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1 e also been associated with disorders on the autism spectrum.
2  a recently introduced diagnostic feature of autism spectrum conditions (ASC).
3 er risk for intellectual disability (ID) and autism spectrum disorder (ASD) and affects an estimated
4 t is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyp
5                     Clinical overlap between autism spectrum disorder (ASD) and attention-deficit/hyp
6 LTD dysregulation in several mouse models of autism spectrum disorder (ASD) and discuss whether LTD d
7                                              Autism spectrum disorder (ASD) and Fragile X syndrome (F
8 mmon monogenic and highly penetrant cause of autism spectrum disorder (ASD) and intellectual disabili
9 communication in children with non-syndromic autism spectrum disorder (ASD) and language impairment i
10                                              Autism spectrum disorder (ASD) and obsessive-compulsive
11           We sequenced 689 participants with autism spectrum disorder (ASD) and other developmental a
12 s neurodevelopmental disorders, particularly autism spectrum disorder (ASD) and schizophrenia (SCZ).
13 orts have demonstrated a higher incidence of autism spectrum disorder (ASD) and substantially elevate
14 psychiatric disorders with high comorbidity: autism spectrum disorder (ASD) and Tourette syndrome (TS
15 the largest collection of trios (5,947) with autism spectrum disorder (ASD) available, including 282
16                                              Autism spectrum disorder (ASD) describes a group of neur
17 oximately one quarter of individuals with an autism spectrum disorder (ASD) display self-injurious be
18                                              Autism spectrum disorder (ASD) encompasses a set of neur
19 tion of emerging epigenetic information with autism spectrum disorder (ASD) genetic results may eluci
20 eviously reported that infants who developed autism spectrum disorder (ASD) had increased cerebrospin
21         Genetic variants conferring risk for autism spectrum disorder (ASD) have been identified, but
22                           Genetic studies of autism spectrum disorder (ASD) have established that de
23                     Genetic risk factors for autism spectrum disorder (ASD) have yet to be fully eluc
24 the association between maternal smoking and autism spectrum disorder (ASD) in offspring have produce
25  been correlated with increased frequency of autism spectrum disorder (ASD) in offspring.
26                         The core symptoms of autism spectrum disorder (ASD) include impaired social c
27                                              Autism spectrum disorder (ASD) involves substantial gene
28                                              Autism spectrum disorder (ASD) is 2 to 5 times more comm
29                                              Autism spectrum disorder (ASD) is a behaviorally defined
30                                              Autism spectrum disorder (ASD) is a complex neurodevelop
31                                              Autism spectrum disorder (ASD) is a complex neurodevelop
32                                              Autism spectrum disorder (ASD) is a constellation of neu
33                                              Autism spectrum disorder (ASD) is a developmental disabi
34                                              Autism spectrum disorder (ASD) is a developmental disord
35                                              Autism spectrum disorder (ASD) is a heterogeneous group
36                                              Autism spectrum disorder (ASD) is a neurodevelopmental d
37                                              Autism spectrum disorder (ASD) is a neurodevelopmental d
38                                     Although autism spectrum disorder (ASD) is a serious lifelong con
39                                              Autism spectrum disorder (ASD) is a serious neurodevelop
40                                              Autism spectrum disorder (ASD) is an increasingly common
41                                              Autism spectrum disorder (ASD) is associated with physio
42                                              Autism spectrum disorder (ASD) is characterized by core
43                                              Autism spectrum disorder (ASD) is characterized by ritua
44                                              Autism spectrum disorder (ASD) is characterized by socia
45                                              Autism spectrum disorder (ASD) is frequently associated
46                                              Autism spectrum disorder (ASD) is known to be more preva
47                                              Autism spectrum disorder (ASD) is marked by social disab
48         A critical step toward understanding autism spectrum disorder (ASD) is to identify both genet
49         Data indicate that the prevalence of autism spectrum disorder (ASD) may be increasing and tha
50                                              Autism spectrum disorder (ASD) occurs in 1 in 68 births,
51 ividuals with a clinical diagnosis of either autism spectrum disorder (ASD) or intellectual disabilit
52 d flame retardants (BFRs) is associated with autism spectrum disorder (ASD) or intellectual disabilit
53 nctional impact of novel mutations linked to autism spectrum disorder (ASD) provides a deeper mechani
54  dysfunction and the high male prevalence in autism spectrum disorder (ASD) remain poorly understood.
