ライフサイエンスコーパス: at the center of

1 Iron lies at the center of a battle for nutritional resource betwe

2 alpha(c), and whether the cavity is located at the center of a cell face or formed at the junction o

3 lts place inflammatory monocyte-derived PGE2 at the center of a commensal-driven regulatory loop requ

4 critical role in protein expression, and is at the center of a complex regulatory network.

5 These issues lie at the center of a conjecture more than a century old, w

6 Stomatal transpiration is at the center of a crisis in water availability and crop

7 , 108 mAs) was 9 mGy (absolute dose measured at the center of a CT dose index phantom).

8 Our study places STIM2 at the center of a feedback module that keeps basal cyto

9 mediated by residues of TMHs 2, 3, 4, and 5 at the center of a four-helix bundle.

10 The third gadolinium atom resides at the center of a hexagonal face of the fullerene.

11 ments of the membrane depth of a Trp residue at the center of a hydrophobic sequence.

12 s where FMR1 is active, the FMR1 promoter is at the center of a large ( approximately 50 kb) domain o

13 discovered that Campylobacter jejuni FlhG is at the center of a multipartite mechanism that likely in

14 the relative occupancy of protein and lipid at the center of a natural membrane.

15 Like the others, this breakpoint occurs at the center of a palindromic sequence.

16 so increased by Wnt, indicating that SOX9 is at the center of a positive feedback loop that enhances

17 ail contains a completely conserved proline, at the center of a predicted beta-coil-beta motif.

18 ts, placing LTB(4) regulation of FLS biology at the center of a previously unrecognized amplification

19 erosol form on a substrate to a small region at the center of a radially symmetric cationic gradient

20 n important biological mediator and has been at the center of a rapidly expanding field focused on un

21 critical gaseous signaling molecule emerging at the center of a rich field of chemical and biological

22 Each is at the center of a rotating stellar disk, surrounded by

23 Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabiliz

24 These data place Elf5 at the center of a stoichiometry-sensitive transcription

25 bosomal protein L10 (E. coli L16) is located at the center of a topological nexus that connects many

26 y a decade after its original identification at the center of a translocation breakpoint in a large S

27 problem solving and decision-making, and is at the center of a variety of cognitive, addictive, mood

28 the timing of motor protein activation lies at the center of a wide range of cellular motile process

29 Staphylococci grow as communities at the center of abscess lesions and are enclosed by pse

30 s) with peptides bound to MHC molecules lies at the center of adaptive immunity.

31 Immune system defects are at the center of aging and a range of diseases.

32 , ultimately, amyloid fibrils, appears to be at the center of Alzheimer's disease (AD) pathology.

33 ation originating from massive O and B stars at the center of an expanding HII bubble, one of which m

34 tudied for centuries, sulfur continues to be at the center of an extensive array of scientific resear

35 -binding site with equal affinity when it is at the center of an oligonucleotide too short to bind to

36 This multiplicity of roles positions ICOS at the center of attention for immunotherapy where manip

37 onvenient methods, biosensing techniques are at the center of attention to improve stem cells charact

38 Reciprocity and repeated games have been at the center of attention when studying the evolution o

39 eters (eta(Q)) for the halogen-bonded anions at the center of bonding environments ranging from appro

40 Residing at the center of cell biology, cellular functions, and d

41 he lower epidermal surface left rimmed pores at the centers of cell rosettes; these were similar in s

42 PARP-1 functions at the center of cellular stress responses, where it pro

43 n of breast cancer metastasis is justifiably at the center of clinical attention.

44 g & Bargh's (H&B's) theory that places goals at the center of cognition, and I discuss two ingredient

45 At the center of computational systems biology are mathe

46 Mus musculus enjoys pride of place at the center of contemporary biomedical research.

47 on outcomes of many key land-use transitions at the center of current policy debates.

48 m-long rod in a horizontal arc, with the eye at the center of curvature of the arc so that the measur

49 rovide insight into the biology of a protein at the center of devastating progeroid diseases.

