ライフサイエンスコーパス: at the single-@1 level

1 ntified substantial differential methylation at the single base level.

2 tunities to investigate small changes in RNA at the single cell level.

3 nique possibility of establishing homologies at the single cell level.

4 he detection of a broad range of metabolites at the single cell level.

5 observed in the dentate gyrus of hippocampus at the single cell level.

6 of routinely generating transcriptomics data at the single cell level.

7 e can identify and quantify complex isoforms at the single cell level.

8 otype, microenvironment, and matrix assembly at the single cell level.

9 ies for the identification of these channels at the single cell level.

10 ates were studied by pulse-chase experiments at the single cell level.

11 anges induced by estradiol in its signalling at the single cell level.

12 ing this method to probe mechanotransduction at the single cell level.

13 ded measurements of transcriptional profiles at the single cell level.

14 nd-specific T cells or also alters responses at the single cell level.

15 and crystal defects with material properties at the single-atom level.

16 gene expression levels and isoform diversity at the single-cell level.

17 lel functional studies of cell heterogeneity at the single-cell level.

18 cells in the human lung and peripheral blood at the single-cell level.

19 mitment have not been studied systematically at the single-cell level.

20 ts, and the features of T-cell pathogenicity at the single-cell level.

21 e cell populations, interrogating 30 markers at the single-cell level.

22 o separate and study normal and leukemic SCs at the single-cell level.

23 ed, there is no treatment of Ca(2+) dynamics at the single-cell level.

24 nuously linked to the chondrogenic phenotype at the single-cell level.

25 d, with extensive growth rate heterogeneity at the single-cell level.

26 frared (FTIR) and deep UV (DUV) microscopies at the single-cell level.

27 BV cccDNA in infected patients, particularly at the single-cell level.

28 chnology allows detection of gene expression at the single-cell level.

29 d systematic way to study signaling pathways at the single-cell level.

30 new three-stage model of the HBV life cycle at the single-cell level.

31 isions, migration, and morphological changes at the single-cell level.

32 ells now enable studying signal transduction at the single-cell level.

33 p is more difficult to elucidate, especially at the single-cell level.

34 at in vivo and a decrease in neuronal firing at the single-cell level.

35 s limited to these G1-like phase macrophages at the single-cell level.

36 x dynamics and heterogeneous responses found at the single-cell level.

37 that stimulus type and intensity is encoded at the single-cell level.

38 rature-response curves of enzymatic activity at the single-cell level.

39 avior and efficacy of activation and killing at the single-cell level.

40 were accompanied by precise firing sequences at the single-cell level.

41 ses, with their degradation kinetics tracked at the single-cell level.

42 ensive yet detailed study of gene expression at the single-cell level.

43 structure and interrogate transcriptome data at the single-cell level.

44 rectly and precisely control neuron activity at the single-cell level.

45 at shows properties of a cleft-like boundary at the single-cell level.

46 e dream of biologists to map gene expression at the single-cell level.

47 use retina tissues, and mouse cornea tissues at the single-cell level.

48 d death protein-1, and the cytotoxic synapse at the single-cell level.

49 on of the preconditioning treatment was done at the single-cell level.

50 these repair activities can also be observed at the single-cell level.

51 al tools to analyze the resulting image data at the single-cell level.

52 Our assay reveals occupancy patterns at the single-cell level.

53 LRRK2 and alpha-synuclein in living neurons at the single-cell level.

54 eady for analysis and visualization of reads at the single-cell level.

55 differentiate into alveolar epithelial cells at the single-cell level.

56 h require direct mechanical contact, applied at the single-cell level.

57 on of neuronal identity and circuit assembly at the single-cell level.

58 de range of metabolic pathways and functions at the single-cell level.

59 d phenotypic cellular markers simultaneously at the single-cell level.

60 terization of phenotypic changes of bacteria at the single-cell level.

61 L) function and regulation defines cell fate at the single-cell level.

62 robe metabolic pathways of carbon substrates at the single-cell level.

63 robes to quantify protein synthesis dynamics at the single-mRNA level.

64 n of visual space, implying visuotopic order at the single-unit level.

65 indicating perturbation response specificity at the single trial level.

66 I" and the "Me" dimensions of the self, even at the single-trial level.

67 vidence accumulation and response activation at the single-trial level.

68 better constrain sequential sampling models at the single-trial level.

69 cling would benefit from direct observations at the single-virus level.

70 n emotion has not been investigated directly at the single-neuron level.

