring events for PUF3 orthol

138 emonstrate that the TM domain of RNF144A has at least two independent roles, membrane localization an

139 RT017 strains have evolved in parallel from at least two independent sources and can readily transmi

140 alpha3beta1 was previously shown to activate at least two independent survival pathways.

141 other, one of which is a composite formed by at least two individuals walking in single file.

142 for T1D is immensely attractive but entails at least two inherent and thus far unresolved hurdles: 1

143 chieved for all lipids that were detected by at least two instrument platforms.

144 We assessed the incidence of patients with at least two insurance claims of flushing, diarrhoea, or

145 s complex contains four molecules, including at least two (IRAK-1 and IRAK-4) active kinases.

146 ranscript levels of five aflatoxin genes and at least two key global regulators of secondary metaboli

147 embryos, suggesting that any combination of at least two KH domains cooperate in tandem to bind RNA

148 ificantly affected by pressure and occurs in at least two kinetically distinct steps.

149 nolocalization experiments demonstrated that at least two laccases (LACCASE5 and LACCASE6) are presen

150 s, and currently survives only in captivity, at least two lines of evidence suggest that tool use is

151 nts with a BRCA1/2 mutation who had received at least two lines of previous chemotherapy.

152 ho are in complete or partial response after at least two lines of treatment; higher efficacy might b

153 spontaneous for distal monolayers containing at least two lipid components, given sufficiently negati

154 ge admitted with ESLD, defined as those with at least two liver decompensation events, were included

155 solid solution and ordered phases involving at least two M n+1AX n end members.

156 Present day eukaryotes employ at least two main defence strategies that emerged as a r

157 ring dendrimer internalization, traceable to at least two major endocytic mechanisms, clathrin-mediat

158 we show that opening of the Strait involved at least two major episodes of erosion.

159 Gradient sensing requires at least two measurements at different points in space.

160 conventional photodetectors, and performing at least two measurements to distinguish left- and right

161 the kinetics of fibril assembly suggest that at least two mechanisms are at play during the lag time:

162 ncer cells to a more resistant state through at least two mechanisms.

163 hat HSV-1 promotes the loss of IFI16 through at least two mechanisms: (i) by ICP0-dependent degradati

164 tection of beta-glucan by host cells through at least two mechanisms: concealment of beta-glucans ben

165 meiosis, we provide evidence that there are at least two meiosis-specific cohesin complexes.

166 nic Renal Insufficiency Cohort Study who had at least two mGFRs and two eGFRs determined concurrently

167 Keeping the milk at this temperature for at least two minutes would allow varying decrease in the

168 rial, we enrolled post-menopausal women with at least two moderate or one severe vertebral fracture a

169 dies demonstrated that RPA binds to ssDNA in at least two modes characterized by different dissociati

170 e, CtrA, and provide evidence that there are at least two modes of interaction between ChpT and CtrA,

171 oliferation of the lung mesenchyme by way of at least two molecular mechanisms: regulating cell-cycle

172 utral state, with high stability lasting for at least two months and high junction formation probabil

173 ts), unlike tomato, banana ripening requires at least two necessary members of the SEPALLATA MADS box

174 We propose the existence of at least two new restriction factors able to block HIV-1

175 flexible, and (ii) with all loops comprising at least two nucleotides, leading to topological dynamis

176 nical response, defined as an improvement in at least two of four symptoms (cough, chest pain, sputum

177 ation of lumen formation by miR-342 involves at least two of its known targets, namely ID4 and DNMT1.

178 34 from 51 (67%) NMOSD sera were positive on at least two of the 12 highly specific assays, leaving 3

179 frailty or prefrailty was defined as having at least two of the following: low muscle mass, self-rep

180 The operational diagnostic criteria (at least two of the following: nutritional deficiency, o

181 able to do so effectively in mutants lacking at least two of the four Arabidopsis DCL proteins.

182 If you put three pigeons in two pigeonholes, at least two of the pigeons end up in the same hole," is

183 In these glomeruli, at least two of the postsynaptic dendrites originated fr

184 Here, we would like to suggest that at least two of the structures reported in that study ar

185 identified in the two pools concordantly by at least two of the tools.

186 blind, placebo-controlled food challenges to at least two of their offending foods.

