ライフサイエンスコーパス: atomic level

1 cules to be analyzed in living cells, at the atomic level.

2 udying non-equilibrium thermodynamics at the atomic level.

3 lignment mechanisms and forces acting on the atomic level.

4 17 binding site has not been described at an atomic level.

5 complex biomolecules and their functions at atomic level.

6 nsights into architectural intimacies at the atomic level.

7 ls of initiation-to-elongation transition on atomic level.

8 ects have remained largely unexplored at the atomic level.

9 structure or to detailed interactions at the atomic level.

10 erpretation of the vibrational spectra on an atomic level.

11 eformation of novel carbon allotropes at the atomic level.

12 composition and structural parameters at the atomic level.

13 of the mechanism of Pol II translocation at atomic level.

14 es an understanding of the NC surface at the atomic level.

15 standing their structure and function at the atomic level.

16 owth rate can be controlled precisely at the atomic level.

17 ermining the nanoparticle composition at the atomic level.

18 ational dynamics of membrane proteins at the atomic level.

19 ing of the crystallization mechanisms at the atomic level.

20 links between structure and function at the atomic level.

21 e structure of known GASright dimers at near atomic level.

22 observing the motion of biomolecules at the atomic level.

23 tunity to study functional mechanisms at the atomic level.

24 rious degrees of freedom now resolved on the atomic level.

25 tures of homodimeric GASright motifs at near-atomic level.

26 e experiments have never been studied at the atomic level.

27 /C regulatory proteins is not defined at the atomic level.

28 n at epitope II remains to be defined at the atomic level.

29 hemes to tailor the surface precisely at the atomic level.

30 out channel inactivation and recovery at the atomic level.

31 to investigate the B-Z-DNA transition at the atomic level.

32 ficult to characterize experimentally at the atomic level.

33 first study of PECVD growth of SWNTs on the atomic level.

34 nce by creating elemental alternation at the atomic level.

35 the nucleotide-binding domain of MsbA at the atomic level.

36 enhance the base pairing specificity at the atomic level.

37 proteins aggregate at high temperature at an atomic level.

38 minants, showing sigma factor mimicry at the atomic level.

39 narity could be controlled chemically at the atomic level.

40 t systems have yet to be investigated at the atomic level.

41 e TiO2(110) surface pre-characterized at the atomic level.

42 hology transition of magnesium alloys at the atomic level.

43 termination of molecular organization at the atomic level.

44 n of pentameric Cys-loop ion channels at the atomic level.

45 pted to reveal the structural features at an atomic level.

46 w nitrosative stress can exert action at the atomic level.

47 r reactions in biological systems at a truly atomic level.

48 y, and decipher associated mechanisms at the atomic level.

49 hiral materials is not yet understood at the atomic level.

50 er, and to local ~0.2 A displacements at the atomic-level.

51 brane proteins embedded in lipid bilayers at atomic-level.

52 h finer effects pertinent at the residue and atomic levels.

53 iding valuable structural information at the atomic-level about the fibril architecture.

54 A folds up to 174 nucleotides in length with atomic-level accuracy (<1.5 A RMSD).

55 ty to design megadalton-scale materials with atomic-level accuracy and controllable assembly opens th

56 novo design of homodimers can be achieved to atomic-level accuracy by beta-strand assembly or through

57 the method consistently produced models with atomic-level accuracy largely independently of starting-

58 structures can be designed from scratch with atomic-level accuracy.

59 beta-sheet curvature can be controlled with atomic-level accuracy.

60 imer showed that the design process had near-atomic-level accuracy: The all-atom rmsd between the des

61 y co-crystal structures of two variants show atomic-level agreement with the corresponding computatio

62 A crystal structure of the cage showed atomic-level agreement with the designed model, while el

63 planar chemical composition at virtually the atomic level, aimed specifically at studying 2D vertical

64 tern of structural changes that occur at the atomic level and from which the detailed network of resi

65 ogical information needs to be decoded at an atomic level and quantum tunnelling has recently been sh

66 high degree of structural homogeneity at the atomic level and that the aggregated protein retains a n

67 ytic performance is further considered at an atomic level and the underlying mechanisms are discussed

68 vide an unbiased description of water at the atomic level and yield information on the underlying mol

69 To characterize these properties at the atomic level, and to understand how the connector withst

70 he forces acting to stabilize amyloid at the atomic level are highly anisotropic, that an optimized i

71 elucidation of functional mechanisms at the atomic level, as well as for further engineering and app

72 he twin, has never been characterized at the atomic level, because such boundary is, in principle, cr

73 be the rapidly evolving state of the art for atomic-level biomolecular simulation, illustrate the typ

74 They may have fractal structures at the atomic level, but a physical mechanism for their organiz

75 ral and chemical properties determined on an atomic level by aberration-corrected scanning transmissi

76 that probes local motions of a system at the atomic level by allowing extraction of dynamical paramet

77 that can be difficult to characterize at the atomic level by conventional methods because they exist

78 s between multiple species is possible at an atomic level by looking at different parameters using di

79 he observed activity was rationalized at the atomic level by molecular dynamics simulations.

