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1 the correct plane of kinetochore-microtubule attachment.
2 tructures through crystal growth by particle attachment.
3  genetic manipulation to facilitate membrane attachment.
4 thesis of the adhesive holdfast required for attachment.
5 nterface and are important for the bacterial attachment.
6  pHlourin tag or a HaloTag to facilitate dye attachment.
7 on nor how these possible cues change during attachment.
8 nsive to Mps1 and to kinetochore-microtubule attachment.
9 cle bridges, aligning the QDs and leading to attachment.
10 hat virus-Sia interactions may aid in virion attachment.
11 d TRAP+ cells in mice that received ligature attachment.
12 henomena involved with cytoskeleton/membrane attachment.
13  detaching incorrect kinetochore-microtubule attachments.
14 ators, such as BubR1 and 3F3/2, to erroneous attachments.
15 Addition of TGF-beta to GF(-) increased RASF attachment (12.7-fold) compared with other matrices and
16 lements and promotes kinetochore-microtubule attachment [8-11].
17 tudy aims to evaluate long-term stability of attachment achieved in infrabony defects (IBDs) by regen
18 ciple be the result of weak, incomplete cell attachment, adhesion is usually too strong for this to o
19 lays the establishment of chromosome bipolar attachment after the disruption of kinetochore-microtubu
20  selectively phosphorylate Ndc80 to regulate attachment and a second, conserved kinase-independent ro
21     The mammalian need for social proximity, attachment and belonging may have an adaptive and evolut
22                   Drugs that can block viral attachment and cell entry independent of antigenic evolu
23 ies on multiple processes such as chromosome attachment and correct spindle positioning.
24 ount the thermodynamics and kinetics of tile attachment and detachment in solution.
25             Permanent devices should enhance attachment and differentiation of stem cells, responsibl
26 coprotein (GP1,2) that is required for virus attachment and entry into cells.
27     Positively charged coatings using direct attachment and formation of a block copolymer were prepa
28 matitis virus containing LUJV GP as its sole attachment and fusion protein (VSV-LUJV), we demonstrate
29 f the HCV envelope, which is responsible for attachment and fusion, could aid in the development of a
30 oating over favorable sites for PAA-nano-ZVI attachment and hence reduce the affinity of PAA-nano-ZVI
31 sulted in a remarkable reduction of HCV cell attachment and infection.
32  of DNA confers straightforward biomolecular attachment and multistep derivatization capabilities to
33 esive capability, effectively promoting cell attachment and proliferation.
34 t kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure a
35 cells to VSV by simultaneously improving VSV attachment and replication.IMPORTANCE Oncolytic virus (O
36 entified residues important for the covalent attachment and selected the FrdA(E245) residue, which co
37     PS-containing liposomes blocked HCV cell attachment and subsequent HCV infection.
38 oatings exhibit very low preferential mussel attachment and ultralow adhesive strengths under both co
39                            Cells showed good attachment and viability on the collagen-coated 3D print
40 rgies for alkoxides with different framework attachments and backbone length/structure agree with mea
41 ly modifies kinetochores to correct improper attachments and ensure faithful chromosome segregation.
42 e conformations implicated in assembly, host attachment, and RNA release.
43            One of these loops mediates viral attachment, and the other participates in making the fiv
44 finity, impaired internalization of integrin attachments, and resulted in ERK-mediated attenuation of
45        We found that kinetochore-microtubule attachments are established even when Dam1 is not phosph
46 nt epithelial sealing with basal lamina (BL) attachment at the interface of the implant and the adjac
47 vention, designed to enhance maternal-infant attachment, began in the third trimester and continued u
48 tically, DISC1 regulates Ndel1's kinetochore attachment, but not its centrosome localization, during
49 ne signals and remains unreceptive to embryo attachment by continuing to proliferate and failing to d
50 k1 activity and that MYPT1 destabilizes k-MT attachments by negatively regulating Plk1 at kinetochore
51 roposed to stabilize kinetochore-microtubule attachments by strengthening electrostatic interactions
52                     Even for the most remote attachment, costs for partial desolvation of the polar g
53 ns indicate that the addition of microtubule attachments could facilitate tracking during rapid micro
54 in kinetochore biorientation and microtubule attachment defects in vivo.
