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1 esion molecule-1 (PECAM-1) expression is pro-atherogenic.
2 nhibit insulin-induced p-Tyr911 and its anti-atherogenic actions (p-Akt/eNOS) in endothelial cells.
3 , synthetic LXR agonists still elicited anti-atherogenic activity in the absence of hepatic LXRalpha,
4 en changes in CaI and on-treatment levels of atherogenic and antiatherogenic lipoproteins, and C-reac
7 ve pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines.
9 ng the mechanisms whereby statins reduce the atherogenic and inflammatory phenotype resulting from a
10 ream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans
11 use some experimental studies have suggested atherogenic and lipotoxicity effects of long-chain and v
15 licit a pro-inflammatory cascade known to be atherogenic and to precipitate acute ischemic events.
17 rmation in response to vascular injury in an atherogenic animal model and explored the molecular mech
18 context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor,
20 n of VLDL secretion reduces plasma levels of atherogenic apolipoprotein B (apoB) lipoproteins but can
21 lbumin excretion relates to higher levels of atherogenic apolipoprotein B fractions in the nondiabeti
24 venous ECs switched its phenotype toward pro-atherogenic by up-regulating the expression of inflammat
25 atients with pediatric psoriasis have a more atherogenic cardiometabolic risk profile, with evidence
26 t increase in free radicals acutely triggers atherogenic changes including inflammation, endothelial
29 ins a target of interest because of its anti-atherogenic, cholesterol removal, and anti-inflammatory
30 ptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) ch
33 Interestingly, HDL from Hp(-/-) mice under atherogenic conditions does not accumulate Hb and is ant
34 s an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry
36 ssified into eight groups: a normal control, atherogenic control and six other experimental groups (f
41 nthesized H2S protects vascular tissues from atherogenic damage by reducing vessel intimal proliferat
42 0.5% kcal from fat) (fructose group, n = 9), atherogenic diet (20% kcal from fructose and 46% kcal fr
43 therogenic diet group, n = 13), and modified atherogenic diet (different source of fat and higher pro
44 mice were fed with either a high-cholesterol atherogenic diet (HCD) or matching normal diet (ND), res
46 atherosclerosis was induced in 18 rabbits by atherogenic diet and double balloon endothelial denudati
47 ression of vascular damage in response to an atherogenic diet by quantifying the in vivo accumulation
48 nd tempers chronic inflammatory responses to atherogenic diet by restraining proinflammatory signalin
50 n rats as well as rabbits, fed on normal and atherogenic diet containing 10% of SL1 and SL2 (experime
52 ild-type and heterozygous counterparts on an atherogenic diet despite having lower levels of apolipop
57 ide transfer protein gene, were placed on an atherogenic diet for 16 weeks, then either made diabetic
61 2% cholesterol and 0.7% cholate by weight) (atherogenic diet group, n = 13), and modified atherogeni
62 oprotein E-deficient (ApoE(-/-)) mice fed an atherogenic diet highlighted DC efficacy in effector T-c
64 ssess an antioxidant protective role against atherogenic diet induced oxidative stress in cardiac, he
66 ificantly inhibited the alteration effect of atherogenic diet on the lipid profile and antioxidant en
67 ant administration of allosamidin and fed an atherogenic diet showed aggravated atherosclerotic lesio
68 ntrol and six other experimental groups (fed atherogenic diet supplemented with different doses of P.
71 streptozotocin-induced diabetes consuming an atherogenic diet, without changes in gross glomerular mo
73 ces or prevents vascular disease, we treated atherogenic diet-fed ldlr(-/-) mice with recombinant ost
86 n observed in the arteries of rabbits fed on atherogenic diets was significantly reduced when structu
88 bly in patients with a significant degree of atherogenic dyslipidaemia (high triglycerides and low HD
89 c target for the treatment and prevention of atherogenic dyslipidemia and NAFLD in young insulin resi
91 rly refined carbohydrate, can exacerbate the atherogenic dyslipidemia associated with insulin resista
92 nonalcoholic fatty liver disease (NAFLD) and atherogenic dyslipidemia associated with the metabolic s
93 hat targeting the central abnormality of the atherogenic dyslipidemia complex, the elevation of trigl
94 e strategy in correcting most aspects of the atherogenic dyslipidemia complex, thereby preventing CVD
95 decades have resulted in an epidemic of the "atherogenic dyslipidemia complex," the main features of
98 lights the potential importance of targeting atherogenic dyslipidemia in diabetic patients with coron
100 ncreasing burden of CVD risk associated with atherogenic dyslipidemia should primarily emphasize the
101 VD risk, at least in part through effects on atherogenic dyslipidemia, a cluster of traits including
103 ue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinic
104 e use of niacin as second-line treatment for atherogenic dyslipidemia, with fibrates reserved for tho
106 ified molecular explanation for fatty liver, atherogenic dyslipoproteinemia, hyperglycemia, and hence
111 sis that the vasculature is altered by known atherogenic effects of chronic HAART or the prolonged in
112 e/FAS-deficient marrow, consistent with anti-atherogenic effects of LXRalpha in the context of FAS de
113 nt sterol levels and CVD, thereby suggesting atherogenic effects of plant sterols or of cholesterol u
114 he exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atheroscle
117 nhancer-mediated inflammatory transcription, atherogenic endothelial responses, and atherosclerosis i
123 , which can be initiated by physiological or atherogenic factors, is a pivotal process in atherogenes
125 Individuals with type 1 diabetes have a less atherogenic fasting lipid profile than those without dia
126 actor-2, leading to reduced plaque growth in atherogenic female LDLR(-/-)ApoB-48-deficient mice.
