ライフサイエンスコーパス: atomic resolution

1 nal methods to describe non-native states at atomic resolution.

2 he molecular basis of Alzheimer's disease at atomic resolution.

3 n only if the protein structure is solved to atomic resolution.

4 mplex DNA origami object to be determined to atomic resolution.

5 neous pore assembly for the AMP maculatin at atomic resolution.

6 spectroscopic tool to explore molecules with atomic resolution.

7 eraction site of ligand-protein complexes at atomic resolution.

8 ic details of the two-metal-ion catalysis at atomic resolution.

9 peptide-activated GLP-1R-Gs complex at near atomic resolution.

10 filament formation of mouse ASC in vitro at atomic resolution.

11 on diffraction to determine the structure at atomic resolution.

12 onconducting states need to be determined at atomic resolution.

13 ligand, and solvent are described with full atomic resolution.

14 aracterize dynamics in diverse RNA motifs at atomic resolution.

15 strain fields in three dimensions with near-atomic resolution.

16 olipin/cytochrome c interaction interface at atomic resolution.

17 d on polymeric microtubules are not known at atomic resolution.

18 s of cryo-electron microscopy maps with near-atomic resolution.

19 of individual platinum nanocrystals at near-atomic resolution.

20 with an anti MUC-1 antibody are reported at atomic resolution.

21 rded and structures to be determined at near-atomic resolution.

22 the one-dimensional boundary states down to atomic resolution.

23 2-gold atom NP (Au102NP)] has been solved to atomic resolution.

24 etermine the 3D structure of nanocrystals at atomic resolution.

25 ed RNAs and solved their X-ray structures at atomic resolution.

26 the translocating peptide inside the pore at atomic resolution.

27 show the consequences of dehydration at near-atomic resolution.

28 ture determination of macromolecules at near-atomic resolution.

29 ated and its crystal structure determined at atomic resolution.

30 1 and an open complex with product fucose at atomic resolution.

31 full-tilt series in electron diffraction to atomic resolution.

32 terization of both structure and dynamics at atomic resolution.

33 ty filter gating in Kv11.1 channels, at near atomic resolution.

34 structure of edge and screw dislocations at atomic resolution.

35 on of the "on" and "off" switching of Ras at atomic resolution.

36 ned from atomic force microscopy images with atomic resolution.

37 not been tested in controlled experiments at atomic resolution.

38 pre-catalytic B complex spliceosome at near-atomic resolution.

39 an antibodies have not been characterized at atomic resolution.

40 ecular interface remain poorly understood at atomic resolution.

41 FIN219-FIP1 while binding with substrates at atomic resolution.

42 termined by cryo-electron microscopy at near-atomic resolution.

43 r structure, kinetics, and thermodynamics at atomic resolution.

44 ponding spectra, which can be interpreted at atomic resolution.

45 systems with back action can be studied with atomic resolution.

46 se dimer by electron cryo-microscopy at near-atomic resolution.

47 eikastus rhodopsin 2 (KR2), was resolved at atomic resolution.

48 ture and surface termination of the NCs with atomic resolution.

49 mer --> dimer --> membrane pore formation at atomic resolution.

50 ctural and dynamic description of CBP-ID4 at atomic resolution.

51 cleotide-driven structural changes in p97 at atomic resolution.

52 , and atomic force microscopy--we report the atomic-resolution (0.5 A) structures of three amyloid po

53 t exciting macromolecular assemblies at near-atomic resolution (3-4.5A), providing biological phenome

54 Although atomic resolution 3D structures of protein native states

55 using nucleotide numbers from representative atomic-resolution 3D structures.

