ライフサイエンスコーパス: atypia

1 gh-risk polyps (> or = 1 cm, villous, severe atypia).

2 patients had upper urinary tract multifocal atypia.

3 varian surface epithelium, lacks cytological atypia.

4 esions characterized by dysplasia and marked atypia.

5 were characterized by morphological nuclear atypia.

6 are follicular neoplasms and cells that show atypia.

7 develop epithelial hyperplasia and cellular atypia.

8 hologically were found to have seminoma with atypia.

9 entiation pattern, and degree of cytological atypia.

10 6 ACF with dysplasia and in 2 of 48 ACF with atypia.

11 ER1(+) T cells lacking significant cytologic atypia.

12 inoma showing varying degrees of cytological atypia.

13 vi with architectural disorder and cytologic atypia.

14 ere negative for genetic alteration (GA) and atypia.

15 t PILs and in nearly all PILs having nuclear atypia.

16 ing squamous metaplasia and mild to moderate atypia.

17 ing patterns also correlated with increasing atypia.

18 plasia (atypia), and 72 benign cases without atypia.

19 and lower levels of concordance for DCIS and atypia.

20 ivity increased significantly with worsening atypia.

21 rn made of large compact nests with variable atypia.

22 nsisted of small lymphoid cells with minimal atypia.

23 f the normal conjunctiva and did not display atypia.

24 ment, in a well-defined cohort of women with atypia.

25 ring a 65-month period revealed 147 cases of atypia.

26 ates the risk of breast cancer in women with atypia.

27 il model to counsel individual patients with atypia.

28 does not further increase risk in women with atypia.

29 ancers (19.9%) occurred among 331 women with atypia.

30 sion initially to form regions of epithelial atypia.

31 prostatic epithelial hyperplasia and nuclear atypia.

32 in the same breast, especially in women with atypia.

33 f the 15 conjunctival PAMs, with and without atypia.

34 situ) carcinoma were as follow: CCL without atypia 1.5% (95% confidence interval [CI] 0.6%-4%), CCL

35 helium but was detected in 7% of SMs, 15% of atypias; 18% of LGDs, 47% of HGDs, and 42% of SCCs.

36 , or LGD (n = 12), but it was found in 9% of atypias (2 of 22), 33% of HGDs (7 of 21), and 54% of SCC

37 rinterpreted; and among benign cases without atypia (2070 interpretations), 87% (95% CI, 85%-89%) wer

38 9,376 women in the BBD cohort, 331 women had atypia (3.5%).

39 m; 7 endometrial hyperplasia with or without atypia; 32 endometrioid endometrial carcinoma (EEC), inc

40 iferative (181 women), or proliferative with atypia (33 women) between 1995 and 2000 and 1,070 unaffe

41 pia (6 of 32; 19%) relative to those without atypia (4 of 19; 21%).

42 n from normal/mild hyperplasia to those with atypia, 4) the degree of dysplasia, and 5) angiogenesis.

43 Verification is less probable for atypia (53.6% overinterpreted and 8.6% underinterpreted)

44 , and LGD, but it was overexpressed in 6% of atypias, 53% of HGDs, and 61% of SCCs.

45 N mutations in endometrial hyperplasias with atypia (6 of 32; 19%) relative to those without atypia (

46 confidence interval [CI] 0.6%-4%), CCL with atypia 9% (95% CI: 5%-14%), and atypical ductal hyperpla

47 yperplasias had focal or diffuse cytological atypia, a feature previously associated with risk for en

48 Tumors displayed cytological atypia, absence of biliary epithelia, loss of reticulin,

49 gressive phenotype characterized by cellular atypia, adenoma and ultimately adenocarcinoma.

50 psy specimens with intraepithelial cytologic atypia, adipophilin results were negative.

51 Of 15 lesions showing atypia alone, 3 (20%) were malignant, all of which were

52 atypia, follicular neoplasms with atypia, or atypia alone.

