ライフサイエンスコーパス: autoactivation

1 beta and C/EBPdelta and later by C/EBPalpha (autoactivation).

2 he active site in the closed form to prevent autoactivation.

3 G, and p.K23R strongly stimulate trypsinogen autoactivation.

4 anisms of JNK2alpha2 autophosphorylation and autoactivation.

5 at is undergoing autophosphorylation through autoactivation.

6 (Tak1), and inhibits its ubiquitination and autoactivation.

7 supported tissue factor-dependent factor VII autoactivation.

8 s it is essential for maximal suppression of autoactivation.

9 as shown to contribute to the suppression of autoactivation.

10 but not other MAPKs and stimulates p38alpha autoactivation.

11 ing that TrcR is involved in transcriptional autoactivation.

12 ession, followed by Stat6-independent GATA-3 autoactivation.

13 recognition motif to allow GATA-3-dependent autoactivation.

14 t this binding is essential for the protease autoactivation.

15 ligomerizes caspase-1 zymogen, promoting its autoactivation.

16 rs to promote procaspase oligomerization and autoactivation.

17 a negatively charged surface for factor XII autoactivation.

18 arin for optimal inhibition by ATIII and for autoactivation.

19 e feedback loop created by Dpp diffusion and autoactivation.

20 ysiological conditions generates thrombin by autoactivation.

21 o unleash activity in the zymogen to produce autoactivation.

22 he autolysis loop of T8 and T9 and inhibited autoactivation.

23 was the activating protease, nor during fXI autoactivation.

24 ouse Ctrc, causing negligible stimulation of autoactivation.

25 g independent C-terminal gp175 self-cleavage autoactivation.

26 e fXI activation by thrombin and promote fXI autoactivation.

27 penetrance, exhibited a smaller increase in autoactivation.

28 and sufficient for caspase-11 induction and autoactivation.

29 also holds for a one-stage scenario and for autoactivation.

30 educed trypsinogen degradation and increased autoactivation.

31 nrichment of the CPC results in local kinase autoactivation, a mechanism that contributes to the spat

32 sing anti-Incenp antibodies, which stimulate autoactivation among bound complexes.

33 activation temporally coupled to matriptase autoactivation and 2) HAI-1 rapidly inhibiting not only

34 ndicate the importance of domain closure for autoactivation and activity regulation, with that event

35 gulation--one configuration further enhances autoactivation and another is essential for autorepressi

36 e cell membrane powerfully induces caspase-8 autoactivation and apoptosis.

37 n of CI bound to its operators influence the autoactivation and autorepression of P(RM) regulation.

38 of the death protease CED-3, leading to its autoactivation and cell death.

39 observed, while in the presence of 1 mM EDTA autoactivation and cleavage at Lys(188) were reduced, an

40 serine protease (MASP)-2, followed by MASP-2 autoactivation and cleavage of C4 and C2 generating the

41 hows complex multiattractor dynamics without autoactivation and cooperativity.

42 e of mediating RXR-dependent transcriptional autoactivation and COUP-TF-dependent repression.

43 Thus, in the presence of 5 mM Ca(2+), autoactivation and digestion of the zymogens after Arg(1

44 Burial of Arg-320 prevents prothrombin autoactivation and directs prothrombinase to cleave at A

45 t into CD8alpha(+) cDCs due to decay of Irf8 autoactivation and diverted to the CD4(+) cDC lineage.

46 itions 401 and 403) that distinguish between autoactivation and effector-triggered activation.

47 In the same context, faster autoactivation and increased trypsin stability caused by

48 3-deleted form of SPC2 that does not undergo autoactivation and is not secreted.

49 The model incorporates autoactivation and lateral inhibition, which are propert

50 -CatK has been speculated to accelerate CatK autoactivation and promote efficient collagen degradatio

51 r of SPAK/OSR1 activity, facilitating kinase autoactivation and promoting phosphorylation of the cotr

52 bited significantly higher stability against autoactivation and proteolysis than zymogens with Asn(21

53 In particular, both TBK1 autoactivation and substrate specificity are likely driv

54 be dephosphorylated by RPTPbeta/zeta; thus, autoactivation and tyrosine phosphorylation of ALK rapid

55 re susceptible to chymotrypsin digestion and autoactivation, and features a shape consistent with rec

56 orylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosp

57 Replacement of D169 prevents caspase-3 autoactivation, and its cleavage at D175 no longer leads

58 C1r in the fibroblast medium underwent autoactivation, and the activated form cleaved C1s.

59 ivation of FXI by factor XIIa, thrombin, and autoactivation; and inactivation of activated FXI (FXIa)

60 Autoactivation appears to be an intrinsic property of ch

61 nown to be an activator of its own promoter (autoactivation) as well as of the plasmid-located bfp op

62 regions of the NRL protein using yeast-based autoactivation assays.

