ライフサイエンスコーパス: autoantibody response

1 region suggests a genetic restriction of the autoantibody response.

2 not detectable within the strong Tg-specific autoantibody response.

3 nts; P=0.02), with marked attenuation of the autoantibody response.

4 B cell depletion reduced the PG-specific autoantibody response.

5 PAD-4 polymorphisms influence the anti-PAD-4 autoantibody response.

6 lung, the target tissue associated with this autoantibody response.

7 for examining the role of T cells in the RF autoantibody response.

8 ing a novel window into the initiation of an autoantibody response.

9 y mature, complex humoral autoimmune anti-Sm autoantibody response.

10 D4+ T cell repertoire required to induce the autoantibody response.

11 onnected group of molecules for a high-titer autoantibody response.

12 regulate two different sets of nephritogenic autoantibody responses.

13 fferentiation processes that underpin Ab and autoantibody responses.

14 ss-switched and hypermutated (mature) Ab and autoantibody responses.

15 oped for autoantigen discovery and profiling autoantibody responses.

16 ith both H(+)K(+)ATPase and intrinsic factor autoantibody responses.

17 ) regulatory T cells (Tregs) that suppressed autoantibody responses.

18 cell stimuli can influence the induction of autoantibody responses.

19 form germinal centers, and produce secondary autoantibody responses.

20 e maturation, rather than the initiation, of autoantibody responses.

21 rce of snoRNP to initiate and maintain these autoantibody responses.

22 s occurs in the face of an anti-Neu5Gc "xeno-autoantibody" response.

23 NZM2328 mice developed 1) accelerated dsDNA autoantibody response, 2) early onset and severe prolife

24 develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later.

25 ral tolerance permits a cross-reactive HIV-1 autoantibody response able to neutralize HIV-1.

26 e show here that ablation of miR-155 reduced autoantibody responses accompanied by a decrease in seru

27 by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyt

28 Patients with UC, and not CD, show mucosal autoantibody response against hTM isoforms, particularly

29 4 wk, AOD progressed to ovarian atrophy with autoantibody response against multiple oocyte Ag of earl

30 e current study, we further investigated the autoantibody response against SPAG16-a protein with unkn

31 Autoantibody response against the small nuclear ribonucl

32 ody targets revealed marked heterogeneity in autoantibody responses against islet cell autoantigens i

33 hesis that NZW genes act to class-switch the autoantibody response, an effect that appears to contrib

34 ssion of Th1-mediated events exacerbated the autoantibody response and augmented IgG1, IgE, and IL-4

35 le manifestations, Th1 cells drive the early autoantibody response and IL-17-producing cells may be r

36 during apoptosis as potential targets of the autoantibody response and our results identify poly(ADP-

37 In this study, autoantibody response and tumor antigen expression are a

38 This study has examined autoantibody responses and autoimmune pathology in a mur

39 s heterozygous mice also showed reduction of autoantibody responses and immunopathology.

40 sulted in increased anti-mouse thyroglobulin autoantibody responses and increased expression of IFN-g

41 parations induced high-avidity anti-CCR5 IgG autoantibody responses, and all five immunized macaques

42 to study the specificity and pathogenesis of autoantibody responses, and to identify and define relev

43 tin, full-blown pathogenic maturation of the autoantibody response appears to require additional inpu

44 autoantigen expression in the cancer and the autoantibody response are associated.

45 suggesting that at the clonal level, chronic autoantibody responses are dynamic and episodic, much li

46 To determine how pathogenic anti-GPS autoantibody responses are regulated, we generated an Ig

47 on suppressed lung mucosa-associated Tfh and autoantibody responses by increasing the gut-homing alph

48 e of type I IFN-mediated signaling, systemic autoantibody responses can be dissociated from glandular

49 Surprisingly, they had a robust autoantibody response comparable with that of the wild-t

50 onged and significant increase of anti-dsDNA autoantibody responses compared with WT mice (week 4 to

51 always had reduced anti-mouse thyroglobulin autoantibody responses, compared with Tg(-) littermates,

52 bserved in vivo, suggesting that a metatypic autoantibody response could play a physiological role in

53 undertaken to determine whether this strong autoantibody response depends on T cell differentiation

54 rm large-scale multiplex characterization of autoantibody responses directed against structurally div

55 Modulation of the autoantibody response disrupts pathogenesis by preventin

56 se disparate clinical outcomes, anticollagen autoantibody responses during CIA did not differ among t

57 KIR4.1 is a target of the autoantibody response in a subgroup of persons with mult

58 The specificity of the autoantibody response in different autoimmune diseases m

59 ally incite autoimmunity, we have traced the autoantibody response in human SLE back in time, prior t

60 ell differentiation to dampen the pathogenic autoantibody response in lupus.

61 ur goal was to analyze the regulation of the autoantibody response in male and female W/B mice bearin

62 tal mercury elicits a genetically restricted autoantibody response in mice that targets the nucleolar

63 study, we showed that the class-switched IgG autoantibody response in MRL/Fas(lpr/lpr) and C57/Sle1Sl

64 trategy to confirm KIR4.1 as a target of the autoantibody response in multiple sclerosis and to show

65 of this type could plausibly perpetuate the autoantibody response in myasthenia gravis, and are a ra

66 These data suggest that the autoantibody response in scleroderma is the immune marke

67 pitope-specific Ab responses and alternative autoantibody responses in a model system in which an ant

68 dy identifies axopathic and/or demyelinating autoantibody responses in a subset of patients with mult

69 Increased diversity of autoantibody responses in acute EAE predicted a more sev

70 of Sle1b on Spt-GC, follicular Th cell, and autoantibody responses in B6.Sle1b mice was B cell auton

71 oked strong germinal centre alloantibody and autoantibody responses in C57BL/6 recipients and develop

72 ome' microarrays to profile the evolution of autoantibody responses in experimental autoimmune enceph

73 mechanisms may be responsible for eliciting autoantibody responses in lpr/lpr mice.