50 This complex question has been at the center of developmental biology for many years.

51 a phylum of meiofaunal organisms, have been at the center of discussions of the evolution of Metazoa

52 mposes into two nonconducting states located at the center of domain walls and edges of domains.

53 The white adipocyte is at the center of dysfunctional regulatory pathways in va

54 Lacteals are lymphatic vessels located at the center of each intestinal villus and provide esse

55 ddle Au layer, which contacts the fluid only at the center of each nanochannel, serves as a working e

56 intain high levels of DNA hydroxymethylation at the center of enhancers in a Tet2-dependent manner, w

57 Mutation of isoleucine-386 at the center of ER46's transmembrane hydrophobic core p

58 at place the leaf nitrogen-Asat relationship at the center of explanations of plant fitness and compe

59 n, acuity and color sensitivity are greatest at the center of fixation and fall off rapidly as visual

60 cretion onto some massive black holes (MBHs) at the centers of galaxies actively powers luminous emis

61 PSZ will hyperfocus on information presented at the center of gaze.

62 Parental education is located at the center of global efforts to improve child health.

63 ~24.5 A. gp12 forms spikes that are anchored at the center of gp13 hexamers.

64 otifs that have location preference, such as at the center of H3K27ac or at the edges of H3K4me3 and

65 ral network of Ga and Ge atoms with Mn atoms at the centers of half the octahedra and Y atoms in the

66 100% conserved in FIS homologues, is located at the center of helix B, and its substitution for alani

67 However, iron lies at the center of host-pathogen competition for nutrition

68 easingly suggests that sub-Saharan Africa is at the center of human evolution and understanding route

69 lpha (TNF-alpha)-converting enzyme (TACE) is at the center of inflammatory processes.

70 recent Keystone Symposium, "Dendritic Cells at the Center of Innate and Adaptive Immunity," organize

71 These results place the macrophage at the center of ischemia-induced arteriogenesis, and th

72 a valine to glutamic acid (V(664)E) mutation at the center of its alpha-helical transmembrane domain.

73 ing the identity of non-contacted base pairs at the center of its binding site.

74 beta (MIP-1beta) by placing a disulfide bond at the center of its dimer interface through a single am

75 rom sequence data, or haplotype assembly, is at the center of major challenges in molecular biology a

76 iew recent experiments that have placed NF-Y at the center of many developmental stress-responsive pr

77 ons involved because catalyzed reactions are at the center of many enterprises of chemical and petrol

78 ns of the Earth and chondritic meteorites is at the center of many important debates.

79 or pH-dependent regulation of Vps34 could be at the center of many PtdIns(3)P-dependent cellular proc

80 The organization of actomyosin networks lies at the center of many types of cellular motility, includ

81 In each shape, the nucleus is positioned at the center of mass and is stretched by microtubules a

82 fs1, which supplies sulfide, thus placing it at the center of mitochondrial FeS cluster biosynthesis.

83 on of protein-protein interactions (PPIs) is at the center of molecular biology considering the unque

84 n of the dystrophin-glycoprotein complex, is at the center of molecular studies of muscular dystrophi

85 5) times that of the Sun) are known to exist at the center of most galaxies with sufficient stellar m

86 and place the dysregulation of RNA pathways at the center of motor neuron degeneration pathogenesis.

87 , acetylcholine receptors (AChRs) accumulate at the center of muscle fibers, precisely where motor gr

88 Ci is a novel and potent target to intervene at the center of neuroinflammation.

89 The United States is at the center of one cluster; European countries make up

90 t is predicted to form an arginine-rich pore at the center of one of the Vps4 hexameric rings.

91 Stars with short orbital periods at the center of our Galaxy offer a powerful probe of a

92 eptide vasopressin, and their receptors--are at the center of physiological and genetic systems that

93 erved that lysosomal marker LAMP-1 localized at the center of podosome rosettes protruding into extra

94 ous small RNAs called the Qrr sRNAs function at the center of quorum-sensing pathways.

95 that MCAK colocalized with NuMA and XMAP215 at the center of Ran asters where its activity is regula

96 ty of glutamate receptor activation from 0.4 at the center of release to 0.1 just 200 nm away.