80 (ITC) and energetics of interactions at the atomic level by molecular modelling.

81 This can be achieved down to the atomic level by the disorder-to-order transformation of

82 cooperative binding sites, supported at the atomic level by their co-crystal structure bound to DNA,

83 Engineering the surface structure at the atomic level can be used to precisely and effectively ma

84 Control of structure at the atomic level can precisely and effectively tune catalyti

85 er, the details of force-generation, and the atomic-level characteristics of the force-induced confor

86 Here we report atomic-level characterization by magic angle spinning (M

87 ation and methodologies opened new vistas to atomic-level characterization of a plethora of chemical

88 py at 9.4 T is demonstrated for the detailed atomic-level characterization of commercial pharmaceutic

89 lution challenges are overcome, enabling the atomic-level characterization of membrane proteins in li

90 Our findings provide an atomic-level characterization of the genome release mech

91 se pathology has been the identification and atomic-level characterization of these conformers.

92 A physical model is presented to explain the atomic-level chemistry and structure of these thermally

93 Here we have found unique evidence of atomic level co-operativity in an inorganic material.

94 s structure to 3.0 A resolution to enable an atomic-level comparison.

95 e focus has progressively turned towards its atomic level comprehension.

96 tance of understanding their behavior at the atomic level, computational modeling, a premier high-res

97 While the atomic-level consequences of cleavage for HIV-1 Env are

98 colloidal nanoplatelets (NPLs), owing to the atomic-level control of their confined direction (i.e.,

99 Modifications of local structure at atomic level could precisely and effectively tune the ca

100 holipid membranes with high affinity, but no atomic level data for AS aggregation in the presence of

101 Six RSV F crystal structures provided atomic-level data on how introduced cysteine residues an

102 Atomic-level defects such as dislocations play key roles

103 These studies provide atomic-level definition of A32-like epitopes implicated

104 With this report, we provide the first atomic-level definition of nonneutralizing CD4-induced e

105 e" mechanical response and uniform molecular/atomic level deformation of the organic biopolymer in th

106 ements are analyzed to reveal details of the atomic-level deformation and flow processes of amorphous

107 he water structure is employed to provide an atomic level description of ligand and protein desolvati

108 molecular dynamics simulations, providing an atomic-level description of alternating access transport

109 Here we present a quantitative, atomic-level description of the functional thermodynamic

110 on cryotomography map, resulting in a pseudo-atomic-level description of the in vivo S-layer, which a

111 hes good agreement between residue-based and atomic-level descriptions of hydrophobicity for five res

112 n favourable cases is it possible to provide atomic-level descriptions of sparsely populated and tran

113 essential in the enzymatic process, complete atomic-level descriptions of these steps are difficult t

114 on reaction, and highlight the importance of atomic-level descriptions.

115 by provides an approach capable of providing atomic-level detail to uncover the nuances of protein/me

116 c acids remains only partially understood at atomic-level detail.

117 understanding of the binding interface with atomic-level detail.

118 idylserine membrane recognition by Tim1 with atomic-level detail.

119 structure of OD4.2.2 with VRC-PG04 provides atomic-level details for an HIV-1 domain recognized by b

120 echniques have been correlated to illuminate atomic-level details of bond breaking and formation duri

121 Atomic-level details of dopant distributions can signifi

122 To obtain atomic-level details of the re activation process, we ca

123 ific protein-protein complexes; however, the atomic level determinants of oligomerization are poorly

124 from such annotations enable the mapping of atomic level differences that may have resulted from con

125 osystem II allows us to identify the precise atomic-level differences between organisms in the vicini

126 ll DNA nanostructure architecture as well as atomic-level DNA and dye chemical structure and composit

127 ains, however, mostly uncharacterized at the atomic level due to its intrinsic flexibility.

