ライフサイエンスコーパス: autocrine

1 ATP release from HMC-1, in turn, causing an autocrine 20% increase in renin release.

2 Thus, the autocrine action of IGF2 regulates adult beta-cell mass

3 endothelial calcium responses arise from the autocrine action of non-neuronal ACh released by the end

4 red with ATP-treated T(H)1 cells, suggesting autocrine action of T(H)17-derived IL-1beta.

5 n through a variety of mechanisms, including autocrine actions that liberate retrograde transmitters.

6 ary human monocytes by a mechanism involving autocrine activation of ionotropic P2X7 receptors (P2X7R

7 "spiking") at the plasma membrane because of autocrine activation of P2Y1 purinoceptors by ATP co-rel

8 enhanced levels of prostaglandin E2 (PGE2), autocrine activation of the macrophage E-prostanoid 4 (E

9 a the canonical Smad2/3 pathway and requires autocrine activation of the receptor tyrosine kinases, p

10 Furthermore, our studies supports an autocrine activation primed by the formation of WNT10B-F

11 identify the endothelin/Ednra pathway as an autocrine activator of Gq signalling in brown adipocytes

12 ecreted by adult beta-cells, functions as an autocrine activator of the beta-cell insulin-like growth

13 Whether this autocrine activity of IGF2 plays a physiological role in

14 Autocrine activity of IL-17A and its receptor induced th

15 While IL-21 is an essential autocrine amplification factor for differentiation of Th

16 against viral pathogens in part through the autocrine and paracrine actions of alpha/beta interferon

17 response to environmental cues by modulating autocrine and paracrine DAF-2 ILS.

18 ing growth factor (TGF)-beta1 contributes to autocrine and paracrine functions in the tumor microenvi

19 Thus, the autocrine and paracrine functions of thromboxane A2 act

20 on and response govern the stimulus-specific autocrine and paracrine functions of TNF.

21 an important neurotransmitter and endocrine, autocrine and paracrine hormone.

22 an important neurotransmitter and endocrine, autocrine and paracrine hormone.

23 Blocking autocrine and paracrine IL4 signaling with the IL4Ralpha

24 enhanced production of this cytokine through autocrine and paracrine loops.

25 release type III IFNs and use these IFNs in autocrine and paracrine manners to restrict ZIKV infecti

26 bute to tumor growth and progression by both autocrine and paracrine mechanisms.

27 g polypeptide (PACAP) is a neuropeptide with autocrine and paracrine neuroprotective properties.

28 , stromal reaction, and angiogenesis through autocrine and paracrine PDGFRbeta signaling.

29 glomerulonephritis, exerting and amplifying autocrine and paracrine proinflammatory effects on bone

30 ell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in

31 phase of inflammation and might serve as an autocrine and paracrine regulator.

32 -) mice in vivo consistent with an important autocrine and paracrine role for ADP in aggregation and

33 To understand the autocrine and paracrine roles that amino acids play in i

34 sly up-regulate GPR91, which functions as an autocrine and paracrine sensor for extracellular succina

35 eotides (such as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleot

36 atures of basal breast cancer: TGFbeta is an autocrine and paracrine signaling factor that drives cel

37 viral miRNA activity not only disrupts IL-1 autocrine and paracrine signaling loops that can alert e

38 esizes gamma-aminobutyric acid, an important autocrine and paracrine signaling molecule and a surviva

39 Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT p

40 that anti-HER3 antibodies able to intercept autocrine and stroma-tumor interactions might strongly i

41 neutrophil recruitment and activation in an autocrine and/or paracrine manner.

42 ree peptide suggesting that it may act in an autocrine and/or paracrine manner.

43 These results suggest that autocrine and/or paracrine signaling via locally generat

44 icated that KIT can promote growth via KITLG autocrine and/or paracrine signaling.

45 We conclude that autocrine androgen action within Leydig cells is essenti

46 ed, ANG1 agonist activity was decreased, and autocrine ANG2 agonist activity was lost, which led to s

47 sential for the agonist activity of ANG1 and autocrine ANG2.

