ライフサイエンスコーパス: atypical protein kinase C

1 gamma inhibitors, but not by an inhibitor of atypical protein kinase C.

2 he apical polarity proteins Bazooka/Par3 and atypical protein kinase C.

3 stream of AKT not dependent on inhibition of atypical protein kinase C.

4 o, possibly in part by spatially restricting atypical protein kinase C, a negative regulator of non-m

5 junctions and actin-based protrusions, bind atypical protein kinase C, activate RAC1, and activate S

6 alpha(-/-) livers also showed a reduction in atypical protein kinase C activity and decreased mRNA an

7 Par-3 associates with Par-6 and atypical protein kinase C and is required for the proper

8 ivation of pro-lipogenic signaling pathways (atypical protein kinase C and protein kinase B) and the

9 s PAR-6 (Partitioning defective 6) and PKC-3/atypical protein kinase C, and the WAVE actin nucleation

10 Moreover, immunostaining of the atypical protein kinase C apical marker, as well as the

11 iPMF requires atypical protein kinase C (aPKC) activity within spinal

12 Helfrich et al. identify a key role for atypical protein kinase C (aPKC) activity, as a componen

13 , including multilumen formation and reduced atypical protein kinase C (aPKC) activity.

14 Defects in signaling through Cdc42 and atypical protein kinase C (aPKC) also cause spindle miso

15 (PI) 3-kinase, which is required to activate atypical protein kinase C (aPKC) and glucose transport d

16 ll fate, including E-cadherin, beta-catenin, atypical protein kinase C (aPKC) and INADL (inactivation

17 Using the epithelial marker atypical Protein Kinase C (aPKC) and other markers to an

18 function is independent of association with atypical protein kinase C (aPKC) and PAR-6.

19 al domain below its typical binding partners atypical protein kinase C (aPKC) and partitioning defect

20 xical defects, we examined the activation of atypical protein kinase C (aPKC) and protein kinase B (P

21 Atypical protein kinase C (aPKC) and protein kinase B (P

22 Partitioning-defective 1 (PAR1) and atypical protein kinase C (aPKC) are conserved serine/th

23 Atypical protein kinase C (aPKC) binds to and phosphoryl

24 he small GTPase Cdc42, acting through a Par6-atypical protein kinase C (aPKC) complex, is required to

25 S) action of the PI3K signaling intermediate atypical protein kinase C (aPKC) constrains food intake,

26 The pathway by which atypical protein kinase C (aPKC) contributes to nerve gr

27 Atypical protein kinase C (aPKC) controls cell polarity

28 y proteins Lethal (2) giant larvae (Lgl) and atypical Protein Kinase C (aPKC) ensures self-renewal of

29 Atypical protein kinase C (aPKC) enzymes signal on prote

30 A new member of the atypical protein kinase C (aPKC) family, designated PKCz

31 effector proteins PAR-3, PAR-6, CDC-42, and atypical protein kinase C (aPKC) form a core unit of the

32 (partitioning-defective) Par3 and Par6, plus atypical protein kinase C (aPKC) function in the formati

33 The role of atypical protein kinase C (aPKC) in insulin-stimulated g

34 re, we examined insulin signaling to Akt and atypical protein kinase C (aPKC) in liver and muscle and

35 view the aberrations of insulin signaling to atypical protein kinase C (aPKC) in muscle and liver tha

36 suppressor Lethal (2) giant larvae (Lgl) and atypical protein kinase C (aPKC) in regulating microtubu

37 another protein complex containing Par-6 and atypical protein kinase C (aPKC) in the rhabdomere stalk

38 Atypical protein kinase C (aPKC) is a key apical-basal p

39 Activity of the atypical protein kinase C (aPKC) is a key output of the

40 Work from diverse systems suggests that the atypical Protein Kinase C (aPKC) is a key regulator of c

41 The atypical protein kinase C (aPKC) is a key regulator of p

42 Atypical protein kinase C (aPKC) is an evolutionarily co

43 Atypical protein kinase C (aPKC) is frequently overexpre

44 The atypical protein kinase C (aPKC) is required for cell po

45 itol 3-kinase (PI3K)-dependent activation of atypical protein kinase C (aPKC) is required for insulin