128 and MBL influence removal and metabolism of atherogenic forms of LDL in the early stages of atherosc
130 oprotein (apo) A-I mediates many of the anti-atherogenic functions attributed to high density lipopro
132 ngthen the theory that apoCIII exerts strong atherogenic functions through both indirect and direct m
133 nment can reduce macrophage inflammatory and atherogenic functions through receptor-mediated signalin
134 which induces endothelial expression of pro-atherogenic genes and the subsequent endothelial dysfunc
136 ely regulated expression of IFNgamma-induced atherogenic genes in human EC and SMC by modulating STAT
137 Apolipoprotein A-I (apoA-I) stabilizes anti-atherogenic high density lipoprotein particles (HDL) in
144 xcept possibly in patients with an increased atherogenic index (triglyceride : HDL-C ratio), or have
147 romatin-dependent signal transduction in the atherogenic inflammatory response, we characterized the
148 Platelet-derived exosomes mediate platelet atherogenic interactions with endothelial cells and mono
149 t here that a cytokine considered to be anti-atherogenic, interleukin-10 (IL10), promotes cholesterol
150 xidative stress are up-regulated by the anti-atherogenic laminar blood flow often seen in straight or
151 ntly blocked the shift in buoyancy from less atherogenic lb-LDL to highly atherogenic sd-LDL, restori
152 atherogenicity that provides a new route to atherogenic LDL and may explain the escalation of cardio
154 portant, blacks had a lower concentration of atherogenic LDL with apo C-III at baseline and after stu
156 genes scavenger receptor BI (SR-BI), an anti-atherogenic lipid exchange mediator, activated internali
157 I, -69.64% to -25.35%]; P < 0.001] and other atherogenic lipid fractions, and it reduced all-cause mo
158 pothesized that orally ingested UFP promoted atherogenic lipid metabolites in both the intestine and
160 flammation, heightened oxidative stress, and atherogenic lipid profile that may increase women's risk
165 ion as a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile in
166 ficacy and safety of mipomersen for reducing atherogenic lipids and lipoproteins in patients with hyp
167 At the top of the checklist for reducing atherogenic lipids and recurrent event risk postmyocardi
168 adhesion by binding its receptor CXCR6, and atherogenic lipids are known to stimulate macrophage adh
169 nce in atherosclerotic plaque, we found that atherogenic lipids up-regulated CXCL16 in primary human
172 nsulin resistance was associated with a more atherogenic lipoprotein cholesterol distribution in all
174 lusion: SULF2 is an unexpected suppressor of atherogenic lipoprotein clearance by hepatocytes and an
176 les produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble pr
177 terolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-den
178 7-fold increase in plasma cholesterol and an atherogenic lipoprotein profile with increased levels of
180 ) the association between very low levels of atherogenic lipoproteins achieved with statin therapy an
182 enetic associations between plasma levels of atherogenic lipoproteins and 25(OH)D were examined in </
183 ervationally is simply a marker for elevated atherogenic lipoproteins and question a role for vitamin
187 e was associated with decreases in levels of atherogenic lipoproteins in patients receiving treatment
191 ency of TGH in mice lowers plasma lipids and atherogenic lipoproteins without inducing hepatic steato
192 cholesterol and AF extended to several other atherogenic lipoproteins, and these associations are unl
193 )D levels are associated with high levels of atherogenic lipoproteins, but whether these 2 risk facto
194 polipoprotein-B (apoB), the major protein of atherogenic lipoproteins, is regulated through posttrans
195 s, evolocumab decreased the concentration of atherogenic lipoproteins, particularly LDL, by accelerat
199 antly increased plasma total cholesterol and atherogenic low-density lipoprotein cholesterol levels i
202 tin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocyte
203 nol levels in the cecum, as well as elevated atherogenic lysophosphatidylcholine (LPC 18:1) and lysop
204 , SAA alters vascular proteoglycans in a pro-atherogenic manner via the stimulation of TGF-beta and m
206 ders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysf
208 ectin provides clues to the inflammatory and atherogenic mechanisms associated with pathological coro
212 quely associates with proinflammatory HDL in atherogenic mice and coronary heart disease (CHD) patien
218 the potential importance of glycation as an atherogenic modification of LDL, factors determining gly
220 declines in total cholesterol (-24.8 mg/dl), atherogenic (non-high-density lipoprotein) cholesterol (
224 , leading investigators to study the role of atherogenic oxidatively modified lipids (oxylipids).
