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1 regulatory domains in maintaining catalytic autoinhibition.
2 gering a conformational switch relieving its autoinhibition.
3 ts function has been hypothesized to involve autoinhibition.
4 peats within the SRR dramatically reinforces autoinhibition.
5 ies to distal ADAMTS13 domains relieves this autoinhibition.
6 t regions of these phospholipases to release autoinhibition.
7 The activity of PMCAs is controlled by autoinhibition.
8 at functions with the CARD to promote CARD11 autoinhibition.
9 gments to elucidate the mechanism of this FV autoinhibition.
10 toxins to protect rhs(+)/wapA(+) cells from autoinhibition.
11 ts binding activity with p53TAD is masked by autoinhibition.
12 to PIP2, and PIP2-induced release of moesin autoinhibition.
13 ht of the fact that Capu can be regulated by autoinhibition.
14 onal change that results in its release from autoinhibition.
15 ane binding of Ste5 triggers release of this autoinhibition.
16 ed by the adjacent repeat Ig20, resulting in autoinhibition.
17 e CdiA-CT and blocks its activity to prevent autoinhibition.
18 of interacting proteins, and modulate enzyme autoinhibition.
19 entral to the maintenance and release of the autoinhibition.
20 ty protein (CdiI) protects CDI(+) cells from autoinhibition.
21 inal region of Sos, in the regulation of Sos autoinhibition.
22 ng of membrane recruitment to the release of autoinhibition.
23 drome protein (WASP) that result in aberrant autoinhibition.
24 -170 conformational changes resulting in its autoinhibition.
25 are caused by the release of talin head-rod autoinhibition.
26 22 of Pax5 is essential for overcoming Ets-1 autoinhibition.
27 tates that contribute to both activation and autoinhibition.
28 152) without force is insufficient to remove autoinhibition.
29 uing against the suggestion that ErbB2 lacks autoinhibition.
30 ro DNA binding activity of ETV4 by relieving autoinhibition.
31 ubiquitinated proteins to the proteasome by autoinhibition.
32 essible ABL catalytic site through relief of autoinhibition.
33 f MICAL and together release MICAL enzymatic autoinhibition.
34 nd lack D(2)R agonist (quinpirole; 1 microM) autoinhibition.
35 letion of the blocking helices relieves this autoinhibition.
36 between the GBD and DAD that mediates Daam1 autoinhibition.
37 t cargo binding to nonmotor regions relieves autoinhibition.
38 suggests that WIP, like WASP, is subject to autoinhibition.
39 perfamily to regulate their activity through autoinhibition.
40 cdc42p and bud6p activate for3p by relieving autoinhibition.
41 access of Brf1 to these sites is limited by autoinhibition.
42 ly activities are thought to be regulated by autoinhibition.
43 e Ig20 structure that supposedly weakens the autoinhibition.
44 gical responses to dopamine D2-receptor (D2) autoinhibition.
45 rming the functional importance of E3-ligase autoinhibition.
46 endently of the well-known N-terminal domain autoinhibition.
47 ut not to recruitment kinetics or release of autoinhibition.
48 talin molecule, thus achieving the state of autoinhibition.
49 cognition helix of the ETS domain to mediate autoinhibition.
50 at the C terminus and its deletion relieves autoinhibition.
51 nding to CBD sterically interferes with this autoinhibition.
52 asmic domain of STIM1 (STIM1-CT) that entail autoinhibition.
53 gulatory element in the RFTS domain-mediated autoinhibition.
54 f the other subunit, possibly accounting for autoinhibition.
55 minal and catalytic domains mediates ARTEMIS autoinhibition.
56 The behavior of ETS1 is further regulated by autoinhibition.
57 rmation by the Arp2/3 complex, indicative of autoinhibition.
58 nating pivotal residues that ensure receptor autoinhibition.