55 t of protein targets potentially involved in attachment, defence and regulation.
56  things, that significantly reduce effective attachment density.
57 sion between heat and mechanical work in the attachment/detachment of two-dimensional materials on/of
58 called pili or fimbriae that serve either as attachment devices or as conduits for secreted substrate
59                             Sister chromatid attachment during meiosis II (MII) is maintained by secu
60 me condensation, and kinetochore-microtubule attachments during early prometaphase of MI.
61  and B contribute to kinetochore-microtubule attachment dynamics, and they uncover an unexpected role
62 rporate particle collision rate and particle attachment efficiency to simulate multiwalled carbon nan
63  and is a member of a novel clade of lipoate attachment enzymes.
64               The main cellular receptor and attachment factor for entry of these orthobunyaviruses a
65 s identified decades later suggests a common attachment factor, at least until 2002.
66 sis that CD169, a type I IFN-inducible HIV-1 attachment factor, offsets antiviral effects of type I I
67 motes HCV infection by functioning as an HCV attachment factor.
68 emonstrate that HSPGs are important cellular attachment factors for AKAV and SBV, at least in vitro,
69 w the contributions of different microtubule attachment features or tension from biorientation to SAC
70 a cohesive passive layer, after initial cell attachment, followed by the formation of a metal concent
71             We propose that adopting a place attachment framing to community provides a means to capt
72                          Using data on place attachment from 5,403 respondents residing locally, nati
73     CNS responses were examined during spore attachment, fungal germination and pre-penetration of th
74                        The RSV F protein and attachment (G) protein were found to be internalized in
75 Regenerative therapy resulted in significant attachment gain after 1 (median: -3 mm, lower/upper quar
76  on specific kinetochore linkages that other attachment geometries cannot provide.
77  the RSV fusion protein (F) or the RSV major attachment glycoprotein (G) between the hemagglutinin-ne
78 ed ephrin receptor-binding motif in the MojV attachment glycoprotein (MojV-G) indicates a differing h
79 cohol-water solvent, and an overall particle attachment growth mechanism was described for the system
80 media and tissue harvesting sites on explant attachment, growth, and phenotype of OMECs cultured from
81                  However, end-on kinetochore attachments have not been observed in Caenorhabditis ele
82 itor capable of efficiently blocking surface attachment, homophilic adhesion, and biofilm accumulatio
83 rmed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 individuals
84 ange in the plane of kinetochore-microtubule attachment in human cells are not known.
85 l behaviors, and highlight the role of human attachment in providing a template for two-brain coordin
86 ent to regulate the stability of kinetochore attachment in vivo.
87 to correct errors in kinetochore-microtubule attachment in Xenopus egg extracts.
88 aration technologies use labels or long-term attachments in their application.
89 ee genetically programmed stages: substratum attachment, intercellular aggregation and architecture m
90 ccount, the effect size of a maternal-infant attachment intervention targeting impoverished pregnant
91         When taking 1.0 mm connective tissue attachment into account, 60% 3D BA-RSA and 50% 2D BSH lo
92                                              Attachment is catalyzed by holocytochrome c synthase (HC
93                                         This attachment is facilitated by bacterial adhesins at the c
94                                         This attachment is observed to correlate with 20% decrease i
95         However, significantly improved cell attachment is observed to silk-fibronectin alloy fibres
96 s indicate that the stability of kinetochore attachment is regulated by Aurora B/Ipl1 kinase and this
97  for stable immobilization, while monovalent attachment is reversible and, in the case of SLBs, leads
98 ever, the strength of microtubule-centrosome attachments is unknown, and the possibility that mechani
99 , we show that Mps1 destabilizes microtubule attachments (K fibers) epistatically to Aurora B, the ot
100 tal growth is predominantly dominated by the attachment kinetics of atomic clusters in the liquid pha
101  0.05) of mean PD (1.4 +/- 0.7 mm), clinical attachment level (CAL) (1.3 +/- 0.8 mm), and BOP (33.4%
102 ) of at least 5 mm and 2 mm loss of clinical attachment level (CAL) after initial non-surgical therap
103    CF was inversely associated with clinical attachment level (CAL) at baseline before therapy in all
104 , probing depth (PD) reduction, and clinical attachment level (CAL) gain in both statin and placebo/n
105                 Probing depth (PD), clinical attachment level (CAL), and bone PD were recorded.
106 ters, including probing depth (PD), clinical attachment level (CAL), IBD depth, and percentage defect
107 index (PI), probing depth (PD), and clinical attachment level (CAL).
