ライフサイエンスコーパス: at the leading edge of

1 of chemoattractants elicit signaling events at the leading edge of a cell even though chemoattractan

2 echanics of the dense branched network found at the leading edge of a crawling cell.

3 The expression of Notch1 was reduced at the leading edge of a healing corneal epithelium both

4 expression of cytosolic PLAC8, CDH3, and VIM at the leading edge of a human colorectal tumor, support

5 The extension of a pseudopod at the leading edge of a migratory cell and the formatio

6 addressed include the rate of actin assembly at the leading edge of a moving cell, the disassembly ra

7 rude forward from the lamellipodium, located at the leading edge of a neuronal growth cone, are neede

8 domains specific for PI(3,4,5)P3 accumulate at the leading edge of a number of migrating cells and t

9 At the leading edge of adherent cells, curvature waves a

10 , the co-localization of RAGE and amphoterin at the leading edge of advancing neurites indicated thei

11 revealed rapid relocation to and clustering at the leading edge of alpha7 nicotinic and M(1) muscari

12 may massively underestimate dispersal rates at the leading edge of an expanding population.

13 trophic position of L. humile remained high at the leading edge of an invasion front but declined, o

14 lation in most new species introductions, or at the leading edge of an ongoing invasion, is likely to

15 from focal adhesions to lamellipodia located at the leading edge of AND-34 overexpressing cells.

16 of coordination of the protrusive activities at the leading edge of ARPC3(-/-) fibroblasts.

17 In addition, p35/Cdk5 kinase concentrates at the leading edges of axonal growth cones and regulate

18 required for the generation of motile force at the leading edge of both lamellipodia and filopodia a

19 d for its proper localization in invadopodia at the leading edge of breast cancer cells during three-

20 sin II assembly, colocalizes with myosin IIA at the leading edge of cancer cells, suggesting direct r

21 2 directly binds and phosphorylates stathmin at the leading edge of cancer cells.

22 calization of a key regulatory protein (tTG) at the leading edges of cancer cells and the important c

23 d a condensation of focal adhesion complexes at the leading edges of cell processes and FAK-paxillin

24 reorganization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca(2+) en

25 he phosphorylation of the myosin light chain at the leading edge of cells and increases the phosphory

26 which translocates to inositol phospholipids at the leading edge of cells during chemotaxis.

27 However, F-actin was polymerized at the leading edge of cells during electrotaxis.

28 o activation of Rac and inactivation of RhoA at the leading edge of cells moving in 3D matrix.

29 show that alpha4beta1 forms transient puncta at the leading edge of cells that begin to protrude lame

30 ling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM

31 ic nucleation model for actin polymerization at the leading edge of cells.

32 o control actin filament length and geometry at the leading edge of cells.

33 trated that SOCE regulates membrane ruffling at the leading edge of cells.

34 ation by hindering the turnover of adhesions at the leading edge of cells.

35 ium, leading to the positioning of adhesions at the leading edge of cells.

36 eceptor, DOCK4, and Dynamin, which is formed at the leading edge of cells.

37 This pathway is prominent at the leading edges of cells where phosphatidylinositol

38 ocalizes with beta1-integrin on lamellipodia at the leading edges of cells.

39 rotein regulated the localization of F-actin at the leading edge of chemokine-stimulated cells and wa

40 or of Ras signaling, C2GAP1, which localizes at the leading edge of chemotaxing cells and is activate

41 and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regula

42 Ras activation occurs at the leading edge of chemotaxing cells, and this local

43 , and activated Rap1 is preferentially found at the leading edge of chemotaxing cells.

44 opy approach showed local activation of RacC at the leading edge of chemotaxing cells.

45 ing cell signaling events, including signals at the leading edge of chemotaxing cells.

46 l activation of TORC2 are tightly controlled at the leading edge of chemotaxing cells.

47 y ubiquitous GTPase that localizes in a ring at the leading edge of constricting plasma membranes dur

48 ldarius and observed a distinct protein belt at the leading edge of constriction furrows in dividing

49 e demonstrate that P2X7 expression increases at the leading edge of corneal epithelium after injury i

50 been proposed to generate the actin network at the leading edge of crawling cells in vivo [3, 4, 8].

