ライフサイエンスコーパス: autoinflammatory disease

1 Ndfip1 deletion in Treg cells results in autoinflammatory disease.

2 uggest classification of PAPA syndrome as an autoinflammatory disease.

3 tivation by NEMO, and its absence results in autoinflammatory disease.

4 ies in patients with Schnitzler syndrome, an autoinflammatory disease.

5 host-regulated actin-dependent processes and autoinflammatory disease.

6 identify IFN-gamma as a mediator of systemic autoinflammatory disease.

7 filamentous bacteria, and an extraintestinal autoinflammatory disease.

8 ional target for therapeutic intervention in autoinflammatory disease.

9 which gain-of-function pyrin mutations cause autoinflammatory disease.

10 anean fever (FMF), the most common Mendelian autoinflammatory disease.

11 nd humans, to a propensity for infection and autoinflammatory disease.

12 hat is associated with a macrophage-mediated autoinflammatory disease.

13 aggerated and sustained responses leading to autoinflammatory disease.

14 ion induced by NALP3 mutants associated with autoinflammatory diseases.

15 entral to the pathogenesis of many monogenic autoinflammatory diseases.

16 d to the addition of gout to the spectrum of autoinflammatory diseases.

17 epidemiologically associated autoimmune and autoinflammatory diseases.

18 ons in CIAS1/cryopyrin are linked to several autoinflammatory diseases.

19 and contributes to the pathology of various autoinflammatory diseases.

20 that LDHA may be targeted therapeutically in autoinflammatory diseases.

21 at contribute to a variety of autoimmune and autoinflammatory diseases.

22 o new treatments for cytosolic DNA-triggered autoinflammatory diseases.

23 nd modulation of exaggerated inflammation in autoinflammatory diseases.

24 rapy of RA and possibly other autoimmune and autoinflammatory diseases.

25 ot in cells of patients afflicted with other autoinflammatory diseases.

26 mutations are associated with autoimmune and autoinflammatory diseases.

27 et juvenile idiopathic arthritis and related autoinflammatory diseases.

28 not in that of patients with other inherited autoinflammatory diseases.

29 tools to address infectious, autoimmune, and autoinflammatory diseases.

30 tial therapeutic target in uveitis and other autoinflammatory diseases.

31 ated genes shared by multiple autoimmune and autoinflammatory diseases.

32 to understand human systemic autoimmune and autoinflammatory diseases.

33 hology associated with several autoimmune or autoinflammatory diseases.

34 mic and local inflammatory conditions called autoinflammatory diseases.

35 receptor signaling, exhibiting a feature of autoinflammatory diseases.

36 IL-1 family because of its role in mediating autoinflammatory diseases.

37 nean fever and several of the other systemic autoinflammatory diseases, a recently recognized group o

38 Autoinflammatory disease and hyperinflammatory syndromes

39 ells affects inflammatory responses in human autoinflammatory disease and in mouse models of inflamma

40 iated alterations in patients with monogenic autoinflammatory disease and opens up possibilities for

41 EFV or pyrin) are associated with hereditary autoinflammatory disease and severe IBD.

42 o recognize and treat patients with systemic autoinflammatory diseases and inform our understanding o

43 tory processes, including infection, sepsis, autoinflammatory diseases, and metabolic diseases.

44 genetic basis of both mendelian and complex autoinflammatory diseases, and with the recognition that

45 The autoinflammatory diseases are a group of conditions that

46 Autoinflammatory diseases are a group of disorders chara

47 Systemic autoinflammatory diseases are caused by mutations in gen

48 The autoinflammatory diseases are characterized by seemingly

49 The systemic autoinflammatory diseases are characterized by seemingly

50 Autoinflammatory diseases are disorders of the innate im

51 Systemic autoinflammatory diseases are driven by abnormal activat

52 Although some autoinflammatory diseases are due to gain-of-function mu

53 The newly recognized group of autoinflammatory diseases are often accompanied by repet

54 Autoinflammatory diseases are often associated with a di

55 cell death implicated in the pathogenesis of autoinflammatory diseases as well as in disorders charac

56 me (TRAPS) is an autosomal dominant systemic autoinflammatory disease associated with heterozygous mu

57 deployment of anti-IL-1 therapies to control autoinflammatory diseases associated with aberrant infla

58 the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1

59 sum, and Acne Syndrome (PAPA syndrome) is an autoinflammatory disease caused by aberrant production o

60 culopathy with onset in infancy (SAVI) is an autoinflammatory disease caused by gain-of-function muta

61 Here, we report an autoinflammatory disease caused by loss-of-function muta

62 or DIRA, to denote this autosomal recessive autoinflammatory disease caused by mutations affecting I

63 Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV, wh

64 rranean fever (FMF) is an IL-1beta-dependent autoinflammatory disease caused by mutations of Mediterr

65 and perhaps treat, lupus nephritis and other autoinflammatory diseases caused by the decreased abilit

