ライフサイエンスコーパス: auditory nerve

1 responses with a sophisticated model of the auditory nerve.

2 n, a procedure that requires survival of the auditory nerve.

3 diameter and neurofilament regulation in the auditory nerve.

4 precise stimulus-driven spike timing in the auditory nerve.

5 cess most likely underlies adaptation in the auditory nerve.

6 bon synapse and spike rate adaptation in the auditory nerve.

7 ng and chronic electrical stimulation of the auditory nerve.

8 annel's ability to effectively stimulate the auditory nerve.

9 unction of terminal unmyelinated portions of auditory nerve.

10 ost always higher than those observed in the auditory nerve.

11 and processes first-order afferents from the auditory nerve.

12 e and sets the stage for cell replacement of auditory nerve.

13 enting the main source for adaptation in the auditory nerve.

14 ere it is localized to ganglion cells in the auditory nerve.

15 vities <1.2 kHz was enhanced relative to the auditory nerve.

16 bnormal synaptic structure in endings of the auditory nerve.

17 lely on the relative timing of spikes in the auditory nerve.

18 e development of spontaneous activity in the auditory nerve.

19 y transmit timing information encoded by the auditory nerve.

20 ial during high-frequency stimulation of the auditory nerve.

21 not block EPSPs produced by stimulating the auditory nerve.

22 cking precision compared with input from the auditory nerve.

23 neration of the spiral ganglion cells of the auditory nerve.

24 which forms the spike initiation site of the auditory nerve.

25 us neurotrophins prevent degeneration of the auditory nerve.

26 -deaf people to electrically stimulate their auditory nerve.

27 it may contribute to spike adaptation at the auditory nerve.

28 lus (CS) applied to the posterior eighth, or auditory, nerve, a positive slope of CR acquisition was

29 e abnormalities persist after restoration of auditory nerve activity by a cochlear implant, the proce

30 This had the benefit that BCs relayed auditory nerve activity even when synapses showed signif

31 ent of a neuronal correlate of tinnitus when auditory nerve activity is reduced due to the earplug.

32 empts to relate organ of Corti structure and auditory nerve activity to the morphology of primary syn

33 is significantly influenced by sound-evoked auditory nerve activity.

34 Examination of the sural nerve and the auditory nerve adjacent to the brainstem showed marked l

35 x in adult mice with a near-complete loss of auditory nerve afferent synapses in the contralateral ea

36 cochlear nucleus (VCN) is from glutamatergic auditory nerve afferents, but the VCN is also innervated

37 tory synapses formed by two distinct inputs, auditory nerve (AN) and parallel fibers (PF), on differe

38 ceives direct tonotopic projections from the auditory nerve (AN) as well as secondary and descending

39 ed this in the mouse cochlear nucleus, where auditory nerve (AN) fibers contact bushy cells (BCs) at

40 onstructed in 3D the trajectories of labeled auditory nerve (AN) fibers following multiunit recording

41 e of sound levels over which firing rates of auditory nerve (AN) fibers grows rapidly with level shif

42 convergent inputs from high-spontaneous rate auditory nerve (AN) fibers, with no special currents and

43 fect neurotransmitter release by presynaptic auditory nerve (AN) fibers.

44 otemporal pattern of discharges across their auditory nerve (AN) inputs ().

45 also induce changes in myelin sheaths of the auditory nerve (AN) is an important issue particularly b

46 nological model of the inner hair cell (IHC)-auditory nerve (AN) synapse successfully explained neura

47 It abbreviated signaling between IHC and the auditory nerve and also balanced differences in decay ki

48 ate in auditory cortex despite nearly absent auditory nerve and brainstem responses, suggesting an im

49 auditory brainstem implants that bypass the auditory nerve and directly stimulate auditory processin

50 putatively reflecting decreased inputs from auditory nerve and increased inputs from nonauditory str

51 ributed to a return of spike activity in the auditory nerve and may help explain cochlear implant ben

52 ells receive excitatory inputs from both the auditory nerve and parallel fibers; cartwheel cells rece

53 ribbons, followed by reduced activity of the auditory nerve and reduced centrally generated wave II a

54 of anemia disrupts normal development of the auditory nerve and results in altered conduction velocit

55 d VGLUT2, are differentially associated with auditory nerve and somatosensory inputs to the CN, respe

56 t occurs in the cochlear nucleus (CN), where auditory nerve and somatosensory pathways converge.