71 ability, without achieving local homeostasis at the single-neuron level.

72 m networks and enable optical nonlinearities at the single-photon level.

73 astable states and observe optical switching at the single-photon level.

74 at applies feedback to a weak optical signal at the single-photon level.

75 zers, we visualized real-time polymer growth at the single-polymer level.

76 control and measurement on gigahertz phonons at the single-quantum level.

77 data and quantitative binding affinity data at the single basepair level.

78 tweezers, we probe pre-TCR bonding with pMHC at the single molecule level.

79 ce imaging to study protein-DNA interactions at the single molecule level.

80 studying electric field breakdown phenomena at the single molecule level.

81 ies, but also their photophysical properties at the single molecule level.

82 -dependent and unassisted membrane insertion at the single molecule level.

83 biogenic volatile organic compounds (BVOCs) at the single particle level.

84 nversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level.

85 mulations, yielding a quantitative agreement at the single particle level.

86 opy methods for characterizing FCC catalysts at the single particle level.

87 ghts to design selective optical nanoheaters at the single particle level.

88 and to monitor the real time damage response at the single telomere level.

89 lution, in thin films, and also in isolation at the single-molecule level.

90 ed, and this activation is poorly understood at the single-molecule level.

91 assay to map in vitro DNA replication errors at the single-molecule level.

92 T-coated NPs and intra-NCs allowed detection at the single-molecule level.

93 noscale and enable the detection of analytes at the single-molecule level.

94 ws a tight association of CIZ1 with Xist RNA at the single-molecule level.

95 anoscale pore, permitting label-free sensing at the single-molecule level.

96 ce DNA, or to investigate chemical reactions at the single-molecule level.

97 chromatin interactions at response elements at the single-molecule level.

98 y to study the mechanics of this interaction at the single-molecule level.

99 triangulene and related open-shell fragments at the single-molecule level.

100 observation of redox processes in real time at the single-molecule level.

101 d to investigate GPCR signaling and dynamics at the single-molecule level.

102 lotype-resolved analysis of telomere lengths at the single-molecule level.

103 ional properties of numerous DNA populations at the single-molecule level.

104 and synthesis by the S. cerevisiae replisome at the single-molecule level.

105 etics of colloidal islands on these surfaces at the single-particle level.

106 ompelling method for fibril surface analysis at the single-particle level.

107 ble of probing short-lived nanoscale species at the single-particle level.

108 lso broadens the photoluminescence linewidth at the single-particle level.

109 antify interactions of bacteria with ligands at the single bacterium level.

110 fluorescent contrast agents detectable even at the single nanoparticle level.

111 etails of the photochemical growth mechanism at the single-nanoparticle level.

112 gh mechanical forces have been characterized at the single cell level [13-16], it remains elusive how

113 Here we demonstrate, by characterizing at the single-cell level a purified and minimally hetero

114 xit from pluripotency and lineage commitment at the single cell level, a potential stepping stone to

115 trate a significant cavity protection effect at the single-photon level-a technique to suppress ensem

116 zed events of structural synaptic plasticity at the single-synapse level after distinct patterns of s

117 rovide quantitative and semiqualitative data at the single-cell level along with important insights i

118 At the single neuron level, although paired-pulse adapta

119 the surface can be controlled and monitored at the single molecule level and finally antibody bindin

120 uctural defects during phase transformations at the single nanoparticle level and offer an additional

121 ovides a quantitative description of lncRNAs at the single-cell level and a universally applicable fr

122 ing surface proteins of different cell types at the single-cell level and distinguishing between the

123 antitative analysis of receptor interactions at the single-cell level and in different cellular compa

124 global intracellular calcium responses both at the single-cell level and in large ensembles simultan

125 apted archaeal organism, grows exponentially at the single-cell level and maintains a narrow-size dis

126 rocesses underlying the origin of resistance at the single-cell level and suggest an analogous role t

127 ic expression patterns of multiple neurexins at the single-cell level and suggest that expression of

128 We sought to dissect mast cell responses at the single-cell level and their potentiation by IL-33

129 l interaction between actin subunit turnover at the single-filament level and mobility at the membran

130 spectroscopy, we interrogate these emitters at the single-molecule level and compare their propertie

131 nderstanding of protein-protein interactions at the single-molecule level and potentially capture sta

132 d transparency enables manipulation of light at the single-photon level and few-photon devices such a

133 Most of the results were confirmed at the single-subject level and were found to be compati

134 ant interest in the variation of drug uptake at the single cell level, and we use ToF-SIMS to show th