108 e primary outcome was the change in clinical attachment level (CAL).
109 dex (mSBI), probing depth (PD), and clinical attachment level (CAL).
110 uch as probing depth (PD), relative clinical attachment level (rCAL), and gingival margin level (GML)
111 achment level (RVAL) and relative horizontal attachment level (RHAL), and intrabony defect depth were
112 index, probing depth (PD), relative vertical attachment level (RVAL) and relative horizontal attachme
113 index, probing depth [PD], vertical clinical attachment level [CAL-V]) were available for patients at
114 GI], bleeding on probing [BOP], and clinical attachment level) and photographs from 53 participants (
115 ed by measurement of probing depth, clinical attachment level, and extent and severity of disease.
116 H loss were noted at the 5.1-5.4 mm clinical attachment level.
117                                              Attachment lifetimes under load decrease monotonically w
118 (HSPG), the highly conserved target of viral attachment ligands (VALs).
119 he impact of alcohol consumption on clinical attachment loss (AL) progression over a period of 5 year
120  on probing (BOP) and combination of BOP and attachment loss (AL).
121                         More severe clinical attachment loss (CAL) was observed in the 3D RSA measure
122 d 3) periodontal status (probing depth [PD], attachment loss [AL]).
123 ull-mouth, six-site periodontal probing, and attachment loss assessment.
124 6) were observed in participants with severe attachment loss than in other participants.
125 at the very high strength of SPB-microtubule attachments may be important for spindle integrity in mi
126  in luciferase-expressing LV12 cells reduced attachment/metastasis to liver to the same level as that
127               The role of these molecules on attachment, migration, and proinflammatory and prodestru
128 ns into three categories: modified residues, attachment modifications, and cross-links.
129  humans, single genes encode enzymes for its attachment (O-GlcNAc transferase (OGT)) and removal (O-G
130                More importantly, nonspecific attachment of 1,4,7-triazacyclononane-1,4,7-triacetic ac
131 xtract or purified enzyme concluded that the attachment of a GlcNAc on the alpha1,3 mannose arm of N-
132 ich each module of enzymes in turn specifies attachment of a particular chemical unit.
133  boundaries within which roughness operates, attachment of a range of colloid sizes to glass with thr
134 ly on palmitoylation, the post-translational attachment of a saturated 16-carbon lipid.
135 termined the effect of Ca(++) on the rate of attachment of a single myosin molecule to a single regul
136  sulphate solution, magnetically impaired by attachment of a strong neodymium magnet or were controls
137                                     Covalent attachment of a synthetic triantennary N-acetylagalactos
138 aragonite spherulites that crystal growth by attachment of ACC particles is more than 100 times faste
139  Rap1b/talin interaction becomes strong upon attachment of activated Rap1b to vesicular membranes tha
140 CB is shown to be recovered only by covalent attachment of amino acid deactivation agents to residual
141 eletons by precipitation from solution or by attachment of amorphous precursor particles as observed
142 yl carbamate substituent owing to the direct attachment of an C(O)OSiR3 group to an isocyanide nitrog
143                 N-glycosylation involves the attachment of an oligosaccharide to selected asparagine
144                                     Covalent attachment of antibodies on 2D PC membrane based off-mat
145  on the electrode surface for the subsequent attachment of ATRP initiators via the phosphate-Zr(4+)-c
146  with ERGO and subjected to further covalent attachment of Azure A (Azu-A) mediator or glucose oxidas
147 ssays, which showed a strong decrease in the attachment of BCs to endothelial cells when MUC1 and CD4
148 esents a new direction for the site-specific attachment of biomolecules to device platforms.