97 Monitoring gene expression is at the center of research for a wide variety of medical,

98 remains a subject of lively debate that lies at the center of research into anthropoid origins.

99 Real-time imaging was performed at the center of restoration by the OCT system (laser ce

100 like subunits form a TFIID-like core complex at the center of SAGA that makes extensive interactions

101 pecific neurons located in the mantle region at the center of segments, adjacent to the nonneurogenic

102 s the mature amyloid fibrils that accumulate at the center of senile plaques.

103 ibitor in metazoan circadian clocks and lies at the center of several feedback loops that regulate ge

104 Such conservation places ILP signaling at the center of sex-related phenomena in early animal d

105 le factor (HIF) transcription factors reside at the center of signaling pathways used by mammalian ce

106 ons confirm the presence of Cu(2+) ions only at the center of single 6-rings that act not only as a c

107 At the center of SNARE complexes is a distinctive zero l

108 n gamma-ray bursts (GRBs), microquasars, and at the center of some galaxies [active galactic nuclei (

109 faces of silica, while generating void space at the center of spheres.

110 tion points of different topological charges at the center of star-shaped microfluidic junctions, whi

111 Intracellular Ca2+ signaling remains at the center of stimulus secretion coupling and its reg

112 Intracellular Ca(2+) signaling remains at the center of stimulus secretion coupling and its reg

113 viral replication, was abundant within cells at the center of such clusters, but often scarce in cell

114 s of growth and development, which have been at the center of the 'green revolution'.

115 same conditions, a spherical EAR was placed at the center of the 10-m layer and intercepted flying i

116 0 new intersubunit interactions per particle at the center of the 20 hexameric capsomeres, which are

117 At the center of the ABA signaling network is a subfamil

118 lpha-helix that sits within the VH CDR3 loop at the center of the antigen binding site.

119 surface and, once proximal to the centrosome at the center of the apical surface, enables cilium form

120 ts that allowed for greater electron density at the center of the aromatic ring showed a greater pote

121 Second, a phenylalanine residue at the center of the ATP pocket strongly affects the abi

122 between the motif and complementary patches at the center of the beta'-COP propeller.

123 rientation of the molecule such that it lies at the center of the bilayer, perpendicular to the bilay

124 arged membrane surface and Arg2320 is poised at the center of the binding interface.

125 to be critical for drug binding, is located at the center of the binding pocket.

126 s indicate that the non-contacted base pairs at the center of the binding site are in the B' state.

127 One region, located at the center of the binding site, has a similar structu

128 2)(n)() type, the nitride ion is not located at the center of the carbon cage but is offset by 0.36 A

129 alent cation is electrostatically stabilized at the center of the cavity of the KcsA potassium channe

130 in an average MinD concentration that is low at the center of the cell and high at the poles.

131 y, the microtubule and organelle-rich region at the center of the cell-the endoplasm-needs to extend

132 At the center of the cells, dark-stained "mediation elem

133 were included in a large T cell invagination at the center of the cellular interface within 1 min of

134 inside the large hydrophobic cavity located at the center of the channel, consistent with the result

135 The arrangement of the OLED at the center of the chip provides for two sensing regio

136 inent role in the sugar-protein interactions at the center of the chitin-binding cleft.

137 A partially occupied U site is located at the center of the cluster.

138 res reveals a flexible joint that is located at the center of the coiled-coil helices.

139 n chelator, is heterogeneous, with a maximum at the center of the colony.

140 mune function in humans, which places leptin at the center of the complex networks that coordinate ch

141 extensive self-complementary dimer interface at the center of the complex, and the EryCII subunits li

142 gments of the two MotB subunits are together at the center of the complex, surrounded by the TM3 and

143 of distinct domains that contact each other at the center of the complex.

144 At the center of the computational cerebellar circuitry

145 stimulus onset, while "perimovement" neurons at the center of the continuum responded only 150 ms be

146 ects, and a reduced density of nerve endings at the center of the cornea.

