ライフサイエンスコーパス: attrition

1 to further define program factors affecting attrition.

2 ir opinions regarding resident education and attrition.

3 f TB highlight different patterns of patient attrition.

4 However, these studies are susceptible to attrition.

5 ematopoietic stem and progenitor cell (HSPC) attrition.

6 pine subtypes showing the greatest degree of attrition.

7 improving patient safety and preventing drug attrition.

8 r patient load was associated with decreased attrition.

9 kill surrounding cells, causing host tissue attrition.

10 o dissatisfaction with nursing and increased attrition.

11 ured, and identified factors associated with attrition.

12 d 12-month assessments, without differential attrition.

13 ary intake information at low cost with less attrition.

14 endments have not changed the annual rate of attrition.

15 of homeostatic proliferation and memory cell attrition.

16 6) were associated with an increased risk of attrition.

17 multiple hypotheses tested and for nonrandom attrition.

18 on repair cycle potentially causing telomere attrition.

19 thened efforts for clients at higher risk of attrition.

20 ong G2/M arrest, indicating massive telomere attrition.

21 1]) had a significantly higher likelihood of attrition.

22 l surgical residency continues to experience attrition.

23 rial fibrillation (AF) ablation demonstrates attrition.

24 vors complete hydration but also detrimental attrition.

25 minimizing the risk of late drug combination attrition.

26 ments were also factors in placement-related attrition.

27 n-6 (omega-6) PUFA intake may accelerate LTL attrition.

28 l treatments for anxiety disorders with less attrition.

29 pendent factor most strongly associated with attrition.

30 sion and that anisotropy would be greater in attrition.

31 iation was associated with increased 6-month attrition.

32 er versus individual trials, compliance, and attrition.

33 ll counts and death, attrition, and death or attrition.

34 itiation may be at greater risk of treatment attrition.

35 nd likely overestimated categorical resident attrition.

36 ore intensive screening were limited by high attrition.

37 s was additively associated with greater LTL attrition (3 herpesviruses vs none, beta = -0.07 and P =

38 The determinants of telomere attrition, a potential marker of cellular aging, are not

39 sential enzyme that counteracts the telomere attrition accompanying DNA replication during cell divis

40 dose of methadone had a lower likelihood of attrition, adjusting for other characteristics.

41 cting the integrity of chromosomes and their attrition after cell division and during aging are evide

42 There have been few data on determinants of attrition after presentation to EDs for nPEP.

43 liation for hypoplastic left heart syndrome, attrition after the Norwood procedure remains significan

44 lungs include defective autophagy, telomere attrition, altered proteostasis, and cell senescence.

45 Reasons for the higher attrition among minority potential donors remain unexpla

46 They include high rates of attrition among young investigators, failure to maintain

47 For telomere attrition, amount of food and begging effort exerted add

48 concerns have been raised regarding patient attrition, an important measure of program quality.

49 assuming 500 participants per group with 30% attrition and a 5% alpha level, we project 80% power to

50 For example, a 3-year trial with 10% attrition and a treatment effect of 50% requires a total

51 Attrition and adverse events (AEs) were similar between

52 In addition, we observed telomere attrition and an increased frequency of micronuclei and

53 n, causes a significant increase in telomere attrition and apoptotic death in all BAC cell lines test

54 ttrition prevalence) or secondary (causes of attrition and characteristics and destination of residen

55 compared with face-to-face resulted in lower attrition and close to equivalent improvement in depress

56 patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along wi

57 o elucidate the microwear characteristics of attrition and erosion in worn natural teeth, we scanned

58 vided into 4 groups, including 2 wear types (attrition and erosion) and 2 locations (anterior and pos

59 T cells at the site of infection and prevent attrition and functional exhaustion.

60 IPT had (nonsignificantly) lower attrition and higher response rates than prolonged expos

61 lex genes can result in accelerated telomere attrition and human disease.

62 treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juven

63 obtain comparative metrics for lifelong LTL attrition and learn about the temporal association of LT

64 To confirm the association between telomere attrition and loss of LLM and ALMBMI, which are highly r

65 Norwood and S2P that both minimizes pre-S2P attrition and maximizes post-S2P survival exists and is

66 only sporadically, with 66% reporting animal attrition and none reporting blinded outcome assessment

67 ain and anterior pituitary and causes tissue attrition and other systemic defects similar to those se

68 a promising alternative to the high rates of attrition and relapse currently observed with agonist ta

69 Attrition and reporting bias were high, whereas selectio

70 Although cohort attrition and small numbers of exclusions at 8 years are

71 animals, such as somatic mutation, telomere attrition and the costs of repair and maintenance, do no

72 ector attitudes are associated with resident attrition and to measure the categorical resident attrit

73 senescence accompanied by enhanced telomere attrition and WRN protein down-regulation.