57 lcium-binding proteins were expressed in the auditory nerve, and CR immunoreactivity labeled the firs

58 potential initiation and propagation in the auditory nerve, and suggest that modulation of these cha

59 ons based on neural population responses for auditory nerve (ANF) input and SBC output to assess the

60 otion of mammalian cochlear function is that auditory nerves are tuned to respond best to different s

61 cochlear turns and a reduced activity of the auditory nerve (auditory brainstem response wave I).

62 gan of Corti initiate electrical activity in auditory nerves before hearing, pointing to an essential

63 ntitative differences between trigeminal and auditory nerve boutons in terms of their localization on

64 coustic emissions, summating potentials) and auditory nerve/brainstem activity (auditory brainstem re

65 constrained by temporal phase locking in the auditory nerve but may instead stem from higher-level co

66 ar implants deliver electrical pulses to the auditory nerve by relying on sophisticated signal proces

67 ending mammalian auditory pathway beyond the auditory nerve can be predicted based on coding principl

68 Sound-evoked spikes in the auditory nerve can phase-lock with submillisecond precis

69 Production of neurospheres from auditory nerve cells was stimulated by acute neuronal in

70 pamine agonist that reduces the sound evoked auditory nerve compound action potential and/or Memantin

71 suprathreshold amplitude of the sound-evoked auditory nerve compound action potential.

72 ed low amplitude negative potentials without auditory nerve compound action potentials.

73 urosphere formation assays showed that adult auditory nerves contain neural stem/progenitor cells (NS

74 eriod surrounding either moderate or massive auditory nerve damage.

75 ostsynaptic disorders affecting unmyelinated auditory nerve dendrites; (iii) postsynaptic disorders a

76 Thus AMPA receptors postsynaptic to the auditory nerve differ from those postsynaptic to paralle

77 n is a standard clinical tool for diagnosing auditory nerve disorders due to acoustic neuromas.

78 it possible to distinguish both synaptic and auditory nerve disorders from sensory receptor loss.

79 Subjects with auditory nerve disorders had normal loudness adaptation

80 greater magnitude in ribbon synapse than in auditory nerve disorders.

81 tween the cochlea's inner hair cells and the auditory nerve, effectively severing part of the connect

82 ode of auditory prosthesis using penetrating auditory-nerve electrodes that permit frequency-specific

83 em, from pulse trains presented with various auditory-nerve electrodes to phase-locked activity of ne

84 ether structural and molecular substrates at auditory nerve (endbulb of Held) synapses in the cochlea

85 The large endings of the auditory nerve, endbulbs of Held, were studied because t

86 lobular bushy cells of the AVCN receive huge auditory nerve endings specialized for high fidelity neu

87 eafness results in synaptic abnormalities in auditory nerve endings.

88 Auditory nerve excitation and thus hearing depend on spi

89 We review the mechanical origin of auditory-nerve excitation, focusing on comparisons of th

90 input, because shocks to the cut end of the auditory nerve excited Golgi cells with excitatory posts

91 te that a subset of glial cells in the adult auditory nerve exhibit several characteristics of NSPs a

92 antly inherited neuropathy of both optic and auditory nerves expressed by impaired visual acuity, mod

93 The auditory nerve feeds information through several paralle

94 ximately 1 year after deefferentation, acute auditory nerve fiber (ANF) recordings were made from les

95 The inner hair cell (IHC)/auditory nerve fiber (ANF) synapse is the first synapse

96 nce the encoding of the onset of synchronous auditory nerve fiber activity.

97 detectors of the coincident firing of their auditory nerve fiber inputs.

98 t the characteristic frequency (CF) of their auditory nerve fiber inputs.

99 ells, which cannot be restored by increasing auditory nerve fiber recruitment.

100 ity) of the auditory periphery by modulating auditory nerve fiber response properties.

