ライフサイエンスコーパス: attenuated strain

1 BL206, a high-virulence strain, and B348, an attenuated strain.

2 ve candidates for further evaluation as live attenuated strains.

3 would benefit from the availability of live attenuated strains.

4 ent in all virulent strains but deleted from attenuated strains.

5 In this study, recombinant live-attenuated (strain 17D) YF viruses were constructed to e

6 rast to previous reports of acpA function in attenuated strains, acpA had a minimal influence on caps

7 Oral immunization with this attenuated strain also produced complete, long-lasting p

8 d by the presence of a 7.5-kb plasmid in the attenuated strain and 7 nonsynonomous single-nucleotide

9 oprotein exhibiting reduced expression in an attenuated strain and plays a role in M. gallisepticum v

10 the efficacy of mucosal vaccination via this attenuated strain and will guide its further development

11 The plasmid was cured from the attenuated strain, but it remained nonlethal.

12 erferon response limits the virulence of the attenuated strain by reducing replication, protection fr

13 coprotein (G) gene, even in most recombinant attenuated strains, can still show substantial adverse o

14 were combined with the envelope genes of the attenuated strain caused milder signs of disease.

15 in were combined with the other genes of the attenuated strain caused severe rash and fever even if t

16 d with 109 colony-forming units of Y. pestis attenuated strains CO99 (pCD1+/DeltaApgm) or KIM6+ (pCD1

17 Edematous peri-infarct myocardium had attenuated strain compared with remote myocardium at day

18 berculosis complex, restores virulence to an attenuated strain containing a point mutation (Arg-515--

19 Protection afforded by attenuated strains correlates in part with the ability o

20 rains, but may not be completely safe as the attenuated strain could cause AIDS in some vaccinated in

21 th altered glycogen metabolism, including an attenuated strain defective for type II secretion.

22 t neonatal mice immunized only once with the attenuated strain DeltaactA-Lm developed robust primary

23 lent strains grew more rapidly in AMphi than attenuated strains despite causing less apoptosis.

24 Live attenuated strains developed for use in animals elicit p

25 or protection against tularemia, although an attenuated strain, dubbed the live vaccine strain (LVS),

26 ently than a virus with the H protein of the attenuated strain Edmonston, whereas cell entry efficien

27 effectively protect against infections with attenuated strains, for example, LVS, but not virulent s

28 We show here that immunization with live, attenuated strains generates plague-protective immunity

29 The attenuated strain grows to higher titers in CHSE cells a

30 y among four strains of M. tuberculosis: the attenuated strain H37Ra, the virulent strains H37Rv and

31 substantially less AMphi apoptosis than the attenuated strain H37Ra.

32 Such attenuated strains have the potential to be used as live

33 Vaccines combining 3 or 4 attenuated strains having different LPS serogroups were

34 rial strains elicit much less apoptosis than attenuated strains, implying that apoptosis is a defense

35 on, protection from disease conferred by the attenuated strain in immunocompetent mice can occur inde

36 r entry, which may affect the tropism of the attenuated strain in vivo.

37 Investigators are examining the attenuated strains in additional in vivo, cell culture o

38 her the plasmid-positive or plasmid-negative attenuated strain, indicating that an active process eli

39 This highly attenuated strain induced long-lived protective systemic

40 cobacterium tuberculosis (M.tb) DK9897 is an attenuated strain, it was isolated from a patient with e

41 en coexpressed with N and P proteins from an attenuated strain, L proteins from two attenuated viruse

42 An attenuated strain, L. monocytogenes dal dat, produced by

43 Infection with the attenuated strain led to influx of activated macrophages

44 berculosis infections and suggests that this attenuated strain may represent a valuable vaccine candi

45 e, we show that prior infection with certain attenuated strains may elicit protective immunity.

46 sis suggests that genes absent or altered in attenuated strains may influence pathogenesis.

47 strain of vaccinia virus (VV) and the highly attenuated strain, modified vaccinia Ankara (MVA).

48 m by which virulent bacteria, in contrast to attenuated strains, modulate human cells to cause diseas

49 etic variants and differing in virulence: an attenuated strain (NiggA) and a virulent strain (NiggV).

50 veloped a vaccine strategy for generating an attenuated strain of an intracellular bacterial pathogen

51 ination with a genetically engineered, live, attenuated strain of Blastomyces dermatitidis carrying a

52 -12 to control a live genetically engineered attenuated strain of Blastomyces dermatitidis given s.c.