60 d kinesin heavy chain (KHC) that relieve KHC autoinhibition, activating motor function in single mole
62 rovide insights into the mechanisms of Notch autoinhibition and activation and pave the way for the f
63 n the kinase hinge region suggests that FGFR autoinhibition and activation are better explained by ch
64 NRR, these studies show that key features of autoinhibition and activation are shared among different
65 nism, suggesting that a diverse mechanism of autoinhibition and activation might be adopted by member
66 lucidate the structural and dynamic bases of autoinhibition and activation of the kinase domain of Ca
70 sphorylated in its SH3 domain which disrupts autoinhibition and allows GukH recruitment by the GK dom
72 thogen C. difficile that is not regulated by autoinhibition and challenge the current dogma that all
73 ctural model of Ezrin-Radixin-Moesin protein autoinhibition and cycling between closed/resting and op
75 e CN-calmodulin complex, relieving enzymatic autoinhibition and enabling CN substrate recognition.
76 ss to the pyrin B-box domain responsible for autoinhibition and hence may be constitutively active.
82 domains reveals a direct correlation between autoinhibition and membrane translocation following PKC
83 proximately 80-residue span is important for autoinhibition and needs to be released from both kinase
84 show that (1) the DAD has dual functions in autoinhibition and nucleation; (2) the FH1, FH2, and DAD
87 rotein lattice via MIT domains also relieves autoinhibition and primes the AAA ATPase cassettes for s
90 osphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the eight Sr
91 critical roles of SFK SH2 domains in kinase autoinhibition and T-cell receptor signaling, monobodies
92 e C terminus of the protein counteracts this autoinhibition and that both the N- and C-terminal regio
93 ogenic regulator, appears to be regulated by autoinhibition and that the possible hinge motion of the
95 ibution of each phosphorylation site to PTEN autoinhibition and the structural basis for the conforma
96 lated in cis, thereby autonomously relieving autoinhibition and thus allowing subsequent adenylylatio
97 3 domain-containing Cb variants by relieving autoinhibition and thus define an alternative GTPase-dri
99 on of the PTEN C-tail phospho-cluster showed autoinhibition, and conformational closure was influence
100 between inhibitory helix stability and ETV6 autoinhibition, and demonstrate that helix unfolding doe
101 s to local unfolding of the HD that relieves autoinhibition, and has important implications for the d
102 structural requirements for cargo transport, autoinhibition, and regulatory mechanisms in myosin V mo
105 esidues of the ankyrin-B linker required for autoinhibition are encoded by a small exon that is highl
108 indings point to KA1-mediated intramolecular autoinhibition as a key regulatory mechanism of human Ch
110 in-1 and kinesin-3 families are regulated by autoinhibition, but little is known about the mechanisms
111 ibited PP2A activity in vitro, suggesting an autoinhibition by amino acid residues 121-163 and its ne
112 tent oncogenic CARD11 mutations must perturb autoinhibition by at least three repressive elements.
114 in homology domain but also facilitates ASK1 autoinhibition by bringing the thioredoxin-binding and k
116 o within the GBD releases this molecule from autoinhibition by disrupting the DID/DAD interactions.
118 nucleotide exchange by the Sec7 domain, and autoinhibition by elements proximal to the PH domain are
119 H) domain; activated Galpha(q) relieves this autoinhibition by interacting with a highly conserved C-
120 e C isozymes, alpha2-chimaerin is subject to autoinhibition by intramolecular contacts, suggesting a
124 his interaction also contributes directly to autoinhibition by precluding a highly conserved dipole-e
125 eighboring cells and protect themselves from autoinhibition by producing specific immunity proteins.
126 inus of the h4xb PMCA causes partial loss of autoinhibition by specifically increasing the Vmax.