56 U1 sub-structures, which together reveal at atomic resolution an almost complete network of protein-

57 hodology established here can be applied for atomic resolution analysis of dynamics in other microtub

58 However, using a combination of advanced atomic-resolution analytical techniques, our data for th

59 diffraction from aligned molecules provides atomic resolution and allows for the retrieval of struct

60 broad approach provided detailed insights at atomic resolution and allows now to identify key residue

61 In silico molecular modeling using atomic resolution and coarse-grained simulations corrobo

62 w being used to determine structures at near-atomic resolution and have great promise in molecular ph

63 n by cryo-electron microscopy has approached atomic resolution and helped solve structures of large m

64 the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that

65 nformational landscapes of Abeta monomers at atomic resolution and provide insight into the early sta

66 as played a major role given its unique near-atomic resolution and sensitivity to the dynamics that u

67 characterize internal motions in proteins at atomic resolution and with time scale sensitivity rangin

68 tion of ICP27 with Aly/REF was elucidated at atomic resolution, and it was shown that three ICP27 res

69 e focused on structural models determined at atomic resolution, and may miss out interesting patterns

70 how many of the SRP-ribosome interactions at atomic resolution, and suggest how the polypeptide-bindi

71 d 7- member rings are directly observed with atomic resolution, and their energy landscape is investi

72 ependency of the intensities associated with atomic-resolution annular dark field imaging line scans

73 ds for probing protein-protein interfaces at atomic resolution are highly desirable.

74 -26.7% and improved mean MOLPROBITY score to atomic resolution at 1.25 A (100th percentile).

75 We were able to determine the atomic-resolution backbone conformation of an antigenic

76 uctures of overlapping ECD fragments at near atomic resolution, built a model of the full ECD, and di

77 Scanning probe techniques provide atomic resolution, but are limited to observations of sl

78 as multi-component ribosomal assemblies with atomic resolution, but is inadequate for disordered syst

79 tructural and compositional information with atomic resolution, but its use is restricted to thin, so

80 t the structure determination of a Au68NP at atomic resolution by aberration-corrected transmission e

81 of the 80alpha and SaPI1 procapsids to near-atomic resolution by cryo-electron microscopy, and show

82 t 3D imaging of dislocations in materials at atomic resolution by electron tomography.

83 ion, we mapped the HSA-Abeta interactions at atomic resolution by examining the effects of HSA on Abe

84 This isomerization has been characterized at atomic resolution by quantitatively interconverting the

85 roscope (STEM) has emerged as a key tool for atomic resolution characterization of materials, allowin

86 reported here establishes the foundation for atomic-resolution characterization of a broad range of a

87 Near-atomic resolution cryo-electron microscopy reconstructio

88 , we report the structure determined by near-atomic resolution cryo-EM of Frh with and without bound

89 Here we present near-atomic resolution cryo-EM structures for flagellar filam

90 Here the authors present near-atomic resolution cryo-EM structures of nine flagellar f

91 Here, we report near-atomic resolution cryo-EM structures, at resolutions ran

92 le protein structure determination from near-atomic-resolution cryo-electron microscopy (cryo-EM) map

93 ls in models that are manually built in near-atomic-resolution cryo-EM maps.

94 efficiency-key bottlenecks in applying near-atomic-resolution cryo-EM to a broad range of protein sa

95 Using near-atomic resolution cryoEM reconstruction and single filam

96 Here, we report the near-atomic resolution cryoEM structures of the Escherichia c

97 The atomic resolution crystal structure of C69G-GES-5 shows

98 uctural basis for this stabilization with an atomic resolution crystal structure.

99 Atomic resolution crystal structures reveal that two dis

100 Here we report atomic-resolution crystal structures of Ca(2+)- and Mg(2

101 Here, we report four atomic-resolution crystal structures of EF-G bound to th

102 Here we report atomic-resolution crystal structures of three such compo

103 terize these dynamic structures by combining atomic-resolution crystal structures with lower-resoluti

104 Near-atomic resolution crystallography supported by in crysta

105 minescent material which has been studied by atomic-resolution Cs -corrected STEM.