55 tivity changes over time in individuals with autism spectrum disorder (ASD) remains unknown.
56                                              Autism spectrum disorder (ASD) represents a set of compl
57                                              Autism spectrum disorder (ASD) risk is influenced by com
58 variants (CNVs), contribute significantly to autism spectrum disorder (ASD) risk.
59                             Individuals with Autism Spectrum Disorder (ASD) seem to have difficulties
60                                  People with autism spectrum disorder (ASD) show atypical attention t
61 n patients with developmental delay (DD) and autism spectrum disorder (ASD) suggests a different path
62 ing whole-genome sequencing of families with autism spectrum disorder (ASD) to build a resource (MSSN
63 rrently, there is no effective treatment for autism spectrum disorder (ASD), a developmental disabili
64 a (SCZ), major depressive disorder (MDD) and autism spectrum disorder (ASD), and CACNA1D for BD and A
65 tor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploins
66 human MET gene imparts a replicated risk for autism spectrum disorder (ASD), and is implicated in the
67 bility (ID) and are strongly associated with autism spectrum disorder (ASD), attention deficit hypera
68 ntal factors contribute to the etiologies of autism spectrum disorder (ASD), but evidence of specific
69 change are among the diagnostic criteria for autism spectrum disorder (ASD), but little research has
70 ationship between peripheral BDNF levels and autism spectrum disorder (ASD), but the findings are inc
71 largement has been observed in children with autism spectrum disorder (ASD), but the timing of this p
72 isorders such as intellectual disability and autism spectrum disorder (ASD), but their dysfunction is
73 hannel NaV1.2 are important risk factors for autism spectrum disorder (ASD), developmental delay, and
74  FMRP loss causing the most common heritable autism spectrum disorder (ASD), fragile X syndrome (FXS)
75 rks in neuropsychiatric disorders, including Autism Spectrum Disorder (ASD), has been well establishe
76 n in at least a subgroup of individuals with autism spectrum disorder (ASD), including in those with
77                             Individuals with autism spectrum disorder (ASD), including those who othe
78 and environmental factors in the etiology of autism spectrum disorder (ASD), our limited understandin
79 syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of
80 pmental process are seen in individuals with autism spectrum disorder (ASD), schizophrenia and intell
81 mber variant most frequently associated with autism spectrum disorder (ASD), schizophrenia, and comor
82   Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting
83                                       Within autism spectrum disorder (ASD), some work has used pupil
84                                           In autism spectrum disorder (ASD), the amygdala undergoes r
85 rce Exchange (AGRE) cohorts of children with autism spectrum disorder (ASD), we find strong statistic
86 nal disturbances are common in children with autism spectrum disorder (ASD), we sought to define the
87 nnectivity have been extensively reported in autism spectrum disorder (ASD), while their effects on t
88 ioral phenotypes.SIGNIFICANCE STATEMENT Many autism spectrum disorder (ASD)-linked mutations disrupt
89                  Recent studies suggest that autism spectrum disorder (ASD)-related behavioral phenot
90 to increase the risk for children to develop autism spectrum disorder (ASD).
91 on in neuropsychiatric conditions, including autism spectrum disorder (ASD).
92 mplicate the serotonin transporter (SERT) in autism spectrum disorder (ASD).
93  few studies have examined associations with autism spectrum disorder (ASD).
94 d 5-HT levels and may influence the risk for autism spectrum disorder (ASD).
95 ntifying phenotype-genotype relationships in autism spectrum disorder (ASD).
96 1A) gene was implicated as a risk factor for autism spectrum disorder (ASD).
97 der with comparatively high co-occurrence of autism spectrum disorder (ASD).
98 y factor influencing perceptual abilities in autism spectrum disorder (ASD).
99 l abnormalities observed in individuals with autism spectrum disorder (ASD).
100 ciated with intellectual disability (ID) and autism spectrum disorder (ASD).