74 hibitory effects of cell-intrinsic (telomere attrition) and cell-extrinsic (chemical- or metabolism-i

75 in senescence markers p53 and p16, telomere attrition, and accompanied CPC exhaustion is evident in

76 of pre-ART CD4+ cell count levels on death, attrition, and death or attrition in HIV treated patient

77 between pre-ART CD4+ cell counts and death, attrition, and death or attrition.

78 d through 12 months, findings are limited by attrition, and further research is needed to assess long

79 on against diamond is consistent with atomic attrition, and inconsistent with fracture or plastic def

80 any trials were short (<12 months), had high attrition, and lacked blinding.

81 coverage, treatment availability, programme attrition, and other factors.

82 was the attenuation of accelerated telomere attrition, and the primary efficacy end point was a 20%

83 However, further reductions in attrition are needed to maximize individual and populati

84 dhood telomere length (TL) and more rapid TL attrition are widely regarded as manifestations of stres

85 lts, by direct observation, establish atomic attrition as the primary wear mechanism of silicon in va

86 Attrition at 24 weeks was similar in the MTX monotherapy

87 re was no association between female sex and attrition at our institution.

88 ntained or could not be confirmed because of attrition at the age of 8 y.

89 ization and strategies to avoid the toxicity attrition at the late stage of drug discovery are discus

90 ethod to identify interns at higher risk for attrition at the start of training, and next steps would

91 3 years was then predicted and adjusted for attrition before S2P by multiplying by the estimate of T

92 sed to evaluate risk factors for (1) patient attrition between the ED and HIV clinic follow-up and (2

93 pective study involvement but was subject to attrition bias caused by passive follow-up.

94 Indication and attrition bias were controlled with propensity score mat

95 ingness from Wave 1-5 and little evidence of attrition bias.

96 All studies were at high risk for attrition bias.

97 itivity analysis was used to assess possible attrition bias.

98 Here, we modeled critical telomere attrition by conditionally inactivating Pot1a, a compone

99 T cell attrition can be compensated for by the production of th

100 Telomere attrition can lead to potentially maladaptive cellular c

101 Telomere attrition can promote genome instability, thereby stimul

102 fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs.

103 a 2-fold higher risk of accelerated telomere attrition compared with the highest decrease in DII (gre

104 ergence of a single solid enantiomorph under attrition conditions.

105 plexity in erosion and greater anisotropy in attrition confirm our hypothesis.

106 omere dysfunction resulting from replicative attrition constrains tumor growth by engaging DNA-damage

107 s successful or average relative to the mean attrition-corrected cognitive development across 15-20 y

108 ed based on likelihood of bias in selection, attrition, detection and performance.

109 lting pellets displayed a high resistance to attrition during fluidization in a bubbling bed.

110 Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resu

111 Furthermore, men had the highest rate of attrition during research (33%) while no women left duri

112 , and nutritional intervention would slow TL attrition during the first two years of life.

113 Our unexpected finding of increased telomere attrition during the first year of life in the intervent

114 Attrition during the period from HIV testing to antiretr

115 The tremendous rate of attrition during the process of metastasis implicates th

116 ervention group suggests that rapid telomere attrition during this critical period could reflect the

117 Attrition elevates fine ash production which, in turn, h

118 f aging (e.g., genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunc

119 ructural and physicochemical (reactivity and attrition) features of the product hydroxide.

120 Fetal oocyte attrition (FOA) is a conserved but poorly understood pro

121 lates into significant and critical telomere attrition following HSCT as compared with unaffected pat

122 Further functional attrition follows subsequent tryptophan number reduction

123 n dentine erosion for complexity and dentine attrition for anisotropy.

124 Stable or decreasing trends in attrition for ART patients were observed in most countri

125 y of age was associated with an accelerated attrition from 4 to 5 y of age (adjusted coefficient: -5

126 ment onto ART, adherence, viral suppression, attrition from ART, and mortality.

127 A survival analysis was conducted comparing attrition from care after ART initiation between the gro

128 High rates of patient attrition from care between HIV testing and antiretrovir

129 As such, it remains unclear if early attrition from care was due to a "healthy cohort" effect

130 first 2 y of college-the window of greatest attrition from science, technology, engineering, and mat

131 uate the association of characteristics with attrition from the methadone program.