63 Autoactivation at a 1:2 dilution was abnormally high in

64 hat mature, inactive enzyme generated during autoactivation at higher pH contained N-terminal extensi

65 ng downstream of focal adhesion kinase (FAK) autoactivation at the point of Src-mediated phosphorylat

66 ypsinogens and documented characteristics of autoactivation, autocatalytic degradation and Ca2+-depen

67 m other MAPK proteins in two major ways; its autoactivation/autophosphorylation is dependent on dimer

68 the propeptide latency motif did not prevent autoactivation but the autolysis rate was somewhat reduc

69 at the membrane is sufficient for caspase-8 autoactivation, but apoptosis could involve a death sign

70 GATA-3-dependent Th2 development and GATA-3 autoactivation, but not Stat6-dependent induction of GAT

71 Aurora A autoactivation by autophosphorylation is promoted by spe

72 DNA binding domain, we were able to overcome autoactivation by AvrPto and identify four classes of sp

73 pose that Smo/Cos2 interactions stimulate Fu autoactivation by concentrating Fu at the membrane.

74 rm oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules.

75 radoxically, CTRC also increases the rate of autoactivation by processing the trypsinogen activation

76 We demonstrate that rapid transcriptional autoactivation by the Amt1 Cu metalloregulatory transcri

77 est that generation of the active enzyme via autoactivation can be accomplished not only in vitro but

78 nterior mandibular cells, since the Deformed autoactivation circuit is normally antagonized by CncB f

79 rypsins, provides an additional mechanism of autoactivation control in the human pancreas.

80 icance of the negative charge of Asp(218) in autoactivation control.

81 an intact Asp(19-22) motif was critical for autoactivation control.

82 Finally, GATA-3 exerts Stat6-independent autoactivation, creating a feedback pathway stabilizing

83 the gatekeeper residue unexpectedly lead to autoactivation due to enhanced autophosphorylation of re

84 interplay of three generic mechanisms: local autoactivation, early long-range inhibition, and late lo

85 utations that change the affinity of a small autoactivation element for EXD protein result in corresp

86 Trypsin-mediated trypsinogen activation (autoactivation) facilitates digestive zymogen activation

87 R repeats are sufficient for inhibiting RPS5 autoactivation; however, the complete LRR domain was req

88 C) is a proteolytic regulator of trypsinogen autoactivation in humans.

89 activated efficiently by FXIIa, thrombin, or autoactivation in the presence of dextran sulfate.

90 Because autoactivation in vitro at the pH values reported for ly

91 Autoactivation in vitro requires phosphorylation of the

92 ed that although TPP I zymogen is capable of autoactivation in vitro, a serine protease that is sensi

93 pression of dorsal markers including itself (autoactivation) in the neuroectoderm is blocked by sog.

94 bbit muscle (RM PhK), as was the hysteresis (autoactivation) in the rate of product formation at pH 6

95 FXII is converted to FXIIa through autoactivation induced by "contact" to charged surfaces.

96 Prothrombin autoactivation induced by histone H4 emerges as a mechan

97 utants of human cationic trypsinogen undergo autoactivation intracellularly, which leads to decreased

98 Zymogen autoactivation is explained by conformational selection,

99 The product of autoactivation is functionally and structurally equivale

100 The kinetics of AMT1 autoactivation is greatly enhanced by homopolymeric (dA-

101 r serum-independent conditions and that this autoactivation is inhibited by PAI-1, a urokinase plasmi

102 Corroboratively, we show that otx2 autoactivation is prevented by retinoic acid.

103 f the mutants, indicating that intracellular autoactivation is responsible for the observed secretion

104 cleavage of factor XI by thrombin, FXIIa, or autoactivation, is a critical enzyme in the amplificatio

105 rmation is typically initiated by factor XII autoactivation, it is also possible to activate factor X

106 the rat proenzyme, at pH 8.0, 37 degrees C, autoactivation kinetics of Asn-21-Tg and Ile-21-Tg were

107 In this model the unusual autoactivation kinetics of tyrosinase are explained by r

108 transcription factor cooperativity, whereas autoactivation leads to a tristable system with an addit

109 Thus, IFN-alpha/beta disrupts the GATA3-autoactivation loop and promotes epigenetic silencing of

110 gest that the leukemic clone can generate an autoactivation loop through S100-A9 expression, NF-kappa

111 that these inhibitors target the matriptase autoactivation machinery rather than the intracellular s

112 zing p53 and suggest that targeting the MDM2 autoactivation mechanism may be useful for therapeutic m

113 In this report we clarify the autoactivation mechanism of Aurora A by demonstrating th

114 The autoactivation mechanism of p38alpha has been found to b

115 states, sustained by a two-component kinase autoactivation mechanism.