127 lacking Snf4 suggested that Snf4 counteracts autoinhibition by the C-terminal sequence of the Snf1 ca
130 tes for the low affinity, which is caused by autoinhibition, by binding to DNA as a cooperative polym
133 large conformational rearrangement, whereby autoinhibition can be relieved by competitive sequestrat
134 ear magnetic resonance spectroscopy that the autoinhibition can be relieved by integrin or integrin r
135 II/III mGluRs maintain an activity-dependent autoinhibition, capable of significantly reducing TRPV1-
140 -1A receptors (5-HT(1A)), separated for 5-HT autoinhibition (dorsal raphe nucleus) and local inhibiti
141 addition, mutants of PLC-beta3 with crippled autoinhibition dramatically accelerated the hydrolysis o
145 osphorylation by Ipl1/Aurora B relieves this autoinhibition, enabling MIND to join an assembling kine
146 Collectively, disruption of normal Zap70 autoinhibition engaged negative feedback mechanisms by w
147 h domain liberates the catalytic domain from autoinhibition, enhancing enzymatic activity toward a pe
148 to probe the effect of the mutations on the autoinhibition equilibrium of the CBD, we find that when
149 To probe further the thermodynamic basis of autoinhibition, ETV6 variants were generated with amino
151 lecular switch that promotes release of BicD autoinhibition following cargo binding to the neighborin
152 imulated by the reversible relief of amidase autoinhibition governed by conserved subcomplexes within
154 -specific up-regulation of GABA(B)R-mediated autoinhibition in CCK(+) BCs promotes aberrant high freq
159 aled a distinctive mechanism for DNA-binding autoinhibition in the ETV1/4/5 subfamily involving a net
160 t this may have significance for maintaining autoinhibition in the non-phosphorylated basal state of
162 andem reveals a pseudosubstrate mechanism of autoinhibition in which the linker region between domain
163 uction enables efficient, stepwise relief of autoinhibition: initial phosphorylation events disrupt t
165 is fragility, we demonstrate how to engineer autoinhibition into the kinase so that phosphotransfer i
166 In contrast to existing models, we find that autoinhibition involves a conformeric equilibrium of the
170 ein, we also have uncovered that IpaH family autoinhibition is achieved by a short-circuiting mechani
171 However, it has also been hypothesized that autoinhibition is assisted by entropic losses caused by
175 s to an osm-3-null mutation, suggesting that autoinhibition is important for OSM-3's biological funct
177 ests that loss of alphaC-beta4 loop-mediated autoinhibition is involved in oncogenic activation of Er
178 echanism whereby the allosteric basis of ERG autoinhibition is mediated predominantly by the regulati
187 ibited by BMP signaling itself, and that BMP autoinhibition is required for resetting ISC pool size t
192 ymphoma (DLBCL) and that disrupt ID-mediated autoinhibition, leading to constitutive NF-kappaB activi
193 that KIF1Bbeta binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1
196 inhibition, we define a new function of ETS1 autoinhibition: maintenance of a monomeric state in the
197 ain, which are all important domains for the autoinhibition mechanism and downstream signal pathway r
200 Many formin proteins are regulated by an autoinhibition mechanism involving intramolecular bindin
202 sts that SmyD1 appears to be regulated by an autoinhibition mechanism, and that unusually spacious ta
204 ression of PTPN22 is partly attributed to an autoinhibition mechanism, in which PTPN22 suppresses its
205 The two-stage activation pathway and the autoinhibition mechanism, which are probably shared by o
208 mily GEFs leads to their activation; similar autoinhibition mechanisms could explain some of these ev
215 stablish a dual role for the macro domain in autoinhibition of ALC1 ATPase activity and coupling to n
216 ion, uncovered how cytochrome c releases the autoinhibition of Apaf-1 through specific interactions w
218 ational change in TFIIIC that overcomes Tfc4 autoinhibition of Brf1 binding and suggest a structural
220 ation between the N and C termini results in autoinhibition of CLIP-170, thus altering its binding to
222 flanking the ERG Ets domain responsible for autoinhibition of DNA binding and solved crystal structu
223 n of the transactivation domain relieves the autoinhibition of Elf3 and enhances Elf3 binding to DNA.
224 We report the molecular basis of DNA-binding autoinhibition of ETS transcription factors ETV1, ETV4 a
227 ins provides a unique mechanism of regulated autoinhibition of exchange activity that is functionally
228 of the hydrophobic helices and sheets to the autoinhibition of IRF-7 in the absence of viral signal.