48 t Nox2 regulates LPS-mediated Ang2-dependent autocrine angiogenesis in HPMECs through the IKKbeta/NF-

49 Furthermore, these studies reveal that autocrine AR signaling in Leydig cells protects against

50 This revealed that autocrine AR signaling is dispensable for the attainment

51 We show that BDNF acts cell autonomous and autocrine, as wildtype neurons are not capable of rescui

52 eta-catenin expression that was dependent on autocrine ATX secretion and LPA signaling.

53 An efficient autocrine-based high-throughput selection system was dev

54 We identified P5 in a high-throughput autocrine-based screening of large combinatorial peptide

55 venom peptide library that was formatted for autocrine-based selection.

56 vel molecular network acting in SCLC linking autocrine BBS and Shh circuitries and suggest Shh inhibi

57 lity to stimulate T cell responses, requires autocrine C3a receptor and C5a receptor (C3ar1/C5ar1) si

58 fate-mapping mice show that TLR-initiated DC autocrine C3ar1/C5ar1 signaling causes expansion of effe

59 Furthermore, WNT2 activated autocrine canonical WNT signaling in primary fibroblasts

60 echanism is through overlapping paracrine or autocrine canonical WNT-beta-catenin signaling in each r

61 via the chemokine receptor CCR5 by inducing autocrine CCR5 ligand release.

62 ted CD28-mediated costimulation, identifying autocrine CD46 signaling as downstream of CD28.

63 HCs are involved in paracrine and autocrine cell signaling, and under pathological conditi

64 ve TGF-beta1 induction of enzymes that cause autocrine cleavage/activation of PAR2, possibly through

65 ur results establish unbiased selection from autocrine combinatorial antibody libraries as a robust m

66 -15ralpha in elderly myotubes confirmed that autocrine concentrations of IL-15 also support myogenesi

67 le is known about the mechanism by which the autocrine CSF1R signaling contributes to tumor progressi

68 Abrogation of autocrine CSF1R signaling in MDA-MB-231 xenografts (a cl

69 Our results suggest that autocrine CSF1R signaling is essential in maintaining lo

70 to constitutive activation of STAT1 through autocrine cytokine signaling, suggesting that subclinica

71 trol of salivary secretion in ticks involves autocrine dopamine activating two dopamine receptors: D1

72 These findings indicate that an "autocrine drug resistance loop" is suppressed by melanoc

73 ssion by transitional B-cells was due to the autocrine effect of IL-10, which in turn leads to decrea

74 MOG-restricted CD4(+) T cells were due to an autocrine effect of IL-1beta/IL-23-mediated induction of

75 Therefore, we investigated the autocrine effect of PGE2 on human adult stem cells from

76 but also most probably through an additional autocrine effect on epidermal cells.

77 adipose depots; however, their paracrine and autocrine effects on de novo adipocyte formation are not

78 n-stimulated DCs in vitro and in vivo due to autocrine effects on the DCs.

79 RAF pathway dependence or (ii) constitutive autocrine EGF receptor (EGFR) signaling driven by c-Jun-

80 alpha6beta4 stimulates invasion by promoting autocrine EGFR signaling through transcriptional up-regu

81 e found that AREG and EREG were required for autocrine EGFR signaling, as knocking down either ligand

82 Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signal

83 for acquired CYP19A1(amp) and promotes local autocrine estrogen signaling in AI-resistant metastatic

84 zation and observed staining consistent with autocrine expression in the tumor cells.

85 g to CNTFRalpha up-regulation, together with autocrine expression of CNTF, was involved in glioma gro

86 is imprinted in the hippocampus acting as an autocrine factor expressed in neural stem cells (NSCs) s

87 -cell proliferation, implicating IL-13 as an autocrine factor in CTCL.