101 th plans to cover services for children with autism spectrum disorder (ASD).
102 ical frequency ranges develops atypically in autism spectrum disorder (ASD).
103 ANK3 gene have been associated with risk for autism spectrum disorder (ASD).
104 ring pregnancy is known to increase risk for autism spectrum disorder (ASD).
105 to maternal FA and pesticides in relation to autism spectrum disorder (ASD).
106 tic development, but functions atypically in autism spectrum disorder (ASD).
107  the regulation of glutamatergic synapses in autism spectrum disorder (ASD).
108 PTEN is mutated in a subset of children with autism spectrum disorder (ASD); however, the mechanism b
109 h improved outcomes for children with severe autism spectrum disorder (ASD); however, there are long
110 tational age (OR, 1.01 [95% CI, 0.81-1.25]), autism spectrum disorder (HR, 0.83 [95% CI, 0.62-1.13]),
111 was somewhat elevated for ADHD with comorbid autism spectrum disorder (OR, 1.76; 95% CI, 1.37-2.26).
112 4), anencephaly (AOR 2.9, 95% CI: 1.0, 8.2), autism spectrum disorder [AOR 1.3, 95% credible interval
113 .2 (one of the most common genetic causes of autism spectrum disorder [ASD]) and assess how these fea
114 npatient or outpatient clinical diagnosis of autism spectrum disorder and attention-deficit/hyperacti
115 howed a positive genetic correlation between autism spectrum disorder and cognitive function in child
116 ain comorbid developmental conditions (i.e., autism spectrum disorder and congenital malformations),
117  in 24 age- and gender-matched patients with autism spectrum disorder and control subjects ranging in
118  gene previously found to be associated with autism spectrum disorder and epilepsy.
119 id-pregnancy serum samples: association with autism spectrum disorder and intellectual disability.
120 and provide insight into the pathogenesis of autism spectrum disorder and intellectual disability.
121 h interactive domain 1B (ARID1B) gene causes autism spectrum disorder and intellectual disability; ho
122 robiota to neurobehavioral diseases, such as autism spectrum disorder and major depression, drawing u
123 plex protein interactome that is enriched in autism spectrum disorder and other NDD candidates.
124                                  People with autism spectrum disorder and other neurodevelopmental di
125 er variations (CNVs), highly associated with autism spectrum disorder and schizophrenia.
126 ates maternal infection as a risk factor for autism spectrum disorder and schizophrenia.
127 d in synaptic homoeostasis are implicated in autism spectrum disorder and sleep-wake control.
128  genes and pathways that are dysregulated in autism spectrum disorder as well as fragile X syndrome.
129        Exclusion of ADHD cases with comorbid autism spectrum disorder attenuated but did not explain
130 ed vs 2.14% of unexposed were diagnosed with autism spectrum disorder by age 15 years, and 12.63% of
131 ted to contribute to approximately 1% of all autism spectrum disorder cases.
132 d a weak but significant association between autism spectrum disorder diagnosis and increased cerebel
133 ought to determine a combined effect size of autism spectrum disorder diagnosis on different measures
134 patients display intellectual disability and autism spectrum disorder due to silencing of the X-linke
135                          Finally, within the autism spectrum disorder group, we studied the relations
136 al 2-AG deficiency in phenotypes relevant to autism spectrum disorder has not been explored.
137 re our findings showed that male adults with autism spectrum disorder have regional differences in br
138 estational age OR, 1.15 [95% CI, 1.06-1.25]; autism spectrum disorder hazard ratio [HR], 2.02 [95% CI
139                                        Child autism spectrum disorder identified after the age of 2 y
140 lity of the parent-mediated intervention for autism spectrum disorder in south Asia (PASS) in India a
141 red with no exposure was not associated with autism spectrum disorder in the child.
142  has been associated with increased risk for autism spectrum disorder in the offspring.
143                             The male bias in autism spectrum disorder incidence is among the most ext
144                                              Autism spectrum disorder is a debilitating condition wit
145                   Our results indicated that autism spectrum disorder is a developmental condition as
146                  It has been postulated that autism spectrum disorder is underpinned by an 'atypical
147           The description of such changes in autism spectrum disorder may clarify pathomechanisms and
148 een unequivocally linked to diseases such as autism spectrum disorder or epilepsy.