116 ntity with PRSS1 and a strong propensity for autoactivation, mutations in PRSS2 are not found in here

117 Whether prothrombin autoactivation occurs in the wild-type under conditions

118 RstR autoactivation occurs when RstR is bound to an operator

119 Virulence is dependent on the autoactivation of a toxin cysteine protease, which is pr

120 The autoactivation of an initiating serine protease upon bin

121 tivation peptide at Phe-18 by CTRC inhibited autoactivation of anionic trypsinogen, although cationic

122 the cationic proenzyme, acidic pH inhibited autoactivation of anionic trypsinogen.

123 to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activa

124 which in turn further led to transcriptional autoactivation of BMI1.

125 e made with EGTA Mg(2)(+) buffer, permitting autoactivation of C3.

126 learning but also represents a mechanism for autoactivation of CaMKII's multifaceted protein-docking

127 Consistent with this notion, autoactivation of cationic Tg was inhibited by the cleav

128 Autoactivation of cationic trypsinogen is proteolyticall

129 es to form a tetramer, which facilitates the autoactivation of CED-3.

130 was to investigate the effect of CTRC on the autoactivation of clinically relevant trypsinogen mutant

131 Autoactivation of factor VII bound to TF in suspension w

132 or, a calcium ionophore known to inhibit the autoactivation of furin.

133 PolyP70 stimulated the autoactivation of FXII and subsequent plasminogen activa

134 tudies implied that this pathway involved an autoactivation of GATA-3 expression, since Stat6-deficie

135 we investigated the molecular basis for the autoactivation of hemolymph protease 14 (HP14), an initi

136 degradation and thereby markedly suppressed autoactivation of human anionic trypsinogen more effecti

137 Autoactivation of human cationic trypsinogen is inhibite

138 ndergo selection for LT mutations to prevent autoactivation of integrated virus replication that woul

139 hanism for oligomerization-driven allosteric autoactivation of IRAK4 that may be general to other kin

140 However, after specification of pre-CD8 DCs, autoactivation of Irf8 became Batf3 dependent at a CD8al

141 Irf8 expression in CDPs required prior autoactivation of Irf8 that was dependent on the transcr

142 In summary, autoactivation of MASP-1 is crucial for the activation o

143 and, moreover, inhibition of MASP-1 prevents autoactivation of MASP-2.

144 Autoactivation of MASPs occurs in two steps: 1) zymogen

145 cs studies further reveal that the timing of autoactivation of matriptase, prostasin activation, and

146 study was to characterize the regulation of autoactivation of mouse trypsinogens by mouse Ctrc.

147 We conclude that autoactivation of mouse trypsinogens is under the contro

148 Autoactivation of N-terminally truncated cationic trypsi

149 The autoactivation of OXS2 may be a commensurate response to

150 portance of CMD-1 for activation of Pemm and autoactivation of Pmga in the serotype M6 Mga.

151 To define the mechanisms for the autoactivation of primed Cds1 and the regulation of this

152 provide a mechanism by which Apaf-1 promotes autoactivation of pro-casp9 through Apaf-1 self-associat

153 ry that regulates proper oligomerization and autoactivation of procaspase-8 and/or procaspase-10 duri

154 influx promotes oligomerization and thereby autoactivation of Pyk2 by stimulating its interaction wi

155 ution of the RPS2 LRR domain resulted in the autoactivation of RPS5, indicating that the LRR domain m

156 copper insult requires rapid transcriptional autoactivation of the AMT1 copper-metalloregulatory tran

157 ctors that are important for promoting rapid autoactivation of the AMT1 gene in response to toxic cop

158 Rapid transcriptional autoactivation of the Candida glabrata AMT1 copper metal

159 that TPX2 stimulates autophosphorylation and autoactivation of the enzyme.