128 pret experimental results and understand the atomic-level dynamics of chemical reactions; (2) illustr

129 outes, (2) functionalization of g-C3N4 at an atomic level (elemental doping) and molecular level (cop

130 on of hydrogen bonding network combined with atomic-level energy minimization on the optimized model

131 focused on the N-lobe and on describing the atomic level events that take place subsequent to remova

132 d adsorbates stronger, thereby providing the atomic-level explanation for the lack of reactivity of s

133 deal about the function of this motor at the atomic level for catalysis and as an integrated element

134 of unequivocal structural information at the atomic level for complex systems is uniquely important f

135 dynamics, and their assembly pathways at an atomic level for the first time, as these are systems no

136 methods, no direct observation of DPD at the atomic level has been reported.

137 to manipulate and visualize single atoms at atomic level has given rise to modern bottom-up nanotech

138 The control of material interfaces at the atomic level has led to novel interfacial properties and

139 g the nature of the molecular species at the atomic level has led to the identification of a unique C

140 crystalline and amorphous structures at the atomic level has not been experimentally observed.

141 his kind of GB motion comes into play at the atomic level has not been fully revealed.

142 uctural modification of nanomaterials at the atomic level has the potential to generate tailor-made c

143 We introduce a simple binary but atomic-level hydrophobicity scale that allows for the cl

144 ucture was experimentally identified via the atomic level imaging.

145 Here we develop an optimized atomic-level imaging condition to measure TiO6 octahedra

146 equencing is providing new opportunities for atomic-level immunogen design.

147 s, uncovering a metabolic link at the carbon atomic level in ammonia metabolism of A. aegypti.

148 d in the interior cavity of the AACs, on the atomic level in the solid state and in solution, accompa

149 This study provides atomic level information for an important drug target to

150 sp3 plus increasing amounts of Cu(I) provide atomic-level information about how a storage protein loa

151 actions early in amyloid assembly and reveal atomic-level information about species barriers in amylo

152 OB has remained ambiguous owing to a lack of atomic-level information about the MMOH-MMOB (hereafter

153 ochemical information, these studies provide atomic-level information on the mechanism of RNase P and

154 ral supramolecular systems not only provides atomic-level information on the mechanisms of their func

155 These results provide atomic-level information on the molecular mechanism of C

156 Over the last 15 years, the availability of atomic-level information on the structure of the CLCs, c

157 To gain additional atomic-level information, the experiments are complement

158 Such atomic-level information, which is not accessible throug

159 lear magnetic resonance spectroscopy to gain atomic level insight into the structural differences bet

160 nitio molecular-dynamics simulations provide atomic-level insight into the nature of these interactio

161 uce a solid-state NMR approach that provides atomic level insights into cell-associated molecular com

162 simulations can provide accurate models and atomic-level insights into TCR recognition of MHC-like m

163 rent oxide monocrystal model systems enables atomic-level insights into the structural, electronic, a

164 ncies present in the samples, thus providing atomic-level insights into the structures of colloidal T

165 of prototypical RRNPP members have provided atomic-level insights into their mechanism and regulatio

166 derstood, largely owing to a lack of in-situ atomic-level insights.

167 with coarse-grained modeling and yields new, atomic-level, insights into HdeA chaperone function that

168 e of huBuChE in complex with 16 revealed the atomic-level interactions and offers opportunities for f

169 The structure and the atomic-level interactions were determined by saturation

170 sonance (NMR) has had commendable success in atomic-level investigation of folded proteins, intrinsic

171 The present NMR-driven study provides an atomic-level investigation of the structural and dynamic

172 duces changes in the structure of NAs at the atomic level is a challenge.

173 formation for its membrane-bound state at an atomic level is available.

174 Understanding homodimer interactions at the atomic level is critical both for elucidating their biol

175 tive site embedded in complex systems at the atomic level is critical to developing efficient photoca

176 nding how proper function is achieved at the atomic level is crucial to advancing multiple avenues of

177 tural evidence for how DnaB functions at the atomic level is lacking.

178 al bonds, structural characterization at the atomic level is most useful.

179 nce under an external magnetic field, at the atomic level is of great interest both fundamentally and

180 ltiple uniform HTS junctions, control at the atomic level is required.

181 in order to approach an understanding at the atomic level, it is necessary in a first step to drastic

182 At the atomic level, it is not known which interactions of clas

183 enge for structural biology is to understand atomic-level macromolecular motions during enzymatic rea

184 ursuit, yet little has been achieved for the atomic-level manipulation of metallic nanomaterials.