147 origin and terminus regions are found mostly at the center of the cross section, balanced by the para

148 ure of the interference, the analytical bias at the center of the cross-sectional profile varied betw

149 Noncoding RNAs are at the center of the CsrA system; target mRNAs are bound

150 1 (EEA1)-positive vesicles are concentrated at the center of the cVAC and, as previously seen, are d

151 At the center of the debate on the emergence of modern h

152 a limited degree of osteoinduction was seen at the center of the defect.

153 At the center of the development of acute care surgery i

154 transforming growth factor-beta, a cytokine at the center of the differentiation of IL-17-producing

155 ission of a tryptophan strategically located at the center of the dimer interface.

156 Aniracetam binds to a symmetrical site at the center of the dimer interface.

157 nding is located between the W15 side chains at the center of the dimeric hydrophobic core, with the

158 The gel thinning rate measured at the center of the dish appears as a robust observable

159 spans southern Nigeria and western Cameroon at the center of the distribution of this species.

160 tide is required to generate a local opening at the center of the DNA junction that is observed by 2-

161 amino acids in the peptides stack with bases at the center of the DNA substrates.

162 e was taken to be on a single chain of bases at the center of the double helix.

163 g that the highest ionic density was located at the center of the drift tube.

164 d the rim of droplet and the point electrode at the center of the droplet, we generate the radial ele

165 rgery, irregular posterior lamellar incision at the center of the eyelid (OR, 6.72; 95% CI, 1.55-29.0

166 oliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic

167 ional twisting, and strong symmetry breaking at the center of the fiber, which provides potential for

168 allel detector planes), the image resolution at the center of the field of view was 0.9-mm FWHM with

169 at a 40 degrees angle), the image resolution at the center of the field of view was 1.0-mm FWHM with

170 imum absolute sensitivity for a point source at the center of the field of view was 7.7%.

171 The average spatial resolution at the center of the field of view was about 1.2 mm, imp

172 canner offers a spatial resolution, measured at the center of the field of view, ranging from 0.6 to

173 low 1.8-mm full width at half maximum (FWHM) at the center of the field of view.

174 The averaged sensitivity was 13.7 cps/kBq at the center of the field of view.

175 The sensitivity of the device is 0.064% at the center of the field, 46-fold lower than the sensi

176 in thin glassy films, we find that particles at the center of the film and those near the surface are

177 A single tryptophan at the center of the five-helix bundle toggled conformat

178 that the Mg(2+)/F(-)/phosphate/water cluster at the center of the fluoride riboswitch is stable by it

179 zation purity in the focal region, observing at the center of the focus a low impurity <3 x 10(-4) in

180 At the center of the fourfold-symmetric structure is a t

181 l changes in the DNA, leading to the bending at the center of the full site, which in turn is depende

182 l domain of each daughter cell is maintained at the center of the growing structure through a combina

183 The protein kinase PDK1, which lies at the center of the growth-factor signaling pathway, po

184 ecognition determinants are a purine located at the center of the hairpin loop (-11G) and a base at t

185 p53 dimer, there was an apparent DNA bending at the center of the half site; when bound with two p53

186 sites plus a single secondary site situated at the center of the hexamer.

187 NCOs peaked at the center of the hot spot but were also broadly dist

188 that the area occupied by protein and lipid at the center of the human red blood cell (RBC) plasma m

189 were used to determine the location of a Trp at the center of the hydrophobic sequence.

190 A Ca2+-binding site is revealed at the center of the hyper-variable surface next to spli

191 preserved in basal ice for millions of years at the center of the ice sheet at Summit, Greenland.

192 mal vesicles, which are recruited and docked at the center of the immune synapse of B-cells.

193 DCs are at the center of the immune system owing to their abilit

194 ly associates with the T cell receptor (TCR) at the center of the immunological synapse.

195 At the center of the initiation pathway, the 13-subunit

196 e phagocytic cup and phagocytosis, which are at the center of the innate immune system function.

197 ly favors overlapping flexible dinucleotides at the center of the integration site.