101 hermore, comparison between SFOAE delays and auditory nerve fiber responses for the barn owl strength

102 ation (Wiener kernel) analyses of chinchilla auditory nerve fiber responses to Gaussian noise to reve

103 innovative system-identification analyses of auditory nerve fiber responses to Gaussian noise to unco

104 s of presynaptic Ca(2+) channels and smaller auditory nerve fiber terminals contacting cochlear nucle

105 s from mammalian inner hair cells (IHCs) and auditory nerve fiber terminals that typically receive in

106 Here we report that several basic auditory nerve fiber tuning properties can be accounted

107 ases of basilar-membrane (BM) vibrations and auditory-nerve fiber responses to tones at a basal site

108 acteristics of each primary afferent (type I auditory-nerve fiber; ANF) are mainly determined by a si

109 Auditory nerve fibers (ANFs) exhibit a range of spontane

110 ule cell domains (GCD) of CN, whereas type I auditory nerve fibers (ANFs) project to the magnocellula

111 nnels and their placement along the axons of auditory nerve fibers (ANFs).

112 ectrophonic responses) from responses of the auditory nerve fibers (electroneural responses), with se

113 range of intensities than those reported for auditory nerve fibers and cochlear nucleus neurons.

114 xtract different features from the firing of auditory nerve fibers and convey that information along

115 NA and NM receive input from bifurcating auditory nerve fibers and initiate processing pathways s

116 ing in SGN, assessed by recordings of single auditory nerve fibers and their population responses in

117 term depression (LTD), whereas those between auditory nerve fibers and their targets do not.

118 to detect the coincident firing of groups of auditory nerve fibers and to convey the precise timing o

119 octopus cells detect coincident firing among auditory nerve fibers and transmit signals along monaura

120 ls in brainstem slices during stimulation of auditory nerve fibers at 35 degrees C.

121 or initiating bursts of action potentials in auditory nerve fibers before the onset of hearing.

122 These results suggest that auditory nerve fibers encode a broad set of natural soun

123 Auditory nerve fibers encode sounds in the precise timin

124 Auditory nerve fibers exhibited a recovery of normal syn

125 Auditory nerve fibers from mutants had normal threshold,

126 Cells excited predominantly by auditory nerve fibers had AMPA receptors with exceptiona

127 n by maintaining the functional integrity of auditory nerve fibers in early life rather than at old a

128 racterized the response properties of single auditory nerve fibers in mice lacking Bassoon, a scaffol

129 Terminals of auditory nerve fibers in the multipolar cell area includ

130 ically by recording spike times from chicken auditory nerve fibers in vivo while stimulating with rep

131 the amount of sound-evoked spike activity in auditory nerve fibers influences terminal morphology and

132 Auditory nerve fibers innervate narrow, topographically

133 s to tones of a basilar membrane site and of auditory nerve fibers innervating neighboring inner hair

134 ndrites of octopus cells cross the bundle of auditory nerve fibers just proximal to where the fibers

135 A reduction in the number of myelinated auditory nerve fibers leads to a reduced maximal firing

136 ontaneous activity, we hypothesized that the auditory nerve fibers might initially form topographical

137 endbulb of Held synapse, which is formed by auditory nerve fibers onto bushy cells (BCs) in the ante

138 ndbulb of Held synapses, which are formed by auditory nerve fibers onto bushy cells in the cochlear n

139 m its high-dimensional sensory inputs-30,000 auditory nerve fibers or 10(6) optic nerve fibers-a mana

140 Auditory nerve fibers reflect this tonotopy and encode t

141 Activity of auditory nerve fibers reflects this frequency-specific t

142 spiral ganglion, to study the projections of auditory nerve fibers representing a narrow band of freq

143 Repetitive stimulation of presynaptic auditory nerve fibers resulted in acute depression of EP

144 In the CN, espin-positive auditory nerve fibers showed a projection pattern typica

145 This wave evokes firing in auditory nerve fibers that are tuned to high frequencies

146 rites of fusiform cells in the deep layer by auditory nerve fibers through synapses that do not show

147 Octopus cells are excited by auditory nerve fibers through the activation of rapid, c

148 cochlea, release glutamate onto the afferent auditory nerve fibers to encode sound stimulation.