88 tide that has been shown to act as paracrine/autocrine factor in various malignancies including prost

89 nd provide evidence that INHBA is a critical autocrine factor that maintains mesenchymal properties o

90 Erdr1 was found to function as an autocrine factor to induce apoptosis through caspase 3.

91 postsynaptic depolarizations, and acts in an autocrine fashion on CCK2 receptors to enhance postsynap

92 We tested whether the PMCA acts in an autocrine fashion to boost pH-sensitive, postsynaptic NM

93 sh that the exosomal pool of LTB4 acts in an autocrine fashion to sensitize neutrophils towards the p

94 and T helper 1 (T(H)1) differentiation in an autocrine fashion.

95 secrete soluble factors that function in an autocrine fashion.

96 We suppose that inverse signaling is an autocrine feedback and fine-tuning system in the communi

97 We propose the presence of an autocrine feedback loop in which Klotho senses the need

98 n through positive or negative paracrine and autocrine feedback loop mechanisms, which could potentia

99 ly, beta2 adrenergic signaling reinforced an autocrine feedback loop of macrophage-derived IL-10 and

100 ized that Klotho in bone cells is part of an autocrine feedback loop that regulates FGF23 expression

101 on of miRNA-146a release did not require the autocrine feedback of interleukin 1beta and tumor necros

102 epidermis, we have previously identified an autocrine FGF signaling induced by loss of Pten in kerat

103 Instead, autocrine FGFR1 and PDGFRalpha signaling, which have not

104 This has predominantly been attributed to an autocrine function that drives MAPK pathway activity.

105 led that glioma-secreted MCSF has no role in autocrine functions and M2 polarization of macrophages.

106 n of endothelial sphingosine 1-phosphate and autocrine, G protein-coupled receptor-dependent signalin

107 iculogenesis can induce GCT by activating an autocrine growth circuit program in GC.

108 endothelial tube formation, but also act as autocrine growth factors for GAB2-induced transformation

109 ombesin (BBS)-like neuropeptides that act as autocrine growth factors.

110 d decrease in invadopodia upon inhibition of autocrine HBEGF/EGFR signaling as well as inhibition of

111 OP9 in the differentiation niche to modulate autocrine Hedgehog (Hh) signaling, thereby promoting GSC

112 ta was further supported by the finding that autocrine IFN-beta but not IFN-alpha promoted survival o

113 are secondary TLR3-response genes requiring autocrine IFN-beta stimulation.

114 was found to be independent of exogenous and autocrine IFN-gamma, or the secondary cytokines TGF-beta

115 to TRADD/FADD/MALT-1- and caspase-8-mediated autocrine IL-1 secretion.

116 y GM-triDAP-activated MDM was independent of autocrine IL-1.

117 that IL-10-expressing macrophages receive an autocrine IL-10 signal.

118 a subset of late phase genes was mediated by autocrine IL-10, which activated STAT3 with delayed kine

119 pulation of human and mouse neutrophils with autocrine IL-17 activity that probably contribute to the

120 to NOD2-initiated early, caspase-1-dependent autocrine IL-18, which dramatically enhanced MAPK, NF-ka

121 Consequently, MK2 impairs secondary autocrine IL-1alpha signaling in DCs, which further decr

122 increasing PRR-induced caspase-1 activation, autocrine IL-1beta secretion, NFkappaB signaling, and, u

123 -2 in anergic CD4(+) T cells, also restricts autocrine IL-2 production by CD8(+) T cells.

124 Together, our findings identified that autocrine IL-2 production operates in a dose-dependent f

125 ed that miR-146a inhibited the production of autocrine IL-6 and IL-21 in 2D2 T cells, which in turn r

126 Neutralization of autocrine IL-6 reversed STAT3 phosphorylation and normal

127 This work demonstrates that autocrine IL-6 signaling in the gut epithelium regulates

128 an important molecular brake that blocks the autocrine IL-6- and IL-21-induced Th17 differentiation p

129 ng survival signals, including NF-kappaB and autocrine IL-6/IL-10 engagement of the JAK-STAT3 pathway

130 terminals and regulates GAD65 expression via autocrine influence on sensory terminal BDNF.