198 h transforming growth factor-beta1 signaling at the center of the interaction network.

199 f the cytokinetic midbody structure, located at the center of the intercellular bridge.

200 f the positively charged Arg-172 of IIB(Man) at the center of the interface.

201 Thus, gD is at the center of the interplay between HVEM and its liga

202 Thus, macrophages are at the center of the invasion microenvironment and are a

203 the presence of an interstitial carbon atom at the center of the iron-molybdenum cofactor (FeMoco) o

204 crotubule end-on capture-shrinkage operating at the center of the IS and not cortical sliding at the

205 end-on capture-shrinkage mechanism operating at the center of the IS.

206 st significant single SNP in this region was at the center of the ITPR3 peak of association (P=1.7 x

207 Substitution of phosphate groups at the center of the junction reveals the importance of

208 eal inlay was implanted under a corneal flap at the center of the light-constricted pupil created wit

209 sfer free energies of 20 amino acid residues at the center of the lipid bilayer of OmpLA.

210 Mutation of four residues, V(151)SNV(154), at the center of the loop (MutA) abrogated fast inactiva

211 4Y and PheH Y138F, variants with the residue at the center of the loop substituted with the residue p

212 lly significant macular edema (CSME), and RT at the center of the macular (RTCM).

213 s from the periplasmic side of F0 to cAsp-61 at the center of the membrane is likely to be mediated b

214 e the two redox-active cysteines are located at the center of the membrane, accessible on both sides

215 residues 214 and 215 in TMH4 and 252 in TMH5 at the center of the membrane.

216 ctions of the force applied via the tip link at the center of the membrane.

217 These findings place DRiPs at the center of the MHC class I antigen processing path

218 the activity of the supermassive black hole at the center of the Milky Way, known as Sagittarius A*

219 If the myocardial cell is placed at the center of the model, all the potential pathologic

220 ween Th1 cells and APC, while CD45 was found at the center of the multifocal IS formed by Th2 cells.

221 ation placed old, cold genes and communities at the center of the networks, and young, hot genes and

222 e the caudate nucleus of the dorsal striatum at the center of the neural stimulus-control learning ma

223 3F-2 with aromatic residues at the center of the nonpolar face partitions closer to

224 At the center of the nuclear pore complex (NPC) is a uni

225 replication terminus region positions itself at the center of the nucleoid.

226 ear structure that positions heterochromatin at the center of the nucleus focusing light on photorece

227 The reactions of peroxyl radicals are at the center of the oxidative degradation of essentiall

228 conjugated particles were immunoagglutinated at the center of the paper channel.

229 The strategic placement of a molecular motor at the center of the particle further suggests a mechani

230 Alveolar macrophages (AM) are at the center of the pathogenesis of the development of

231 on to simulate stretch along the nerve fiber at the center of the PC.

232 plexes reveal one inhibitor molecule located at the center of the PD-L1 homodimer, filling a deep hyd

233 nexpected site for binding an [Fe-S] cluster at the center of the PduT pore.

234 t few transitions, possible steps take place at the center of the peptide chain; subsequently, severa

235 max) and quenching the fluorescence of a Trp at the center of the peptide sequence.

236 red at the shoulder of the plaque and in 30% at the center of the plaque.

237 nel function by affecting the hinging motion at the center of the pore-lining transmembrane helix tha

238 e interior wall, causing a partial narrowing at the center of the pore.

239 olving a single ring of hydrophobic residues at the center of the pore.

240 In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spina

241 he channel, are located in the D-loop region at the center of the predicted dimer interface.

242 E and F move outward from the proton channel at the center of the protein, and helix D tilts inward.

243 h binding sites are located in a deep cavity at the center of the protein.

244 Four ion-binding sites cluster at the center of the protein: one specific for Ca(2+) an

245 ore than one hundred years ago, attention is at the center of the psychological enterprise.

246 and P1parS is the presence of a 21-bp insert at the center of the pWR100parS site.

247 ne and, surprisingly, the preferred size was at the center of the range, the same optimum size as rec

248 tion that features a deep hydrophobic pocket at the center of the receiver domain interface.