149 ceive their primary excitatory input through auditory nerve fibers via large, axosomatic synaptic ter

150 te-level functions, and adaptation of single auditory nerve fibers were measured in chinchillas with

151 white cats had partial hearing and possessed auditory nerve fibers with a wide range of spontaneous a

152 at encodes the timing of firing of groups of auditory nerve fibers with exceptional precision.

153 can cause a selective loss of high-threshold auditory nerve fibers without affecting absolute sensiti

154 f the wave I potential (generated by primary auditory nerve fibers) but normal amplitudes of the more

155 In whole-cell recordings from targets of auditory nerve fibers, octopus and T stellate cells, min

156 neurons receive excitatory input from either auditory nerve fibers, parallel fibers, or both fiber sy

157 ular to the tonotopically organized array of auditory nerve fibers, placing the earliest arriving inp

158 e and timing of the postsynaptic response in auditory nerve fibers.

159 a their ribbon synapses into firing rates in auditory nerve fibers.

160 may underlie fundamental characteristics of auditory nerve fibers.

161 cells is converted into a firing pattern in auditory nerve fibers.

162 ing of midbrain neurons approximated that of auditory nerve fibers.

163 wn as an obligatory relay center for primary auditory nerve fibers.

164 pattern of firing in the tonotopic array of auditory nerve fibers.

165 ous activity and no sound-evoked activity in auditory nerve fibers.

166 e input from slowly conducting, unmyelinated auditory nerve fibers.

167 d, reliable, and precise spike generation in auditory nerve fibers.

168 very similar to that reported for individual auditory nerve fibers.

169 t noise exposure, is associated with loss of auditory nerve fibers.

170 connections between cochlear hair cells and auditory nerve fibers; however, there is no clinical tes

171 illa cochlea were inferred from responses of auditory-nerve fibers (ANFs) to threshold- and moderate-

172 shape changes of threshold tuning curves of auditory-nerve fibers along the cochlea.

173 The responses to sound of auditory-nerve fibers are well known in many animals but

174 ear implants cannot activate selectively the auditory-nerve fibers having low characteristic frequenc

175 otential tuning curves against the tuning of auditory-nerve fibers in experimental animals and use co

176 Some investigators have claimed that the auditory-nerve fibers of humans are more sharply tuned t

177 from existing records of cat and chinchilla auditory-nerve fibers on the basis of their characterist

178 etect the coincident activation of groups of auditory nerve fibres by broadband transient sounds, com

179 es the frequency response of the innervating auditory nerve fibres However, the data supporting these

180 ry ganglion cells and central and peripheral auditory nerve fibres within the cochlea.

181 ency-bandwidth dependence similar to that of auditory nerve fibres, and yield significantly greater c

182 a gives rise to V-shaped tuning functions in auditory nerve fibres, but by the level of the inferior

183 bly increased spontaneous activity of single auditory nerve fibres, while concanavalin A had no effec

184 emperature-sensitive auditory neuropathy) or auditory nerve fibres.

185 kely to induce neurotransmitter release onto auditory nerve fibres.

186 taneous and the sound-evoked activity of the auditory nerve fibres.

187 r, the mechanisms responsible for initiating auditory nerve firing in the absence of sound have not b

188 abnormally high levels during high rates of auditory nerve firing, or that calcium-dependent process

189 noninvasive electrophysiological measure of auditory nerve function and has been validated in the an

190 eive most of their excitatory input from the auditory nerve; fusiform cells receive excitatory inputs

191 ts in the ongoing timing of responses in the auditory nerve, generally but not always resulting in sh

192 As sound-evoked responses from the auditory nerve grew progressively weaker following dener

193 electrode array that directly stimulates the auditory nerve, has greatly benefited many individuals w

194 with animal models, computational modeling, auditory nerve imaging, and human temporal bone histolog

195 e examined the regenerative potential of the auditory nerve in a mouse model of auditory neuropathy.

196 ansmit phase-locked action potentials of the auditory nerve in a pathway that contributes to sound lo

197 Synapses of the contralateral auditory nerve in early implanted cats also exhibited sy

198 as evaluated by unilaterally stimulating the auditory nerve in media containing the metabotropic glut

199 mass potentials recorded on the cochlea and auditory nerve in the cat.

200 receptors while unilaterally stimulating the auditory nerve in vitro.