132 d both with race/ethnic group membership and attrition from the registry.

133 early insulin independence, long-term graft attrition gradually reverts recipients to exogenous insu

134 Accelerated telomere length attrition has been associated with psychological stress

135 Whether program director attitudes affect attrition has been unclear.

136 e that secondary fragmentation, specifically attrition, has in transforming primary pyroclasts upon t

137 Previous studies of resident attrition have variably included preliminary residents a

138 ficient mice exhibit subfertility, germ cell attrition, ICL sensitivity and tumour predisposition, wi

139 on assessed trends in 6- and 12-month cohort attrition (ie, the proportion of patients in each cohort

140 , to enhance reproducibility through reduced attrition, improved reporting, and adopting an approach

141 Nonignorable attrition in a longitudinal survey can lead to bias in e

142 rinatal cardiomyocyte growth, maturation and attrition in a precocial large mammal, sheep (Ovis aries

143 nd-muscle TL model shows more pronounced LTL attrition in ASCVD patients than controls.

144 AAV9-Tert treatment after telomere attrition in bone marrow cells rescues aplastic anemia a

145 onstration of investigating the influence of attrition in cohort studies using information that has b

146 ate target exposure is a major cause of high attrition in drug discovery.

147 e during adulthood suggesting that increased attrition in early life is more likely to be a major exp

148 aring did not appear to be a risk factor for attrition in either men or women.

149 unt levels on death, attrition, and death or attrition in HIV treated patients.

150 h causal and potentiating roles for telomere attrition in human diseases.

151 ficient efficacy is the most common cause of attrition in late-phase drug development.

152 ndritic branching, prominent dendritic spine attrition in PL pyramidal neurons, and working memory de

153 layed features of senescence and progressive attrition in polyfunctionality, which in turn led to imp

154 ey bee colonies have suffered from increased attrition in recent years, stemming from complex interac

155 r more high quality reporting in the area of attrition in student nursing, whether this is due to pla

156 es reporting on the prevalence and causes of attrition in surgical residents, as well as the characte

157 treatment TB recurrence were major points of attrition in the new smear-positive TB cascade.

158 Attrition in the program was 18.8% (16 of 85).

159 ic damage and to mesenchymal stem cell (MSC) attrition in vivo.

160 replicative ageing and undergo age-dependent attrition in vivo.

161 hemes were nursing workforce related ("nurse attrition," "inexperienced workforce," "limited mentorin

162 h change over a short period, and if rate of attrition is affected by naturalistic factors such as st

163 ing early population decline, since telomere attrition is associated with aging processes and acceler

164 experimentally produced tephra to show that attrition is likely to occur in all explosive volcanic e

165 s complexly related to oncogenesis: telomere attrition is protective by enforcing senescence or apopt

166 Accelerated telomere attrition is the result of mutations in telomere repair

167 To further reduce ART attrition, it is imperative that patient education and h

168 and significantly increases/expedites their attrition, leading to apoptosis.

169 ter enrollment is through interview or exam, attrition leads to missing information for nonrespondent

170 Variations in attrition may be explained by program director attitudes

171 h a robust lymphocyte response, and telomere attrition may contribute to the age-associated decline o

172 20% reduction in the annual rate of telomere attrition measured at 24 months.

173 correct for nonresponse bias under different attrition mechanisms, including weighting adjustments, m

174 ugh taz1Delta telomeres experience transient attrition mediated by replication fork stalling, this is

175 Our findings suggest that telomere attrition might represent a novel mechanism mediating th

176 Dried pulps were milled into flour with attrition milling machine (0.5mm sieve size).

177 l senescence, DNA damage (including telomere attrition), mitochondrial dysfunction, a pro-inflammator

178 uce clinician-rated superior improvement and attrition more frequently than does CBT.

179 longates telomeric DNA to compensate for the attrition occurring during each cycle of DNA replication

180 ellular aging, with the majority of lifetime attrition occurring during the first 4 y.