149 PAMAM-Dendrimers/AuNPs was used for covalent attachment of CA125-antibody and completing the sandwich
150 ing cell internalization by active pathways, attachment of cargo molecules to CPPs invariably reduces
151 hetases (aaRSs), which not only catalyse the attachment of cognate amino acids to their respective tR
152                   Self-assembly via oriented attachment of crystalline nanoparticles is discussed as
153 organelles, is specifically required for the attachment of different building blocks to the 4'-positi
154  a novel method that integrates the covalent attachment of DNA handles to target proteins with a sele
155            This method not only improves the attachment of DNA to metal surfaces but also represents
156 , but the mechanisms underlying the covalent attachment of FAD remain to be fully elucidated.
157                                         Upon attachment of fungal colony microsamples to glassy carbo
158 ia metal-surface-diffusion-assisted oriented attachment of individual nanoparticles, and the interact
159 L51 complex is important for maintaining the attachment of infected cells to their surroundings throu
160                                              Attachment of ligature to a second maxillary molar induc
161 anobacterial T-type lyases, which facilitate attachment of linear tetrapyrrole chromophores to Cys-15
162 th chemotaxis and by promoting rapid surface attachment of motile cells.
163             N-myristoylation is the covalent attachment of myristic acid to the N terminus of protein
164 unctionalities are readily cationized by the attachment of Na(+) during electrospray ionization opera
165  glycerol biosensor was developed via direct attachment of NAD(+)-glycerol dehydrogenase coenzyme-apo
166 n spectroscopies and FE-SEM, which indicated attachment of NR on po-Gr sheets.
167 t of Cur1 on prions parallels effects of the attachment of nuclear localization signal to Sis1, indic
168           This mechanism results in a higher attachment of particles on oil in comparison with adsorp
169 an synthase (DMATS) superfamily catalyze the attachment of prenyl or prenyl-like moieties to diverse
170 cess referred to as pupylation, the covalent attachment of prokaryotic ubiquitin-like protein Pup to
171 esented as an effective route to enhance the attachment of Pt-NP and to improve the structure stabili
172 ersible through detachment and successive re-attachment of reversibly-binding tethers.
173                 We demonstrate here that the attachment of spores to the intestine is essential in th
174 ed glycosylation often involves the covalent attachment of sugar moieties to the hydroxyl group of se
175                                          The attachment of sulfur and hydrocarbons to the surfaces of
176                                              Attachment of SUMO moieties to internal lysines in Ubc9
177 sting of drug loading onto the nanocarriers, attachment of targeting ligands, dynamics of drug releas
178 f external stirring or chemical and physical attachment of the enzyme.
179 ucei cell shape (associated with the lateral attachment of the flagellum) may be an adaptation associ
180                This complex orchestrates the attachment of the GPI anchor to the C terminus of precur
181                                              Attachment of the Influenza A virus onto host cells invo
182 a kinetoplastid-specific kinesin facilitates attachment of the junction to the microtubules in the ma
183 nmol m(-2) in the Gotland Deep, probably via attachment of the mercury compounds to sinking particles
184 s the genomic RNA (gRNA) and is required for attachment of the phage to the host pilus.
185   We demonstrate that CenpE-mediated lateral attachment of the second sister can persistently generat
186 eater processivity is correlated with faster attachment of the tethered head from this vulnerable sta
187        Furthermore, we provide evidence that attachment of the tethered head is irreversible, suggest
188 ism.IMPORTANCE Herpesviruses enter cells via attachment of the virion to the cellular surface and fus
189 nthesis of the lipoyl cofactor, which is the attachment of two sulfhydryl groups to C6 and C8 of a pe
190                                          The attachment of ubiquitin (Ub) or Ub-like (UBL) proteins t
191                    However, LDLR-independent attachment of VSV to HPAF-II cells was dramatically impr
192          Our data show a dramatically weaker attachment of VSV to HPAF-II cells, the most resistant h
193               Our data show very inefficient attachment of VSV to the most resistant human PDAC cell
194 LR expression levels but did not improve VSV attachment or LDL uptake in HPAF-II cells.
195 lectively release antimicrobial agents after attachment or within oral biofilms, resulting in their d
196 master regulator" of kinetochore-microtubule attachment, other mitotic kinases likely contribute to H
197 agellum, which is then remodeled into a thin attachment pad associated with flagellum shortening.