201 can be bypassed by directly stimulating the auditory nerve; in agreement with the stereausis hypothe

202 pathy were probably related to a decrease of auditory nerve input accompanying axonal disease.

203 mEPSCs in cells with auditory nerve input alone were inhibited by philanthoto

204 ns in the central auditory system to reduced auditory nerve input in the absence of elevated hearing

205 Deprivation of auditory nerve input in young mice results in dramatic n

206 Auditory nerve input to the principal neurons of the AVC

207 The dorsal cochlear nucleus (DCN) integrates auditory nerve input with a diverse array of sensory and

208 CN) where principal cells integrate primary, auditory nerve input with modulatory, parallel fiber inp

209 Golgi cells probably receive auditory nerve input, because shocks to the cut end of t

210 in the parallel fiber inputs, but not in the auditory nerve inputs innervating the same DCN principal

211 us cells prevent firing if the activation of auditory nerve inputs is not sufficiently synchronous an

212 n of intensity selectivity from nonselective auditory nerve inputs remain largely unclear.

213 r ultrastructural characteristics of primary auditory nerve inputs were similar across the rostral an

214 gnocellular ventral CN (VCN), which receives auditory nerve inputs.

215 al and thus lowers the response threshold to auditory nerve inputs.

216 ve phase-locking precision relative to their auditory nerve inputs.

217 l tonotopically based representations in the auditory nerve, into perceptually distinct auditory-obje

218 It has been believed that loss of the auditory nerve is irreversible in the adult mammalian ea

219 ange adaptation observed at the level of the auditory nerve is located peripheral to the spike genera

220 Damage to the auditory nerve is postulated to trigger compensatory lon

221 The auditory nerve is the primary conveyor of hearing inform

222 of the current investigation was to generate auditory nerve-like glutamatergic neurons from ES cells.

223 brainstem response wave-V in noise reflects auditory nerve loss.

224 (pancreatic beta-cell, hematopoietic cells, auditory nerve) maintained normal function but pachytene

225 Deaf patients without an intact auditory nerve may be helped by the next generation of a

226 eural coding, predicted from a computational auditory nerve model, with perception of vocoded speech

227 A phenomenological auditory-nerve model was used to verify that the interau

228 otentials." Ribbon synapses between IHCs and auditory nerve neurons are responsible for converting re

229 itory system is very immature at birth, with auditory nerve neurons initially exhibiting very low or

230 and after deafferentation of the excitatory auditory nerve (nVIII) inputs.

231 ificity of the primary afferent axons of the auditory nerve occurs in late gestation or early postnat

232 of the spiral ganglion neurons (SGNs) of the auditory nerve occurs with age and in response to acoust

233 wave, we recorded from single fibers in the auditory nerve of anesthetized cat in response to harmon

234 c stimulation or electric stimulation of the auditory nerve or the brainstem.

235 ith disruption of the first heminodes at the auditory nerve peripheral terminal.

236 NF application induced significant growth of auditory nerve presynaptic boutons that convey the condi

237 postnatal maturation of the primary afferent auditory nerve projections from the cat cochlear spiral

238 re therefore potential targets for promoting auditory nerve regeneration.

239 Toward the eventual goal of auditory nerve replacement, the aim of the current inves

240 typical neurons in primary visual cortex or auditory nerve, respectively.

241 nd 85% from injections of the trigeminal and auditory nerves, respectively) were apposed to somata or

242 y, NO-GC stimulation exacerbated the loss of auditory nerve response in aged animals but attenuated t

243 term effects of cochlear de-efferentation on auditory nerve response properties in adult chinchillas.

244 luated the effects of contralateral noise on auditory nerve responses as a measure of the individual

245 s to pairs of stimuli, based on single-fiber auditory nerve responses at 70 and 50 dB sound pressure

246 rm treatment with a NO-GC stimulator altered auditory nerve responses but did not affect OHC function

247 e examined the trial-to-trial variability of auditory nerve responses during short-term rate-adaptati

248 shift in BF that characterizes maturation of auditory nerve responses during the same period.