106 Atomic resolution data show that Dss1 is disordered and

107 Our structure provides the first atomic-resolution data on any part of a claudin molecule

108 iterative refinement promises to provide an atomic resolution description of the alternate conformat

109 etermined at 2.2-A resolution and provide an atomic-resolution description of the architecture of its

110 apabilities of the methodology for obtaining atomic-resolution descriptions of dynamic systems.

111 mples are heterogeneous, which has prevented atomic-resolution determination of their structures and

112 sh an approach, for the first time, to probe atomic resolution dynamic profiles of a microtubule-asso

113 erimental data and theory for characterizing atomic-resolution dynamics in biological systems.

114 Here we determined the atomic resolution electron cryo-microscopy (cryo-EM) str

115 al approach to obtain a rigorously validated atomic resolution electron cryo-microscopy structure.

116 d scanning transmission electron microscopy, atomic resolution electron energy loss spectrum-mapping

117 We determined the STIV structure using near-atomic resolution electron microscopy and X-ray crystall

118 e the reactors during the meltdowns based on atomic-resolution electron microscopy of CsMPs discovere

119 While electron microscopes can now provide atomic resolution, electron beam induced specimen damage

120 nformers by cryo electron microscopy to near-atomic resolution, elucidating the molecular basis of he

121 ty to image light elements in soft matter at atomic resolution enables unprecedented insight into the

122 Atomic resolution energy dispersive X-ray spectroscopy r

123 Using NMR spectroscopy, we develop an atomic resolution ensemble description of MKK7, revealin

124 n, we successfully construct and validate an atomic resolution ensemble of human immunodeficiency vir

125 ff10 force field as well as to determine an atomic resolution ensemble.

126 ational molecular dynamics (MD) to determine atomic resolution ensembles of biomolecules require the

127 -defined hydrocarbon binding pocket provides atomic resolution evidence for the extended lipid anchor

128 en previously observed in Raman spectra, but atomic-resolution evidence for this interaction remains

129 The integration of atomic-resolution experimental and computational methods

130 tunnelling maps of spin-resolved states with atomic resolution, finding interference processes from w

131 rRNA expansions can leave distinctive atomic resolution fingerprints, which we call "insertion

132 By reaching near-atomic resolution for a wide range of specimens, single-

133 The structures observed at atomic resolution for this peptide model system may offe

134 f directly obtaining structural data at near-atomic resolution, for many molecules the attainable res

135 tors allowed structure determination to near-atomic resolution from 35,000 ribosome particles.

136 mics simulations of biomolecular crystals at atomic resolution have the potential to recover informat

137 nts in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come togeth

138 Here, we establish at atomic resolution how T-STAR and Sam68 bind to RNA, reve

139 It has not been observed at the atomic resolution how the polymerase advances one nucleo

140 Here we present atomic-resolution images of the same basic structures of

141 ssion electron microscopy (STEM) has enabled atomic resolution imaging at significantly reduced beam

142 Using atomic-resolution imaging and electron spectroscopy, the

143 Atomic-resolution imaging in an aberration-corrected sca

144 Here, the authors use atomic-resolution imaging to demonstrate facet dependent

145 Here, we combine atomic-resolution imaging using atomic force microscopy

146 on with bicrystal experiments and systematic atomic-resolution imaging, we are now able to pinpoint i

147 ty in the subunit-subunit interface, seen at atomic resolution in crystals, can explain the large var

148 Studying biomolecules at atomic resolution in their native environment is the ult

149 While NMR provides structural information at atomic resolution, increased spectral complexity, chemic

150 Despite these advances, however, obtaining atomic resolution information describing the higher leve

151 This represents atomic resolution information for a full-length virus-co

152 exemplify the uniqueness of NMR in providing atomic resolution information into key dynamic processes

153 NMR spectroscopy is able to provide atomic-resolution information for ribosome-nascent chain

154 To date, no atomic-resolution information on peptide-TAP interaction

155 discovery benefits immensely from access to atomic-resolution information, structure-based virtual s