46 Individual loss of either atypical protein kinase C (aPKC) isoform, PKCzeta or PKC

47 Atypical protein kinase C (aPKC) isoforms are overexpres

48 Atypical protein kinase C (aPKC) isoforms zeta and lambd

49 The atypical protein kinase C (aPKC) isotypes PKClambda/iota

50 Atypical protein kinase C (aPKC) isozymes function in ep

51 Atypical protein kinase C (aPKC) isozymes modulate insul

52 We identify the Cdc42/Par6/atypical protein kinase C (aPKC) Par polarity complex as

53 Previously, we demonstrated that atypical protein kinase C (aPKC) phosphorylates the Par-

54 In this paper, we report that atypical protein kinase C (aPKC) phosphorylates Yrt to p

55 mal development, a complex of Par3, Par6 and atypical protein kinase C (aPKC) plays a central role in

56 b complex also binds the conserved Par3/Par6/atypical protein kinase C (aPKC) polarity cassette that

57 Cdc42 and its effector complex Par6-atypical protein kinase c (aPKC) regulate multiple steps

58 We identified the atypical protein kinase C (aPKC) scaffold protein p62 as

59 Cdc42 localizes Par6-atypical protein kinase C (aPKC) to AJs, where this comp

60 large (Dlg) links the Par complex component atypical Protein Kinase C (aPKC) to the essential spindl

61 Mitotic neuroblasts localize atypical protein kinase C (aPKC) to their apical cortex.

62 Association of an atypical protein kinase C (aPKC) with an adapter protein

63 cell lines have suggested that both Akt and atypical protein kinase C (aPKC) zeta/lambda are translo

64 Here, we show that atypical protein kinase C (aPKC), a protein associated w

65 blasts show ectopic cortical localization of atypical protein kinase C (aPKC), and a decrease in aPKC

66 e report that Par6B and its binding partner, atypical protein kinase C (aPKC), are required to regula

67 organisms, cell polarity is regulated by the atypical protein kinase C (aPKC), Bazooka (Baz/Par3), an

68 Here we show that atypical protein kinase C (aPKC), is required for Wnt-me

69 lin-regulated brain protein kinases, Akt and atypical protein kinase C (aPKC), were maximally increas

70 It has recently been shown that atypical protein kinase C (aPKC), which is apically enri

71 The protein atypical protein kinase C (aPKC)--a component of the Par

72 We identified a novel function for the atypical protein kinase C (aPKC)-binding domain of Par3

73 In addition, we show that atypical protein kinase C (aPKC)-mediated cell polarity

74 The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been

75 linositol 3-kinase (PI 3-kinase), as well as atypical protein kinase C (aPKC).

76 has been identified as an insulin-responsive atypical protein kinase C (aPKC).

77 protein complex including PAR-3, PAR-6, and atypical protein kinase C (aPKC).

78 elps to position both adherens junctions and atypical protein kinase C (aPKC).

79 h is necessary for the apical maintenance of atypical protein kinase C (aPKC).

80 two independent neuroblast defects: abnormal atypical protein kinase C (aPKC)/Numb cortical polarity

81 on, functions, regulation, and targeting of "atypical" protein kinase C (aPKC) isoenzymes in vivo.

82 basolateral cell polarity markers including atypical-protein kinase C (aPKC), Discs-large (Dlg), and

83 ontain a highly similar profile of proteins (atypical protein kinase C [aPKC], Cdc42, Sec8, Rab11a, a

84 unctions and polarity, the polarity complex (atypical protein kinase C [aPKC]-PAR6-PAR3) were downreg

85 (PI) 3-kinase and its downstream effectors, atypical protein kinase Cs (aPKCs) (zeta/lambda/iota) an

86 hat AMPK increases glucose transport through atypical protein kinase Cs (aPKCs) by activating proline

87 ndent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glu

88 complex that can include Cdc42-GTP, Par6 and atypical protein kinase Cs (aPKCs).