229 philin and explains a possible mechanism for autoinhibition of its function through an intramolecular
233 phorylation at Thr-696 and Thr-853 causes an autoinhibition of MLCP that accounts for Ca(2+) sensitiz
234 escribed Ca(2+)-dependent C2 domain-mediated autoinhibition of Nedd4-2 is not observed under our repo
237 of DIR gives insight into the regulation of autoinhibition of pDA VTA neurons, and the resulting lon
238 of p38gamma to PTPN4 abolishes the catalytic autoinhibition of PTPN4 and thus activates the phosphata
240 res of cFMS provide further insight into the autoinhibition of receptor-tyrosine kinases via their re
242 s a template for SNARE complex assembly, and autoinhibition of synaptobrevin binding contributes to e
244 nd active Arf GTPases that, in turn, relieve autoinhibition of the catalytic Sec7 domain through an u
245 2+)-bound calmodulin (Ca(2+)/CaM) to relieve autoinhibition of the catalytic subunit (CNA) by its C t
246 no)benzoic acid (PT-1), which attenuates the autoinhibition of the enzyme AMPK, for the design and sy
250 at this compact docking is important for the autoinhibition of the kinase domains and for setting the
251 partners, allowing common properties such as autoinhibition of the motor and microtubule binding to a
252 result of a folded conformation that allows autoinhibition of the N-terminal motor by the C-terminal
253 d trafficking domains relieves linker region autoinhibition of the VSE to produce maximal activation
258 cient to initiate the partial removal of the autoinhibition on the integrin binding site of IgFLNa-R2
261 on of Sec7, the trans-Golgi Arf-GEF, through autoinhibition, positive feedback, dimerization, and int
266 an motor or stalk mutations attenuate Kif21a autoinhibition, providing in vivo evidence for mammalian
267 regulation of CaMKII function, manifested as autoinhibition (pT305 phosphorylation) followed by autoa
268 in leukocytes alpha) and mouse diaphanous 1, autoinhibition regulates a novel membrane localization a
271 we demonstrate that phosphorylation-enhanced autoinhibition requires the presence of phenylalanine or
272 ver pathogenic Parkin mutations disrupt this autoinhibition, resulting in a constitutively active mol
273 cs, we also demonstrated that disrupting the autoinhibition results in a vastly activated enzyme comp
274 m its role in the CXXC domain-mediated DNMT1 autoinhibition, serves as an important regulatory elemen
275 HCN channel gate; cAMP binding relieves this autoinhibition so that opening becomes more favorable th
276 ral determinants for open-state trapping and autoinhibition, such that two distinct mechanisms for cA
278 led that FGFR2 uses a less stringent mode of autoinhibition than FGFR1, which was also manifested in
279 served and nondegenerate determinants of CBD autoinhibition that extends beyond the originally propos
280 timing of nuclear entry, or transcriptional autoinhibition, the phospho-occupancy at Ser826/Ser828 i
281 n of mitotic kinases that neutralizes Haspin autoinhibition through a mechanism dependent on multisit
282 termed "diaphanous formins" are regulated by autoinhibition through interaction between an N-terminal
283 ues in site 2 (Ser(396)-Ser(405)) alleviates autoinhibition to allow interaction with CBP (CREB-bindi
284 B cell lymphoma somehow perturb ID-mediated autoinhibition to confer CARD11 with the dysregulated sp
286 ains unclear how such binding events relieve autoinhibition to unmask the VCA segment and activate th
287 01/-02 and mDia2-DAD peptides, which disrupt autoinhibition, to examine the roles of mDia inactivatio
288 tol 4,5-bisphosphate and cargo relieves this autoinhibition, triggering clathrin recruitment and henc
289 ll, Holderfield and colleagues show that RAF autoinhibition underpins this paradox, further complicat
294 residues in the DNA recognition helix affect autoinhibition, we define a new function of ETS1 autoinh
295 To test the role of dimerization in ligand autoinhibition, we introduced structure-based mutations
296 gions of the Kinesin-1 tail are required for autoinhibition, we searched for a second molecule that c
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