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1 apabilities in the presence or absence of an autoinducer.
2 in the complex still retained tightly bound autoinducer.
3 ze the cell response to an exogenously added autoinducer.
4 AI-2 sensor protein, LuxP, in a complex with autoinducer.
5 ter the ability of the bacteria to access an autoinducer.
6 blages supplemented with exogenous, purified autoinducer.
7 on-wide detection of signal molecules called autoinducers.
8 n and detection of secreted molecules called autoinducers.
9 nse to extracellular signal molecules called autoinducers.
10 unicate via secreted signal molecules called autoinducers.
11 of extracellular signalling molecules called autoinducers.
12 receptors for acyl-homoserine lactone (AHL) autoinducers.
13 from a microorganism that also produces AHL autoinducers.
14 tection of small signalling molecules called autoinducers.
15 n of low-molecular-weight molecules known as autoinducers.
16 by means of chemical signal molecules called autoinducers.
17 and detection of signalling molecules called autoinducers.
18 ecrete hormone-like compounds referred to as autoinducers.
19 mediated by small molecule signals known as autoinducers.
20 e with extracellular signal molecules called autoinducers.
21 using extracellular signal molecules termed autoinducers.
22 using extracellular signal molecules called autoinducers.
23 g, and responding to signal molecules called autoinducers.
24 up-wide detection of signal molecules called autoinducers.
25 exchange of chemical signal molecules called autoinducers.
26 nother by exchanging chemical signals called autoinducers.
27 of extracellular signaling molecules called autoinducers.
28 s no resemblance to previously characterized autoinducers.
29 of extracellular signalling molecules called autoinducers.
30 cteria secrete hormone-like compounds called autoinducers.
31 e required for competence are quorum-sensing autoinducers.
32 oduce and detect diffusible molecules called autoinducers.
33 ion of extracellular signal molecules called autoinducers.
34 nse to extracellular signal molecules called autoinducers.
35 that are regulated by imported oligopeptide autoinducers.
36 the most rapid to respond to quorum-sensing autoinducers.
37 diated by small signaling molecules known as autoinducers.
38 hanging diffusible signal molecules known as autoinducers.
39 to express the autoinducer molecule cholera autoinducer 1 (CAI-1) (shown previously to prevent virul
40 yme involved in the biosynthesis of cholerae autoinducer-1 (CAI-1), the major Vibrio cholerae autoind
41 atio of signal to cell number for V. harveyi autoinducer-1 and E. coli autoinducer-2 varied as the cu
42 sis of polyamines, N-acylhomoserine lactone (autoinducer-1), and production of vitamins and other bio
44 ne, which encodes an enzyme that synthesizes autoinducer 2 (AI-2) in other gram-negative bacteria.
45 y network for the uptake of Escherichia coli autoinducer 2 (AI-2) is comprised of a transporter compl
51 tein interacts with cognate and heterologous autoinducer 2 (AI-2) signals and suggested that the rbsD
55 of the LuxS-associated quorum sensing signal autoinducer 2 (AI-2), it was demonstrated that this orth
56 cross-species bacterial communication signal autoinducer 2 (AI-2), produced by the purified enzymes P
58 LuxS is responsible for the production of autoinducer 2 (AI-2), which functions in Vibrio harveyi
66 nd increased intracellular concentrations of autoinducer 2 (AI-2); hence, YdgG enhances transport of
67 The gene expression data also suggested that autoinducer 2 uptake was repressed upon exposure to epin
68 hen present with another signaling molecule, autoinducer 2, at high concentrations) and determined th
75 via a family of molecules generically termed autoinducer-2 (AI-2) is essential for many phenotypes.
81 ene product is an integral component of LuxS/autoinducer-2 (AI-2) quorum-sensing systems in bacteria.
83 . cholerae colonization, that R. obeum luxS (autoinducer-2 (AI-2) synthase) expression and AI-2 produ
87 hile most autoinducers are species specific, autoinducer-2 (AI-2), first identified in the marine bac
88 scores of bacteria, and its signal molecule, autoinducer-2 (AI-2), is synthesized as a product of 1-c
89 O157:H7 as well as E. coli K-12 produces the autoinducer-2 (AI-2), which is synthesized by the produc
90 strate that these spirochetes utilize a LuxS/autoinducer-2 (AI-2)-based quorum-sensing mechanism to r
94 synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably
95 e salvage pathway, the SAM radical pathways, autoinducer-2 biosynthesis, and menaquinone biosynthesis
96 These data indicate that V. harveyi uses autoinducer-2 for quorum sensing, while the other molecu
98 is technique was applied to the detection of autoinducer-2 from Escherichia coli and Vibrio harveyi i
100 for bacterial colonization or infection, and autoinducer-2 has been proposed as a universal interspec
101 r outer membrane protein; luxS, encoding the autoinducer-2 synthase; nadE, encoding an essential NAD
102 Although V. harveyi was able to keep the autoinducer-2 to cell number ratio constant, the ratio o
104 abolic pathways and limits the production of autoinducer-2, a molecule proposed to play a central rol
105 ed by a quorum sensing (QS) signal molecule, autoinducer-2, to express surface-displayed fusions cons
106 ion were regulated by quorum sensing through autoinducer-2, which is synthesized by the product of th
107 and norepinephrine, and bacterially produced autoinducer 3 (AI-3), through two-component systems.