185 of significant progress in recent years, the atomic level mechanism of the DNA synthesis reaction has

186 ion binding in ClC-ec1 and reveal a putative atomic-level mechanism for the decoupling of H+ transpor

187 ular dynamics simulations to investigate the atomic-level mechanism of conformational coupling in the

188 Despite intense research efforts, the atomic-level mechanism transmitting chemical energy from

189 The atomic-level mechanisms by which G protein-coupled recep

190 een implicated in human disease, the precise atomic-level mechanisms remain opaque, greatly hampering

191 show that the reaction is dominated by three atomic-level mechanisms, an indirect reaction proceeding

192 ict how mutations and small molecules affect atomic-level mechanisms, disrupt systems-level networks,

193 at understanding reaction barriers based on atomic-level mechanisms.

194 Despite extensive structural studies, atomic-level mechanistic details of such structural tran

195 An atomic-level mechanistic understanding of the switching

196 s has been characterised to a level where an atomic-level membrane model is available, but the roles

197 ion mechanism is essential to determining an atomic-level model of kinesin action.

198 s of PECAM-1 allow for the development of an atomic-level model of the interactions that PECAM-1 form

199 mentary steps in the activation process, and atomic-level modeling of the effects of missense mutatio

200 uss the three best-studied MCPs highlighting atomic-level models for shell assembly, targeting sequen

201 ata with molecular dynamics simulations gave atomic-level models of representative conformational sta

202 and highlights the need for next-generation atomic-level models of the ion atmosphere.

203 Atomic-level molecular dynamic simulations are capable o

204 Here, we elucidate the atomic-level nature of Cs and Rb incorporation into the

205 e binding of CsrA to RNA is understood at an atomic level, new mechanisms of gene activation and repr

206 We suggest that an atomic level of detail is, in general, necessary for the

207 dissociation remains to be understood at the atomic level of detail.

208 le control over nanoscale pore sizes with an atomic level of precision.

209 the severity of genetic perturbations at the atomic level of protein structure.

210 Until one reaches a near-atomic level of resolution, there are not necessarily re

211 the first time the crystal structure, at the atomic level, of a dehydrated form of a DNA duplex and d

212 odynamics and the structural features, at an atomic level, of the thermal unfolding of Ros87 and comp

213 mics of dislocations and their impact at the atomic level on the lattice structure of graphene.

214 formation generation that make use of either atomic-level or coarse-grained representations.

215 Protein catalysis requires the atomic-level orchestration of side chains, substrates an

216 Here, we discover that interfaces of such atomic level order can also emerge ubiquitously in large

217 d has been actively investigated approaching atomic level patterning.

218 This work provides atomic-level perspective on the inhibition of SETD8 by s

219 ll zerovalent, nonmetallic clusters as novel atomic-level photocatalysts.

220 Determining a complete atomic-level picture of how minerals grow from aqueous s

221 lity to design and construct structures with atomic level precision is one of the key goals of nanote

222 cale device structures, the ultimate goal is atomic-level precision.

223 ination of three-dimensional structures with atomic-level precision.

224 The atomic-level process of CH4-SnO2 interaction and tempera

225 chanisms that guide these transitions at the atomic level promises to impact our understanding of fun

226 However, it has found little use in atomic-level protein structure determination due to the

227 es and molecular diodes that are amenable to atomic-level re-engineering.

228 scopy and scattering techniques to obtain an atomic-level, real-time view of the transition state in

229 Understanding how proteins function at the atomic level relies in part on a detailed characterizati

230 10), yet the mechanism of recognition at the atomic level remains unclear.

231 The interaction between Orai1 and CaM at the atomic level remains unknown.

232 i30-membrane interplay works structurally at atomic level resolution in Arabidopsis (Arabidopsis thal

233 estigation of an exciting class of solids at atomic-level resolution.

234 tility of the new approach, we show that the atomic-level scale rationalizes the hydration of two hyd

235 overlap between the timescales accessible to atomic-level simulations and those on which the fastest-

236 ceptor), a prototypical family A GPCR, using atomic-level simulations in which the modulators spontan

237 ing conformational changes that occur during atomic-level simulations of biomolecules such as protein

238 Atomic-level simulations suggest that the agonist-indepe

239 Here we use atomic-level simulations to elucidate the nucleotide-rel

240 Realizing atomic-level spatial control over qubits, the fundamenta

241 decoys and was compared to those of existing atomic-level statistical potentials which incorporate or

242 NMR can provide residue specific atomic level structural information, but its implementat

243 cular dynamics allows us to predict specific atomic-level structural and dynamical changes in an enzy

244 olloidal nanoclusters as a function of their atomic-level structural characteristics.