160 In contrast, autoactivation of the executioner caspase-3 and -6 zymog

161 er, the molecular mechanisms responsible for autoactivation of the initiating protease remains poorly

162 s activation is indirect, being achieved via autoactivation of the per promoter which ensures suffici

163 ess, can be initiated and accelerated by the autoactivation of the type 2 transmembrane serine protea

164 entral for ABA signaling is the ABA-mediated autoactivation of three monomeric Snf1-related kinases (

165 I prosegment fragments, and switch effective autoactivation of TPP I proenzyme toward less acidic pH

166 Increased intrapancreatic autoactivation of trypsinogen mutants has been hypothesi

167 ably, dimer TF(L)LZ efficiently promoted the autoactivation of VII to VIIa in solution in contrast to

168 Additionally, we show that trafficking and autoactivation of wild type FGFR2 is glycosylation-depen

169 cosylation led to increased contact-mediated autoactivation of zymogen FXII, resulting in excessive a

170 effect on the levels of trypsin generated by autoactivation or by enterokinase at pH 8.0 in 1 mm Ca2+

171 be grouped into five categories: activation, autoactivation, partial inhibition, substrate inhibition

172 The autoactivation pathway may allow Abl family kinases to i

173 nt with this indication of a possible direct autoactivation pathway, we also observed that heterologo

174 e show that exd function is required for the autoactivation phase of Dfd expression in the posterior

175 ee conditions and provide evidence that this autoactivation plays a key role in regulating the intrin

176 Autoactivation primes Fu for additional CK1-dependent ph

177 We present evidence to demonstrate this autoactivation process is a trans-activation event that

178 e-switch model predicts the well-established autoactivation process, approximately 40% of the known M

179 hibition (pT305 phosphorylation) followed by autoactivation (pT286) of CaMKIIalpha in the hippocampus

180 The zymogen autoactivation rate of MASP-1 is approximately 3000-fold

181 pH values, Thr-21-Tg showed markedly higher autoactivation rates than the two other zymogens.

182 charomyces cerevisiae, we identified a novel autoactivation region in mammalian MEK1 that is involved

183 p38alpha autoactivation requires an interaction of p38alpha with

184 sequence resulted in a profound decrease in autoactivation, significantly greater than for any singl

185 Phosphorylation of the autoactivation site of the Src family kinases Lyn and/or

186 rs from human factor XI in that it undergoes autoactivation slowly in the presence of dextran sulfate

187 In the autoactivation stage, primed Cds1 molecules dimerize via

188 e made for MASP-2, and rate constants of the autoactivation steps as well as the possible cross-activ

189 The autoactivation steps of MASP-1 were separately quantifie

190 In addition, Nudel protease autoactivation temporally coincides with vitelline membr

191 facile production of enzymes through zymogen autoactivation that is broadly applicable to trypsin-lik

192 domains within HP14 are required for proHP14 autoactivation that is stimulated by its interaction wit

193 For activation by thrombin, or during autoactivation, the data support a cis-activation mechan

194 re generated and spread from sites of kinase autoactivation, thereby regulating cell division.

195 FXI undergoes autoactivation to FXIa in the presence of heparin.

196 ther by prekallikrein or by prekallikrein-HK autoactivation to generate kallikrein.

197 Instead, an increased propensity to autoactivation under acidic conditions might be relevant

198 e we demonstrate concentration-dependent BAK autoactivation under cell-free conditions and provide ev

199 We conclude with the suggestion that agr autoactivation, unlike classical enzyme induction, can o

200 fect was completely rescued by inhibition of autoactivation via (1) inclusion of the small molecule t

201 Instead, inhibition of autoactivation via cleavage of the autolysis loop is the

202 The rate of autoactivation VII-Q10E32 with soluble tissue factor was

203 Plasma autoactivation was assessed by using a chromogenic assay

204 The rate of autoactivation was decreased substantially for A253 with

205 left unresolved the issue of whether GATA-3 autoactivation was direct or indirect.

206 To clarify the mechanism of JNK2alpha2 autoactivation, we have generated a series of chimeric c

207 To identify the mechanism of autoactivation, we have performed a series of molecular

208 cluster in the N-terminal domain also cause autoactivation when mutated.

209 ion of MASPs occurs in two steps: 1) zymogen autoactivation, when one proenzyme cleaves another proen

210 he trypsinogen activation peptide stimulates autoactivation, whereas cleavage of the calcium binding

211 Ile mutation stabilizes the zymogen against autoactivation, whereas it has no effect on catalytic pr

212 ) and Asp(21) resulted in 2-3-fold increased autoactivation, whereas the Asp(22) --> Ala mutant autoa

213 d that Gln-6 and His-9 were not critical for autoactivation, whereas Val-2, Ile-5, and Met-8 were.

214 endent dysregulation of cationic trypsinogen autoactivation, which results in elevated trypsin levels

215 The D226N mutant undergoes hydrolytic autoactivation with a half-life of 9.3 days at 37 degree

216 H 8.0, 37 degrees C, pure zymogens underwent autoactivation with concomitant trypsinolytic degradatio

217 supported factor X activation and factor VII autoactivation with essentially wild-type enzyme kinetic