ライフサイエンスコーパス: at the level of

1 y deciphered molecular pathways are reviewed at the level of (1) clastic cell adhesion in the externa

2 iclust databases cluster UniProtKB sequences at the level of 90%, 50% and 30% pairwise sequence ident

3 taneous and site-selective Zn(II) metalation at the level of a dipyrrin versus tren unit triggers a p

4 We hypothesize that drugs acting at the level of a gene expression module specific to PD

5 magnitude of the associated traction forces at the level of a single cell.

6 dy characterizes mitochondrial aging profile at the level of a single neuron in its native environmen

7 ivating mutations on signaling systems, even at the level of a single protein.

8 n cocoa flavanols and methylxanthines exists at the level of absorption, in which the methylxanthines

9 TGF-beta is regulated at the level of activation, but how TGF-beta is activate

10 of myeloid origin, while integrins function at the level of adhesion, the importance of lectins rema

11 This bias occurred at the level of aligning short reads to reference genome

12 However, the regulation of gene expression at the level of an individual cell involves reactions be

13 involving participation by the thioglycoside at the level of an intermediate diazoalkane.

14 el of electrical synapse molecular asymmetry at the level of an intracellular scaffold that is requir

15 resentation, further establishing that, even at the level of ARC(AgRP) neurons, choices are remarkabl

16 MS) for the determination of minor actinides at the levels of attogram/liter in urine samples to meet

17 a specific region, without parallel changes at the level of behavior.

18 TNKS regulates destruction complex activity at the level of both Axin and APC2, providing further me

19 istance might be caused by allelic variation at the level of both gene expression and amino acid sequ

20 ALAM1 is also positively regulated by MALAT1 at the level of both transcription and RNA stability.

21 o binocular signals are processed distinctly at the levels of both cortical activity in human MT and

22 disparity-based signals are mostly separate at the levels of both fMRI responses in area MT and perc

23 cognitive processes in memory are supported at the level of brain systems and network representation

24 Modulation at the level of C3, a multifaceted orchestrator of the c

25 f the cmp-5 inhibitory mode revealed it acts at the level of C5 activation.

26 We find critical slowing down in the data at the level of California and the United States in the

27 At the level of CD8 responses, vigorous ex vivo response

28 Homologies at the level of cell types and even discrete neural circ

29 his organization by promoting self-avoidance at the level of cell types, promoting normal development

30 At the level of cell-to-cell junctions, HGF attenuates t

31 At the level of cell-to-substrate junctions, HGF augment

32 lk between interferons and TNF is integrated at the level of chromatin to reprogram inflammatory resp

33 Interestingly these new factors operate at the level of chromatin, which reinforces a notion of

34 integration of TCR signaling largely occurs at the level of chromatin, which we propose plays a cruc

35 However, the impact of STDP at the level of circuits, and the mechanisms governing i

36 genes are highly evolutionarily plastic both at the level of coding sequence and expression across A.

37 g question is whether ribosome heterogeneity at the level of core ribosomal proteins (RPs) exists and

38 This plasticity occurs at the level of cortical maps and individual neurons in

39 Regulation of gene expression at the level of cytoplasmic polyadenylation is important

40 Crucially, significance is established at the level of differentially methylated regions (DMRs)

41 Pathway choice is made at the level of DNA end resection, a nucleolytic process

42 eutic tools to fix disease-causing mutations at the level of DNA.

43 vast landscape of somatic variants that act at the level of domain families altering pathways known

44 IRS-2 requires the microtubule cytoskeleton at the level of downstream effector activation.

45 As mice are restricted to infection at the level of DPP4, the MERS-CoV receptor, we generate

46 Managers (clusters) at the level of duty commander or equivalent were random

47 ach may be classical pathway (CP) inhibition at the level of early component C1.

48 HCS showed opposite patterns of spatial bias at the level of early sensory processing, as assessed wi

49 ells, which is in line with a SCID phenotype at the level of early T cell development in the thymus.