149 een described in individuals presenting with autism spectrum disorder or mild intellectual disability
150 al stage, stronger genetic links with either autism spectrum disorder or schizophrenia.
151                 The neuroanatomical bases of autism spectrum disorder remain largely unknown.
152 nsight into the neural substrates underlying autism spectrum disorder social symptom severity, and fu
153 mpared with unexposed siblings (incidence of autism spectrum disorder was 3.40 per 1000 person-years
154                             The incidence of autism spectrum disorder was 4.51 per 1000 person-years
155 Tract-based spatial statistics revealed that autism spectrum disorder was associated with significant
156 vious observations of a higher risk of child autism spectrum disorder with serotonergic antidepressan
157 ed together in typical and atypical (notably autism spectrum disorder) groups: imitation, biological
158  retardation, Down syndrome, cerebral palsy, autism spectrum disorder).
159  social interaction is a defining feature of autism spectrum disorder, a neurodevelopmental disorder
160 on deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly conside
161 or treating social deficits in patients with autism spectrum disorder, and common genetic variants in
162 f syndromic intellectual disability (ID) and autism spectrum disorder, and somatic mutations are link
163 populations - specifically, individuals with autism spectrum disorder, ASD - may further illuminate s
164 (2-AG) have been reported in mouse models of autism spectrum disorder, but a causal role for striatal
165 tric and neurodegenerative diseases, such as autism spectrum disorder, depression and Alzheimer's dis
166          A specific combination of symptoms (autism spectrum disorder, developmental regression, fail
167 higher rates than UK controls of symptoms of autism spectrum disorder, disinhibited social engagement
168 rios across four neuropsychiatric disorders: autism spectrum disorder, epileptic encephalopathy, inte
169 ificantly enriched for genes associated with autism spectrum disorder, giving support to the idea tha
170 or speech and language and are implicated in autism spectrum disorder, in which language function can
171 direct measures of IQ to measure symptoms of autism spectrum disorder, inattention and overactivity,
172 omatin-remodeling subunit, in short stature, autism spectrum disorder, intellectual disability, and c
173 al disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and s
174 ing aggregated data from 9,246 families with autism spectrum disorder, intellectual disability, or de
175 ne of the most prevalent monogenic causes of autism spectrum disorder, making it imperative to unders
176 increased risk of small for gestational age, autism spectrum disorder, or attention-deficit/hyperacti
177 ity in the etiology across schizophrenia and autism spectrum disorder, PVI circuits are altered in th
178 oter, enriched in subgroups of children with autism spectrum disorder, reduces transcription and disr
179 es of many neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's
180 t (attention-deficit/hyperactivity disorder, autism spectrum disorder, schizophrenia, bipolar disorde
181 it/hyperactivity disorder, eating disorders, autism spectrum disorder, substance use disorders, anxie
182  typically developing individuals but not in autism spectrum disorder, the magnitude of social predic
183 mutations have recently been associated with autism spectrum disorder, which parallels previous evide
184 fficulties that enhance the understanding of autism spectrum disorder- and schizophrenia-related dime
185 ocial stimuli are significantly enriched for autism spectrum disorder-related genes.
186 been linked to neurological diseases such as autism spectrum disorder.
187 me, epilepsy, major depressive disorder, and autism spectrum disorder.
188 ocial signal was altered in individuals with autism spectrum disorder.
189 cluding schizophrenia, bipolar disorder, and autism spectrum disorder.
190 attention-deficit/hyperactivity disorder and autism spectrum disorder.
191 ation increases the likelihood of developing autism spectrum disorder.
192 sability, and the most common known cause of autism spectrum disorder.
193 n deficit/hyperactivity disorder (ADHD), and autism spectrum disorder.
194 , 1.6%-2.6%) of children were diagnosed with autism spectrum disorder.
195 delay/intellectual disability, epilepsy, and autism spectrum disorder.
196 pressant exposure during pregnancy and child autism spectrum disorder.
197 plicated as a central node of dysfunction in autism spectrum disorder.