181 e-rich and -limited sites, show that patient attrition occurs at each stage of the human immunodefici

182 ment on the HAM-D only (odds ratio=1.67) and attrition (odds ratio=1.67) were more frequent in pharma

183 cent fungal infections will cause increasing attrition of biodiversity, with wider implications for h

184 increased age, Wnt5a loss caused progressive attrition of dendrite arbors and spines in Cornu Ammonis

185 n systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and redu

186 doubly-deficient in Erk1 and Erk2 show rapid attrition of hematopoietic stem cells and immature proge

187 RWHAP-funded facilities may face attrition of highly qualified providers.

188 There was also rapid attrition of Irf6-cKO molars following eruption.

189 parator, an intention-to-treat analysis, and attrition of less than 30% at 1 year or less than 40% at

190 ng a more individualized approach to address attrition of licensed nurses in LTC may be the most succ

191 The attrition of neural progenitor cells involves p53-depend

192 HSCs out of their dormant state provoked the attrition of normal HSCs and, in the case of mice with a

193 mer's disease share protein derangements and attrition of postmitotic cells.

194 librium measures of block can result in high attrition of potentially low-risk drugs.

195 h a response would be predicted to result in attrition of preexisting memory to heterologous infectio

196 Attrition of residents from general surgery training pro

197 ations that develop and promotes the gradual attrition of residual effector-like CD127(lo), KLRG-1(hi

198 Furthermore, attrition of T effectors generated in the secondary, but

199 The attrition of telomeres, the ends of eukaryote chromosome

200 iological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retentio

201 blasts, documenting the anticipated telomere attrition on a global telomere-by-telomere basis as well

202 xceptionally stable, with little evidence of attrition or cellular turnover.

203 .41-3.26), and a 23% decrease in the odds of attrition (OR, 0.77; 95% CI, .63-.95).

204 ticipate which residents are most at risk of attrition out.

205 rs across a 1-year period predicted telomere attrition over the same period-for every major life stre

206 , and 36 months (49%/39%) showed significant attrition (P < .0001) over time.

207 Sex, diagnostic test, follow-up time, attrition, patient symptomatic status, and microbiologic

208 l treated patients were 2.63 deaths and 5.32 attritions per 100 person-years, respectively.

209 Greater overall telomere attrition predicts mortality and aging-related diseases

210 The pooled estimate for the overall attrition prevalence among general surgery residents was

211 To summarize the estimate of attrition prevalence among general surgery residents.

212 Main Outcome and Measure: Attrition prevalence of general surgery residents.

213 cluded all studies reporting on the primary (attrition prevalence) or secondary (causes of attrition

214 ering an appealing opportunity to reduce the attrition problem in drug discovery.

215 very, improved general health, and abolished attrition produced by a near maximum-tolerated dose of P

216 tudies of prognostic factors: participation, attrition, prognostic factor measurement, confounding me

217 d 202 respondents were from historically low-attrition programs (27.8% vs 8.4% 10-year attrition rate

218 e more likely than their counterparts at low-attrition programs to agree with this statement: "I feel

219 ttrition programs were more likely than high-attrition programs to use resident remediation (21.0% vs

220 High- and low-attrition programs were compared.

221 Low-attrition programs were more likely than high-attrition

222 Program directors at high-attrition programs were more likely than their counterpa

223 Residents from high-attrition programs were more likely to seriously conside

224 Program directors at low-attrition programs were more likely to use resident reme

225 -six respondents were from historically high-attrition programs, and 202 respondents were from histor

226 CI: 0.40-0.79), but significantly higher ART attrition rate (AHR: 1.17, 95% CI: 1.03-1.33).

227 iated inflammation could modify the telomere attrition rate after a 5-y follow-up of a Mediterranean

228 hed HSC reserves at birth, their accelerated attrition rate afterward, or both are are reflected in s

229 , both the cost to launch a new drug and the attrition rate are increasing.

230 The attrition rate for anticancer drugs entering clinical tr

231 s in neglected diseases, and there is a high attrition rate in target-based drug discovery for these

232 should not be surgeons." The overall 5-year attrition rate of 8.8% was significantly lower than prev

233 The attrition rate of functioning allografts beyond the firs

234 nority patients, is the much higher registry attrition rate of racial/ethnic minorities compared with

235 Each program had an annual attrition rate ranging from 0.73% to 6.0% (median [IQR],

236 The attrition rate was 13.7% and was balanced across the 2 g

237 o 12 weekly sessions of PATH or ST-CI (14.8% attrition rate).

238 Voluntary attrition rate, involuntary attrition rate, and incidence of child rearing among res

239 Voluntary attrition rate, involuntary attrition rate, and incidenc

240 was brief, safe, and inexpensive, with a low attrition rate, it was not effective for reducing pain-r

241 ow-attrition programs (27.8% vs 8.4% 10-year attrition rate, P = .04).