66 Schnitzler syndrome is an adult-onset autoinflammatory disease characterized by urticarial exa

67 Polymorphisms in NOD1 are associated with autoinflammatory diseases characterized by uveitis such

68 adaptor protein PSTPIP2 are the cause of the autoinflammatory disease chronic multifocal osteomyeliti

69 ense mutations in NLRP3 result in a group of autoinflammatory diseases collectively known as the cryo

70 bryonic lethality, macrothrombocytopenia and autoinflammatory disease develop in mice carrying hypomo

71 utations in its B30.2/SPRY domain causes the autoinflammatory disease familial Mediterranean fever by

72 stinct interleukin-1beta (IL-1beta)-mediated autoinflammatory diseases: familial Mediterranean fever

73 he genes and proteins mutated in many of the autoinflammatory diseases has broadened our understandin

74 the hereditary periodic fever subset of the autoinflammatory diseases has continued to expand.

75 cterization of a growing number of monogenic autoinflammatory diseases has provided important insight

76 The study of autoinflammatory diseases has uncovered mechanisms under

77 le, the role of IL-1, novel entities such as autoinflammatory diseases have been described.

78 Advances in our understanding of the autoinflammatory diseases have led to renewed interest i

79 1R1, is broadly used to treat autoimmune and autoinflammatory diseases; however, blocking IL-1 increa

80 We define six categories of autoinflammatory disease: IL-1beta activation disorders

81 epidemiologically associated autoimmune and autoinflammatory diseases, implicating the innate immune

82 We have now identified an autoinflammatory disease in mice driven by IL-18, but no

83 We describe a patient with an autoinflammatory disease in which the main clinical feat

84 Unlike other autoinflammatory diseases in which anti-TNF therapy is l

85 evelopment of novel biological therapies for autoinflammatory diseases, including IBD.

86 e association of mutations in NLR genes with autoinflammatory diseases indicates an important functio

87 Autoimmune and autoinflammatory diseases involve interactions between g

88 ase-interacting protein 2 (PSTPIP2), lead to autoinflammatory disease involving extramedullary hemato

89 tor antagonist (IL-1Ra) deficiency is a rare autoinflammatory disease involving neonatal onset of pus

90 Our understanding of the etiology of autoinflammatory disease is growing rapidly.

91 the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated

92 Autoinflammatory diseases manifest inflammation without

93 erlie familial Mediterranean fever and other autoinflammatory diseases, may predispose to vasculitis.

94 The autoinflammatory disease mevalonate kinase deficiency (M

95 nd F-BAR protein that has been implicated in autoinflammatory disease, most notably in the PAPA syndr

96 P3/CIAS1/PYPAF1 gene are associated with the autoinflammatory diseases Muckle-Wells syndrome (MWS), f

97 mic juvenile idiopathic arthritis (sJIA), an autoinflammatory disease of unknown etiology, this appro

98 n proposed as useful therapeutics in various autoinflammatory diseases or amelioration of inflammator

99 iligo alone, with an extended autoimmune and autoinflammatory disease phenotype, or with both.

100 Patients with autoinflammatory diseases present with noninfectious fev

101 tible to environmental mycobacteria and have autoinflammatory disease presentations.

102 Here we review these monogenic autoinflammatory diseases, ranging from periodic fever s

103 questions that are expected to be central in autoinflammatory disease research in the coming decade.

104 ponsible for the development of a persistent autoinflammatory disease resembling chronic recurrent mu

105 Blau syndrome is an autoinflammatory disease resulting from mutations in the

106 t that the definition of what constitutes an autoinflammatory disease should be reassessed.

107 This new phenotype encompasses an autoinflammatory disease showing similarities to many as

108 Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated p

109 flammasome defect that expands the monogenic autoinflammatory disease spectrum to include MAS and sug

110 e, and cause the autosomal dominant systemic autoinflammatory disease spectrum, termed cryopyrin-asso

111 ations in NFKB1 and suggest that a subset of autoinflammatory diseases, such as Behcet disease, can b

112 Recognizing autoinflammatory disease symptom patterns, performing ap

113 Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world'

114 His case highlights IL-1Ra deficiency as an autoinflammatory disease that is distinct from neonatal-

115 well established genetic model of autoimmune/autoinflammatory disease that resembles systemic lupus e

116 he cause of a life-threatening but treatable autoinflammatory disease that underscores the divergent

117 matoses are a group of complex heterogeneous autoinflammatory diseases that all demonstrate excessive

118 w, we describe the genetically characterized autoinflammatory diseases, we summarize our understandin

119 Autoinflammatory diseases were first recognized nearly 2

120 Autoinflammatory disease, which is bone marrow-derived y

121 Finally, we analyse key features of autoinflammatory diseases, which are helpful to distingu

122 ely activate these pathways underlie several autoinflammatory diseases with diverse clinical features

123 ean fever (FMF) is the most common monogenic autoinflammatory disease worldwide.