131 rinsic inflammatory mediator that exerted an autocrine influence on tumor growth by coordinately link

132 a broad paracrine manner within the CNS; by autocrine influences from the CCAP neurons themselves; a

133 that enhances TGF-beta signaling, limits the autocrine inhibitory effects of IL-2, and thereby promot

134 efore introducing a potential novel model of autocrine/intracrine action of S1P that still involves i

135 tting interrogation of the specific roles of autocrine Leydig cell AR signaling through comparison to

136 ortantly, a positive feedback loop involving autocrine LIF, LIFR, and STAT4 drove sustained IL-6 tran

137 In particular, the existence of autocrine, ligand-dependent Hh signaling in SCLC has bee

138 These results provide strong support for an autocrine, ligand-dependent model of Hh signaling in SCL

139 ressed TNF-mediated induction of an IFN-beta autocrine loop and downstream expression of IFN-stimulat

140 NF is expressed, suppressed this IL-10-STAT3 autocrine loop and expression of late phase genes.

141 Expression of the autocrine loop components regulating PGE2 production and

142 osteosarcoma cell lines; engagement of this autocrine loop leads to tumor cell proliferation, invasi

143 r, death receptor 4, sensitizing cells to an autocrine loop of TRAIL-mediated cell death.

144 tence of BMP alterations and existence of an autocrine loop promote CML-primitive cells' TKI resistan

145 tence of HBEGF & NRGs/ERBBs/YAP/HBEGF & NRGs autocrine loop that controls ovarian cell tumorigenesis

146 on of both GM-CSF and GM-CSFR, triggering an autocrine loop that further enhances STAT5 signaling and

147 munity, Komarowska et al. (2015) describe an autocrine loop that is initiated by cardiac-expressed he

148 P1), a suppressor of miR-146a, suggesting an autocrine loop.

149 indirectly through an IL-3-mediated basophil autocrine loop.

150 ted pathways and predict novel paracrine and autocrine loops involving cytokines, chemokines, and gro

151 NFAT1 nuclear translocation, suggesting that autocrine LPA synthesis promotes NFAT1 transcriptional a

152 y be to selectively protect osteocytes in an autocrine manner against glucocorticoid-induced cell dea

153 -defective ccRCC could induce invasion in an autocrine manner and angiogenesis in a paracrine manner.

154 flammasome-tolerizing factor that acts in an autocrine manner to control activation of the NLRP3 infl

155 local neurosteroids acting in a paracrine or autocrine manner to enhance GABAA R function.

156 s released from and binds to shed POSs in an autocrine manner to facilitate RPE phagocytosis through

157 ells produce a source of Wnt that acts in an autocrine manner to modulate reparative dentinogenesis.

158 da1, which functions in both a paracrine and autocrine manner to protect trophoblast and non-trophobl

159 on of Fo helper CD4(+)T cells and acts in an autocrine manner to reduce antigen receptor and toll-lik

160 to produce IL-21, which, in turn, acts in an autocrine manner to support robust IL-13 production.

161 ve TGF-beta, which might otherwise act in an autocrine manner to sustain PSCs in an active state and

162 e of self-renewal capacity through EP2 in an autocrine manner, and PGE2 secretion is down-regulated b

163 otein kinase 2, induced K19 expression in an autocrine manner, invadopodia formation and cell invasio

164 NF-kappaB signaling axis in a paracrine and autocrine manner, leading to bromodomain protein 4 (BRD4

165 beta-catenin signaling in hepatocytes in an autocrine manner, thereby contributing to timely conclus

166 ch store and release glycine that acts in an autocrine manner.

167 eukin-6, which induces STAT3 signaling in an autocrine manner.

