ライフサイエンスコーパス: atopic dermatitis

1 Working Party Criteria for the Definition of Atopic Dermatitis).

2 Working Party Criteria for the Definition of Atopic Dermatitis).

3 tokine frequently associated with asthma and atopic dermatitis.

4 asthma, allergic rhinitis, food allergy, and atopic dermatitis.

5 ly correctable cellular defects that lead to atopic dermatitis.

6 vaccination that may develop in humans with atopic dermatitis.

7 d in the management of chronic itch, notably atopic dermatitis.

8 reventative strategy to reduce the burden of atopic dermatitis.

9 n = 825; 79.5%), defined as children with no atopic dermatitis.

10 sets and PBMCs from patients with asthma and atopic dermatitis.

11 ous allergic diseases ranging from asthma to atopic dermatitis.

12 nal atopic status did not affect the risk of atopic dermatitis.

13 ation and selection of the IgE repertoire in atopic dermatitis.

14 play a critical role in the pathogenesis of atopic dermatitis.

15 practice and in future clinical research on atopic dermatitis.

16 rmatitis as a spontaneous nonrodent model of atopic dermatitis.

17 show that IL-4 and IL-13 are key drivers of atopic dermatitis.

18 ggered by microbes, such as in patients with atopic dermatitis.

19 as isolated from PBMCs of five children with atopic dermatitis.

20 y was determined by using the mouse model of atopic dermatitis.

21 /Tnd mice, which normally do not suffer from atopic dermatitis.

22 pathogenesis and microbiome modifications in atopic dermatitis.

23 his study used a spontaneous model of canine atopic dermatitis.

24 urface pH has been reported in patients with atopic dermatitis.

25 rently in human clinical trials for treating atopic dermatitis.

26 asthma, allergic rhinitis, food allergy, and atopic dermatitis.

27 b3a (mice) and SERPINB3/B4 (humans) early in atopic dermatitis.

28 ere associated with the persistent infantile atopic dermatitis.

29 es such as chronic sinusitis with polyps and atopic dermatitis.

30 us disorders, including acne, psoriasis, and atopic dermatitis.

31 uce the risk of allergic diseases, including atopic dermatitis.

32 pectively, when compared to children without atopic dermatitis.

33 fect on treatment adherence of TCS phobia in atopic dermatitis.

34 ses including asthma, allergic rhinitis, and atopic dermatitis.

35 inflammatory diseases, including asthma and atopic dermatitis.

36 lly helpful in preventing the development of atopic dermatitis.

37 IgE sensitization in patients suffering from atopic dermatitis.

38 costeroids in adults with moderate-to-severe atopic dermatitis.

39 plicated in the etiology and exacerbation of atopic dermatitis.

40 ms (2.2 [1.2-4.3]) and doctor's diagnosis of atopic dermatitis (1.9 [1.0-3.4]) in childhood, and sens

41 EH was associated with atopic dermatitis (11.72 [9.48-14.49]).

42 2.14-3.38); epithelial conditions, including atopic dermatitis (2.75, 1.23-6.16); and hypertension (1

43 cative of Ag selection was reduced to 11% in atopic dermatitis (24% in asthma).

44 Atopic dermatitis, a chronic inflammatory skin disease w

45 ay a fundamental role in the pathogenesis of atopic dermatitis, a chronic relapsing inflammatory skin

46 using the following keywords: "psoriasis," "atopic dermatitis," "acne," "vitiligo," "seborrheic derm

47 Atopic dermatitis (AD) affects 15% to 25% of children an

48 inflammation, particularly in patients with atopic dermatitis (AD) and AD-like congenital disorders,

49 gen that colonizes the skin of patients with atopic dermatitis (AD) and aggravates their disease.