135 f human face processing have been identified at the single neuron level, and studies providing causal

136 lies in specifying latent stochastic models at the single-cell level, and then aggregating these mod

137 are heterogeneous and functional properties at the single cell level are poorly documented leading t

138 We show that DHS patterns at the single-cell level are highly reproducible among i

139 cular, relevant differences in DNA stability at the single-molecule level are demonstrated by analyzi

140 Imaging at the single-cell level around the defects allowed us t

141 model for studying neuron-virus interactions at the single-cell level as well as via bulk biochemistr

142 Not only can maNCB identify m(6)A at the single-base level but it also can quantify the ex

143 information transfer to approximately 1 bit at the single-cell level but allows 3-4 bits of informat

144 iability is crucial for quantitative biology at the single-cell level but has been challenging for th

145 n to separate patients from healthy controls at the single-subject level, but it remains unclear whet

146 We analyzed solute transport at the single liposome level by monitoring the coinciden

147 amin and monitored SK channel nanoclustering at the single molecule level by combining atomic force m

148 g the progression of the invasion front, and at the single-cell level by examining changes in cellula

149 ate the effect of IL-33 on mast cell biology at the single-cell level by showing that IL-33 potentiat

150 y interactions in ligand binding was studied at the single-molecule level by combined force spectrosc

151 ancement of light-harvesting complex 2 (LH2) at the single-molecule level by coupling to a gold nanoa

152 ident between clones, by RNA-sequencing, and at the single-cell level, by RNA-FISH, and is not attrib

153 Epigenomic variation at the single-cell level can rapidly create cancer heter

154 tivity, although appearing highly disordered at the single-neuron level, can form dynamical coherent

155 fferentiation status, patient survival, and, at the single-cell level, cancer stem cell markers.

156 abilize formation of the ChlID-MgADP complex at the single molecule level; ChlD was attached to an at

157 However, at the single-channel level, chronic co-incubation great

158 At the single-cell level, CI and II deficiencies were co

159 elop a 4-colour fluorescence reporter system at the single-virus level, combined with computational m

160 F142L enhanced CaM-dependent RyR2 inhibition at the single channel level compared with CaM-WT.

161 escence analysis in solution and on surfaces at the single-protein level confirmed the importance of

162 ding telomerase gene expression and splicing at the single cell level could yield insights into the r

163 The direct access to many-body physics at the single-particle level demonstrated by our results

164 d reliably in the vast majority of the deaf, at the single subject level, despite the absence of hear

165 Moreover, at the single-nephron level, diabetes-related renal hemo

166 At the single-trial level, differential patterns of resp

167 3D tracking at the single-cell level displayed increased migration s

168 pt abundance correlates with cellular volume at the single-cell level due to increased global transcr

169 irectly measure electron-phonon interactions at the single-mode level, especially their effect on pho

170 semblies difficult and quantitative analysis at the single molecule level essential.

171 When examined at the single-cell level, following growth in both media

172 ns opportunities to chemically tailor SWCNTs at the single chirality level for nanotube sorting, on-c

173 unbiased acquisition of multiparametric data at the single-cell level for hundreds of cells simultane

174 ains (VH+VL or TCRbeta/delta+TCRalpha/gamma) at the single-cell level for typical samples containing

175 At the single molecule level, force spectroscopy experim

176 namics and interactions in individual cells, at the single-molecule level, from the inside out, and a

177 How CI devices engage the brain at the single neuron level has remained largely unknown,

178 of high-throughput RNA sequencing (RNA-seq) at the single-cell level has already led to profound new

179 e different characteristics are interrelated at the single-cell level has been difficult because of t

180 d in patients by pulse oximetry, variability at the single-cell level has not been previously measure

181 The advent of high throughput RNA-seq at the single-cell level has opened up new opportunities

182 nce energy transfer (FRET) studies performed at the single molecule level have unique abilities to pr

183 usly quantifying protein and gene expression at the single-cell level have the power to identify cell

184 The study of biomolecular interactions at the single-molecule level holds great potential for b

185 Here, we studied at the single molecule level how HDL particles interact

186 concentration affect the Mk-E fate decision at the single cell level in MEPs and found that short ha

187 ach for rapid identification of AMR bacteria at the single cell level in their natural conditions.

188 pe specific and ubiquitously expressed genes at the single cell level in whole-mount zebrafish embryo

189 nteraction of endogenous Munc13-4 with Rab11 at the single molecule level in neutrophils.