50 lation of mRNA translation complexes stalled at the level of elongation and/or termination.

51 ed that cultural differences can be observed at the level of emotional reactivity and regulation [6],

52 rmined that the antiviral effect was exerted at the level of endosomal processing of the incoming cap

53 At the level of entry, differences in the amino acid seq

54 nt progression phenotypes were also affected at the level of epithelial-to-mesenchymal transition and

55 ization of FLA4, with N-glycosylation acting at the level of ER-exit and O-glycosylation influencing

56 nsequences of inhibiting this kinase cascade at the level of ERK.

57 en previously overlooked mitochondrial genes at the level of eukaryotic supergroups.

58 s, indicating that Zn affects Fe homeostasis at the level of Fe sensing.

59 istent with expectations for atomic hydrogen at the level of four parts in 10(4).

60 ervations that challenge lepton universality at the level of four standard deviations.

61 ly lake-specific, species-specific, or occur at the level of functional group.

62 , as biological systems maintain homeostasis at the level of functional networks robustly controlling

63 erential DRD3 signaling in beta-cells occurs at the level of G-protein release.

64 y receptor-specific desensitization, evident at the level of Galphaq activation, phosphatidylinositol

65 difies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins,

66 (the one with the positive feedback located at the level of gene transcription) is superior in descr

67 rotein production of cytokines was regulated at the level of gene transcription, which was dependent

68 lopment; however, this effect does not occur at the level of gene transcription.

69 rsors of circulating memory cell populations at the levels of gene expression and chromatin accessibi

70 and confirmed their functional significance at the levels of gene transcription, synaptic regulation

71 the information utilized by these methods is at the level of genes, limiting analyses to variants tha

72 hat NRP1 regulates HH signaling specifically at the level of GLI transcriptional activator function.

73 positively interacting with NK cell priming at the level of glycolytic gene transcription.

74 Rare STAG2 mutations can amplify at the level of GMPs, from which it may drive the transf

75 ferentially by postsynaptic ionic mechanisms at the level of granule cells.

76 Do we observe sufficient variation at the level of groups of considerable size for group se

77 pirical case for the importance of selection at the level of groups on cultural variation.

78 rding natural selection: If variation exists at the level of groups, if this variation is heritable,

79 ompeting groups, then selection will operate at the level of groups.

80 nct cell types, suggesting cross-talk occurs at the level of hormone transport between these signalin

81 tion in the Ca(2+) signalling pathway occurs at the level of hormone-induced inositol 1,4,5 trisphosp

82 effects are opposite and in part controlled at the level of Hsf1 expression and DNA binding.

83 insights gained from analysis of expression at the level of individual cell types.

84 The study of epigenetic heterogeneity at the level of individual cells and in whole population

85 ne adds an autocrine mechanism, fine control at the level of individual cells is achieved.

86 s increasingly used to study gene expression at the level of individual cells.

87 es have addressed their spatial organization at the level of individual cells.

88 ted, little is known about biofilm structure at the level of individual cells.

89 rum, which allowed investigation of the drug at the level of individual cells.

90 n charge state distribution (CSD) as well as at the level of individual charge states.

91 d that horizontal cells can also act locally at the level of individual cone photoreceptors.

92 s of interest, such as pathways, rather than at the level of individual edges.

93 tal at the ward level and work-home conflict at the level of individual employees, taking into accoun

94 We also find good quantitative agreement at the level of individual genes between two techniques

95 Performing stochastic simulations at the level of individual hexamers allows us to identif

96 ls by using TTA as a continuous variable and at the level of individual hospitals by using TTA as a c

97 xecution of sequential motor action patterns at the level of individual motoneurons.

98 iments that study neural encoding of stimuli at the level of individual neurons typically choose a sm

99 r connectivity patterns that can be captured at the level of individual nodes and edges.

100 search mandate for improving risk prediction at the level of individual patients.

101 ningful quantification of costs and outcomes at the level of individual patients.

102 nder extraction of exchange rates unreliable at the level of individual peptides.