50 Atopic dermatitis (AD) and allergic contact dermatitis (

51 nce indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivi

52 The association between atopic dermatitis (AD) and cardio-metabolic risk factors

53 e aimed to determine the association between atopic dermatitis (AD) and cardiovascular events in the

54 CD8(+) and activated T-cell subsets in AA vs atopic dermatitis (AD) and control blood.

55 The association between atopic dermatitis (AD) and food allergy (FA) is not full

56 ed T cells in lesional skin of patients with atopic dermatitis (AD) and psoriasis (PSO) might be dire

57 Atopic dermatitis (AD) and psoriasis are driven by alter

58 Atopic dermatitis (AD) and psoriasis pathogeneses involv

59 ols and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis.

60 Atopic dermatitis (AD) appears to be more common in regi

61 Disease flares of established atopic dermatitis (AD) are generally associated with a l

62 cells (LC) in the epidermis of patients with atopic dermatitis (AD) carry the high-affinity receptor

63 The lack of standardized nomenclature for atopic dermatitis (AD) creates unnecessary confusion for

64 nutrition and adiposity have been linked to atopic dermatitis (AD) development.

65 ond classic "allergic"/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with

66 Atopic dermatitis (AD) has been linked with psychiatric

67 Patients with atopic dermatitis (AD) have an abnormal skin barrier and

68 seasonal influenza vaccine in patients with atopic dermatitis (AD) have not been carefully character

69 cia areata (AA) and vitiligo associated with atopic dermatitis (AD) in a large cohort of US women, th

70 ted the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to t

71 Atopic dermatitis (AD) is a chronic inflammatory skin di

72 Atopic dermatitis (AD) is a chronic pruritic inflammator

73 Atopic dermatitis (AD) is a chronic relapsing skin disea

74 Atopic dermatitis (AD) is a chronic skin inflammation th

75 Atopic dermatitis (AD) is a common chronic inflammatory

76 Atopic dermatitis (AD) is a common chronic skin disorder

77 Atopic dermatitis (AD) is a common illness of childhood.

78 Atopic dermatitis (AD) is a common inflammatory skin dis

79 Atopic dermatitis (AD) is a common skin disorder.

80 Atopic dermatitis (AD) is a complex skin disease frequen

81 Atopic dermatitis (AD) is a complex, chronic, inflammato

82 Atopic dermatitis (AD) is a highly prevalent condition t

83 Atopic dermatitis (AD) is a paradigmatic chronic inflamm

84 Atopic dermatitis (AD) is a prevalent disease with varia

85 Because atopic dermatitis (AD) is a relapsing remitting disease,

86 Atopic dermatitis (AD) is a Th2-dominated inflammatory s

87 Atopic dermatitis (AD) is an inflammatory skin condition

88 Atopic dermatitis (AD) is an inflammatory skin disease c

89 Atopic dermatitis (AD) is associated with a heterogeneou

90 Atopic dermatitis (AD) is characterized by epidermal bar

91 Atopic dermatitis (AD) is characterized by intense pruri

92 Atopic dermatitis (AD) is characterized by robust immune

93 and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to

94 The pathogenesis of atopic dermatitis (AD) is multifactorial and complex.

95 Atopic dermatitis (AD) is the most common inflammatory d

96 Atopic dermatitis (AD) is the most common pediatric skin

97 and represent the main T-cell population in atopic dermatitis (AD) lesions.

98 Current atopic dermatitis (AD) models link epidermal abnormaliti

99 Atopic dermatitis (AD) patients mount IgE antibody respo

100 Approximately half of all atopic dermatitis (AD) patients subsequently develop ast

101 Atopic dermatitis (AD) presents a large unmet need for t

102 , our therapeutic armamentarium for treating atopic dermatitis (AD) was still primarily topical corti

103 n, less acidic skin, and fissured skin), and atopic dermatitis (AD) with a severe and persistent cour

104 cluding food allergy, drug hypersensitivity, atopic dermatitis (AD), allergic conjunctivitis, and air

105 strointestinal disease (EGID), patients with atopic dermatitis (AD), and nonatopic healthy control (N

106 from healthy control subjects, patients with atopic dermatitis (AD), and patients with psoriasis.