198  barrier that functions to prevent bacterial attachment, penetration, and invasion on PAR4-AP-modifie
199 nse bodies (Z-disks) of striated muscles and attachment plaques of smooth muscles.
200 gions of low complexity often found near the attachment point of bacterial cell wall-anchored protein
201 ave triplet ground states depending upon the attachment position on the azulene core.
202 ideband electromagnetic field records of the attachment process were obtained for 4 negative strokes
203 suggest assembly occurs via an opportunistic attachment process.
204         The ideal biomaterial should promote attachment, proliferation and growth of cells.
205 ad cytotoxic assay and displayed higher cell attachment, proliferation and mineralization than the HC
206 dhesion, and antimicrobial and specific cell-attachment properties.
207               In this study, the Soluble NSF-Attachment Protein (SNAP) subfamily of TPR containing pr
208 a membrane SNAREs syntaxin-1 and soluble NSF attachment protein (SNAP)-25.
209 y approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and s
210 re immunized with only a RABV expressing the attachment protein of CDV vaccine strain Onderstepoort s
211                                    The viral attachment protein of RSV has many surprising features,
212 a subunits with the soluble N-ethylmaleimide attachment protein receptor (SNARE) complex of the vesic
213 he soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein syntaxin-1 a
214  a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein that is know
215 uble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE) proteins comprise th
216    Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins play a majo
217 E (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)- and phospholipid-binding p
218 E (soluble N-ethylmaleimide-sensitive fusion attachment protein receptor)-dependent anterograde traff
219 as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs)].
220 ed two neutralizing antibodies that bind the attachment protein sigma1 of reovirus.
221  animals immunized with a combination of CDV attachment protein- and fusion protein-expressing recomb
222                   The two SNAPs (soluble NSF attachment proteins) differ by only five amino acids.
223                                 Thus, end-on attachment provides geometry-specific molecular cues or
224                               Differences in attachment rate at this advanced stage correlate with lo
225 ance over which myosin binding increases the attachment rate of neighboring molecules.
226  the process, myosin binding accelerates the attachment rate of neighboring myosin molecules, adding
227  excluding HA + ROCK and its effect on early attachment rates and proliferation was studied on forty-
228 iptome-wide similarities between the opossum attachment reaction and implantation in rabbits and huma
229 that occurs in eutherians is derived from an attachment reaction in the ancestral therian mammal whic
230 at the ability to shift from an inflammatory attachment reaction to a noninflammatory period of pregn
231 ee soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins into a parallel fou
232 IM-1 promotes HCV infection by serving as an attachment receptor for binding to PS exposed on the HCV
233  domain-containing protein 1 (TIM-1) are HCV attachment receptors.
234 2, but not SDC-3 or SDC-4, are bona fide HCV attachment receptors.
235 dularity, the latter provides a preferential attachment regime.
236 tion-resistant protein structure, via matrix attachment regions.
237 s (DeltaE<5); while acylation (covalent acid attachment) resulted in DeltaE 5-15.
238 twork that grows according to a preferential attachment rule, while nodes are simultaneously removed
239 SCs based on clamped and hybrid preferential attachment schemes, and show that they perform well in t
240             There were both genetic data and attachment security data for 220 children (110 intervent
241  this work, dual electrochemical pH and cell-attachment sensor arrays were developed for the real-tim
242 radation of this mutant, implying that other attachment sites and/or proteolytic pathways exist.
243 n organization revealed that all chondroitin attachment sites are located in unstructured regions.
244 ubule-binding Ska complex, which enriches at attachment sites prior to anaphase onset to dampen chrom
245 regulation of kinetochore microtubule (k-MT) attachment stability.
246 te of lensectomy (if performed), and retinal attachment status at last visit.
247                              The microtubule attachment status of kinetochores therefore optimizes mi
248 ts and using kinetochore markers specific to attachment status, we reveal a spatially defined role fo
249   The proposed network growth process favors attachment that is preferential not to an individual's d
250 nhibits anaphase but also corrects erroneous attachments that could lead to missegregation and aneupl
251 on of the tail results in prematurely stable attachments that restrain spindle elongation.