103 We find that contact guidance is determined at the level of individual protrusions, which are indivi

104 nce of biological processes has been studied at the levels of individual biochemical reactions and or

105 sis may regulate transcription predominantly at the level of initiation.

106 n the heart at the level of PDH, rather than at the level of insulin signaling.

107 at this complex regulates the ALV life cycle at the level of integration.

108 s a new approach to understanding the cortex at the level of its underlying genetic code, and rapid t

109 , glycolysis and the TCA cycle are uncoupled at the level of lactate, which is a primary circulating

110 essure (IOP) and intracranial pressure (ICP) at the level of lamina cribrosa could have important imp

111 vation interferes with salt responses mainly at the level of lateral roots and that large natural var

112 We use comprehensive, high-frequency data at the level of load balancing authorities to parameteri

113 blished role in reward processing, operating at the level of local ventral tegmental area neurons, MO

114 induced P-UAEC proliferation; which converge at the level of MAPKs with the signalling mechanisms med

115 At the level of mechanistic understanding, the molecular

116 s gene expression was significantly silenced at the level of messenger RNA and protein after ischemia

117 Cholinergic dysfunction at the level of MGB may affect speech understanding nega

118 At the level of milk production, four watersheds account

119 We found by psychophysical studies that at the level of minimal recognizable images a minute cha

120 some of which are epigenetically programmed at the level of miRNA regulation.

121 r understanding of higher cognitive function at the level of molecular and neuronal circuits.

122 the characterization of cultured stem cells at the level of morphology and of the macroscopic patter

123 Sepsis remains a major health problem at the levels of mortality, morbidity, and economic burd

124 expressing their genomes, and the defect was at the level of mRNA accumulation.

125 ted ER-mediated gene expression up to 2-fold at the level of mRNA transcripts.

126 olecular mechanisms of beta-cell dysfunction at the level of mRNA translation under such conditions.

127 ort, we demonstrate that Rictor is regulated at the level of mRNA translation via heat-shock transcri

128 from stationary-phase samples, in particular at the level of mRNA.

129 found that MSA down-regulated integrin beta3 at the levels of mRNA and protein, and disrupted cluster

130 Gene expression is extensively regulated at the levels of mRNA stability, localization and transl

131 OR (mechanistic target of rapamycin) pathway at the level of mTORC1 and also regulates the transcript

132 as converges with the PI3K/Akt/mTOR pathway at the level of mTORC1, working together to drive the gr

133 The results of the present study show that at the level of myotubes MTM1 mutations do not dramatica

134 Here we investigated this issue at the level of natural physiological activity of OH cel

135 cribed genome, apart from ribosomal RNAs, is at the level of noncoding RNA genes.

136 Ambrisentan preserved GFR at the level of nondisease controls and prevented the de

137 gree of conservation between human and mouse at the level of not only gene expression but also epigen

138 iting HIV-1 infection of resting CD4 T cells at the level of nuclear import.

139 parative transcriptomic and genomic analysis at the level of one single plant cell type, the root hai

140 -GTP also regulates adhesion in immune cells at the level of, or downstream of, Radil.

141 uring a dual control of unwanted cell death: at the level of p53/CEP-1 and at the executioner caspase

142 y promotes metabolic remodeling in the heart at the level of PDH, rather than at the level of insulin

143 ated regulation of IL-17A and IL-22 occurred at the level of PGE2 This was confirmed by in vivo cyclo

144 ve feedback mechanisms, acting predominantly at the level of phytoene synthase-1 (PSY1), and feed-for

145 sample at a time, as a cohort of samples; or at the level of population, providing the user with a co

146 traits with significant genetic correlation at the level of predicted expression; of these, eight we

147 nd immunity, the microbiota regulates cancer at the level of predisposing conditions, initiation, gen

148 attentive information processing dysfunction at the level of primary auditory cortex.