190 binding and nucleosome-remodeling activities at the single molecule level in real time.

191 n of other's hand actions and gaze direction at the single neuron level in the ventral premotor corte

192 rithms have been proposed to detect variants at the single nucleotide level in mixed samples.

193 ap these processes with a spatial resolution at the single-carbon level in a molecule with a pentacen

194 hm to quantify changes in nuclear morphology at the single-cell level in response to physical cues fr

195 to profile expressions of hundreds of genes at the single-cell level in situ and provided a map of s

196 isition gating methods, which enable imaging at the single-cell level in the beating heart in the mou

197 Parallel measurements of [Cl(-)]i and pHi at the single-cell level in the mouse cortex showed the

198 r complexes containing diverse channel types at the single-complex level in sensory neurons, dependen

199 e of DNA nano-circles, which were visualized at the single-molecule level in a fluorescence microscop

200 orescent protein variants that is detectable at the single-molecule level in live Escherichia coli ce

201 Analysis of RNA dynamics and localization at the single-molecule level in living cells has been pr

202 few studies have examined neural correlates at the single-unit level in a behavioral task that probe

203 dy uniquely examines encoding in rodent mOFC at the single-unit level in response to cues that predic

204 p approach was used to link molecular events at the single-cell level into the events at the populati

205 At the single-unit level, irradiance-dependent increases

206 y to track intracellular peptide proteolysis at the single cell level is of growing interest, particu

207 and large, encode such predictive processes at the single neuron level is unknown.

208 r, quantitative characterization of proteins at the single-cell level is challenging due to the tiny

209 emporal interrogation of signal transduction at the single-cell level is necessary to answer a host o

210 d plays an important role in development but at the single-cell level is only essential in dividing m

211 to be highly localized, characterizing them at the single-defect level is of particular importance.

212 g the mechanistic details of their operation at the single-molecule level is hampered by the diffract

213 Obtaining substantial nonlinear effects at the single-photon level is a considerable challenge t

214 Their stable emission at the single-molecule level makes these compounds good

215 To analyze cellular reprogramming at the single-cell level, mass cytometry was used to sim

216 to detect Ub and to identify Ub linkage type at the single-molecule level may provide a novel tool fo

217 At the single-cell level, neurons exhibited heterogeneou

218 At the single-cell level, noise arises from multiple sou

219 l types and provide new biochemical insights at the single organelle level not available from organel

220 We observe dynamics at the single-cell level not predicted by epigenomic ana

221 Electrochemical gating at the single molecule level of viologen molecular bridg

222 bility to measure the properties of proteins at the single-molecule level offers an unparalleled glim

223 cation of ESR at the nanoscale (for example, at the single-cell level or on individual nanoparticles)

224 At the single-channel level, oxidation of the cardiac ry

225 sting platforms providing such functionality at the single-node level present steep scalability chall

226 t, and, when doped into a diamagnetic matrix at the single-ion level, produces a large energy barrier

227 The ability to detect disease markers at the single molecule level promises the ultimate sensi

228 generate full-length HCV envelope sequences at the single-molecule level, providing a data set with

229 anscriptome and in vitro functional analyses at the single-cell level reveal a concurrent increase in

230 PCR analysis at the single-cell level revealed that RORC2 mRNA was ex

231 High-resolution analyses at the single-channel level showed that, when open, R138

232 n of the spatial organization of the synapse at the single-molecule level.SIGNIFICANCE STATEMENT The

233 itatively measuring noise in gene expression at the single cell level: single molecule FISH (smFISH)

234 ypothesized that differences in dye kinetics at the single-cell level, such as ABCG2 transporter-medi

235 lopment based on two building blocks: first, at the single macrophage level, sugar-based amphiphilic

236 These data reveal at the single cell level that focused US modulates the a

237 With this platform, we confirmed at the single event level that, after docking of the tem

238 Here we show at the single-cell level that early stage metastatic cel

239 display profound transcriptional variability at the single-cell level that predicts which cells will

240 We monitored at the single-molecule level the activity of the prototy

241 ring learning have been extensively examined at the single neuron level, the coding strategies employ

242 Our findings thus explain, at the single neuron level, the important subthalamic ro

243 At the single-channel level, the weak agonism is reveale

244 nal investigation of lymphocyte interactions at the single-cell level through microfluidic cell pairi

245 y-step tutorial for visualizing each dataset at the single-cell level, through the commonly used Inte