156 Our results provide atomic resolution insight into how a small molecule bind

157 se molecular dynamics simulations to provide atomic-resolution insight into the influence of choleste

158 These data provide long sought after near-atomic resolution insights into how MACPF/CDC proteins a

159 Instead, they enable atomic-resolution insights into the native cell states o

160 -state NMR is a powerful technique to obtain atomic-resolution insights into the structure and dynami

161 a three-dimensional interaction network with atomic-resolution interaction interfaces, we find that d

162 nsional protein interactome network with the atomic-resolution interface resolved for each interactio

163 of electron microscopic investigations with atomic resolution into the third dimension.

164 isordered structures such as dislocations at atomic resolution is expected to find applications in ma

165 ing the process of oxygen ion migration with atomic resolution is highly desirable for designing nove

166 ion of cryo-EM structures to the point where atomic resolution is now achievable.

167 t NCP has been studied by crystallography at atomic resolution, little is known about the structures

168 ters whose computational investigation at an atomic resolution may not be currently feasible using co

169 ent strategy to inactivate TNFalpha, but the atomic-resolution mechanism of its inactivation remains

170 lly exfoliated samples, as confirmed by both atomic resolution microscopic imaging and electrical tra

171 olecular dynamics simulations, we present an atomic resolution model of human RNF169 binding to a ubi

172 ectron microscopy (cryo-EM), we establish an atomic resolution model of the RSV CA tubular assembly u

173 Finally, it provides an atomic-resolution model of the primary neutralizing anti

174 These atomic resolution models capable of explaining the obser

175 Although atomic resolution models of both open and closed states

176 enic analysis, guided by homology mapping in atomic resolution models of Kir2.1, Kir2.3, and Kir4.1/5

177 We construct atomic resolution models of thousands of candidate subst

178 vances in molecular simulations provide near-atomic-resolution models of the dynamics of the organiza

179 eric complex, rather than generate detailed, atomic-resolution models.

180 can be tuned by protein engineering to allow atomic-resolution NMR studies of specific protein struct

181 otosystem II (PSII) from cyanobacteria at an atomic resolution, no corresponding structure of the euk

182 STM and atomic-resolution non-contact AFM imaging reveal rectang

183 rystal structure of the material, as well as atomic-resolution observation of the carbon atom positio

184 These atomic-resolution observations offer a basis for rationa

185 structure for the apo form of AgmNAT with an atomic resolution of 2.3 A, which points towards specifi

186 cryo-electron microscopy structures at near-atomic resolution of Hsp104 in different translocation s

187 There are no structures at atomic resolution of oligomers formed by full-length amy

188 methods to determine the structures at near-atomic resolution of the influenza hemagglutinin trimer,

189 of the HK signal transduction mechanism with atomic resolution on a full-length construct lacking onl

190 Here we review recent atomic-resolution or near-atomic resolution structures o

191 These results prove that atomic-resolution protein dynamics is accessible even af

192 A combination of atomic-resolution protein X-ray crystallographic structu

193 scopy structure of ASC(PYD) filament at near-atomic resolution provides a template for homo- and hete

194 ructure of an RING-between-RING E3 ligase at atomic resolution, providing insight into this disease-r

195 Near-atomic-resolution reconstructions can now be obtained, n

196 nnelling microscopy (STM) investigation with atomic resolution revealed previously unknown surface fe

197 we describe the urea transport mechanism at atomic resolution, revealed by unrestrained microsecond

198 The SCFG/MRF models are constructed using atomic-resolution RNA 3D structures.

199 Atomic resolution scanning transmission electron microsc

200 y ex-situ investigations, allowing the first atomic resolution scanning transmission electron microsc

201 ly weak superstructure phenomena revealed by atomic-resolution scanning TEM (STEM) and single-crystal

202 Atomic-resolution scanning transmission electron microsc

203 and is corroborated by aberration-corrected atomic-resolution scanning transmission electron microsc

204 Atomic-resolution scanning transmission electron microsc

205 detecting self-assembly without the need for atomic-resolution scanning tunneling microscopy.