149 at miR-23b regulated CSC phenotypes globally at the level of proliferation, cell cycle, self-renewal,

150 the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mT

151 Rather, BOK is controlled at the level of protein stability by components of the e

152 BCL-2 family member BOK, which is controlled at the level of protein stability by ER-associated degra

153 ttle is known about functional relationships at the level of protein-protein interactions, which are

154 atients exhibited no suppressed TCR response at the level of proximal TCR signaling (activation/phosp

155 research aimed at addressing these questions at the level of psychological process and neural mechani

156 ion by a message-passing algorithm operating at the level of redundant neural populations.

157 At the level of renal tubules, ambrisentan treatment pre

158 s compared to healthy controls, particularly at the level of resting-state networks.

159 In PBLs, the block occurs at the level of reverse transcription, reducing the accu

160 cytokinetic furrowing is primarily regulated at the level of RhoA activation.

161 y unappreciated restriction for lentiviruses at the level of RT that acts independently of dNTP conce

162 ng calculations are increasingly carried out at the level of scaffolds rather than compounds, and sca

163 or hyperreflective, and their visualization at the level of SCP and deep capillary plexus (DCP) on O

164 on compared with those born to lean mothers, at the level of secreted immune mediators and transcript

165 s, the athb5 mutant did not show a phenotype at the level of seed germination, but it did at a cellul

166 ent of the zero-field ground-state splitting at the level of seven parts in 10(13) are important achi

167 e highly similar to primary cortical neurons at the level of single cells but suggest that current la

168 to correlate gene expression with phenotype at the level of single cells.

169 al categories, but also exist systematically at the level of single evolutionary families of protein

170 he nanomechanics of GAG.protein interactions at the level of single GAG chains, which provides new mo

171 teractions is compatible with those observed at the level of single neurons in primates, usually broa

172 processing can be most clearly distinguished at the level of single neurons.

173 he structural mechanisms of clot contraction at the level of single platelets.

174 unctional consequences of cocaine and stress at the level of single spines.

175 ise interrogation of neuronal function, even at the level of single synapses.

176 e of defects in action potential propagation at the level of single T-tubules, recently observed in d

177 How these sensory channels are integrated at the level of single thalamic cells is not well unders

178 n human piriform cortex, with robust effects at the level of single trials.

179 gher-order organization of complex networks--at the level of small network subgraphs--remains largely

180 bnormalities in functional neurotransmission at the level of specific interneuron populations has bee

181 nked to various human TMS responses recorded at the level of spinal cord and muscles.

182 y functional, but also structural plasticity at the level of spine dynamics in the adult brain.

183 side, but with the related theoretical work, at the level of state-of-the-art calculations of both th

184 tact, and reduced activity was only observed at the level of striatonigral afferents.

185 ring interference with inflammasome activity at the level of such regulators.

186 ong the FcepsilonRI signaling pathway occurs at the level of Syk-FcepsilonRI interactions, with key o

187 d accounts of how negative images are formed at the level of synaptic plasticity rules, cells, and ci

188 rovascular perfusion and molecular signaling at the level of TBC1D4 and glycogen synthase in muscle.

189 nhibition is crucial for auditory processing at the level of the auditory brainstem, which is respons

190 ernum, and 9.3 and 4.7 muSv/h, respectively, at the level of the bladder.

191 At the level of the brain, the delay of insulin signalin

192 in humans, we determined skin sodium content at the level of the calf in 99 patients with mild to mod

193 n demonstrated a mid-esophageal diverticulum at the level of the carina.

194 g at the spinomedullary junction, decussates at the level of the caudal pole of the facial nerve nucl

195 standing these transitions and their outcome at the level of the cell and organism has become one of

196 The regulation of force generation at the level of the cell, however, is still far from elu

197 aintains the efficacy of purifying selection at the level of the cell, the absence of recombination c

198 anisms by which GLP-1 and serotonin interact at the level of the central nervous system.

199 Some "signal void" spots were detected at the level of the choriocapillaris in 15 patients (88.

200 lectivity around large choroidal vessels and at the level of the choriocapillaris on OCT (P < 0.001).