246 e made it possible to measure RNA expression at the single-cell level, thus paving the way for explor

247 through the measurement of synaptic activity at the single-cell level, thus providing a fuller unders

248 (mPFC), but how the two structures cooperate at the single-cell level to generate associated cognitiv

249 ropose that signaling networks exploit noise at the single-cell level to increase population-level in

250 s to give a likelihood that links parameters at the single-cell level to observables at the populatio

251 onse in the presence of the drug doxycycline at the single-cell level to reveal their heterogeneous M

252 Using TIRF microscopy at the single molecule level, transient formation of hom

253 At the single channel level, UBP684 produced a dramatic

254 of STAT3 correlate with the refractory state at the single-cell level under conditions of both sponta

255 ls, and measured reaction-diffusion dynamics at the single-cell level up to the multicell scale.

256 body-antigen binding events can be monitored at the single molecule level using single molecule local

257 ngle influenza virus and specific antibodies at the single particle level using near-field optical tr

258 t mechanisms, we followed developing T cells at the single-cell level using Bcl11b knock-in fluoresce

259 By measuring telomerase activity at the single-cell level using quantitative ddPCR techni

260 ation of non-activated lymphocyte cell types at the single-cell level using refractive index (RI) tom

261 Colicinogenic populations were followed at the single-cell level using time-lapse microscopy, an

262 barnase under the action of mechanical force at the single-molecule level using optical tweezers.

263 rties and force generation capacity of Kif15 at the single-molecule level using optical tweezers.

264 we probed the mechanism of protein flipping at the single molecule level, using HIV-1 reverse transc

265 erized more than 1400 telomere fusion events at the single-molecule level, using a combination of hig

266 information about dynamic chemical processes at the single-molecule level, using advancements in the

267 d decoding of the participant's memory state at the single-trial level, using multivariate pattern cl

268 th serum-free medium (from 13.5 to 78%), but at the single cell level we observed a broad distributio

269 At the single neuron level, we find that chronic sleep d

270 At the single unit level, we found that ensembles of put

271 how Fus3 controls the fate decision process at the single-cell level, we developed a specific transl

272 At the single-cell level, we found that not all episomes

273 nalysing HSC transcriptomes and HSC function at the single-cell level, we identify increased molecula

274 ique that can probe multiple signaling nodes at the single-cell level, we interrogate TCR signaling d

275 th the levels of other maternal determinants at the single-cell level, we propose that Wun2 is used a

276 At the single-cell level, we show that uniquely identifi

277 pecific inhibitors and quantitative analysis at the single-cell level, we systematically characterize

278 At the single-molecule level, we probe the behavior of t

279 Tandem (MS/MS) analyses at the single cell level were conducted for selected add

280 lack thereof, neural oscillatory activities at the single trial level were further calculated with t

281 ntified spontaneous redox signals in neurons at the single mitochondrion level where transients of gl

282 we monitor real-time self-assembly dynamics at the single nanoparticle level, which reveal marked si

283 ws quantification of contractile performance at the single-cell level, which should be valuable to di

284 tochastic fluctuations and feedback topology at the single-molecule level, which provides novel insig

285 p, we were able to visualize click chemistry at the single-molecule level, which revealed a long-live

286 also intimately related to spiking responses at the single-unit level, which themselves carry predict

287 hat the dorsal CA1 is relatively homogeneous at the single cell level, while ventral CA1 is highly he

288 It is unclear whether co-expression analysis at the single-cell level will provide novel insights int

289 Tracking NPs at the single-cell level with current technologies is co

290 insight into global DNA methylation dynamics at the single-cell level with high temporal resolution a

291 to compare glioblastoma expression profiles at the single-cell level with those obtained from bulk t

292 The capability to screen a range of proteins at the single-molecule level with enhanced selectivity i

293 tural and functional imaging in living cells at the single-molecule level with minimal perturbations

294 In addition, we quantify DMSP incorporation at the single-cell level, with DMSP-degrading bacteria c

295 ion of global intracellular calcium analysis at the single-cell level within a large population simul

296 ral DNAs in various human biological samples at the single-molecule level without target amplificatio

297 d active demethylation cycle is demonstrated at the single-molecule level, without the need for chemi

298 tion of brown adipocytes (BAs), particularly at the single cell level, would be of substantial benefi

299 ng events and characterize synapse formation at the single-molecule level, yielding insights into the

300 Investigating chemistry at the single cell level yields a more accurate represen