108 ly with a bacterial quorum sensing molecule, autoinducer 3 (AI-3), to affect bacterial virulence and
109 inducing (Ti) plasmid in the presence of the autoinducer 3-oxooctanoyl-homoserine lactone (OOHL).
110 produced by the intestinal microbial flora, autoinducer-3 (AI-3), and the host hormones epinephrine
111 als from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephr
113 of coral cell-free culture fluid (CFCF) and autoinducer (a quorum sensing signaling molecule) on cor
114 nsing regulator TraR and its inducing ligand autoinducer (AAI) are soluble in Escherichia coli, where
116 ommunication; however, a recently discovered autoinducer AI-2 has been proposed to serve as a 'univer
119 e positively regulated by the quorum-sensing autoinducer AI-2, which in turn activates a two-componen
122 p in the biosynthetic pathway of the type II autoinducer (AI-2) in both Gram-positive and Gram-negati
123 r species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bact
125 HEC produces another, previously undescribed autoinducer (AI-3) whose synthesis depends on the presen
129 via the family of related homoserine lactone autoinducers, AI-2 is a unique, 'universal' signal that
130 hich is regulated by signal molecules called autoinducers (AIs) can protect V. cholerae against preda
131 ibrio harveyi produces and responds to three autoinducers (AIs), and this sensory information converg
132 which extracellular signal molecules, called autoinducers (AIs), are released, accumulate, and are sy
137 nals that elicit new gene expression include autoinducers, amino acids, peptides, proteins, and carbo
138 etection of a diffusible signaling molecule (autoinducer) among a multicellular group, it is consider
139 nce leads to a tradeoff between accessing an autoinducer and accessing nutrients, which determines th
140 ioluminescent even after treatment with both autoinducer and aldehyde, substrate additions that typic
141 the permeability of the cell membrane to the autoinducer and the symmetry of autoinducer diffusion) w
143 ested for induction by a set of 33 synthetic autoinducers and analogues, and was most strongly induce
144 substrate analogues also limits synthesis of autoinducers and hence causes reduction in biofilm forma
145 sease has led to the elucidation of numerous autoinducers and their corresponding QS signaling pathwa
147 hi or other populations for members that use autoinducers and/or other mechanisms to limit colonizati
148 ranslocated to the nucleus in the absence of autoinducer, and truncated LasR-based proteins functione
149 bacteria use acylated homoserine lactones as autoinducers, and Gram-positive bacteria use processed o
150 mmunicate via the secretion and detection of autoinducers, and in V. cholerae, QS represses biofilm f
151 nhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dosed onto healthy tes
152 Detection of and response to the V.harveyi autoinducers are accomplished through two two-component
153 lyses suggested that the observed effects of autoinducers are mediated in part through the quorum sen
158 ododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signaling molecule to coordinate the ex
159 to generate a cyclic lactone, that it is an autoinducer as well as a cross-inhibitor, and that all o
160 AttM) that hydrolyzes acylhomoserine lactone autoinducers, as well as two putative dehydrogenases (At
162 ention such that other previously identified autoinducers be reevaluated for additional biological fu
163 The deduced AvhR protein has characteristic autoinducer binding and DNA binding domains and is uniqu
172 nd bacteria were supplemented with exogenous autoinducers CAI-1 or AI-2 produced by recombinant strai
174 promote intraspecies communication, but one autoinducer, called AI-2, is produced and detected by a
176 ired for synthesis of the biofilm dispersion autoinducer cis-2-decenoic acid in the human pathogen Ps
177 ex with the centrally important oligopeptide autoinducer competence and sporulation factor (CSF, also
184 brane to the autoinducer and the symmetry of autoinducer diffusion) we construct the solution of the
186 mproved by using enrichment media containing autoinducers either expressed from cloned synthase genes
190 acterium tumefaciens, there is no endogenous autoinducer for SdiA in E.coli: the E.coli genome does n
192 that phagocyte-derived oxidants target these autoinducers for inactivation as an innate defense mecha
196 een shown to secrete a signal related to the autoinducer II (AI-2) of the signal system 2 pathway in
199 e full-length LuxR has not been purified, an autoinducer-independent N-terminally truncated form of L
200 esigned to precisely translate extracellular autoinducer information into internal changes in gene ex
201 on reaching a threshold concentration, these autoinducers interact with transcription factors to regu
202 oretical model, cells synthesize and secrete autoinducers into the environment, up-regulate their pro
205 ation density increases, the accumulation of autoinducers leads to co-ordinated changes in gene expre
208 roteins were only activated by their cognate autoinducer ligand and not by N-butyryl-L-homoserine lac
211 s can enter mammalian cells and suggest that autoinducers may influence gene expression in host cells
212 On the basis of our findings, quorum sensing autoinducers merit further investigation as biomarkers f
213 e presence of an acylated homoserine lactone autoinducer molecule [N-(3-oxohexanoyl) homoserine lacto
214 hia coli Nissle 1917 (Nissle) to express the autoinducer molecule cholera autoinducer 1 (CAI-1) (show
220 ed in response to the concentration of small autoinducer molecules that are also released by the bact
224 erium Vibrio harveyi exclusively detects the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lacto
226 ein SdiA of Escherichia coli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has
227 as cultured with and without added exogenous autoinducers [N-(3-oxododecanoyl) homoserine lactone and
228 d by quorum sensing via TraR and its cognate autoinducer, N-(3-oxo-octanoyl)-L-homoserine lactone.