168 3, another member of the STAT family, via an autocrine mechanism involving interferon beta (IFNbeta)

169 creased EGFL7 expression and secretion is an autocrine mechanism supporting growth of leukemic blasts

170 prevented hypoxia-induced cell death via an autocrine mechanism through the LDL receptor-related pro

171 It operates via an autocrine mechanism to elevate STAT1 and induce internal

172 ed and released from hemocytes may act in an autocrine mechanism to stimulate or maintain phagocytic

173 When one adds an autocrine mechanism, fine control at the level of indivi

174 e been shown to regulate themselves using an autocrine mechanism.

175 Autocrine motility factor (AMF) enhances invasion by bre

176 Autocrine motility factor (AMF) is a tumor-secreted cyto

177 Furthermore, we found that Nr4a1 repressed autocrine NE production in macrophages by recruiting the

178 lyphosphate, which is used as a signal in an autocrine negative feedback loop to regulate cell prolif

179 which metabolism of APP results in possible autocrine or paracrine Abeta production to drive the mic

180 also produced by immune cells and acts as an autocrine or paracrine fashion to regulate the function

181 molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface

182 molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface

183 ation of 5 specific cell surface GPCRs in an autocrine or paracrine fashion.

184 e RBP4, therefore, may have a more important autocrine or paracrine function that is confined within

185 isms: first, via an intrinsic activity as an autocrine or paracrine growth factor and, second, via an

186 al cell functions via its interaction, in an autocrine or paracrine manner, with P2 purinergic recept

187 cells and regulate cellular processes in an autocrine or paracrine manner.

188 tumors in mice via its ligand, KITLG, in an autocrine or paracrine manner.

189 and multicentric Castleman's disease through autocrine or paracrine mechanisms during latency or prod

190 ns attenuates neurite outgrowth, pointing to autocrine or paracrine mechanisms for its growth-promoti

191 nfluence responses to disease states through autocrine or paracrine mechanisms.

192 Autocrine or paracrine signaling by beta interferon (IFN

193 that naive hESCs secrete Wnts that activate autocrine or paracrine Wnt/beta-catenin signaling to pro

194 e target organs and its ability to act as an autocrine, paracrine, and endocrine factor.

195 lites signal to various target tissues in an autocrine, paracrine, and endocrine manner, thereby dete

196 ing cells can produce signals that act in an autocrine, paracrine, or endocrine manner.

197 t in papillary thyroid cancer tumors and the autocrine-paracrine conversion of SOD3 expression, which

198 As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling

199 The sequential cell-specific regulation of autocrine/paracrine and juxtacrine signaling accounted f

200 mmune cell-derived complement production and autocrine/paracrine C3ar1/C5ar1 signaling as crucial int

201 n and secretion of Wnt ligands to sustain an autocrine/paracrine canonical beta-catenin signaling loo

202 , the decreased response to and secretion of autocrine/paracrine IL-10, IL-4, IL-22 and thymic stroma

203 Secreted LEP activates an autocrine/paracrine loop through binding to the LEP rece

204 NF produced by cardiomyocytes, suggesting an autocrine/paracrine loop.

205 ike growth factor 1 (IGF1) is secreted in an autocrine/paracrine manner by GCs and activates the IGF1

206 at targeting the secretion of extracellular, autocrine/paracrine mediators of glioma stem-like cell s

207 has been thought to depend on endocrine and autocrine/paracrine modulators.

208 ats modulated by neuroendocrine peptides via autocrine/paracrine pathways.

209 Our findings unveil a novel autocrine/paracrine pro-homeostatic RPE cell signaling t

210 drocytes (AC) and demonstrate its role as an autocrine/paracrine pro-survival factor.

211 ynthesis, our findings reveal an LTB4-driven autocrine/paracrine regulatory effect.