51 activated alpha(M)beta(2) integrin clusters at the leading edge of crawling neutrophils, allowing ca

52 y mechanism for controlling signaling events at the leading edge of directionally migrating cells.

53 Receptors on the growth cone at the leading edge of elongating axons play critical gu

54 n is most likely related to its localization at the leading edge of emerging protrusions.

55 um synthesizes high-density storage granules at the leading edges of engulfing membranes.

56 d evolution of distinctive phenotypic traits at the leading edges of expansions.

57 nsformed fibroblasts: ezrin was concentrated at the leading edge of extending pseudopodia of Fos-tran

58 ly that co-localizes with the Arp2/3 complex at the leading edge of fibroblasts, and co-immunoprecipi

59 h proteins is colocalized with actin patches at the leading edge of growth cones.

60 and increased levels of CASK and E-cadherin at the leading edge of healing wounds, consistent with i

61 cking its cargo-binding tail moves laterally at the leading edge of lamellipodia and induces filopodi

62 vealed a new finding: ZO-1 was also detected at the leading edge of lamellipodia, especially in motil

63 cate that Ena/VASP proteins rapidly exchange at the leading edge of lamellipodia, whereas virtually n

64 that microglial cells express CB2 receptors at the leading edge of lamellipodia, which is consistent

65 tion and triggers CA IX protein accumulation at the leading edge of lamellipodia.

66 The presence of an "arc" of Rac2 at the leading edge of leukocyte pseudopodia and PLD2 ph

67 and increased Stat3 activity was identified at the leading edge of lung tumors invading adjacent non

68 are actin- and fimbrin-containing adhesions at the leading edge of macrophages.

69 cytomas, and colocalizes with RAC1 and CDC42 at the leading edge of migrating astrocytoma cells.

70 are actin-rich fingerlike protrusions found at the leading edge of migrating cells and are believed

71 integrin and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patte

72 more, beta2-adaptin is enriched in adhesions at the leading edge of migrating cells and depletion of

73 a1 and Kir4.2 colocalized in focal adhesions at the leading edge of migrating cells and inhibition or

74 e data we show that Larp1 protein is present at the leading edge of migrating cells and interacts dir

75 ow that PKA activity gradients are generated at the leading edge of migrating cells and provide addit

76 r basis of the formation of 'sticky fingers' at the leading edge of migrating cells and show that an

77 cortex upon chemoattractant stimulation and at the leading edge of migrating cells and this localiza

78 within the treadmilling actin filament array at the leading edge of migrating cells are interdependen

79 Dcx localization and function are regulated at the leading edge of migrating cells by a balance of k

80 directional sensing and pseudopod extension at the leading edge of migrating cells during chemotaxis

81 ivation of the Par6-PKCzeta complex by Cdc42 at the leading edge of migrating cells promotes both the

82 Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulat

83 t state, but the phosphorylated CaD is found at the leading edge of migrating cells where dynamic act

84 phorylation of GSK-3beta occurs specifically at the leading edge of migrating cells, and induces the

85 Filopodium, a spike-like actin protrusion at the leading edge of migrating cells, functions as a s

86 Focal adhesions are dynamic constructs at the leading edge of migrating cells, linking them to

87 At the leading edge of migrating cells, protrusion of th

88 leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression o

89 role in the stabilization of focal contacts at the leading edge of migrating cells, the mechanisms a

90 and phospho-alpha4 were in distinct clusters at the leading edge of migrating cells, whereas unphosph

91 AG3 protein partially colocalizes with actin at the leading edge of migrating cells, wherein active a

92 ed PKA biosensor to reveal activation of PKA at the leading edge of migrating cells.

93 ck180/Elmo complex to promote Rac activation at the leading edge of migrating cells.

94 Wave-2 is required for actin polymerization at the leading edge of migrating cells.

95 actin to facilitate lamellipodial protrusion at the leading edge of migrating cells.

96 clathrin and AP2 in clathrin-coated pits and at the leading edge of migrating cells.

97 ociated with sites of dynamic actin assembly at the leading edge of migrating cells.