242 Drug development has a high attrition rate, with poor pharmacokinetic and safety pro

243 th follow-up at 90% power and assuming a 25% attrition rate.

244 tion and to measure the categorical resident attrition rate.

245 Five-year attrition rates (2010-2011 to 2014-2015 academic years)

246 High attrition rates (30%-45% in all trials) were associated

247 The average mortality and ART attrition rates among all treated patients were 2.63 dea

248 orical general surgery residents and 10-year attrition rates for each program.

249 pound development and address the increasing attrition rates of lead compounds within the pharmaceuti

250 Moreover, short follow-up periods and high attrition rates often impede translation of study result

251 Residency attrition rates remain a great challenge for general sur

252 monocultures of human hepatocytes, with high attrition rates remain major challenges.

253 rations of cardiomyocytes experienced higher attrition rates than predecessors.

254 Attrition rates were similar for lithium and divalproex

255 Many trials had short durations and high attrition rates, lacked blinding, and did not assess lon

256 ever, were not associated with different LTL attrition rates.

257 valent among programs with historically high attrition rates.

258 Additionally, attrition remained stable or decreased across both measu

259 iscrepancies in the prevalence and causes of attrition reported among surgical residents in previous

260 s revealed that TPMs do not prevent telomere attrition, resulting in cells with critically short and

261 ion, is introduced to quantify the degree of attrition (secondary fragmentation) from grain size data

262 Methods to account for bias owing to attrition strengthened the magnitude of some association

263 ) did not accelerate the rate of islet graft attrition, suggesting resistance to humoral rejection.

264 gitudinal models accounting for differential attrition, survival, and time-varying confounding, with

265 maintain consecutive openings and stochastic attrition terminates the release; 2) if the number of Ry

266 ent TB recurrence are considerable points of attrition that may contribute to ongoing TB transmission

267 The high rates of attrition that occur in drug development are widely rega

268 In a sensitivity analysis accounting for attrition, the effect on alcohol per typical drinking oc

269 past 10 years have put pay to a mechanical 'attrition' theory of OA and place the induction and acti

270 leukocyte TL (LTL) at birth or a faster LTL attrition thereafter.

271 ncreased DNA damage, which causes progenitor attrition through apoptosis.

272 inatal cardiomyocyte growth, maturation, and attrition to stimuli associated with birth.

273 Telomere attrition unleashes genomic instability, promoting cance

274 83%, and weekly compliance was 62%, without attrition until the month before death.

275 Accounting for potential selective attrition (using inverse probability weights) did not al

276 Attrition was 18% and the analysis included all50partici

277 ross all 9 countries, 6- and 12-month cohort attrition was 21% and 29%, respectively, with no decreas

278 Attrition was lower in the ASA24/AMPM study group than i

279 The difference in LTL attrition was not associated with age during adulthood s

280 Increased 12-month attrition was observed in semiurban facilities and those

281 the study was halted early, because telomere attrition was reduced in all 12 patients who could be ev

282 Age-related telomere attrition was restricted to sinusoidal cells (i.e., Kupf

283 Attrition was significantly higher among female compared

284 To characterize potential bias from attrition, we evaluated differences in associations betw

285 ent, restriction, and inverse probability of attrition weighting) to mitigate these biases in analyse

286 models incorporating inverse probability of attrition weighting, and in models using cognitive score

287 plement, demographic information, and annual attrition were collected from the program directors for

288 Previous human studies of telomere attrition were predominantly conducted on leukocytes.

289 The most common reported causes of attrition were uncontrollable lifestyle (range, 12%-87.5

290 familiar males and also showed less telomere attrition when living next to male kin.

291 Males also had more rapid telomere attrition when living next to unfamiliar male neighbors,

292 larger samples to compensate for significant attrition when using online CBT.

293 90]) had a significantly lower likelihood of attrition, whereas clients who reported a history of sex

294 nism: wear via atom-by-atom removal ('atomic attrition'), which can be modelled using stress-assisted

295 cture-gradient induced by surface mechanical attrition, which allowed us to capture in one sample all

296 o incomplete telomere extension and telomere attrition, which are hallmarks of these diseases.

297 eneral surgery programs have relatively high attrition, with female residents more likely to leave th

298 pendently associated with greater 3-year LTL attrition, with no association found for Epstein-Barr vi

299 Attrition within the CD4(+)T cell compartment, high vire

300 did initiate ART within 90 d, the hazard of attrition within the first 10 mo did not differ between