ライフサイエンスコーパス: attenuator

1 tulate that four-gene LRCs act as 'universal attenuators'.

2 allows formation of an intrinsic terminator (attenuator).

3 8, CTLA-4, PD-1, ICOS, or B and T lymphocyte attenuator.

4 substitutions in the T/U-tract of the pyrBI attenuator.

5 r hairpin and U-tract specified by the pyrBI attenuator.

6 tion via ligation of the B- and T-lymphocyte attenuator.

7 fied inhibitory molecule, B and T lymphocyte attenuator.

8 cleavage to occur prior to synthesis of the attenuator.

9 leader peptide encoded by a transcriptional attenuator.

10 tenuator and up to 20.0 for the 20-cm radius attenuator.

11 ttenuator and up to 2.8 for the 20-cm radius attenuator.

12 dditional role in causing termination at the attenuator.

13 sion of upstream genes, and thus LRCs act as attenuators.

14 mple of the PyrR family of pyrimidine operon attenuators.

15 binding riboswitches and other transcription attenuators.

16 SV oncolysis can be overcome with interferon attenuators.

17 regulatory molecules, cytotoxic T-lymphocyte attenuator-4 (CTLA-4), lymphocyte activation gene-3 (LAG

18 Ribo-attenuators allow riboswitches to be treated as truly mo

19 Mutagenesis of these functional attenuators allowed us to create a total of 11 new chime

20 that, as well as inhibiting the aptamer, the attenuator also acts as a structural guide, much like a

21 lymphocyte antigen-4 and B and T lymphocyte attenuator also interact with class 1A PI3K.

22 vators, including a small molecule-triggered attenuator and a group of five mutually orthogonal ribor

23 The 5' attenuator and DED1 dependence of RNA2 suggest that, des

24 he effects depended upon the identity of the attenuator and its orientation but only one of 16 sequen

25 transcriptional initiation site between the attenuator and the ilvG gene.

26 by factors of up to 1.8 for the 10-cm radius attenuator and up to 2.8 for the 20-cm radius attenuator

27 by factors of up to 4.5 for the 10-cm radius attenuator and up to 20.0 for the 20-cm radius attenuato

28 the construction of several transcriptional attenuators and activators, including a small molecule-t

29 membrane proteins, BTLA (B and T lymphocyte attenuator) and CD160.

30 g ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitory

31 The attenuator anneals to conserved bases in the catalytic c

32 d ribozyme-attenuated probe), a 3' terminal "attenuator" anneals to conserved bases in the catalytic

33 Antisense RNA transcription attenuators are a key component of the synthetic biology

34 NF-kappaB), an amplifier (C/EBPdelta) and an attenuator (ATF3) forms a regulatory circuit that discri

35 receptors, of which both B and T lymphocyte attenuator (BTLA) and CD160 engage herpesvirus entry med

36 he Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160, both of which limit inflamm

37 e Ig superfamily members, B and T lymphocyte attenuator (BTLA) and CD160, limits the activation of T

38 the interaction between B- and T-lymphocyte attenuator (BTLA) and herpesvirus entry mediator (HVEM)

39 bed inhibitory receptors, B and T lymphocyte attenuator (BTLA) and programmed death-1 (PD-1), in the

40 nown HVEM ligands such as B and T lymphocyte attenuator (BTLA) and the T lymphocyte receptor LIGHT.

41 The B and T lymphocyte attenuator (BTLA) appears to act as a negative regulator

42 red coinhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) i

43 We present evidence that B and T lymphocyte attenuator (BTLA) coinhibitory signaling is required to

44 B and T lymphocyte attenuator (BTLA) functions as a negative regulator of T

45 Dardenne et al show that B- and T-lymphocyte attenuator (BTLA) functions as an inhibitory receptor on

46 Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator

47 mediator (HVEM) and the B- and T-lymphocyte attenuator (BTLA) inhibit B and T cell activation.