245 e, we review what has been learned from this atomic-level structural characterization of affinity mat

246 To address the dearth of atomic-level structural characterization of heterochiral

247 to derive direct correspondence between the atomic-level structural correlations and reported proper

248 Our results elucidate non-intuitive atomic-level structural details of DX-based DNA nanopart

249 H-sensing intersubunit interface in GPC, but atomic-level structural information is unavailable.

250 ntic in vivo diffraction studies can produce atomic-level structural information.

251 Atomic-level structural investigations revealed three at

252 Murray et al. report an atomic-level structural model for FUS LCD fibrils that a

253 pathological aggregation, and we present an atomic-level structural model for the TDP-43 dimer based

254 Building on an atomic-level structural model of a low-light-adapted chr

255 Users build atomic-level structural search queries within PyMOL and

256 model of the D3R derived from the available atomic level structure, and comparisons to the receptor

257 rates, we conclude that there is no fractal atomic-level structure associated with the packing of al

258 Together with other details, our atomic-level structure may provide a foundation for stru

259 bes for the first time (to our knowledge) an atomic-level structure of alphaalpha-striated muscle tro

260 esidues are determined in the context of the atomic-level structure of the antibody-antigen complex,

261 made on the introduction of new methods for atomic-level structure refinement, local structure quali

262 We used the atomic-level structure to reengineer gp120 cores to pref

263 characterizing and describing the disordered atomic-level structure.

264 with available electron microscopy maps and atomic level structures from NMR spectroscopy and x-ray

265 Our atomic level study allows analyzing the vesicle surface

266 can even increase during annealing motivates atomic-level study of dislocation structures of both <00

267 Atomic level synthetic control over a polymer's chemical

268 Our study elucidates at atomic level that the hydrophobicity and substitution ge

269 otein partner BOLA2, we characterized at the atomic level the interaction of apo BOLA2 with the apo a

270 is a starting point for understanding at an atomic level the mechanism driving the mammalian circadi

271 y sheltering the quantum state in the ground atomic levels, the storage time is increased by almost t

272 experimental data probing WDM states at the atomic level to test current models and those performed

273 ransmission electron microscopy to probe the atomic-level transformations at Cu2O/Cu interfaces as th

274 The atomic-level transformations of all reactant moieties, t

275 (1)H photo-CIDNP for characterizing, at the atomic level, transient species involved in electron-tra

276 This finding provides an atomic level understanding for developing highly efficie

277 dings are extremely important in view of the atomic level understanding of structural modification an

278 and first principles calculations to provide atomic level understanding of the structure and properti

279 ncy and discover new active combinations, an atomic-level understanding and control of the catalyst s

280 Despite recent advances in atomic-level understanding of drug and inhibitor interac

281 ic active sites are the prerequisites for an atomic-level understanding of the catalytic mechanism an

282 ovides an important platform for probing the atomic-level understanding of the fundamental mechanisms

283 and provide a starting point for a detailed atomic-level understanding of the mechanisms of SOD1 oli

284 Thus, quantitative atomic-level understanding of the relationships between

285 This has provided an atomic-level understanding of the water-TiO2 interaction

286 nd a detailed study of their function at the atomic level using FTIR difference spectroscopy.

287 it P450 2B4 (CYP2B4) and rabbit cytb5 at the atomic level, utilizing NMR techniques.

288 The structure represents the first atomic-level view of an oligomeric array formed by a mem

289 flexibility, and in an attempt to provide an atomic-level view of this flexibility, we have performed

290 lucidate the Nup37-Nup120 interaction at the atomic level, we carried out crystallographic analyses o

291 To understand CDR3 editing at the atomic level, we determined the structure of a human mel

292 At the atomic level, we have observed distinct structural state

293 ntal understanding of their properties on an atomic level, we investigate single crystals of CH3NH3Pb

294 To elucidate the underlying mechanism at the atomic level, we modeled the Tsn/MHC I complex using all

295 Performing strain analysis at the atomic level, we reveal that strain gradients induced in

296 formational determinants of allostery at the atomic level were examined in molecular dynamics simulat

297 lattices with fully ordered Ge and Pb at the atomic level, which is unusual for elements of the same

298 relationship of RNA both in real time and at atomic level will have a profound impact in advancing ou

299 isms of drug resistance at the molecular and atomic levels will aid in the design and development of

300 rporation of even 30% Eu2+ is possible on an atomic level, with 2-10% Eu2+ giving the peak quantum ef