53 a suggestion of a decreased risk of EH with atypia among current smokers.

54 ely matched with 20 patients with C-MIN with atypia and 20 with C-MIN without atypia regarding tumor

55 primary acquired melanosis (PAM; 11 without atypia and 4 with atypia) and five were conjunctival mel

56 Increased cell size, frequent nuclear atypia and a collapse of apoptosis were observed.

57 nic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from

58 of patients with a CNB diagnosis of CCL with atypia and atypical ductal hyperplasia associated with C

59 NB diagnosis of CCL without atypia, CCL with atypia and atypical ductal hyperplasia associated with C

60 HPV-16 E6 is associated with marked nuclear atypia and concomitant accumulation of centrosomes.

61 ias, which vary in the extent of cytological atypia and degree of architectural complexity.

62 the development of urothelial preneoplasia (atypia and dysplasia), neoplasia, and metastasis and was

63 h the tumors were small, they showed nuclear atypia and exhibited features of human ccRCC.

64 a was detected in 15 women (50%) with ductal atypia and in seven women (47%) with discordant histopat

65 aepithelial neoplasia) with striking nuclear atypia and invasive, poorly differentiated carcinoma.

66 s, all mice developed PTC displaying nuclear atypia and marker expression characteristic of the human

67 picious atypia group: melanoma versus severe atypia and melanoma versus moderate atypia had P-values

68 elluarity, pleomorphic nucleoli, cytological atypia and necrosis, and positive staining for alpha-smo

69 6 to 2.12) for proliferative changes without atypia and of 1.27 (95 percent confidence interval, 1.15

70 for lesions exhibiting proliferation without atypia and OR = 1.5 (95% CI, 0.4 to 5.6) for the diagnos

71 ulation of enlarged liver cells with nuclear atypia and pleomorphism, frequent binuclearity, and mini

72 ree survival rates (P = 0.041) in C-MIN with atypia and significantly lower recurrence-free (P = 0.00

73 early RNA+ lymphoid infiltrate with variable atypia and subcutaneous involvement.

74 with atypical hyperplasia, multiple foci of atypia and the presence of histologic calcifications may

75 local recurrence in patients with C-MIN with atypia and with an increased risk of local recurrence, l

76 melanosis (PAM; 11 without atypia and 4 with atypia) and five were conjunctival melanomas.

77 n situ (DCIS), 72 with atypical hyperplasia (atypia), and 72 benign cases without atypia.

78 15 papillary, 37 (55%) of 67 papillary with atypia, and 10 (71%) of 14 carcinoma in situ duct lesion

79 in one papilloma with florid hyperplasia and atypia, and 10 other PBD lesions were negative for genet

80 y acquired melanosis with moderate to severe atypia, and conjunctival melanoma) that provided suffici

81 f the lesions were follicular neoplasms with atypia, and four (44.4%) of these were malignant, includ

82 without atypia, in 10 of the 20 C-MINs with atypia, and in all 20 CMs.

83 timated risk of breast cancer for women with atypia, and individual risk estimates showed poor concor

84 astic nevi with structural and architectural atypia, and melanoma.

85 hundred ninety men with HGPIN, or HGPIN and atypia, and no PCa on prostate biopsy were randomly assi

86 ate-onset hyperplasia, umbrella cell nuclear atypia, and rare-occurring low-grade, superficial papill

87 ut atypia, follicular neoplasms with atypia, atypia, and suspicious for malignancy.

88 ylation markers (MYOD1 and RUNX3), glandular atypia, and TP53 mutation status.

89 ries, follicular neoplasms and cells showing atypia are included in a broad "suspicious" category, wi

90 onfirmed atypical hyperplasia of the breast (atypia) are at high risk for breast cancer.

91 women who had proliferative disease without atypia as compared with women who had nonproliferative d

92 selectively exhibited focal areas of nuclear atypia associated with less organized epithelia.