48 B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that inter

49 B and T lymphocyte attenuator (BTLA) is a negative regulator of T cell acti

50 B and T lymphocyte attenuator (BTLA) is a recently identified inhibitory Ig

51 The B and T lymphocyte attenuator (BTLA) is a recently identified member of the

52 entry mediator (HVEM) to B and T lymphocyte attenuator (BTLA) is known to activate an inhibitory sig

53 ammed death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) is linked with dysregulation and exhau

54 , we investigated whether B and T lymphocyte attenuator (BTLA) plays a similar role in functional imp

55 the coinhibitory receptor B and T lymphocyte attenuator (BTLA) predominantly on CD4(+) T cells but al

56 B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and

57 ressed elevated levels of B and T lymphocyte attenuator (BTLA) relative to CD5(-) B cells, as opposed

58 B and T lymphocyte attenuator (BTLA) was initially identified as expressed

59 To determine the roles of B and T lymphocyte attenuator (BTLA), a CD28 family coinhibitory receptor,

60 find that activating the B and T lymphocyte attenuator (BTLA), a coinhibitory receptor for T cells,

61 Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing g

62 as a ligand that binds to B and T lymphocyte attenuator (BTLA), an immunoglobulin super family member

63 ently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an impo

64 entry mediator (HVEM) or B and T lymphocyte attenuator (BTLA).

65 the Ig superfamily member B and T lymphocyte attenuator (BTLA).

66 , programmed death-1, and B and T lymphocyte attenuator (BTLA).

67 lated recently and termed B and T lymphocyte attenuator (Btla).

68 the inhibitory receptor, B and T lymphocyte attenuator (BTLA).

69 hibitory Ig family member B and T lymphocyte attenuator (BTLA).

70 ath-ligand 1 (PD-L1), and B and T lymphocyte attenuator (BTLA); (iii) increasing CD8(+) T cells and P

71 ulin inhibitory receptor, B and T lymphocyte attenuator (BTLA); and the natural killer cell-activatin

72 The B and T lymphocyte attenuator (BTLA, CD272) is a novel coinhibitory molecul

73 B and T lymphocyte attenuator (BTLA; CD272) can deliver inhibitory signals

74 gram death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling

75 The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamil

76 lar levels of CTP prevent termination at the attenuator by a mechanism that requires the nontemplate

77 ion of transcription termination at the pyrG attenuator by CTP were demonstrated.

78 e demonstrate our ability to create chimeric attenuators by fusing sequences from five different tran

79 rpes virus entry mediator B and T lymphocyte attenuator/CD160 pathways.

80 a cis-complementary regulatory nucleic acid (attenuator) controls the ability of the aptamer to bind

81 ities of sense-antisense duplexes and of the attenuator-core duplexes correlate with observed rates o

82 f-cleavage of transcripts with a full-length attenuator could not be restored efficiently by renatura

83 and provide design principles for RNA-based attenuator devices to be used in synthetic biology and R

84 ergy control (SC) motif embedded within the "attenuator domain" of CCAAT/enhancer-binding protein alp

85 that MIM tuning, aided by a digital tunable attenuator (DTA), can automatically adjust MIM operation

86 memory and possibly functions as a molecular attenuator during signal transduction.

87 show that a previously described frameshift attenuator element does not actually affect frameshiftin

88 ct genetic evidence for a role of BI-1 as an attenuator for cell death progression triggered by both

89 antisense sequence linking the ribozyme and attenuator frees the core to fold into an active conform

90 sions between the engineered transcriptional attenuator from plasmid pT181 and natural antisense RNA

91 igonucleotides that directly paired with the attenuator gave up to 1760-fold activation.

92 in HeLa cell extracts demonstrated that the attenuators give rise to premature termination of transc

93 The potential attenuator has been identified and point-mutated.

94 ammed death receptor-1 or B and T lymphocyte attenuator have persistent inflammation out to 15 days f

95 g and in situ hybridization show that the Hh attenuator Hhip is downregulated.

96 oduced a novel genetic element called a ribo-attenuator in Bacteria.

97 in the reporter genes tested, but acts as an attenuator in combination with upstream sequences.

98 dy identifies A20 as an antigen presentation attenuator in control of antitumor immune responses duri

99 elicolor is regulated by a ribosome-mediated attenuator in the 5' leader of its mRNA region.