198 ically diagnosed with fragile X syndrome and autism spectrum disorder.
199  system is overactivated in individuals with autism spectrum disorder.
200 ly presents with intellectual disability and autism spectrum disorder.
201 contrasting language performance observed in autism spectrum disorder.
202 ultiple forms of intellectual disability and autism spectrum disorder.
203 nces in white matter networks in adults with autism spectrum disorder.
204 otion recognition, relationship quality, and autism spectrum disorder.
205 cally developing children, and children with Autism Spectrum Disorder.
206 ome is the most common monogenetic cause for autism spectrum disorder.
207 rapies to help ameliorate social deficits in autism spectrum disorder.
208 area affected in both fragile X syndrome and autism spectrum disorder.
209  many neurodevelopmental disorders including autism spectrum disorder; however, little is known about
210        Social deficits are a core symptom of autism spectrum disorder; however, the perturbed neural
211                                              Autism spectrum disorders (ASD) and attention-deficit/hy
212 n are part of the phenotypic overlap between autism spectrum disorders (ASD) and schizophrenia.
213                                              Autism spectrum disorders (ASD) are a group of genetic d
214                                              Autism spectrum disorders (ASD) are characterized by dif
215                                              Autism spectrum disorders (ASD) are characterized by imp
216                                              Autism spectrum disorders (ASD) are common, complex and
217             Intellectual disability (ID) and autism spectrum disorders (ASD) are genetically heteroge
218                                              Autism spectrum disorders (ASD) are more common among bo
219                Over 70% of the children with autism spectrum disorders (ASD) are positive for these a
220 ess in understanding the genetic etiology of autism spectrum disorders (ASD) has fueled remarkable ad
221             The number of diagnosed cases of Autism Spectrum Disorders (ASD) has increased dramatical
222               Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized t
223                                              Autism spectrum disorders (ASD), and their pathogenesis,
224 nly implicated factors in neurodevelopmental autism spectrum disorders (ASD), characterized, in part,
225 f heritable intellectual disability (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS
226 tor 5 (mGluR5) have therapeutic potential in autism spectrum disorders (ASD), including tuberous scle
227 Risk (HR or LR, respectively) for developing Autism Spectrum Disorders (ASD).
228 rus I (RCrusI), are consistently reported in autism spectrum disorders (ASD).
229 bserved in young children with or at risk of Autism Spectrum Disorders (ASD).
230 ring of schizophrenia, bipolar disorder, and autism spectrum disorders (ASD).
231 eurotypical adults and may increase risk for autism spectrum disorders (ASD).
232 rome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD).
233  the neurodevelopmental deficits observed in autism spectrum disorders (ASD).
234 pain sensitivity is commonly associated with autism spectrum disorders (ASDs) and affects the life qu
235 stnatal onset neurological disorders such as autism spectrum disorders (ASDs) and intellectual disabi
236                                              Autism spectrum disorders (ASDs) and obsessive compulsiv
237 dent that there is a genetic contribution to autism spectrum disorders (ASDs) and other neural disord
238 e de novo synonymous mutations identified in autism spectrum disorders (ASDs) and schizophrenia (SCZ)
239      With an onset under the age of 3 years, autism spectrum disorders (ASDs) are now understood as d
240 have been described in some individuals with autism spectrum disorders (ASDs) as well as their family
241  (LGD) mutations contribute significantly to autism spectrum disorders (ASDs) but have been primarily
242                                Patients with autism spectrum disorders (ASDs) commonly experience abe
243 een prenatal exposure to antidepressants and autism spectrum disorders (ASDs) in children, with incon
244      Understanding the mechanisms underlying autism spectrum disorders (ASDs) is a challenging goal.
245            The male bias in the incidence of autism spectrum disorders (ASDs) is one of the most nota
246 hanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown.
247 coding polymorphism has been associated with autism spectrum disorders (ASDs) within a subgroup of pa
248 sory hypersensitivity is a common symptom in autism spectrum disorders (ASDs), including fragile X sy
249 itrk5 and Shank3, reported models of OCD and autism spectrum disorders (ASDs).
250 st that prenatal infection increases risk of autism spectrum disorders (ASDs).