252 infection involves multiple steps, from cell attachment, through endocytic trafficking towards the tr
253 nt into which they become engulfed following attachment to a cell surface, in order to gain access to
254                          Haptomonads form by attachment to a surface via a large bulge at the base of
255  activated donors allows their high yielding attachment to almost any amino acid, peptide or protein
256  disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally alphavbeta
257 us (HCV) requires multiple receptors for its attachment to and entry into cells.
258                                    Following attachment to cell surface receptors, reovirus is intern
259 antibody neutralizes HAstV by blocking virus attachment to cells.
260 nt patho-physiological processes through its attachment to different amino acids in proteins.
261 ronger FAK and paxillin phosphorylation upon attachment to fibronectin.
262 equires parasite surface proteins to provide attachment to host cells and extracellular matrices.
263 as not due to sterol dependence of bacterial attachment to host cells, which was similar with all ste
264 cell surface molecules playing a role in VSV attachment to host cells.
265 mposed of DraE subunits, responsible for the attachment to host cells.
266                                 However, VSV attachment to HPAF-II cells was dramatically improved by
267          This charge reversal eliminates DNP attachment to model membranes containing the highest LPS
268  facilitates retention of a gut commensal by attachment to mucin.
269 ports WTA precursors to the cell surface for attachment to peptidoglycan.
270 point (SAC) to detect and signal the lack of attachment to spindle microtubules, and delay anaphase o
271 l reduction does not alter initial bacterial attachment to surfaces but reduces biofilm formation.
272 ded' on the reef without the need for manual attachment to the benthos.
273 ng phage particles, thereby preventing their attachment to the cell exterior.
274 ow the SPKTG motif is essential for covalent attachment to the cell wall.
275                                           CM attachment to the ECM is mediated by integrin complexes
276                            Integrin-mediated attachment to the extracellular matrix (ECM) is required
277 r model also includes detail of the skeleton attachment to the fluidlike lipid bilayer membrane, incl
278 nt outgrowth of CNS neurons in vitro by cell attachment to the high density of arginine-glycine-aspar
279  microscopy, we observe the initial particle attachment to the membrane, then particle wrapping, and
280 DRC1 to form the base plate of N-DRC and its attachment to the outer doublet microtubule.
281 he ATP-dependent activation of MIA and MIA's attachment to the phosphopantetheine moiety of NosJ.
282 ge-sensor domain adopts a non-domain-swapped attachment to the pore and contacts the cytoplasmic Ca(2
283  four communities that each shared a type of attachment to the reef and that spanned conventional loc
284 ding visual pigment regeneration and retinal attachment to the RPE.
285 served on the cell viability during the cell attachment to the surface of immune-reactive biochips an
286 roducing an (R)-stereocenter at its point of attachment to the track.
287 ium to IL1B2 during conceptus elongation and attachment to the uterine surface.
288  induced upon loss of integrin-mediated cell attachments to the surrounding extracellular matrix (ECM
289           Here, a facile topotactic-oriented attachment (TOA) process to grow highly oriented perovsk
290 s elucidate the role of roughness in colloid attachment under both favorable and unfavorable conditio
291 nd to provide the upper and lower bounds for attachment under favorable and unfavorable conditions, r
292 tes stabilization of kinetochore-microtubule attachments via the Ska complex and that this mechanism
293 imary mechanical anchor for the KIF16B-cargo attachment, we measured the adhesion forces and detachme
294 arkable reductions of HCV infection and cell attachment, whereas SDC-3 and SDC-4 knockouts did not af
295 endothelial coverage and minimizing platelet attachment while enhancing the mechanical properties of
296 o stabilize the sensors and promote bacteria attachment while preventing non-specific cell and protei
297 hese ultrathin materials have good interface attachment with Cu, improving the scratch resistance and
298 e collector sites favorable for PAA-nano-ZVI attachment within these media appear to have been screen
299 rientation, likely stabilizing sister end-on attachment, yet cannot induce Mad1 loss from that kineto
300 try into the FP and nucleating the flagellum attachment zone (FAZ), which adheres the flagellum to th

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