187 At least two of these activities are dependent upon the

188 At least two of these motifs are crucial for adhesion by

189 In 10T1/2 cells expressing Jun, at least two of three alleles per cell were induced, a s

190 Phosphorylation of at least two of three conserved sites in the activation

191 ivity of nested polymerase chain reaction in at least two of three regions (pre-S, S, and pre-core/co

192 ted between intact and degraded cartilage in at least two -omics levels, 16 of which have not previou

193 ion frequency in DNA methylation patterns of at least two orders of magnitude higher than somatic mut

194 ha9alpha10 ligands characterized to date are at least two orders of magnitude less potent on human vs

195 oxygen, it requires that Archean magmas had at least two orders of magnitude lower fO2 than modern m

196 an increase the specificity of sequencing by at least two orders of magnitude over and above that ach

197 duction of CD8(+) T cell responses targeting at least two otherwise subdominant epitopes.

198 Genetic alterations in at least two out of four genes were found in 95% of the

199 85646, we identified 56 proteins enriched in at least two out of the three experimental approaches.

200 nly apparent when surveillance data included at least two outbreaks and the intervening inter-epidemi

201 ounting for 68% of all paid claims), 16% had at least two paid claims (accounting for 32% of the clai

202 ormation of a cluster of Lgr5+ cells between at least two Paneth-cell-rich domains establishes the si

203 At least two parallel pathways impair peptidoglycan synt

204 otein was observed to be at equilibrium with at least two partially unfolded forms (PUFs).

205 ne dinucleotide-binding domain is split into at least two parts in all classes studied here.

206 conclude that PTHR recycles rapidly through at least two pathways, one involving the ASRT complex of

207 variants that segregated with severe COPD in at least two pedigrees.

208 At least two peptides were selected to represent peanut,

209 ern Asia fat-tail and European sheep, reveal at least two phylogeographically distinct genepools of f

210 We uncovered at least two plausible genes harboring CNV loci that are

211 dividual SOM fractions revealed the presence at least two pools of different turnover times (per SOM

212 ic, is found to adopt in its protonated form at least two populations of distinct structures in the g

213 tostatin(-) fibers were observed, suggesting at least two populations of NPY fibers within the BLA.

214 st samples from all patient categories, with at least two prevalent structures.

215 l, or fallopian tube carcinoma, had received at least two previous platinum-based chemotherapy regime

216 Of patients who had received at least two previous regimens including bortezomib and

217 posarcoma or leiomyosarcoma who had received at least two previous systemic regimens for advanced dis

218 onary vessels of the mouse heart derive from at least two progenitor pools, the sinus venosus and end

219 at direct active teaching in humans exhibits at least two properties (open-endedness and content opac

220 At least two proteins encoded by PEDV have been identifi

221 e cooperativity, implying the involvement of at least two protonation sites.

222 We further confirmed that at least two PTPS-2-producing species, Aldercreutzia equ

223 nt sepsis-serious infection plus presence of at least two "quick" Sequential Organ Failure Assessment

224 However, many studies involve at least two random factors (e.g., participants and the

225 single-cell analysis reveals the presence of at least two rate limiting steps.

226 A cascade is defined as the combination of at least two reaction steps in a single reaction vessel

227 detected thousands of circRNAs supported by at least two read counts, followed by successful experim

228 R1 can be cleaved by caspase or calpain into at least two receptor fragments.

229 s that for an efficient oxygen up-regulation at least two regulation mechanisms must be playing hand

230 en together, our results show that ICP0 uses at least two regulatory mechanisms to differentiate its

231 Phylogenetic analysis suggests that at least two regulatory uORFs (namely, in SLC35A4 and MI

232 rium systems is a natural meeting point for (at least) two research areas: nonlinear optical spectros

233 a extraction were completed independently by at least two researchers.

234 This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) t

235 This mechanism is conserved in at least two rodents and humans, making NOX4 a prime tar

236 eal that the Petunia lineage has experienced at least two rounds of hexaploidization: the older gamma

237 Peroxisome proliferation occurs by at least two routes, division of existing peroxisomes an

238 ve impairment as having one of these domains at least two SDs below population norms or at least two

239 rial division has been shown to proceed with at least two sequential constriction steps: the endoplas

240 ors into the T-cell fate is characterized by at least two sequential developmental stages.

241 haemoglobin of 20 g/L or higher observed in at least two serial measurements 1 week apart and sustai

242 At least two serious problems exist.

243 at least one confirmed H1N1pdm09 illness or at least two seroconverters were included.