249 s will enable multicompartmental modeling of auditory nerve responses elicited by afferent chemical n

250 Tympanal vibrations and auditory nerve responses reveal that localization errors

251 Yet inner hair cell (IHC) ribbons and auditory nerve responses showed significantly less deter

252 The characteristics of auditory nerve responses to sound have been described ex

253 easurements of basilar membrane velocity and auditory nerve responses to sound, has demonstrated sign

254 inor signal transformations, the polarity of auditory-nerve responses does not conform with tradition

255 Near-threshold, auditory-nerve responses to low-frequency tones are sync

256 normal media, unilateral stimulation of the auditory nerve resulted in darker Y10B immunolabeling of

257 sly published basilar membrane vibration and auditory nerve single unit data.

258 We report the developmental profile of the auditory nerve spike generator with a focus on NaV1.1, N

259 on from the turtle by pairing trigeminal and auditory nerve stimulation.

260 macaques using a stimulus design employed in auditory nerve studies of pitch encoding.

261 he influence of neurotrophin gene therapy on auditory nerve survival and peripheral sprouting in Pou4

262 ynaptic components at the level of the first auditory nerve synapse in the auditory brainstem.

263 o constant, nondamaging noise and found that auditory nerve synapses changed to facilitating, reflect

264 port describes the morphologic plasticity of auditory nerve synapses in response to ototoxic deafenin

265 High reliability at specialized auditory nerve synapses in the cochlear nucleus results

266 AMPA receptors expressed at auditory nerve synapses in the mammalian and avian cochl

267 lopment of synaptic function was examined at auditory nerve synapses in the rostromedial region of th

268 In accordance, auditory nerve synapses in the VCN are functional at E15

269 However, receptors at auditory nerve synapses on cells that also receive paral

270 We examined the effects of CHL at auditory nerve synapses onto bushy cells in the mouse an

271 Thus, auditory nerve synapses regulate excitability through an

272 However, high Pr also causes auditory nerve synapses to depress strongly when activat

273 reflect a homeostatic, adaptive response of auditory nerve synapses to reduced activity.

274 This is particularly important at auditory nerve synapses, where the presence and timing o

275 MPA receptor by increasing GluR4 subunits in auditory nerve synapses.

276 from noise-induced loss of Inner Hair Cell - Auditory Nerve synaptic connections.

277 ns associated with loss of Inner Hair Cell - Auditory Nerve synaptic connections.

278 The results show that trigeminal and auditory nerve terminal fields occupy primarily the soma

279 Thus, elimination of auditory nerve terminals and pruning of axonal branches

280 c auditory nerve terminals, although rostral auditory nerve terminals contained a greater concentrati

281 ansmission at the end-bulb synapse formed by auditory nerve terminals onto the soma of neurons in the

282 The percentage of primary auditory nerve terminals was larger in caudal AVCN, wher

283 volume fraction were similar for axosomatic auditory nerve terminals, although rostral auditory nerv

284 eak conditioned stimulus (CS) applied to the auditory nerve that immediately precedes an unconditione

285 In auditory nerve, this form of adaptation is likely mediat

286 timing information from neural spikes in the auditory nerve (time code) and the spatial distribution

287 riven spike timing, or phase locking, in the auditory nerve (time code), and the spatial distribution

288 amine the timing of action potentials in cat auditory nerve to broadband noise presented at different

289 rease in adaptation to sound statistics from auditory nerve to midbrain to cortex is an important sta

290 ea activated proximal myelinated portions of auditory nerve to restore hearing.

291 tion potential that is transmitted along the auditory nerve to the cochlear nucleus in the brainstem

292 Axons are extended from the bundle of auditory nerve toward some of the new hair cells, sugges

293 echanical tuning was broad and did not match auditory nerve tuning characteristics.

294 Auditory nerves were similarly small but increased in fi

295 refining precise timing information from the auditory nerve, whereas SCs discard precise timing infor

296 h reduces fidelity at central targets of the auditory nerve, which could affect perception.

297 s an intrinsic regulation of output from the auditory nerve, which could be targeted for therapeutic

298 e findings demonstrate that treatment of the auditory nerve with neurotrophic factors may be relevant

299 (tINs) in the hindbrain, at the level of the auditory nerve, with long, ipsilateral, descending axons

300 cer molecules were delivered into the locust auditory nerve without destroying its function, simultan