212 sulin-like growth factor-1 receptor (IGF-1R) autocrine/paracrine signaling in patients with renal cel

213 We found that HBZ promotes a BDNF/TrkB autocrine/paracrine signaling pathway that is known to e

214 Restoring autocrine/paracrine SLIT2 signaling was also sufficient

215 d, eventually, dampening a positive EGF-EGFR autocrine/paracrine stimulation loop induced by the post

216 ist in Mobilan-infected cells established an autocrine/paracrine TLR5 signaling loop resulting in con

217 , mediated by LPA1-, Gi-, and COX1-dependent autocrine/paracrine TXA2 release and consequent TP activ

218 Soluble (autocrine/paracrine) and contact-mediated (juxtacrine) s

219 th factor (FGF) signaling pathways formed an autocrine/paracrine-positive feedback loop to drive the

220 Here, we have identified an autocrine pathway linking nuclear factor of activated T

221 ocytes promotes biliary proliferation via an autocrine pathway.

222 synoviocytes, indicating the presence of an autocrine PDGFR activation loop that involved endogenous

223 study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade.

224 transmitter, and also is the key trigger for autocrine positive feedback and paracrine circuits that

225 and tumor formation were associated with the autocrine production of cytokines previously provided by

226 Autocrine production of cytokines was increased in muscl

227 ted B-cell (ABC) subtype and is triggered by autocrine production of IL-6 and IL-10.

228 tes cAMP-dependent lipolysis in part via the autocrine production of PGI2.

229 Unexpectedly, we also observed enhanced autocrine production of prostaglandin I2 (PGI2, also cal

230 phorylation of ErbB3 that is associated with autocrine production of the ErbB3 ligand neuregulin-1 (N

231 hase of JNK phosphorylation was dependent on autocrine production of tumor necrosis factor alpha (TNF

232 egulate proliferation and TCR signaling, and autocrine production of VEGF by T cells contributes to t

233 crystals, NLRP3 inflammasome activation, and autocrine proinflammatory cytokine signaling.

234 PY), acting via its Y2 receptor (Y2R), is an autocrine proliferative and angiogenic factor crucial fo

235 Adenosine triphosphate (ATP) release and autocrine purinergic signaling via P2Y2 receptors at the

236 PKC signaling is thus implicated in autocrine regulation of beta cell function.

237 ion with tumor-associated macrophages and an autocrine regulation of CSF1R in the tumor cells themsel

238 F9(+) MOLM-14 cells, in a biphasic manner by autocrine regulation, whereas it decreases that of chron

239 PGE2 exerted an autocrine regulatory function in MSCs by triggering E-Pr

240 Here, we report a miRNA-based autocrine regulatory pathway that controls differentiati

241 Our data provide mechanistic insight into an autocrine regulatory signaling loop that regulates beige

242 ion of TSG6 in TSG6(+/+) mice, suggesting an autocrine role for TSG6 in transitioning macrophages.

243 G WT control skin, we assessed the potential autocrine role of epidermal-derived eicosanoids in FLG-a

244 We evaluated the autocrine role of GnRH in the regulation of cholangiocyt

245 STAT3 is required for maintaining autocrine Schwann cell survival signaling, and inactivat

246 in isolated myocytes, suggesting continuous autocrine secretion of A2 into a restricted diffusion co

247 We propose that autocrine secretion of exosomes powerfully promotes dire

248 FcepsilonRI stimulation of MCs promotes autocrine secretion of HK-1, which signals through NK1R

249 oted migration of a2Neu was dependent on the autocrine secretion of IL-8 from a2Neu.

250 same ECs, we identified a novel function of autocrine Sema3d signaling in regulating Actin network o

251 ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of alpha

252 taining exon 6), which enhances the TGFbeta1 autocrine signaling and induces fibroblasts to transdiff

253 However, recent studies have demonstrated autocrine signaling by complement activation in intracel

254 unction approach, we show that CSF1-mediated autocrine signaling in MAMs is downstream of FLT1 and ca

255 uggested the involvement of a C3/C3 receptor autocrine signaling loop in regulating tumor growth.

256 We show that BRCA1-IRIS activates two autocrine signaling loops, brain-derived neurotrophic fa

257 ion of DP1, suggesting a possible intracrine/autocrine signaling mechanism.