201 ns, which corresponded to OCTA flow deficits at the level of the choriocapillaris.

202 equent activation of Th2 and Th1 lymphocytes at the level of the conjunctiva reflects the late-phase

203 rresponds to areas of capillary nonperfusion at the level of the DCP.

204 Interstitial cells of Cajal at the level of the deep muscular plexus (ICC-DMP) in th

205 ea in BRVO eyes was significantly lower only at the level of the deep network when compared to the fe

206 Cs highlighting self-organisation principles at the level of the entire embryo.

207 e gut are described, with a focus on targets at the level of the epithelium.

208 ular presynaptic and postsynaptic components at the level of the first auditory nerve synapse in the

209 y 7.2-18.0-MHz PLT-1204BX transducer focused at the level of the flexor tendon.

210 gnosed in children, including interrogations at the level of the genome, epigenome, and transcriptome

211 n about the consequences of this duplication at the level of the genome, the epigenome, and gene expr

212 lustrate how these two pathways may converge at the level of the glia to contribute to neuropsychiatr

213 sion, both at individual partition level and at the level of the global concentration.

214 the majority of analyses and findings remain at the level of the group.

215 eline, 399 (97%) women had prolapse above or at the level of the hymen.

216 We hypothesized that an interaction at the level of the immune system may contribute to this

217 ble to fit and predict pre/postsurgical data at the level of the individual as well as the population

218 Exposure and health outcome data at the level of the individual can be difficult to obtai

219 hich sophisticated functionality is realized at the level of the individual particles.

220 ling transduction pathways that cause cancer at the level of the individual patient.

221 tion (randomly varying block sizes) was done at the level of the individual with a computer-generated

222 vioral universals and yet extreme plasticity at the level of the individual-if, and only if, we accou

223 dictions and observations are typically made at the level of the individual.

224 y conditioned long-term memory that operates at the level of the initial processing of sensory inform

225 ERCP at the level of the intact papilla in long limb Roux-en-

226 The occlusion of the pore at the level of the intracellular gate appears to be sec

227 entral gain upstream of the cochlear nucleus at the level of the lateral lemniscus, and to long-lasti

228 difference found in the location of the CRVT at the level of the LC between diagnostic groups.

229 richness was >25% lower, and flight activity at the level of the light was 70% greater.

230 fant dyads suggested that these variants act at the level of the maternal genome.

231 ns of human cyt c that, along with mutations at the level of the maturation system, are associated wi

232 rate (FDR)-controlled metabolite annotation at the level of the molecular sum formula, for high-mass

233 Because control of muscle is realized at the level of the motor unit (MU), it seems important

234 these effects may be attributable to changes at the level of the myofilaments.

235 or pole, positive staining was only observed at the level of the nerve fiber layer.

236 sm by which they activate caspase-1 diverges at the level of the pannexin-1/ATP/P2X7 axis.-Parzych, K

237 , indicating that plasticity was not induced at the level of the periphery but rather at the afferent

238 be obtained by excitation energy dissipation at the level of the phycobilisome (PBS), the cyanobacter

239 ment, ERalpha-36 rapidly associates with Src at the level of the plasma membrane, initiating downstre

240 s not been reported for a low-income country at the level of the population, hospital, or intensive c

241 cantly more nasally compared to healthy eyes at the level of the prelamina.

242 rates information from multiple senses, even at the level of the primary sensory areas.

243 We measured the PA:A ratio at the level of the pulmonary artery bifurcation on CT s

244 ur study suggests altered autonomic circuits at the level of the PVN, which can contribute to autonom

245 esthetized and awake, freely moving mice and at the level of the retina and dorsal lateral geniculate

246 channel result in abnormal electrophysiology at the level of the retinal neurons.