230 eudomonas aeruginosa, along with its cognate autoinducer, N-butyryl homoserine lactone (C(4)-HSL), re
232 These results indicate that TDA acts as an autoinducer of its own synthesis and suggest that roseob
234 endent of the lux promoter and unaffected by autoinducers or the level of lux expression, but the add
236 nce in Vibrio fischeri ES114 is activated by autoinducer pheromones, and this regulation serves as a
239 of sigma 38 and dgt leads to a model for how autoinducer production is controlled under changing phys
240 Elucidating the mechanisms that control autoinducer production is, thus, pertinent to understand
243 ce of the native acylated homoserine lactone autoinducer, provided that they stabilize a closed confo
244 hat at high cell density (in the presence of autoinducers), quorum sensing represses TTS in V. harvey
245 e polymorphism for the identification of agr autoinducer receptor specificity groups within a populat
247 oth environmental factors and quorum sensing autoinducers regulate the metabolism and/or processing o
251 Here we demonstrate that the Vibrio cholerae autoinducer (S)-3-hydroxytridecan-4-one, termed CAI-1, i
252 orum-sensing circuits, each consisting of an autoinducer-sensor pair, to control the expression of ge
253 nsing circuit of V. cholerae consists of two autoinducer/sensor systems, CAI-1/CqsS and AI-2/LuxPQ, a
255 acteria recognize two different forms of the autoinducer signal, both derived from 4,5-dihydroxy-2,3-
257 hat bacterial quorum sensing signals, called autoinducers, signal to eukaryotic cells, mimicking horm
262 luxS mutant, unable to produce the bacterial autoinducer, still responds to a eukaryotic cell signal
266 e shown a heterogeneous promoter activity of autoinducer synthase genes, suggesting that some of the
268 nd we also found that ainS, which encodes an autoinducer synthase, mediates repression of luminescenc
270 was similar to members of the LuxI family of autoinducer synthases and was predicted to be the only a
275 ation also affects the synthesis of the AI-3 autoinducer that activates enterohemorrhagic Escherichia
276 ion of extracellular signal molecules called autoinducers that elicit population-wide changes in gene
277 and release chemical signal molecules called autoinducers that increase in concentration as a functio
278 ports indicate that the signaling molecules (autoinducers) that mediate QS in Pseudomonas aeruginosa
280 non-thermal plasma to modify and degrade AHL autoinducers thereby attenuating QS-dependent virulence
281 h their own production and the production of autoinducers, thereby establishing internal and external
282 marine bacterium, Vibrio harveyi, uses three autoinducers to achieve intra-species, intra-genera and
286 ilizes hormone-like compounds referred to as autoinducers to regulate bacterial gene expression.
287 ous environmental factors and quorum sensing autoinducers to regulate the metabolism of various nucle
288 cluding Vibrio cholerae, the accumulation of autoinducers triggers repression of genes responsible fo
289 in the complex, together with the variety of autoinducer-type molecules that can apparently act as fo
292 ll density in the presence of quorum-sensing autoinducers, V. cholerae represses these behaviours at
294 nt groups of signalling molecules, including autoinducers, virulence factors and morphogenic substanc
295 gene rhlI and the production of the C(4)-HSL autoinducer were increased in the ptxR mutant, while the
297 nase that acts as the receptor for the CAI-1 autoinducer which is produced by the CqsA synthase.
298 e bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor
300 rial community contained in extracellular QS autoinducers with the intracellular environmental inform
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