89 ioning-defective proteins Par3 and Par6, and atypical protein kinase C (aPKCzeta and aPKClambda), whi

90 d NF-kappaB and suggested the involvement of atypical protein kinase C (aPKCzeta/lambda/iota) as an i

91 Two enzymes, protein phosphatase 2A and atypical protein kinase C, are associated with the tight

92 ted proteins include PAR-3/Bazooka and PKC-3/atypical protein kinase C at the apical membrane domain,

93 ve now shown that one or more members of the atypical protein kinase C group, as exemplified by the z

94 bs-PALS1 (Stardust)-PATJ and Cdc42-Par6-Par3-atypical protein kinase C, have been implicated in the a

95 ding to formation of a complex between IRAK, atypical protein kinase C interacting protein, p62, and

96 work demonstrated an essential role for the atypical protein kinase C interacting protein, p62, in n

97 Here we show that the atypical protein kinase C-interacting protein, p62, whic

98 regulation and colocalization of MT1-MMP and atypical protein kinase C iota (aPKCiota) in hormone rec

99 that NGF induces co-association of IRAK with atypical protein kinase C iota (PKC) and that the iota P

100 s to assess the roles of the related factors atypical protein kinase C iota and zeta (prkciota, prkcz

101 c drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kin

102 Rab2 requires atypical protein kinase C iota/lambda (aPKC iota/lambda)

103 Here we identify atypical protein kinase C iota/lambda (aPKC-iota/lambda)

104 Activation of atypical protein kinase C iota/lambda (aPKCiota/lambda)

105 ious studies have shown that Rab2 stimulates atypical protein kinase C iota/lambda (aPKCiota/lambda)

106 Atypical protein kinase C iota/lambda (PKCiota/lambda) i

107 The small GTPase Rab2 requires atypical protein kinase C iota/lambda (PKCiota/lambda) k

108 tein complex consisting of mPar3, mPar6, and atypical protein kinase C is selectively localized to th

109 se in the amount of a constitutively active, atypical protein kinase C isoform found in brain, protei

110 Protein kinase Mzeta (PKMzeta) is an atypical protein kinase C isoform that has been implicat

111 Both Akt and the atypical protein kinase C isoform zeta (PKCzeta) have be

112 ein kinase Mzeta (PKMzeta), a brain-specific atypical protein kinase C isoform, is important for main

113 hPar-6 also binds directly to an atypical protein kinase C isoform, PKCzeta, and forms a

114 The atypical protein kinase C isoform, protein kinase C-zeta

115 ptor (EGFR)-mediated local translation of an atypical protein kinase C isoform, protein kinase Mzeta

116 y however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta

117 Atypical protein kinase C isoforms (aPKCs) transmit regu

118 In this study, we show that an atypical protein kinase C isozyme, PKCzeta, associates f

119 Yet CaG activated an atypical protein kinase C isozyme, protein kinase Czeta,

120 ver, they highlight a potential link between atypical protein kinase C isozymes and Rho signaling pat

121 embryonic tissues, and show that it encodes atypical protein kinase C lambda (aPKC lambda).

122 (a PDZ and CRIB domain protein) and aPKC (an atypical protein kinase C) localize apically in fly and

123 r 6 acts as a scaffold protein to facilitate atypical protein kinase C-mediated phosphorylation of cy

124 N-cadherin/LLGL1 interaction is inhibited by atypical protein kinase C-mediated phosphorylation of LL

125 Of these, the ternary Par3-atypical protein kinase C-Par6 polarity complex mediates

126 The conserved complex of Par3, Par6 and atypical protein kinase C phosphorylates and inactivates

127 e signaling pathways in INS-1 cells revealed atypical protein kinase C (PKC) as a novel intracellular