244 72/180) of dyads allocated to iCST completed at least two sessions per week, with 22% (39/180) comple

245 ability or development, Ankrd1(-/-) mice had at least two significant wound-healing phenotypes: exten

246 Amorphous carbon as a stationary phase has at least two sites of interaction with analytes: basal-p

247 tis (at least three sites with CAL >4 mm and at least two sites with PD >3 mm, not in the same site o

248 At least two sodium ions bind before aspartate.

249 me-consuming and required the application of at least two software packages to convert HPTLC chromato

250 This competition is biased by at least two sources of information: the changing sensor

251 y 50%, indicating that this release was from at least two sources.

252 nce that such signaling noise can arise from at least two sources: (i) stochastic activities of adapt

253 We suggest the existence of at least two spatially distinct types of paracellular ch

254 e discovered that the recorded area includes at least two spatially segregated subnetworks that diffe

255 genes that have been positively selected in at least two species.

256 to show that synapsis of DNA ends occurs in at least two stages that are controlled by different NHE

257 The prevalence of severe impairment (ie, at least two standard deviations below normative mean) w

258 addition, our results suggest that there are at least two steps of incorporation of alpha-synuclein m

259 although 88% of proteins in our network has at least two structures in Protein Data Bank (PDB), only

260 e to college, and (b) have been evaluated in at least two studies.

261 om these OCs exhibits two kinetic phases and at least two subpopulations of ternary complexes.

262 le to one of the marker antibiotics and with at least two subsequent microbiological culture results

263 There are at least two subsets of monocytes: classical or proinfla

264 report that OSNs that express TAARs comprise at least two subsets that are biased to express TAARs ra

265 We show that ROC is composed of at least two subunits of NAD(+)-dependent retinol dehydr

266 In the inner ear, at least two systems regulate the planar polarity of sen

267 en colonic adenocarcinoma growth relied upon at least two targets of thrombin-mediated proteolysis, p

268 Previously, it was thought that at least two taus in the trimeric DnaX complex were requ

269 lthy participants without periodontitis with at least two teeth showing PreGR >/=2 mm were randomized

270 Individuals showing at least two teeth with proximal (clinical AL) progressi

271 number above 1 between January and June, and at least two thirds of infections being unnoticed.

272 We found loss of DNH in at least two thirds of iRBD subjects, which approaches t

273 ialyzed with a catheter instead, may explain at least two thirds of the mortality benefit observed in

274 that improved treatment was responsible for at least two thirds of the reduction in breast cancer mo

275 V ejection fraction is robustly preserved in at least two-thirds of older adults with prevalent HF (S

276 database for the United States, we show that at least two-thirds of the decline in organic aerosol ca

277 dependencies provides evidence of motions on at least two time scales.

278 of 35.9 Pg yr(-1) of soil eroded in 2012, is at least two times lower.

279 origins of the Yersinia pestis lineage to be at least two times older than previous estimates.

280 1]), whereas patients with LDH concentration at least two times the upper limit of normal (n=70) had

281 had undergone surgery with levator procedure at least two times.

282 , and mutational signature analysis revealed at least two to four genetic subclones per sample.

283 al teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different cli

284 received pembrolizumab for >/= 6 months and at least two treatments beyond confirmed CR could discon

285 different initiating CNS injuries can elicit at least two types of "reactive" astrocytes with strikin

286 At least two types of enzymes were found to be involved

287 mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: no

288 presence of one or more species that contain at least two units of the chiral entity.

289 It requires at least two unpaired nucleotides at the 5' end of its s

290 that Escherichia coli RppH (EcRppH) requires at least two unpaired nucleotides at the RNA 5' end and

291 At least two vestibular areas are located at this site:

292 Rotaviruses use at least two viral multifunctional proteins to directly

293 is protein is necessary for the secretion of at least two VirB substrates that have a periplasmic int

294 endosomes, together with the recruitment of at least two Vps4 hexamers.

295 gnal and show that Lte1 activates the MEN in at least two ways.

296 ulosis (TB) can help guide drug discovery in at least two ways.

297 luences serotoninergic neurotransmission via at least two ways: (1) by provoking a release of seroton

298 g degrees of spatial overlap, maintained for at least two weeks of the herring spawning period.

299 ncreased the storage life of pork nuggets by at least two weeks, i.e. from 21 days to 35 days at 4 +/

300 ic withdrawal syndrome was defined as having at least two Withdrawal Assessment Tool-Version 1 scores