251 on of the protein E6AP is directly linked to autism spectrum disorders (ASDs).
252 red in some psychiatric disorders, including autism spectrum disorders (ASDs).
253 nancy are associated with increased risk for autism spectrum disorders (ASDs).
254 ne product E6AP protein is a common cause of autism spectrum disorders (ASDs).
255 ffecting gaze behavior toward faces, such as autism spectrum disorders and congenital prosopagnosia.
256 ining 1 (PTCHD1) is mutated in patients with autism spectrum disorders and intellectual disabilities
257 hat these rearrangements are associated with autism spectrum disorders and mirror phenotypes of obesi
258 BP5 CNV found in 0.5%-1% of individuals with autism spectrum disorders and schizophrenia and whose re
259                This pattern was strongest in autism spectrum disorders and schizophrenia, and weakest
260 tiple neurodevelopmental disorders including autism spectrum disorders and schizophrenia.
261 ogy of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia.
262 human Shank copy number variations (CNVs) on Autism spectrum disorders and schizophrenia.
263                                              Autism spectrum disorders are a group of pervasive neuro
264                                              Autism Spectrum Disorders are characterized by difficult
265                                      Because autism spectrum disorders are neurodevelopmental disorde
266 ysiology of macrocephaly/autism syndrome and autism spectrum disorders featuring dysregulated mTOR si
267                                              Autism spectrum disorders identified by diagnoses from i
268 ltural bridges shaped public discourse about autism spectrum disorders on Facebook over the course of
269 icated in neurodevelopmental disorders, like autism spectrum disorders or attention-deficit hyper-act
270 a profile of traits that have been linked to autism spectrum disorders, and are thought to encompass
271      Neurodevelopmental disorders, including autism spectrum disorders, are highly male biased, but t
272 mood affective disorders, anxiety disorders, autism spectrum disorders, attention deficit/hyperactivi
273 ntribute to many clinical disorders, such as autism spectrum disorders, corpus callosum agenesis, Jou
274 ed clusters for enrichment of schizophrenia, autism spectrum disorders, developmental delay and intel
275 able research into the genetic background of autism spectrum disorders, environmental factors are lik
276 tive immune system function is implicated in autism spectrum disorders, including Fragile X syndrome.
277 y of neurodevelopmental disorders, including autism spectrum disorders, intellectual disability and s
278 though human RIM-BPs have been implicated in autism spectrum disorders, little is known about the rol
279 ation carriers from mothers of children with autism spectrum disorders, the comparison group.
280 understanding of the complex neurobiology of autism spectrum disorders, valid disease models are pivo
281  translation of dyrk1a, a Down syndrome- and autism spectrum disorders-related gene, is dependent on
282 es or contribute to the pathogenesis of some autism spectrum disorders.
283 ritable cause of intellectual disability and autism spectrum disorders.
284 s neuromotor deficits in startle disease and autism spectrum disorders.
285 isorders and are among the most prevalent in autism spectrum disorders.
286 cial interaction is a diagnostic hallmark of autism spectrum disorders.
287 vior toward faces, such as prosopagnosia and autism spectrum disorders.
288 ing protein, Rbfox1, as a candidate gene for autism spectrum disorders.
289 ng VIPUR to de novo variants associated with autism spectrum disorders.
290 ttention deficit/hyperactivity disorder, and autism spectrum disorders.
291 the possibility of personalized medicine for autism spectrum disorders.
292 ctions with central molecular hubs linked to autism spectrum disorders.
293 ar disease states such as CHARGE syndrome or autism spectrum disorders.
294 standing DA developmental conditions such as autism spectrum disorders.
295 d to human hyperekplexia/startle disease and autism spectrum disorders.
296 ore, our finding of enrichment was unique to autism spectrum disorders; brain gene expression signatu
297 logy of neurodevelopmental disorders such as autism spectrum disorders; neurodegenerative disorders s
298 eneration of epilepsy, neuropathic pain, and autism spectrum disorders; thus, it is important to char
299                                      The AQ (Autism-Spectrum Quotient) scores were elevated in the sy
300  neuropsychiatric disorders like bipolar and autism spectrum where 40 Hz ASSR deficits have been docu

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