229 oprotein cholesterol (LDL-C) levels or total atherogenic particle burden (apolipoprotein B100) is les
230 ts provide evidence of decreased exposure to atherogenic particles in carriers of the minor SORT1 all
231 isk is more closely related to the number of atherogenic particles than to the total mass of choleste
232 in therapy, on-treatment levels of LDL-C and atherogenic particles were associated with residual risk
234 ant associations for non-HDL cholesterol and atherogenic particles: apolipoprotein B and ion mobility
235 e (GSK) 3alpha/beta in the activation of pro-atherogenic pathways and the accelerated development of
236 -seq approaches identified activation of pro-atherogenic pathways involving a complex interplay of hi
239 g values, compared to SS, NASH showed a more atherogenic postprandial lipoprotein profile, an altered
240 with PPAR agonists can reduce the burden of atherogenic postprandial lipoproteins and improve vascul
241 medically important ligands, such as HIV-1, atherogenic postprandial remnant lipoproteins, and molec
243 mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride-rich lipoproteins
244 tial inflammatory response that precedes the atherogenic process by targeting different steps of the
247 cess during atherosclerosis, thereby linking atherogenic processes and pathological angiogenesis.
251 advances highlight important cell biological atherogenic processes, including mechanotransduction and
252 ment of LDL lipid subfractions toward a less atherogenic profile [decreased small LDL IIIb (-44 +/- 2
254 emonstrated that miR-155 plays a key role in atherogenic programming of macrophages to sustain and en
255 s study examines whether obesity accelerates atherogenic progression or adverse outcomes after corona
256 KS silencing could selectively suppress the "atherogenic," proliferative phenotype of VSMCs without c
257 ndothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and
259 c adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL
260 e molecule with insulin-sensitizing and anti-atherogenic properties, suppresses pro-inflammatory gene
263 receptors for Ccl5 and Ccl2 are important in atherogenic recruitment of neutrophils and monocytes, we
266 P = 5.5 x 10(-8)), suggesting that targeting atherogenic remnant cholesterol may reduce cardiovascula
267 hrough their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice.
268 owing in part to the accompanying burden of atherogenic remnant particles, small dense low-density l
269 d metalloproteases (ADAMs) and stimulate pro-atherogenic responses, endothelial inflammation and perm
273 f a cohort with detailed characterization of atherogenic risk factors, including surrogate markers of
275 h that NOR1 serves a previously unrecognized atherogenic role in mice by positively regulating monocy
279 e results suggest that GSK3alpha plays a pro-atherogenic role, possibly by mediating the effects of e
280 acrophage-targeted uPA overexpression reveal atherogenic roles for both uPA and Plg and are a useful
281 yancy from less atherogenic lb-LDL to highly atherogenic sd-LDL, restoring the percent distribution o
282 es during sleep in absence of concurrent pro-atherogenic settings (i.e., genetic propensity or dietar
284 tly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal tra
290 xidized low-density lipoprotein (ox-LDL), an atherogenic stimulus, reduced PIAS3 expression, an effec
293 n margarines should be improved by replacing atherogenic TFA and SFA with beneficial ones, in order t
294 nd apo A-I and, therefore, appear to be less atherogenic than is a low-fat, high-carbohydrate diet.
295 pro-atherogenic regions is a potential anti-atherogenic therapeutic approach, but it has been extrem
297 s, whereas expression of the potentially pro-atherogenic type B scavenger receptor CD36 was decreased
298 originate through the delipidation of larger atherogenic VLDL and large LDL and from direct de novo p
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