206 Here we report a detailed experimental atomic-resolution secondary-electron microscopy analysis

207 Cryo-EM structure at near-atomic resolution showed that the 982-aa PcV CP is forme

208 he thermodynamic contributions to binding at atomic resolution showing significant differences in the

209 rful tool for studying molecular dynamics at atomic resolution simultaneously for a large number of n

210 isition with a phase plate that enables near-atomic resolution single particle reconstructions.

211 Atomic-resolution single-crystal X-ray structures of the

212 our experiments using X-ray diffraction and atomic resolution STEM-HAADF electron microscopy.

213 our knowledge, our study presents the first atomic resolution structural characterization of a clien

214 e, adequate methodologies reliably providing atomic resolution structural details are still lacking.

215 However, atomic resolution structural techniques cannot keep pace

216 Our approach lays the foundation for atomic-resolution structural analysis of other microtubu

217 -modification sites that are consistent with atomic-resolution structural data.

218 ein interaction data with the specificity of atomic-resolution structural information derived from co

219 approach uses multiple-sequence alignments, atomic-resolution structural information, and riboswitch

220 Our near-atomic resolution structure clearly shows that SpoIIIAG

221 ctron microscopy, here we determine the near-atomic resolution structure of a human APC/C-MCC complex

222 Here, we present an atomic resolution structure of a monomorphic form of Abe

223 In this study, we report the first atomic resolution structure of a stable G-hairpin formed

224 DNA to 2.3 A resolution providing the first atomic resolution structure of any TIA protein RRM in co

225 Our near-atomic resolution structure of CVA6 A-particle complexed

226 Here, we solved the atomic resolution structure of helical MAVS(CARD) filame

227 Here, we present the near-atomic resolution structure of one of these proteins, Sp

228 Here, we report the atomic resolution structure of the IgNAR constant domain

229 An atomic resolution structure of the PG9_N100(F)Y fragment

230 Here, we describe the near-atomic resolution structure of the phi6 double-shelled p

231 We expect the technique to pave the way for atomic-resolution structure analysis applicable to a wid

232 ization of the RAG1/2 signal-end complex for atomic-resolution structure elucidation.

233 our knowledge, this study reports the first atomic-resolution structure of a microtubule-associated

234 Here, we present an atomic-resolution structure of a native contracted Vibri

235 divided into three main types, and the first atomic-resolution structure of a type III RNA-guided imm

236 We report the atomic-resolution structure of an active form of the OCP

237 a single structure calculation to obtain the atomic-resolution structure of the ASC filament.

238 The atomic-resolution structure of the C-terminal truncated

239 ving Cys367 in keratin 14 (K14) occurs in an atomic-resolution structure of the interacting K5/K14 2B

240 ay/neutron (XN) crystallography to obtain an atomic-resolution structure of the protease triple mutan

241 tering and microscopy data, to determine the atomic-resolution structure of the recently discovered p

242 idal pores under certain conditions, but the atomic-resolution structure of these pores is unknown.

243 an X-ray free-electron laser, leading to an atomic-resolution structure with accurate rotamer assign

244 EM) are enabling generation of numerous near-atomic resolution structures for well-ordered protein co

245 systems, new methods are required to obtain atomic resolution structures from biological material un

246 ge datasets are required for achieving quasi-atomic resolution structures of biological complexes.

247 Here we report atomic resolution structures of Bud23-Trm112 in the apo

248 Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered macromole

249 e we review recent atomic-resolution or near-atomic resolution structures of NSF and of the 20S super

250 is feasible to use cryo-EM to determine near-atomic resolution structures of protein complexes (<500

251 come one of the most powerful techniques for atomic resolution structures of protein fibrils.