74 used to study islet and other organ-specific autoantibody responses in parallel.

75 Autoantibody responses in patients and mice were dose-de

76 urther evidence that TLRs play a key role in autoantibody responses in SLE, we found that autoimmune-

77 ction and could therefore promote pathogenic autoantibody responses in SLE.

78 FNs might be critical for amplifying overall autoantibody responses in systemic lupus erythematosus.

79 particle (VLP)-based immunogens could induce autoantibody responses in well-characterized transgenic

80 Anti-nuclear autoantibody responses, including anti-dsDNA, were seen

81 ion of linear epitopes and the complexity of autoantibody responses, including the broad spectrum of

82 further investigate the pathogenesis of the autoantibody response induced by peptide immunization, w

83 The anti-Smith (Sm) autoantibody response is highly specific for systemic lu

84 nducible regulatory T cells that can control autoantibody responses is a potential avenue for the tre

85 ection of a self-molecule as a target for an autoantibody response may be a consequence of the proinf

86 It has been suggested that these novel autoantibody responses may be immune system reactions to

87 of IL-17 and IL-21 and the inflammatory and autoantibody responses observed in these autoimmune mice

88 Autoimmune ovarian disease (AOD) and oocyte autoantibody response of day 3-thymectomized (d3tx) mice

89 Little is known about the anti-alpha-fodrin autoantibody response on a molecular level.

90 Proteomic monitoring of autoantibody responses provides a useful approach to mon

91 es, the relative contributions of T cell and autoantibody responses remain largely undefined.

92 inea pigs not only develop antimitochondrial autoantibody responses similar to human PBC, but also de

93 CD4(+) T cells, and a robust, variegated IgG autoantibody response targeting multiple components of c

94 in 0 (P0), which was the principal target of autoantibody responses targeting nerve proteins.

95 Overall, the highest correlations among the autoantibody responses tested were in the endemic contro

96 WT mice, CD28(-/-) mice have lower anti-MTg autoantibody responses than do WT mice.

97 lyclonal and sustainable anti-mTNF-alpha IgG autoantibody response that lasts for at least 40 weeks.

98 by which a toxin such as mercury elicits an autoantibody response that predominantly targets a singl

99 Ns drove T cell-mediated inflammation and an autoantibody response that targeted abundant, tissue-res

100 its a genetically restricted, anti-nucleolar autoantibody response that targets fibrillarin, a 34-kDa

101 ritical in the initiation and maintenance of autoantibody responses that are a hallmark of systemic l

102 g linked to foreign Th epitopes induces weak autoantibody responses that are predominantly of the IgM

103 Estrogen enhances antibody and autoantibody responses through yet to be defined mechani

104 hTSHR A-subunit protein fails to divert the autoantibody response to a nonpathogenic form.

105 We conclude that autoantibody response to diverse native GBM Ags was indu

106 ed approach to identify the initiation of an autoantibody response to identify the sites and cell dif

107 In this study, we evaluated the autoantibody response to native insulin after administra

108 cobacterial T cell epitope elicited a strong autoantibody response to native ubiquitin.

109 selvagem [FS]) in which the pathogenic IgG4 autoantibody response to the self-antigen desmoglein 1 (

110 be a straightforward HLA-class II-restricted autoantibody response to the thyroid stimulating hormone

111 Autoantibody responses to apoA-I can be polyclonal and i

112 atosus clearly dissociate genetic control of autoantibody responses to classic lupus antigens and kid

113 Autoantibody responses to DNA topoisomerase I (Topo I) a

114 We concluded that autoantibody responses to EGFR hold the potential of ful

115 uggest that measurement of T-cell as well as autoantibody responses to FcepsilonRIalpha could improve

116 e inverse relationship between IFN-gamma and autoantibody responses to FcepsilonRIalpha may signify d

117 IFN-gamma and autoantibody responses to FcepsilonRIalpha were inversel

118 HLA-A*24 genotype and autoantibody responses to insulin (IAA), glutamate decar

119 cally diagnosed with type 2 diabetes exhibit autoantibody responses to islet autoantigens.

120 esponses, using cellular immunoblotting, and autoantibody responses to islet proteins, before transpl

121 esponses, using cellular immunoblotting, and autoantibody responses to islet proteins, before transpl

122 observations that concomitant or coupling of autoantibody responses to proteins which are associated

123 molecular-intrastructural diversification of autoantibody responses to the components of Ul snRNPs in

124 l help may play a crucial role in regulating autoantibody responses to the HA in HA104 mice.

125 Autoantibody responses to these MAA have been shown to r

126 The breadth of autoantibody responses, together with the absence of con

127 f specific autoantigens that might stimulate autoantibody responses under proinflammatory conditions.

128 Strong autoantibody responses were also induced by conjugated p

129 Autoantibody responses were measured in serum samples.

130 elopment of SAT and anti-mouse thyroglobulin autoantibody responses were reduced.

131 Myd88 is required for anti-DNA and anti-RNA autoantibody responses, whereas Fcer1g is not expressed

132 ete Freund's adjuvant enhanced their insulin autoantibody response with a higher level and longer per

133 The association of a specific autoantibody response with distinct disease phenotypes i

134 clear ribonucleoprotein (snRNP) and anti-DNA autoantibody responses with some changes in isotype swit