98 of the actin network that drives protrusion at the leading edge of migrating cells.

99 with paxillin to rudimentary focal complexes at the leading edge of migrating cells.

100 phs the formation of branched actin networks at the leading edge of migrating cells.

101 orces that would otherwise impede protrusion at the leading edge of migrating cells.

102 eas the cytoplasmic APC protein concentrated at the leading edge of migrating cells.

103 sor to reveal activation of Rab13 by DENND2B at the leading edge of migrating cells.

104 ze P-Rex1 guanine nucleotide exchange factor at the leading edge of migrating cells.

105 zyxin recruits zyxin to force-bearing sites at the leading edge of migrating cells.

106 (IQGAP1) is recruited and overlaps with ARF6 at the leading edge of migrating cells.

107 l migration is the formation of lamellipodia at the leading edge of migrating cells.

108 perties in that it predominantly accumulates at the leading edge of migrating cells; however, the pat

109 ction in a complex at adherens junctions and at the leading edge of migrating endothelial cells to mo

110 and beta-catenin at cell-cell junctions and at the leading edge of migrating endothelial cells.

111 ZO-1's appearance at the leading edge of migrating fibroblasts makes it a

112 We also find ZW10 enriched at the leading edge of migrating fibroblasts, suggesting

113 entation of sparsely labeled F-actin network at the leading edge of migrating human keratinocytes, re

114 found to be concentrated in the lamellipodia at the leading edge of migrating MDA-MB-231 cells.

115 to also result in reduced filamentous actin at the leading edge of migrating neurons, associated wit

116 Precise optoPlexin activation at the leading edge of migrating osteoblasts readily ind

117 s of Arp2, Arp3, cofilin, and phosphocofilin at the leading edges of migrating cells, in wound-healin

118 ctioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coord

119 bstratum interfaces, at focal adhesions, and at the leading edges of migrating cells.

120 egulates contractile force and Rac1 activity at the leading edge of migratory cells and the spine hea

121 les in their more stable regions - localizes at the leading edge of migratory cells and trims microtu

122 s localized and was preferentially activated at the leading edge of migratory cells in response to ad

123 but they have only been extensively studied at the leading edges of migratory fibroblasts, where the

124 Arp2/3 complex is concentrated at the leading edge of motile Acanthamoeba, and its loca

125 f cell surface tissue transglutaminase (tTG) at the leading edge of motile cancer cells.

126 rk assembly and disassembly in two contexts--at the leading edge of motile cells and in the actin com

127 es the formation of branched actin filaments at the leading edge of motile cells and in the comet tai

128 RhoA is activated at the leading edge of motile cells by unknown mechanism

129 The actin filament network at the leading edge of motile cells relies on localized

130 Studies of actin dynamics at the leading edge of motile cells with single-molecule

131 nique capability of producing pushing forces at the leading edge of motile cells without the implicat

132 ex nucleates and cross-links actin filaments at the leading edge of motile cells, and its activity is

133 the formation of the dendritic actin network at the leading edge of motile cells, but it is still unc

134 However, at the leading edge of motile cells, talin colocalises w

135 plex stimulates formation of actin filaments at the leading edge of motile cells.

136 rane ruffles and in a gradient of activation at the leading edge of motile cells.

137 flow toward the cell center, such as occurs at the leading edge of motile cells.

138 ly of a branching network of actin filaments at the leading edge of motile cells.

139 the structure of the actin filament network at the leading edge of motile cells.

140 cleates actin filaments to generate networks at the leading edge of motile cells.

141 tin filament branches during endocytosis and at the leading edge of motile cells.

142 These sites colocalized with beta-actin mRNA at the leading edge of motile myoblasts, confirming that

143 the dynamics and geometry of actin networks at the leading edges of motile cells, and one that has c

144 sides of actin filaments and is concentrated at the leading edges of motile cells.