247 important modulator of breathing, including at the level of the retrotrapezoid nucleus (RTN), where

248 Pigmentary changes at the level of the RPE occur early in the disease cours

249 peptide system in cardiovascular regulation at the level of the RVLM and highlight that this system

250 n initiator of cardiac hypertrophic response at the level of the sarcolemma, but the pathways underpi

251 At the level of the sarcomere, the structural unit of th

252 xample of multisensory integration occurring at the level of the sensory thalamus, and provide eviden

253 Substitution at the level of the side chain methylene afforded compou

254 makes it possible to build models formalized at the level of the single retailer.

255 lated with speed and that this is controlled at the level of the spinal cord.

256 e N-methyl D-aspartate receptor with opioids at the level of the spinal cord.

257 DR-1m was 9.4, and 4.9 muSv/h, respectively, at the level of the sternum, and 9.3 and 4.7 muSv/h, res

258 ion was performed accounting for correlation at the level of the surgeon and the hospital, and adjust

259 mone sorting and secretory granule formation at the level of the TGN are still elusive.

260 I, 1.41 to 2.75); amputations were primarily at the level of the toe or metatarsal.

261 but a greater risk of amputation, primarily at the level of the toe or metatarsal.

262 anagement from 41% to 16%, while gatekeeping at the level of the township hospital would retain corre

263 were measured using T1-weighted axial slices at the level of the umbilicus and the upper border of th

264 ascular distances from both femoral arteries at the level of the upper border of the symphysis pubis

265 conditions play a role in driving phenomena at the level of the whole system.

266 nce and also fails to induce anaerobic genes at the level of the wild type.

267 id Diachasmimorpha longicaudata (Braconidae) at the levels of the ovipositor and its individual valve

268 as an inhibitor of the PKR/PACT interaction at the level of their DRBDs using high-throughput screen

269 tivity in the mouse SNc circuit is conferred at the level of three glutamate afferents: dorsal raphe

270 ve, but many functional signs of aging occur at the level of tissues rather than cells and are theref

271 The block occurs at the level of transcription and is accompanied by the

272 xpression patterns and gene dosage responses at the level of transcription are consistent with select

273 signaling pathways can impinge on each other at the level of transcription factors, thereby providing

274 -2 and IL-8 P4-PRWT transrepression occurred at the level of transcription initiation and was mediate

275 cyclin B1 expression is controlled primarily at the level of transcription initiation.

276 L-6, CCL5) was reduced in oxLDL-loaded cells at the level of transcription.

277 regulates at least one of the other DtxR TFs at the level of transcription.

278 t chain, xCT, and that this occurs, in part, at the level of transcription.

279 ike 3D aggregates strongly upregulated ErbB3 at the level of transcription.

280 ed that half of affected genes are regulated at the level of transcriptional pausing.

281 ntly associated with functional consequences at the level of transcriptional regulation of innate imm

282 f gene expression and its regulation working at the levels of transcriptional initiation, elongation

283 onana, to high and low concentrations of CO2 at the level of transcripts, proteins and enzyme activit

284 n expression was sequence-specific, occurred at the level of translation and was dependent on helicas

285 ches, which are predicted to regulate mostly at the level of translation initiation.

286 ity may be to provide a regulatory mechanism at the level of translation.

287 t facets of T-cell activation are controlled at the level of translation.

288 icating that manganese antagonized Fe mainly at the level of transport.

289 arrier and that GA-ABA interaction may occur at the level of transport.

290 oma-induced retinal dysfunction by operating at the level of tumor-associated microglial activation.

291 describe a recurrent cancer-specific lesion at the level of ubiquitin production.

292 ther as a stable trait across individuals or at the level of variability within individuals.

293 rios of competition bear distinct signatures at the level of variance.

294 At the level of vascular gene expression, 3.5 months' di

295 At the level of vascular network morphology, 7 months' d

296 peration between these receptors is required at the level of Vav1 for synergistic NF-kappaB activatio

297 At the level of ventricular myocytes, Stim1 silencing or

298 system of managed referral with gatekeeping at the level of village clinics would reduce proportions

299 hat Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functio

300 in spoken object naming reflected variation at the level of word-retrieval processes.