100 mmed death receptor-1 and B and T lymphocyte attenuator in the regulation of allergic airway inflamma

101 There is a strong attenuator in the rpmG-fpg intergenic region and three t

102 sted met the criteria for a Tat-suppressible attenuator in vivo.

103 s process is governed by DNA elements called attenuators in concert with cellular transcription facto

104 There also appear to be attenuators in the yggX-mltC and mltC-nupG intergenic re

105 on, but lend little support to their role as attenuators in vivo.

106 o protein family and function as cytoplasmic attenuators in Wnt and TGFbeta signaling.

107 ther a potential riboswitch or transcription attenuator involved in the regulation of cell division.

108 n enzyme-substrate pair that functions as an attenuator is a generalizable strategy that enables this

109 We show that the trp attenuator is a weak intrinsic terminator due to low GC

110 ly, because both the input and output of the attenuator is RNA, we show how these variants can be con

111 ion of the TRAP, between the aptamer and the attenuator, is complementary to a target nucleic acid, s

112 ompetitive IRE1alpha Kinase-Inhibiting RNase Attenuators-KIRAs-that allosterically inhibit IRE1alpha'

113 en-4, programmed death-1, B and T lymphocyte attenuator, LAG3, T-cell immunoglobulin and mucin domain

114 terminate at a putative Rho-factor-dependent attenuator located in the tyrS-pdxY intercistronic regio

115 specialized DNA elements, such as the Fab-7 attenuator, might play a general role in controlling the

116 ements with activating roles, and uncovered 'attenuator' motifs with repressive roles in active chrom

117 nsin DEFB103 acts as both a stimulant and an attenuator of chemokine and cytokine responses: a dichot

118 We identified miR-211 as a putative attenuator of cholinergic-mediated seizures by intersect

119 uggest that the inflammasome functions as an attenuator of colitis and CAC.

120 aspase-1 (IL-1beta-converting enzyme) and an attenuator of cytokine responsiveness to septic infectio

121 SCL3 seems to act as an attenuator of DELLA proteins.

122 f the mutation (named provisionally adr, for attenuator of drug resistance) into representatives of m

123 2 functions in cardiac valve formation as an attenuator of EMT by repressing GATA4 activity within th

124 The pyrBI attenuator of Escherichia coli is an intrinsic transcrip

125 s been considered as a potentially important attenuator of inflammation.

126 and uncover a function for FBXW7alpha as an attenuator of inflammatory signalling.

127 ings, this work identifies Alph as a general attenuator of MAPK signaling in Drosophila.

128 d-type cells with the cytokine BAFF, a known attenuator of p18(INK4c) function in B lymphocytes, was

129 MDM2, the cellular attenuator of p53, discriminates the FXXPhiPhi motif of

130 complexes regulate a common novel target and attenuator of RAS signalling, AJM-1 (Apical Junction Mol

131 We have discovered that Coronin1B is a novel attenuator of ROCK signaling.

132 iate level of backscatter and is the largest attenuator of signal at 850 nm.

133 support the hypothesis that myostatin is an attenuator of skeletal muscle growth in adult men and co

134 DAPK2 therefore comprises a new candidate attenuator of stress erythropoiesis.

135 The HD moiety of GalphatGDP is an attenuator of the activated catalytic core, whereas in t

136 PCD, increased BAX inhibitor-1, an effective attenuator of the death programs in eukaryotes, and rest

137 Thus, mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which i

138 nal mechanism whereby AUF1 acts as a crucial attenuator of the inflammatory response, promoting the r

139 sting that it does not act as a conventional attenuator of transcription.

140 we identified tmem88a, a recently described attenuator of Wnt signaling, as a discrete regulator of

141 location of the lesion in circularly-shaped attenuators of 10- and 20-cm radii, with and without att

142 iscs large proteins as tumor suppressors and attenuators of cell division, in T lymphocytes, DLGH1 fu

143 large-scale RNAi screen designed to identify attenuators of RAS signalling during vulval development.

144 , including coinhibitory molecules and other attenuators of TCR signaling, with a focus on their cont

145 vant beta2AR physiologic function, acting as attenuators of the acute response, and represent specifi

146 gulators of G-protein signaling (RGS) act as attenuators of the G-protein signal cascade by binding t

147 of Btn and Btnl molecules to act as specific attenuators of tissue-associated inflammatory responses.