107 ammatory skin disease, such as psoriasis and atopic dermatitis (AD), another tryptophan metabolism en

108 considered an efficient treatment option for atopic dermatitis (AD), but a global assessment of gluco

109 Sleep disturbance is common in children with atopic dermatitis (AD), but effective clinical managemen

110 as been used for decades in the treatment of atopic dermatitis (AD), but evidence of its effectivenes

111 Atopic dermatitis (AD), food allergy, allergic rhinitis,

112 Even in those without atopic dermatitis (AD), infants with upper-quartile day

113 Atopic dermatitis (AD), psoriasis (PS), and contact derm

114 Atopic dermatitis (AD), the most common chronic inflamma

115 s (KLKs) including KLK5 has been reported in atopic dermatitis (AD).

116 inflammatory diseases such as psoriasis and atopic dermatitis (AD).

117 rstand the epidemiology, cost, and burden of atopic dermatitis (AD).

118 en with the common inflammatory skin disease atopic dermatitis (AD).

119 d allergy, which is commonly associated with atopic dermatitis (AD).

120 the treatment of allergic disorders such as atopic dermatitis (AD).

121 n chronic inflammatory skin diseases such as atopic dermatitis (AD).

122 lay a critical role in the chronification of atopic dermatitis (AD).

123 s with birch pollen allergy with and without atopic dermatitis (AD).

124 isk factor identified for the development of atopic dermatitis (AD).

125 ome samples epidemiologically stratified for atopic dermatitis (AD).

126 ry surgeries and as a maintenance therapy of atopic dermatitis (AD).

127 tion of early weaning with the occurrence of atopic dermatitis (AD).

128 been suggested as important risk factors for atopic dermatitis (AD).

129 coccus aureus is associated with severity of atopic dermatitis (AD).

130 e major predisposing genetic risk factor for atopic dermatitis (AD).

131 area is associated with an increased risk of atopic dermatitis (AD).

132 netic defects in FLG strongly associate with atopic dermatitis (AD).

133 ittle is known about the inpatient burden of atopic dermatitis (AD).

134 ot been defined in patients with early-onset atopic dermatitis (AD).

135 a regarding the long-term clinical course of atopic dermatitis (AD).

136 lay an essential role in initiation of early atopic dermatitis (AD).

137 its positive reactions in a high fraction of atopic dermatitis/AD and healthy individuals.

138 d five main atopic outcomes (asthma, wheeze, atopic dermatitis, allergic rhinitis and IgE) were asses

139 ted efficacy for patients with psoriasis and atopic dermatitis, although the biologic target and mech

140 ng a daily moisturizer as prevention against atopic dermatitis among high-risk newborns.

141 ha/gamma inverse agonist, in mouse models of atopic dermatitis and acute irritant dermatitis.

142 Atopic dermatitis and allergic sensitization had signifi

143 In combination, atopic dermatitis and allergic sensitization had strong

144 also a positive additive interaction between atopic dermatitis and allergic sensitization in their ef

145 ylococcus aureus (S. aureus) is increased in atopic dermatitis and can result in increased severity o

146 ory (allergic rhinitis and asthma) and skin (atopic dermatitis and eczema) allergies.

147 er in utero exposures may affect the risk of atopic dermatitis and emphasize the importance of the ea

148 luate the association between emollient use, atopic dermatitis and FLG mutations, respectively, with

149 vivo studies, fresh blood from patients with atopic dermatitis and healthy control subjects was analy

150 AD CHRONOS), adults with moderate-to-severe atopic dermatitis and inadequate response to topical cor

151 involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their functio

152 or the development of novel therapeutics for atopic dermatitis and other atopic diseases.

153 lopment of effective and safe treatments for atopic dermatitis and other inflammatory disorders of th

154 l therapeutic approaches in the treatment of atopic dermatitis and psoriasis showed that promising su

155 n chronic inflammatory skin diseases such as atopic dermatitis and psoriasis.