93 py, improving the ability to detect cellular atypia associated with neoplasia.

94 rchromasia are principal features of nuclear atypia associated with precancerous and cancerous change

95 to the lumen (hobnailing) and severe nuclear atypia at 6 months of age.

96 128 patients were subsequently found to have atypia at excision.

97 Two eyes had minimal cellular atypia at the conjunctival epithelium.

98 tiginous) proliferation of cells with marked atypia at the DEJ, especially in interpapillary spaces;

99 ms without atypia, follicular neoplasms with atypia, atypia, and suspicious for malignancy.

100 exhibited erythrocytosis and megakaryocytic atypia but normal platelet number.

101 ion with erosions and ulcers, and epithelial atypia by 6 dpi in the descending colon.

102 5% CI, 12%-15%) were underinterpreted; among atypia cases (2070 interpretations), 48% (95% CI, 44%-52

103 patients with a CNB diagnosis of CCL without atypia, CCL with atypia and atypical ductal hyperplasia

104 Within nodules, there was cellular atypia consistent with nodular dysplasia.

105 is, including conjunctiva without epithelial atypia (controls); conjunctival intraepithelial neoplasi

106 of invasive breast cancer and benign without atypia diagnoses is highly probable; estimated predictiv

107 and appearance of papillary hyperplasia with atypia displayed a delayed pattern.

108 ho were diagnosed with complex EH or EH with atypia during the period 1985-2003 and whose diagnoses w

109 elevations in risk were seen with multifocal atypia (eg, three or more foci with calcifications [RR,

110 Ductal hyperplasia with and without atypia exhibited higher PTEN protein levels than normal

111 categories are follicular neoplasms without atypia, follicular neoplasms with atypia, atypia, and su

112 categorized as follicular neoplasms without atypia, follicular neoplasms with atypia, or atypia alon

113 ions with benign pathologic findings without atypia found to be concordant with imaging at a consensu

114 ween suspicious melanoma and each suspicious atypia group: melanoma versus severe atypia and melanoma

115 s severe atypia and melanoma versus moderate atypia had P-values of 0.0077 and 0.0009, respectively.

116 atypical alveolar hyperplasia, and isolated atypias) had a high proportion of cells strongly positiv

117 cells grouped as either benign or high-grade atypia (HGA) [>/=high-grade dysplasia].

118 eat biopsy was recommended because of ductal atypia in 30 patients, discordant imaging and histopatho

119 cent of women, proliferative lesions without atypia in 30 percent, and atypical hyperplasia in 4 perc

120 f adenomas and the size, type, and degree of atypia in 479 patients in a polyp prevention trial were

121 ihood of benign core biopsy findings without atypia in malignant calcifications versus masses (7% vs

122 a benign intraductal papilloma in each, with atypia in one.

123 olve before the development of morphological atypia in these epithelia.

124 were detected in none of the C-MINs without atypia, in 10 of the 20 C-MINs with atypia, and in all 2

125 sion (65%), performed more often as grade of atypia increased (P < .001).

126 Tumor nuclear grade (atypia) increased with tumor height and by tumor locatio

127 Tumor nuclear grade (atypia) increased with tumor height.

128 Its ability to discriminate women with atypia into those who did and did not develop breast can

129 Although cytologic atypia is minimal, studies for T-cell clonality confirm

130 epithelioid melanocytes with mild cytologic atypia, low mitotic activity, focal necrosis, and ulcera

131 cytology shows a follicular neoplasm without atypia, malignancy rates of 8% or less may allow nonsurg

132 ith HMB45 (96% specificity, 97% sensitivity; atypia marker).

133 n demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by

134 For CCL without atypia, more studies with a long-term follow-up are requ

135 a low prevalence of false-negative diagnoses atypia must be interpreted as potential malignancy.