53 e show that the genomes of a virulent and an attenuated strain of CMV are maintained in hematopoietic

54 , into the genome of CVB3/0, an artificially attenuated strain of coxsackievirus B3, at the junction

55 ro) recognition sites, into the genome of an attenuated strain of CVB type 3 (CVB3/0) at the junction

56 24 h after intravaginal inoculation with an attenuated strain of herpes simplex virus type 2 (HSV-2)

57 Intravaginal inoculation of mice with an attenuated strain of herpes simplex virus type 2 (HSV-2)

58 at these individuals may be infected with an attenuated strain of HIV-1; however, a common genetic ba

59 nonprogression may include infection with an attenuated strain of human immunodeficiency virus type 1

60 ts530, a candidate live-virus vaccine, is an attenuated strain of human respiratory syncytial virus (

61 17D virus with the corresponding genes of an attenuated strain of Japanese encephalitis virus (JE), S

62 rvive and clear high-dose challenges with an attenuated strain of L. monocytogenes that is incapable

63 We therefore have produced a highly attenuated strain of L. monocytogenes that requires D-al

64 In this study, we used an attenuated strain of Listeria monocytogenes as a vaccine

65 pecific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was c

66 We hypothesized that an attenuated strain of Lm would be safe and induce long-la

67 titumor potential of a novel viral agent, an attenuated strain of measles virus (MV), derived from th

68 ng gene 1-/- (RAG1-/-) mice infected with an attenuated strain of MHV-JHM.

69 The attenuated strain of Mycobacterium bovis known as bacill

70 Bacille Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that is used wi

71 Bacille Calmette-Guerin (BCG) is a live, attenuated strain of Mycobacterium bovis used widely for

72 Bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is widely used

73 replication, and transynaptic passage of an attenuated strain of PRV (PRV-Bartha) injected into rat

74 Intravitreal injection of the attenuated strain of pseudorabies virus (PRV Bartha) res

75 ss this question, retrograde transport of an attenuated strain of pseudorabies virus (PRV) from the n

76 question, retrograde tract tracing using an attenuated strain of pseudorabies virus (PRV-Bartha) was

77 ssessed using intracerebral injections of an attenuated strain of pseudorabies virus, a neurotropic a

78 Madrid E is an attenuated strain of R. prowazekii, while Breinl is a vi

79 (WT) control mice were injected i.v. with an attenuated strain of Salmonella enterica Typhimurium (WB

80 ability to kill Escherichia coli (F18) or an attenuated strain of Salmonella typhimurium (sseB) in vi

81 ine was delivered by oral gavage by using an attenuated strain of Salmonella typhimurium as carrier.

82 ry have shown that infection of mice with an attenuated strain of Salmonella typhimurium causes a mar

83 e mice 3 to 7 days after inoculation with an attenuated strain of Salmonella typhimurium produced hig

84 ys after infection of C3HeB/FeJ mice with an attenuated strain of Salmonella typhimurium, there is pr

85 derived maltose-binding protein (MBP) in an attenuated strain of Salmonella typhimurium.

86 Furthermore, a unique attenuated strain of Salmonella was generated for gene d

87 In addition, a novel attenuated strain of Salmonella, which exhibited efficie

88 rom mice that had resolved infection with an attenuated strain of Salmonella.

89 adult rhesus macaques immunized with a live, attenuated strain of SIV (SIVmac239Deltanef).

90 RNA replicon vector system, derived from an attenuated strain of the alphavirus Venezuelan equine en

91 In summary, an attenuated strain of the Creutzfeldt-Jakob disease agent

92 to MHV into RAG1(-/-) mice infected with an attenuated strain of the virus results in the rapid and

93 received an intracerebral inoculation of an attenuated strain of Theiler's murine encephalomyelitis

94 herefore have endeavored to isolate a highly attenuated strain of this organism for use as a vaccine

95 at parenteral immunization with a new highly attenuated strain of this organism provided complete pro

96 ine melanoma by intratumoral injection of an attenuated strain of Toxoplasma gondii (cps) that cannot

97 MVA is an attenuated strain of vaccinia virus (VACV) that is a pop

98 Modified vaccinia virus Ankara (MVA) is an attenuated strain of vaccinia virus (VV) that has attrac

99 ed on an RNA replicon vector derived from an attenuated strain of Venezuelan equine encephalitis viru

100 A molecularly cloned attenuated strain of Venezuelan equine encephalitis viru

101 Infection with attenuated strains of ASFV leads to the upregulation of

102 It also may be useful in creating novel live-attenuated strains of bacteria for use as vaccine candid

103 Attenuated strains of C. trachomatis do not exist, so th

104 Thus, unlike attenuated strains of F. tularensis, Schu4 induced broad

105 st majority of work has been conducted using attenuated strains of Francisella that do not cause dise

106 hrough biosecurity and vaccination with live attenuated strains of ILTV and vectored vaccines based o

107 In this report, we evaluate virulence-attenuated strains of Listeria monocytogenes as vaccine

108 Both virulent and attenuated strains of M. tuberculosis could activate the

109 ion, inactivation of these genes may lead to attenuated strains of M. tuberculosis for the developmen

110 d suggest that to induce optimal protection, attenuated strains of M. tuberculosis should persist lon

111 antituberculosis drugs and for derivation of attenuated strains of M. tuberculosis.