258 stimulated their growth through an activin A autocrine signaling pathway, a hypothesis confirmed by a

259 nism, which likely involves activation of an autocrine signaling pathway.

260 of the VM-inhibiting miRNAs, suggesting that autocrine signaling stimulating VM is regulated by ZEB1-

261 s unregulated HGF-MET signaling and enhanced autocrine signaling through VEGF and PDGF.

262 ctivated expression of HGF, resulting in its autocrine signaling via MET.

263 in reducing VEGFR2 phosphorylation caused by autocrine signaling, but VEGFR2 phosphorylation was comp

264 nostimulants is complicated by paracrine and autocrine signaling, which obscures the origin of a prop

265 growth of several tumor types driven by IL6 autocrine signaling.

266 intaining the stemness of stem cells through autocrine signaling.

267 receptor complex, the latter enhancing IL-15 autocrine signaling.

268 g IDO by transcriptional deregulation of the autocrine-signaling loop IDO-AHR-IL6, which blocks kynur

269 r, these findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR-CaMKII-de

270 Thus, we show ACh is an autocrine signalling molecule released from endothelial

271 hich they drive non-canonical, ERK-dependent autocrine signalling that is required for fibrogenic pro

272 T subsequently promotes axon regeneration by autocrine signalling through the SER-7 5-HT receptor.

273 local sphingolipid synthesis and shows that autocrine sphingolipid signaling within the endothelium

274 those mediating autoimmunity, and subsequent autocrine stimulation is vital for T cell expansion and

275 Autocrine stimulation of A2a receptors causes cyclic ade

276 re we found that in activated human T cells, autocrine stimulation of the complement receptor CD46, a

277 During autocrine stimulation, the expressions of DCT and CAV1 a

278 on of STAT3, which in turn promotes a second autocrine stimulus to increase S100A8/9 complex (calprot

279 provide evidence for an association between autocrine TGF-beta and PDGFR-mediated invadosome formati

280 on and mammosphere formation, dependent upon autocrine TGF-beta signaling.

281 tructive phenotype has been shown to involve autocrine TGF-beta that triggers formation of matrix-deg

282 down-regulation of ShcA expression enhanced autocrine TGF-beta/Smad signaling and target gene expres

283 We have identified an autocrine TGF-beta1 signaling that up-regulates both Met

284 Exogenously applied or autocrine TNC increased BTIC growth through an alpha2bet

285 This activity was maintained through autocrine TNF-alpha secretion, which formed an NF-kappaB

286 eicosanoid metabolism that could serve as an autocrine trigger of inflammation and impaired late epid

287 pDC) produced type 1 IFNs, which, through an autocrine type 1 IFN receptor-dependent pathway, induced

288 differentiated Th1 cells to prevent abberant autocrine type I IFN and downstream signaling.

289 We also demonstrate a role for autocrine type I IFN signaling in bacterial LPS-induced

290 unction is to transduce signals triggered by autocrine type I IFNs.

291 ession in tumor cells was seen, and blocking autocrine VEGF signaling abolished vascular tumor develo

292 Inhibition of paracrine or autocrine VEGF signaling had no effect on phospho-AKT or

293 to study the molecular mechanisms underlying autocrine VEGF signaling in HCC cells and evaluate the c

294 HCC cells and evaluate the critical role of autocrine VEGF signaling on sorafenib treatment efficacy

295 ment for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the en

296 -pathway mutations, suggesting activation by autocrine Wnt ligands and/or paracrine Wnts emanating fr

297 pathway mutations, suggesting activation by autocrine Wnt ligands and/or paracrine Wnts from the BM

298 Our data suggest that autocrine Wnt signaling in the outer bulge maintains ste

299 icient MM cells exhibited strongly decreased autocrine Wnt/beta-catenin pathway activity and reduced

300 The consequent potentiation of the autocrine Wnt/beta-catenin signalling induces the transc