148 sis indicate that Rho functions as a global "attenuator" of transcription, acting at the 5'UTR of hun

149 o acid (UAA) can be used as a small-molecule attenuator or activator of gene transcription, and the l

150 The fungal arginine attenuator peptide (AAP) is a regulatory peptide that co

151 The Arg attenuator peptide (AAP) is an evolutionarily conserved

152 The fungal arginine attenuator peptide (AAP) is encoded by a regulatory upst

153 ate translation of the uORF-encoded arginine attenuator peptide (AAP) is important for regulation.

154 m open reading frame (uORF) encoding the Arg attenuator peptide (AAP) that confers negative translati

155 The evolutionarily conserved fungal arginine attenuator peptide (AAP), as a nascent peptide, stalls t

156 n reading frame (uORF) encoding the arginine attenuator peptide (AAP).

157 a arg-2 uORF encodes the 24-residue arginine attenuator peptide (AAP).

158 e and contains removable, variable thickness attenuator plates (copper or lead) to modulate the photo

159 RS operon exhibited a unique feature with an attenuator present between ygiW and firR that caused the

160 er 93 kDa (2)H,(15)N-labeled Trp RNA-binding attenuator protein tumbling with a correlation time tauc

161 etween the HVEM and BTLA (B and T lymphocyte attenuator) receptors.

162 p represses transcription through the leader-attenuator region of the ilvGMEDA operon.

163 rom its predicted binding site in the second attenuator region.

164 genes is limited to the leader sequences of attenuator-regulated operons.

165 provide evidence that termination at the trp attenuator requires forward translocation of RNA polymer

166 The observation that the attenuator requires the presence of TRAP bound to the na

167 ingular example of a leader mRNA with tandem attenuators responding to different signals.

168 Previously, formation of the attenuator RNA structure was believed to be solely respo

169 fields as radio-frequency electronics, micro-attenuators, sensors and many others.

170 nfluenced, in part, by whether the available attenuator sequence could form structures with the riboz

171 tenuated probes (TRAP) design, antisense and attenuator sequences are appended onto the catalytic cor

172 ging task and to deviations from the assumed attenuator size and shape.

173 on of the antiterminator, and thus allow the attenuator structure to form constitutively, do not resu

174 ator and the thickness of the mercury in the attenuator system.

175 as fitted with a computer-controlled mercury attenuator that facilitated changes in dose rates as des

176 ozyme is a stretch of nucleotides termed the attenuator that functions to base-pair with and unfold t

177 The MFAO-2s outperform clioquinol, a metal attenuator that has been investigated for the treatment

178 ry is creating larger families of orthogonal attenuators that function independently of each other.

179 ficient hearts are impervious to hypertrophy attenuators, that mitochondrial metabolism regulates car

180 This suggests that in the presence of the attenuator, the cleavage-active ribozyme fold is not the

181 d the process of low-dose image acquisition, attenuator thickness calculation, mask generation, mask

182 sequences, suggesting that tight binding of attenuator to the core is assisted by a long antisense p

183 of inhibiting SOCS1, an antigen presentation attenuator, to break self tolerance and induce effective

184 atment, but not cotreatment, with interferon attenuators valproate, Jak1 inhibitor, or vaccinia virus

185 effect of the presence or absence of the his attenuator was assessed under these conditions as well.

186 ge of the ribozyme followed by a full-length attenuator was increased by decreasing the rate of trans

187 Termination of transcription at the attenuator was strongly promoted by the combination of P

188 t more fully and explore its role as an anti-attenuator, we examined the ability of several natural a

189 tions on termination efficiency at the pyrBI attenuator were also measured in vitro, which corroborat

190 Surprisingly, only 23 nt of attenuator were needed for strong inactivation of cleava

191 transcriptional fusions that lacked the leu attenuator were used, expression from the leu promoter v

192 The exception is BTLA (B and T lymphocyte attenuator), which instead interacts with the tumor necr

193 e studies suggest that Fab-7 functions as an attenuator, which weakens gene expression by reducing en

194 he 5' end of the transcript and the putative attenuator within the coding sequence were required for