128 Here, we have identified PI3-K-regulated atypical protein kinase C (PKC) isoform PKCzeta as an up

129 The atypical protein kinase C (PKC) isoform PKCzeta, which i

130 In this study, we evaluated the role of the atypical protein kinase C (PKC) isoform, PKC zeta, in LP

131 The atypical protein kinase C (PKC) isoform, PKCzeta, has be

132 We hypothesized that an atypical protein kinase C (PKC) isoform, which lacks a p

133 Atypical protein kinase C (PKC) isoforms are required fo

134 The atypical protein kinase C (PKC) isoforms lambda and zeta

135 , wortmannin and LY294002, and inhibitors of atypical protein kinase C (PKC) isoforms, zeta and lambd

136 brane translocation of classical, novel, and atypical protein kinase C (PKC) isoforms.

137 y GTPases and the polarity complex Par6/Par3/atypical protein kinase C (PKC) play a key role in the s

138 erial derived products was the activation of atypical protein kinase C (PKC) zeta and association of

139 Atypical protein kinase C (PKC) zeta is an important reg

140 e reported that ceramide mediates binding of atypical protein kinase C (PKC) zeta to its inhibitor pr

141 induces the formation of a complex formed of atypical protein kinase C (PKC)-zeta and beta-catenin at

142 ,4,5-trisphosphate (PIP3), and activation of atypical protein kinase C (PKC).

143 lternative transcriptional start site in the atypical protein kinase C (PKC)zeta isoform, which remov

144 PDZ proteins PAR-3 and PAR-6, as well as an atypical protein kinase C (PKC-3), to the anterior.

145 Atypical protein kinase Cs (PKCs) (aPKCzeta and lambda/i

146 ide biochemical and functional evidence that atypical protein kinase C (PKCzeta) and polarity (Par) c

147 There is increasing evidence that the atypical protein kinase C, PKCzeta, might be a therapeut

148 lization of apical junction markers, such as atypical protein kinase C, RhoA and beta-catenin.

149 ssion of protein kinase C iota (PKCiota), an atypical protein kinase C that is activated by oncogenic

150 PKM-zeta) is a constitutively active form of atypical protein kinase C that is exclusively expressed

151 are essential for the apical localization of atypical protein kinase C, the Par3-LGN-Inscuteable comp

152 he PB1 domain in p62 binds the PB1 domain of atypical protein kinases C, the MAPK kinase, MEK5, and t

153 eukin-21, and the ancestral polarity protein atypical protein kinase C to one side of the plane of di

154 rt this effect in part through activation of atypical protein kinase C, upregulation of lipogenesis,

155 more Frizzled3 endocytosis and activation of atypical protein kinase C was observed on the side of gr

156 In the cysts, F-actin bundles and atypical protein kinase C were at the apical membrane, E

157 (389) and Thr(421)/Ser(424), whereas Akt and atypical protein kinase C were not involved in this acti

158 tor-alpha (TNF-alpha) or serum and stimulate atypical protein kinase C zeta (PKC zeta) activity, resu

159 Atypical Protein Kinase C zeta (PKCzeta) forms Partition

160 Atypical protein kinase C zeta (PKCzeta) is known to tra

161 bunit of the glutamate AMPA receptor and the atypical protein kinase C zeta isoform (PKMzeta).

162 aling in neural progenitors was dependent on atypical protein kinase C zeta, a mediator of stem cell

163 meostasis operates through the activation of atypical protein kinase C zeta, leading to GRK2-driven G

164 SQSTM1)/p62 is an interacting partner of the atypical protein kinase C zeta/iota and serves as a scaf

165 t contents were unchanged, and the amount of atypical protein kinase C zeta/lambda (aPKC zeta/lambda)

166 beta-associated kinase 1, Akt/PKB, ERK, and atypical protein kinase C zeta/lambda.

167 a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks t

168 Also, increased levels of the atypical protein kinase C, zetaPKC, was shown to negativ