145 R/WAVE complex controls actin polymerization at the leading edges of moving cells, but its mechanism

146 To drive growth at the leading edge of myelin at the interface with the

147 that inhibits axonal growth, activates GSK-3 at the leading edge of neuronal growth cones and in Sema

148 ns suggest that the pericellular proteolysis at the leading edge of neutrophils not only facilitates

149 e, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiologic

150 signals that lead to the activation of Mac-1 at the leading edge of PMNs, thereby allowing RBC captur

151 table receptors for ATX, which are localized at the leading edge of polarized cells.

152 etwork immediately under the plasma membrane at the leading edge of rapidly moving cells consists of

153 eral PKC isoforms colocalized with L-plastin at the leading edge of SDF-1alpha-stimulated lymphocytes

154 ound that L-plastin colocalized with F-actin at the leading edge of SDF-1alpha-stimulated T lymphocyt

155 lmost constant chemoattractant concentration at the leading edge of single pseudopods during their gr

156 2+) influx is required for positive feedback at the leading edge of spontaneously polarized macrophag

157 membrane ruffles and lamellae usually found at the leading edge of spreading cells.

158 Abi1 colocalizes with phosphorylated alpha4 at the leading edge of spreading cells.

159 Peridermal cells at the leading edge of Spry-mutant eyelids showed reduce

160 The precise mechanisms governing invasion at the leading edge of squamous cell carcinoma (SCC) and

161 e associated with periodontitis, is abundant at the leading edge of subgingival plaque, where it inte

162 trate an association between actin anchoring at the leading edge of T24 cells and the establishment o

163 icularly in men and women 40-60 years of age at the leading edge of the 'baby boom' demographic expan

164 mplex, which sediments in glycerol gradients at the leading edge of the 10S terminal uridylyltransfer

165 IF4E-eIF4G-eIF3-40S interactions place eIF4E at the leading edge of the 40S subunit, and mRNA is thre

166 that Acam and myosin VI precisely colocalize at the leading edge of the actin cones and that myosin V

167 TNP-470 reduced the permeability of BEVs at the leading edge of the advancing vascular plexus as

168 Our analyses reveal that at the leading edge of the biofilm, highly coherent grou

169 of the embryonic shield, a slight thickening at the leading edge of the blastoderm during the formati

170 t cell cluster that forms a wedge-shaped cap at the leading edge of the blastoderm.

171 e uropod is thought to aid integrin adhesion at the leading edge of the cell by removing steric hindr

172 ubtilis, FtsZ plays a role in ring formation at the leading edge of the cell division septum.

173 hoinositide lipids PI(3,4,5)P3 and PI(3,4)P2 at the leading edge of the cell in response to an extern

174 bset of "leader cells" that extend filopodia at the leading edge of the cell sheet.

175 y forming lamellipodia-actin-rich extensions at the leading edge of the cell that have been well char

176 us MSP polymerization to the plasma membrane at the leading edge of the cell thereby generating protr

177 rix, production of transient focal complexes at the leading edge of the cell, and retraction of the r

178 ntering locally activated small G protein(s) at the leading edge of the cell, becomes activated and p

179 romoting actin-dependent membrane protrusion at the leading edge of the cell, but the molecular mecha

180 biology that particularly affect structures at the leading edge of the cell, including the structure

181 sphatidylinositol-3,4,5-trisphosphate signal at the leading edge of the cell.

182 involving formation of a scaffolding complex at the leading edge of the cell.

183 During migration, GFP-myosin VII is found at the leading edge of the cell.

184 nsion and formation of new actin barbed ends at the leading edge of the cell.

185 focal nucleation and polymerization of actin at the leading edge of the cell.

186 d a vesicle derived from the plasma membrane at the leading edge of the cell.

187 on by securing the formation of lamellipodia at the leading edge of the cell.

188 atenin homologue Armadillo (Arm) accumulates at the leading edge of the cleavage furrow, and later to

189 use a population of migratory myofibroblasts at the leading edge of the closing VBW that express the

190 in turns over throughout the cone, with that at the leading edge of the cones turning over with sligh

191 teinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating

192 migration is driven by cell wall remodeling at the leading edge of the engulfing membrane, with pept

193 ced in the dermis and granulation tissue and at the leading edge of the epidermis in the healing woun

194 mistry studies demonstrated MMP-9 expression at the leading edge of the epithelial wound, in the the

195 he black hole, by incorporating a shock wave at the leading edge of the expansion of the galaxies, ar

196 at the 100-200-nm submembraneous compartment at the leading edge of the extending lamellipod constitu

197 was slightly more abundant than PI(3,4)P(2) at the leading edge of the forming cup.