156 are important in asthma, food allergies, and atopic dermatitis and their respectively developed antag

157 and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode

158 Information about atopic dermatitis and use of emollients was obtained fro

159 Pruritus is a cardinal symptom of atopic dermatitis, and an increased cutaneous sensory ne

160 is, food allergy, rhinitis, itch, urticaria, atopic dermatitis, and asthma.

161 s dermatological diseases such as psoriasis, atopic dermatitis, and cancer.

162 ls have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (

163 genesis of atopic diseases including asthma, atopic dermatitis, and food allergies.

164 e of the microbiome in patients with asthma, atopic dermatitis, and food allergy.

165 d in lesional skin biopsies of patients with atopic dermatitis, and incubation of keratinocytes with

166 ed to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hype

167 role of keratinocytes in the pathogenesis of atopic dermatitis, and the animals lacking BRAF and RAF1

168 a, and 1.12 (95% CI 0.92-1.37, p = 0.27) for atopic dermatitis, and the effect size on log-transforme

169 Patients with atopic dermatitis are frequently colonized by Staphyloco

170 Patients with persistent infantile atopic dermatitis are more likely to develop asthma by 6

171 IgE transcripts from preschool children with atopic dermatitis are significantly less mutated, clonal

172 uch as asthma, rhinitis, food allergies, and atopic dermatitis, are generally classified by the tissu

173 It is important to recognizing atopic dermatitis as a common and disabling disease not

174 robiome, and highlight the utility of canine atopic dermatitis as a spontaneous nonrodent model of at

175 ected with at least one of the conditions of atopic dermatitis, asthma, or allergic rhinoconjunctivit

176 tes to skin inflammation in diseases such as atopic dermatitis, but the signaling pathways involved a

177 Children were also assessed for atopic dermatitis by using the diagnostic criteria of th

178 Canine atopic dermatitis (CAD) is a chronic inflammatory skin d

179 keratinocytes cause a disease akin to human atopic dermatitis, characterized by IgE responses and lo

180 as alopecia areata, vitiligo, psoriasis and atopic dermatitis, common variants have been identified

181 Atopic dermatitis comorbidities extend well beyond the m

182 In reviewing atopic dermatitis comorbidities, Councilors of the Inter

183 The risk of atopic dermatitis decreased in a dose-dependent manner w

184 Atopic dermatitis, defined as an itchy rash on typical l

185 wever, a specific description of subtypes of atopic dermatitis depending on the timing of onset and p

186 Atopic dermatitis disease severity as assessed by patien

187 ribution, IgE transcripts from children with atopic dermatitis displayed a dominance of the otherwise

188 ($/QALY) for each moisturizer in preventing atopic dermatitis during a 6-month time window.

189 atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic

190 mab was approved for use in the treatment of atopic dermatitis (eczema).

191 ent knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PR

192 derable number of adults still suffered from atopic dermatitis evaluated both by questionnaire (17.1%

193 in (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by marked improvement after

194 the clinical observation that patients with atopic dermatitis experience increased sensitivity to mi

195 llow-up of more than 10 years, reported that atopic dermatitis, family asthma, early-life exposure to

196 Children from this cohort with data on atopic dermatitis from birth to 6 years of age were incl

197 t new results obtained by uploading a recent atopic dermatitis GWAS meta-analysis to examine the gene

198 Patients with persistent infantile atopic dermatitis had a higher risk of asthma before 6 y

199 ion with common FLG mutations, children with atopic dermatitis had significantly higher urinary level

200 Atopic dermatitis has profound impacts on patient and fa

201 ead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic me

202 opportunistically evaluated in patients with atopic dermatitis; however, they often failed to demonst

203 responses in adults with moderate-to-severe atopic dermatitis in a dose-dependent manner, without si

204 ss analysis was used to identify subtypes of atopic dermatitis in childhood based on the course of sy

205 it to PASTURE data separated 4 phenotypes of atopic dermatitis in childhood: 2 early phenotypes with

206 r domestic dog exposure affected the risk of atopic dermatitis in children during the first 3 years o

207 hat S. aureus colonization precedes onset of atopic dermatitis in children.