249 rotation velocity sensitive to DNA sequence at the center of the recombination crossover site, torsi

250 The loop possesses a hydrophobic core at the center of the region with an unusual basic residu

251 Repair at the center of the repeat resulted in deletion of appr

252 within the dodecamer and a Lys-Trp-Lys triad at the center of the ring are important for oligomerizat

253 mages tracing the shock wave as it converges at the center of the ring before reemerging as a divergi

254 s for their electrostatic surface potentials at the center of the rings.

255 Although SRPK1 initially binds at the center of the RS domain phosphorylating in an ord

256 ive site of SRPK1 docks in a flexible manner at the center of the RS domain.

257 A channel-like region at the center of the S1-S4 helical bundle fills rapidly

258 m the whole scan range and Dw from the image at the center of the scan range provided an easily obtai

259 The fluorescence of a Trp at the center of the sequence and its sensitivity to que

260 he original gold triangular frame is visible at the center of the silver nanoplate).

261 Heights measured at the center of the ST exceeded those in the modiolar a

262 bursts from the young pulsar PSR J1846-0258, at the center of the supernova remnant Kes 75.

263 that CARD11 scaffold function and occupancy at the center of the synapse are negatively regulated by

264 Instead, the HIV Env accumulated with TCR at the center of the synapse, altered the kinetics of TC

265 AG is created with a persistent focus of DAG at the center of the synapse.

266 regulator of F-actin generation, Coronin 1A, at the center of the T cell interface with the antigen p

267 l activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell inte

268 a dipolar far field and a polarity reversal at the center of the terminal zone.

269 A C-terminal Pro-Cys motif is localized at the center of the tetramer and forms reversible enzym

270 bisecting the femur and tibia and converging at the center of the tibial spine tips.

271 t that a double mutation at i, i+4 positions at the center of the TM domain dimer eliminates the barr

272 eport here the effects of structural changes at the center of the turn, Gly25-Ser26, on Abeta42 confo

273 At the center of the type 1 inflammatory response is the

274 At the center of the vertebrate notochord is a large flu

275 ncentration and offer electron-dense regions at the center of the vesicle.

276 the earmuff domains, and a pronounced cleft at the center of the Vps75 dimer.

277 At the center of the wound, neither EMD nor amelogenin h

278 , Cdc42p forms a novel Fus2p-dependent focus at the center of the zone of cell fusion (ZCF) and remai

279 The peaks located at the centers of the doublets are obtained from simulta

280 nin exhibited normal junctional localization at the centers of the tumors but were reduced or delocal

281 have been shown to bind the histone H3 tail at the center of their beta-propeller structure.

282 ssential for assembly and trafficking and is at the center of their quality control mechanism.

283 immune cells with staphylococci replicating at the center of these lesions.

284 rboxykinase (Pck; EC 4.1.1.32) is the enzyme at the center of these metabolic rearrangements.

285 ll-known breast cancer tumor suppressor, are at the center of this choice.

286 At the center of this debate is the assertion that agric

287 At the center of this dsRNA binding epitope, and common

288 At the center of this failure is insufficient training f

289 of the wild house mouse revealed instability at the center of this hot spot.

290 At the center of this large sRNA regulatory network is t

291 At the center of this mechanism is the Get3 homodimer, w

292 graph theory, we identified 14 TFs that lie at the center of this network, including Flo8, Mss11, an

293 At the center of this pathway is gut microbiota-dependen

294 -2)RIU, with peak sensitivity of 3x10(-7)RIU at the center of this range.

295 yelodysplastic syndrome 1 (MDS1) are located at the center of this region, and their DNA copy number

296 gical inflammation and place the endothelium at the center of this regulatory network.

297 Proteins are targeted to the protease at the center of this system, the proteasome, by ubiquit

298 after cross-linking paired Cys substitutions at the center of TMHs within subunit a.

299 Epidemiology is at the center of translational science.

300 overed virus, tobacco mosaic virus (TMV) was at the center of virus research.