112 g of RLORF4 and the finding that four of six attenuated strains of MDV contained deletions within RLO

113 ined through the use of eosinophil-deficient/attenuated strains of mice that have demonstrated novel

114 Mice infected with attenuated strains of mouse hepatitis virus, strain JHM,

115 viously reported that macrophage exposure to attenuated strains of pathogenic mycobacteria at multipl

116 d the direction of transport of virulent and attenuated strains of PRV, utilizing injections into the

117 r murine flank inoculation with virulent and attenuated strains of pseudorabies virus (PRV).

118 Cold-adapted, temperature-sensitive (ts), attenuated strains of respiratory syncytial virus have b

119 tes of inoculation for wild-type but not for attenuated strains of S. enterica serovar Typhimurium.

120 te the safety and protection induced by live attenuated strains of S. pneumoniae containing combinati

121 We therefore tested DeltaphoP-phoQ attenuated strains of Salmonella enterica serovar Typhim

122 Attenuated strains of simian immunodeficiency virus (SIV

123 cine/challenge experiments that utilize live attenuated strains of simian immunodeficiency virus (SIV

124 could match, or come close to matching, live attenuated strains of SIV in the degree of protection if

125 otective immunity in monkeys inoculated with attenuated strains of SIV is associated with a complex a

126 irus-specific antibody responses elicited by attenuated strains of SIV that was closely associated wi

127 monkeys experimentally infected with various attenuated strains of SIV was characterized by using a c

128 aques but not in macaques infected with live attenuated strains of SIV.

129 ease cholera have focused on the use of live attenuated strains of the causative organism, Vibrio cho

130 Live attenuated strains of V. cholerae that have been used bo

131 rences between the ORF S/Ls of wild-type and attenuated strains of VZV.

132 ass-associated peptides from cultures of two attenuated strains of Yersinia pestis [KIM D27 (pgm-) an

133 hrough immune responses generated with live, attenuated strains or F1 subunit vaccines.

134 ins generally are not good tracers, but some attenuated strains perform well.

135 eceiving intravenous challenge with the same attenuated strain prior to tick passage.

136 is, producing tetra-acylated lipid A, and an attenuated strain producing a Y. pseudotuberculosis-like

137 Inhalational MtbDeltasigH, a stress-response-attenuated strain, protected against lethal TB in macaqu

138 This is the first report of a defined live attenuated strain providing protection against the inhal

139 he smooth virulent strain 2308, in the rough attenuated strain RB51 disruption of the 14-kDa protein'

140 ating that an active process elicited by the attenuated strain reduces inflammation and disease.

141 ge also suggest that a release defect in the attenuated strain reduces the apparent rate of viral tra

142 These attenuated strains retained the ability to colonize the

143 y 30 CFU of S. aureus RN6390 or the isogenic attenuated strains RN6911 (agr mutant), ALC136 (sar muta

144 ely with the level of attenuation; the least-attenuated strain, SIVmac239Delta3, gave the greatest pr

145 Therefore, highly attenuated strains such as modified vaccinia virus Ankar

146 45 was not detected in high-passage, culture-attenuated strains, suggesting that LipL45 is a virulenc

147 ture-tagged mutagenesis screen identified an attenuated strain that featured an insertional disruptio

148 this study, we examined the efficacy of new attenuated strains that are able to synthesize d-alanine

149 e theory, founded on studies with laboratory-attenuated strains, that suggests mutators are rare amon

150 o by its earlier name, Francisella novicida) attenuated strains, the DeltaiglB and DeltafopC strains,

151 With such attenuated strains, the tumor:liver ratios ranged betwee

152 The novel attenuated strains used in these studies were S. flexner

153 that administration of viable yeast of this attenuated strain vaccinates against lethal pulmonary ex

154 ur approach for production of candidate live attenuated strains was to identify mutations that did no

155 rensis Live Vaccine Strain (LVS) and related attenuated strains, we combined the control of in vitro

156 Macaques vaccinated with the attenuated strain were either solidly or partially prote

157 ctors in V. cholerae; however, many of these attenuated strains were still reactogenic in human volun

158 serovar Typhi strain CVD 908-htrA is a live attenuated strain which may be useful as an improved ora

159 (CTS2 and CTS3) were disrupted to yield the attenuated strain, which was unable to endosporulate and

160 l within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the

161 -associated changes were demonstrated in the attenuated strain with significant downregulation of a p

162 ay serve as a viable strategy to derive live attenuated strains with potential for development as eff

163 logies can be applied to FMD virus to obtain attenuated strains with potential for further developmen

164 rulence mechanisms and the creation of other attenuated strains with vaccine potential.