198 span and length revealed that most filopodia at the leading edge of the growth cone achieved signific

199 for by the 'push' of plus-end actin assembly at the leading edge of the growth cone.

200 t pinpoint membrane poration can be produced at the leading edge of the HeLa cell in standoff distanc

201 , the organization of the actin cytoskeleton at the leading edge of the invaginating furrows became p

202 g cell division while maintaining a position at the leading edge of the invaginating septum.

203 d, subsequently, the initiation of FA growth at the leading edge of the lamella.

204 rbed ends, resulting in actin polymerization at the leading edge of the lamellipodium in carcinoma ce

205 the existence of an actin-rich purse string at the leading edge of the lateral epidermis and provide

206 on Rho-mediated contraction of an actin ring at the leading edge of the lesion.

207 brings the prospective mesoderm and endoderm at the leading edge of the marginal zone into vertical a

208 invasion of the mesodermal-endodermal tissue at the leading edge of the mesodermal mantle might be th

209 actile and migratory proteins preferentially at the leading edge of the migratory front.

210 on of myonuclear translocation: Kinesin acts at the leading edge of the nucleus, whereas Dynein acts

211 eV backward-directed beam is mainly produced at the leading edge of the plasma column.

212 is migration is promoted by the leader cells at the leading edge of the pLLP, which express the G pro

213 fferentiated HL-60 cells, mAbp1 was enriched at the leading edge of the polarized cell.

214 for Don1p, which forms a ring-like structure at the leading edge of the prospore membrane during meio

215 s assembly of the Don1p-containing structure at the leading edge of the prospore membrane via interac

216 Ssp1, a protein found at the leading edge of the prospore membrane, is stabili

217 Mutations of single amino acid residues at the leading edge of the recognition helix are rarely

218 nd that P-selectin-PSGL-1 bonds were relaxed at the leading edge of the rolling cell, compressed unde

219 n these organisms, FtsZ is located in a ring at the leading edge of the septum.

220 ic and coordinated organization of the cells at the leading edge of the sheet.

221 paxillin colocalize in the membrane ruffles at the leading edge of the spreading cells, providing a

222 s were 4-fold more sensitive to contact made at the leading edge of the T cell compared with the tail

223 re 3-fold more sensitive to APC contact made at the leading edge of the T cell than with contact made

224 ike invasive species in nature, cancer cells at the leading edge of the tumor possess a different phe

225 ssed during glioma progression, particularly at the leading edge of the tumor.

226 red, as these macrophages failed to localize at the leading edge of the vascular plexus and at vascul

227 unds examined, basal keratinocytes and cells at the leading edge of the wound expressed keratins K5 a

228 ed the number of proliferating keratinocytes at the leading edge of the wound, suggesting that VEGF s

229 was visible in a few epithelial basal cells at the leading edge of the wound.

230 6 mRNA expression primarily in the epidermis at the leading edge of the wound.

231 ing to the suppression of cell proliferation at the leading edge of the wound.

232 -localize to the cortical actin cytoskeleton at the leading edges of the cell.

233 nd integrin-dependent lamellipodial crawling at the leading edges of the epidermal tongue.

234 ore restricted in their habitat associations at the leading edges of their range margins, but some sp

235 ion and actin-membrane anchorage, is present at the leading edge of these migrating epithelia and is

236 uced tumors, Activin signaling may be active at the leading edge of these tumors.

237 This flexible loop, juxtaposed at the leading edge of transcription bubble, has been pr

238 d fibroblasts for degrading stromal collagen at the leading edge of tumor invasion.

239 day 8.5 in the mouse, proliferation of cells at the leading edge of ventral-lateral endoderm, where t

240 strate an inability to activate EGF receptor at the leading edge of wounds, and we demonstrate that t

241 lying that Zip2 and associated proteins move at the leading edge of Zip1 polymerization.