208 bservations suggest that S. aureus may cause atopic dermatitis in some individuals.

209 for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection o

210 conservative estimate of the annual costs of atopic dermatitis in the United States is $5.297 billion

211 s associated with a strongly reduced risk of atopic dermatitis in two independent birth cohorts and i

212 dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical tre

213 Atopic dermatitis is a chronic inflammatory skin disease

214 Atopic dermatitis is an inflammatory, pruritic skin dise

215 s as it was used in the PEER cohort to treat atopic dermatitis is associated with an increased risk o

216 While the etiopathogenesis of atopic dermatitis is complex and poorly understood, neon

217 type 2 immune response asthma, rhinitis, and atopic dermatitis is lagging behind.

218 The role of mast cells in atopic dermatitis is not completely understood.

219 Atopic dermatitis is the most commonly used term and app

220 r, the effect of dog exposure on the risk of atopic dermatitis is unresolved.

221 Eczema (atopic dermatitis) is associated with an increased risk

222 ed murine atopic dermatitis model, and human atopic dermatitis lesions.

223 idermal and dermal features of MC903-induced atopic dermatitis-like disease and suppresses the produc

224 VT transgenic mice that develop spontaneous atopic dermatitis-like disease that is dependent on T he

225 ential protective role in the development of atopic dermatitis-like disease.

226 l administration of HOCl hydrogel (0.05%) on atopic dermatitis-like lesions in NC/Nga mice model as w

227 (RA) on wild-type mouse skin induces a human atopic dermatitis-like phenotype that is triggered by an

228 ) ) mice, a model for IL-17A-induced chronic atopic dermatitis-like skin inflammation.

229 People with atopic dermatitis may change their occupation because of

230 er investigation are targeted for psoriasis, atopic dermatitis, melanoma, hidradenitis suppurativa, a

231 pidermal keratinocytes, a DFE-induced murine atopic dermatitis model, and human atopic dermatitis les

232 of atopic dermatitis using the NC/Tnd murine atopic dermatitis model.

233 valuations by a dermatologist in adults with atopic dermatitis (n = 261).

234 6,761), childhood onset asthma (n = 15,008), atopic dermatitis (n = 40,835), and elevated IgE level (

235 Atopic dermatitis often precedes the development of othe

236 fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals

237 er, it is unclear if S. aureus is a cause of atopic dermatitis or a consequence of the abnormal epith

238 skin lesions of humans diagnosed with either atopic dermatitis or allergic contact dermatitis as well

239 ing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood

240 st have assessed TCS phobia in patients with atopic dermatitis or their caregivers.

241 Atopic dermatitis (or eczema) is a chronic inflammatory

242 owering alleles were associated with asthma, atopic dermatitis, or elevated IgE levels (p >/= 0.2).

243 levels were associated with risk of asthma, atopic dermatitis, or elevated serum IgE levels, using M

244 evels conferred an increased risk of asthma, atopic dermatitis, or elevated total serum IgE, suggesti

245 disease (hay fever: OR: 5.50 [3.42-9.00] and atopic dermatitis: OR 3.76 [2.14-6.61]), and drug use (L

246 y innocuous, it has strong associations with atopic dermatitis pathogenesis and has become the leadin

247 role of interleukin 4 and interleukin 13 in atopic dermatitis pathogenesis.

248 assessing corticosteroid phobia in Japanese atopic dermatitis patients.

249 e TOPICOP scale was developed previously for atopic dermatitis patients.

250 were used to analyze the association between atopic dermatitis phenotypes and other allergic diseases

251 cute itch and in a transgenic mouse model of atopic dermatitis produced by overexpression of the TH2

252 The Quality of Life Index for Atopic Dermatitis (QoLIAD) and the Dermatology Life Qual

253 Given the possibility of atopic dermatitis-related systemic immune activation, fu

254 Overall, atopic dermatitis represents a major health expenditure

255 eported, but confirmation of their link with atopic dermatitis requires longitudinal studies.