136 mous metaplasia (SM; n = 28), and epithelial atypia (n = 34) were compared with that in low-grade dys

137 Clinicopathological features (eg, atypia, necrosis, and clinical outcome) did not appear t

138 There was absence of cytologic atypia of surface epithelium.

139 Atypia of the mammary ductal epithelium develops at abou

140 it causes, although the frequent cytological atypia of the stromal cells suggests that they may be ne

141 s) and a fine-needle aspiration diagnosis of atypia of undetermined significance or follicular lesion

142 a previous fine-needle aspiration report of "atypia of undetermined significance" or "follicular lesi

143 that are classified as indeterminate (i.e., atypia of undetermined significance/lesion of undetermin

144 al examination and lower frequency of marked atypia on melanocytes in the basal cell layer; it presen

145 Of 74 follicular neoplasms without atypia, only 5 (6.8%) were malignant, and none of these

146 Transection margins were involved with atypia or carcinoma in 32 patients (51%).

147 The presence of atypia or carcinoma in situ at the ductal resection marg

148 redicts a low likelihood that a diagnosis of atypia or DCIS would be verified by a reference consensu

149 sional biopsy after needle biopsy because of atypia or discordance, final surgical pathologic analysi

150 In 30 patients with 33 lesions without atypia or malignancy, sclerosing adenosis was the major

151 agnosed as suspicious for malignancy or with atypia or unusual associated histologic findings should

152 The negative predictive values for "atypia (or follicular lesion) of undetermined clinical s

153 ms without atypia, follicular neoplasms with atypia, or atypia alone.

154 tive biopsy margin, increasing with grade of atypia (P < .001); 127 of 196 with positive biopsy margi

155 proliferating lymphatics than did C-MIN with atypia (P </= 0.001).

156 assification accuracy consisted of glandular atypia, P53 abnormality, and Aurora kinase A positivity,

157 , primary acquired melanosis with mild or no atypia, primary acquired melanosis with moderate to seve

158 C-MIN with atypia and 20 with C-MIN without atypia regarding tumor size, tumor location, tumor exten

159 epithelial melanocytic proliferation without atypia represents increased numbers of normal-appearing

160 detected, including a lesion with high-grade atypia resembling lentiginous forms of malignant melanom

161 s with mucinous metaplasia and columnar cell atypia resembling low-grade PanIN in rats.

162 trial adenocarcinomas with prominent nuclear atypia, resembling human Type II cancers.

163 None of the five hyperplasias without atypia showed sigma-hypermethylation.

164 equivocal cases as well as between different atypia subgroups in the group of suspicious samples.

165 ohistochemical staining and in the degree of atypia, suggesting that multiple biopsies are necessary

166 In the four women who did not have atypia, the procedure was diagnostic and appears to have

167 By 6 months, more extensive nuclear atypia, thickened "reactive" stroma, and basement membra

168 asive carcinoma and, in some cases, cellular atypia (VIN).

169 RR of breast cancer with atypia was 3.88 (95% CI, 3.00 to 4.94).

170 The relative risk associated with atypia was 4.24 (95 percent confidence interval, 3.26 to

171 omplete correlation between GAs and anatomic atypia was suggested.

172 ative, proliferative, and proliferative with atypia were 0.4 (95% confidence interval (CI): 0.2, 0.7)

173 Actinic damage and squamous atypia were found in grafts of all groups receiving UV t

174 Among those, 331 women with atypia were identified by our study pathologists.

175 Women with atypia were identified from the Mayo Benign Breast Disea

176 mice, colonic lesions, including epithelial atypia, were reversible, although a small percentage (5

177 ere identified in another PBD lesion without atypia, whereas another lesion from this second patient

178 th tumor height and by tumor location (least atypia with iris tumors).

179 0% of patients, and markers of risk (LCIS or atypia) with the potential to influence future decisions

180 affected lung revealed alveolar type II cell atypia, with numerous abnormal lamellar bodies.

181 lesion from this second patient had minimal atypia without GAs.