252 Here we review how combining atomic resolution structures of smaller domains with spa

253 Although atomic resolution structures of the connector and differ

254 tron microscropy (cryo-EM) to determine near-atomic resolution structures of the human PIC in a close

255 uence-dependent nuclear factors require near-atomic resolution structures of the nucleosome core cont

256 chanism of cycloaddition, we have determined atomic resolution structures of the pyridine synthases i

257 Recent atomic or near-atomic resolution structures of three physiologically si

258 We present the first atomic resolution structures of three such replication p

259 odeling of actin-tropomyosin, and docking of atomic resolution structures of tropomyosin to actin fil

260 The near atomic resolution structures of Venezuelan equine enceph

261 The recent near-atomic resolution structures revealed that the interlaci

262 interrogate detailed hypotheses arising from atomic resolution structures.

263 copy is a prime technique for characterizing atomic-resolution structures and dynamics of biomolecula

264 o-EM) has achieved the determination of near-atomic-resolution structures by allowing direct fitting

265 Atomic-resolution structures have recently been determin

266 Unexpected similarities: Atomic-resolution structures of CO2- and NCO(-)-bound ni

267 SAXS data are consistent with atomic-resolution structures of DEBS fragments.

268 Atomic-resolution structures of four VHP analogues were

269 High- to atomic-resolution structures reveal the structural eleme

270 persion of the parameters from a database of atomic-resolution structures.

271 ctions requires detailed maps in the form of atomic-resolution structures.

272 ents in solution NMR spectroscopy facilitate atomic resolution studies of sparsely populated, transie

273 antly reduced this size limitation, enabling atomic-resolution studies of molecular machines in the 1

274 We have characterized these interactions at atomic resolution suggesting that these compounds steric

275 of GroEL-bound substrates and to describe at atomic resolution the events between substrate binding a

276 The full-length structure visualizes at atomic resolution the N-terminal HerA-ATP synthase domai

277 nd out, we use here in-cell NMR to follow at atomic resolution the thermal unfolding of a beta-barrel

278 ur results are instrumental in explaining at atomic resolution the weakened ability of dexamethasone

279 ron microscopy to measure with nanoscale and atomic resolution the widths, motion, and topological st

280 Here we directly quantify with atomic-resolution the charge distribution for manganite-

281 ive state (C/O), this work recapitulates, at atomic resolution, the key conformational changes of a p

282 To explore recognition at atomic resolution, the structures of three fragment comp

283 By comparing these structures at near-atomic resolution, they are able to propose a detailed m

284 lizes an antibiotic bound to any ribosome at atomic resolution, this establishes cryo-EM as a powerfu

285 ex situ and in situ electron microscopy with atomic resolution to show that the modular palladium-cer

286 t the X-ray crystal structure of ProTx-II to atomic resolution; to our knowledge this is the first cr

287 b scores"), we quantify hub-like behavior in atomic resolution trajectories for the first time.

288 Atomic resolution transmission electron microscopy was u

289 quent strain relaxation, which we show using atomic-resolution transmission electron microscopy to oc

290 Atomic-resolution transmission electron microscopy was u

291 nanoparticles has been limited by less than atomic resolution typically achieved by environmental tr

292 icroscopy (cryoEM) and led to a wave of near-atomic resolution (typically approximately 3.3 A) recons

293 ral major capsid protein, elucidated at near-atomic resolution using cryo-electron microscopy, is str

294 materials physics that can now be studied at atomic-resolution via transmission electron microscopy o

295 This work provides an unprecedented atomic-resolution view of evolutionary trajectories crea

296 on of several RP subunits has yielded a near-atomic-resolution view of much of the complex.

297 f mature Japanese encephalitis virus at near-atomic resolution, which reveals an unusual "hole" on th

298 enforcing symmetry facilitates reaching near-atomic resolution with fewer particle images, it unfortu

299 (STEM) provides structure and composition at atomic resolution, with the sensitivity to directly reve

300 We report an atomic resolution X-ray crystal structure containing bot