256 Atopic conditions (atopic dermatitis, rhinitis, and asthma) belong to the m

257 dies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of E

258 A model using a combination of atopic dermatitis (risk), pollen allergy (protection), I

259 th moderate-to-severe AD (six area, six sign atopic dermatitis [SASSAD] score: geometric mean, 22.3 [

260 tem Severity Score, and Six Signs, Six Areas Atopic Dermatitis Scale).

261 se severity, such as the Severity Scoring of Atopic Dermatitis (SCORAD) index, or the incidence of AD

262 was AD severity evaluated using the Scoring Atopic Dermatitis (SCORAD) index, with scores ranging fr

263 best correlated with patient-reported global atopic dermatitis severity (Kendall tau = 0.336, P < 0.0

264 us species, concurrent with decreased canine atopic dermatitis severity.

265 er, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and

266 eous microbiome and skin barrier function in atopic dermatitis, show the impact of antimicrobial ther

267 corticosteroid treatment for 1 year improved atopic dermatitis signs and symptoms, with acceptable sa

268 ion of TLR1, TLR6, IL-25, and IL-33 in human atopic dermatitis skin lesions with high house dust mite

269 In a cohort of 14 dogs with canine atopic dermatitis, the skin microbiota were longitudinal

270 ier function and the cutaneous microbiota in atopic dermatitis, this study used a spontaneous model o

271 33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy.

272 To identify different phenotypes of atopic dermatitis using a definition based on symptoms b

273 d the role of skin pH in the pathogenesis of atopic dermatitis using the NC/Tnd murine atopic dermati

274 diversity increased (P < 0.001) and scoring atopic dermatitis values decreased (P < 0.001) in all in

275 The prevalence of atopic dermatitis was 16.1%.

276 ded-to-treat with BCG to prevent one case of atopic dermatitis was 21 (12-76).

277 Atopic dermatitis was associated with higher systolic BP

278 Clinical atopic dermatitis was diagnosed in 466/2,052 (22.7%) chi

279 Atopic dermatitis was diagnosed prospectively according

280 The lifetime prevalence of atopic dermatitis was high (34.1%), and a considerable n

281 hly mutated (7.2%), somatic mutation rate in atopic dermatitis was less than half as high (3.4%).

282 Diagnosis of bronchial asthma and atopic dermatitis was made, but she rejected therapy exc

283 PSAC2000 and COPSAC2010 cohorts, the risk of atopic dermatitis was significantly lower in children wi

284 In both countries the incidence rate of atopic dermatitis was stable during the study periods.

285 Atopic dermatitis was the most commonly used term in stu

286 ess the patient-level and societal burden of atopic dermatitis, we comprehensively reviewed the liter

287 Associations between dog exposure and atopic dermatitis were analyzed by Cox proportional haza

288 Emollient use and atopic dermatitis were associated with modestly increase

289 , maternal asthma, infant bronchiolitis, and atopic dermatitis were associated with persistent wheeze

290 Using latent class analysis, 4 phenotypes of atopic dermatitis were identified depending on the onset

291 strated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-m

292 However, the same might not apply to atopic dermatitis, which is often the first manifestatio

293 ved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the

294 Conversely, atopic dermatitis with allergic sensitization increased

295 lergies were 5 times more at risk to develop atopic dermatitis with an early-persistent phenotype com

296 quencing on a cohort of patients with severe atopic dermatitis with and without comorbid infections,

297 he IgE repertoire of preschool children with atopic dermatitis with regard to signs of superantigen-l

298 Atopic dermatitis without allergic sensitization was not

299 Atopic dermatitis without concomitant allergic sensitiza

300 factor in treatment failure in patients with atopic dermatitis, yet it has been sparsely described in