ライフサイエンスコーパス: autoinhibitory

1 results suggest that the acidic domains are autoinhibitory.

2 On the other hand, both local and autoinhibitory 5-HT(1A) binding inversely modulated the

3 in autoregulatory elements of PDZRhoGEF, the autoinhibitory "activation box" and the "GEF switch," wh

4 suggest the C-terminal domain may contain an autoinhibitory activity.

5 elices at the base of the active site and an autoinhibitory (AI) segment in the regulatory M domain a

6 ins characterized by an intrinsic N-terminal autoinhibitory alpha-helix.

7 vation, through a putative disruption of the autoinhibitory alphaL-helix on the C terminus of RSK2, u

8 that, similar to BRAGs, its PH domain is not autoinhibitory and strongly potentiates nucleotide excha

9 m with their catalytic Sec7 domain, which is autoinhibitory and supports a positive feedback loop in

10 Other classes of formins lack the autoinhibitory and/or Rho-binding domains and thus are l

11 Our data indicate that WASP displaces the autoinhibitory Arp3 C-terminal tail from a hydrophobic g

12 The removal of an autoinhibitory beta-hairpin loop from genotype 2a HCV NS

13 ts suggest that the role of AIM2(PYD) is not autoinhibitory, but generating a structural template by

14 itionally, we found that Mpk1 binds near the autoinhibitory C terminus of Swi4, suggesting an activat

15 via caspase-3-mediated cleavage of the Panx1 autoinhibitory C-terminal domain.

16 (PH) domain of Cdc24p, which functions in an autoinhibitory capacity, and was required, along with ot

17 We show that RIG-I uses its autoinhibitory CARD2-Hel2i (second CARD-helicase inserti

18 of the NRR, suggesting that it releases the autoinhibitory clamp on the heterodimerization domain im

19 Formation of the autoinhibitory complex greatly reduces the coupling effi

20 he first functional characterization of this autoinhibitory complex, which may be a major form of the

21 This autoinhibitory complex, with A-kinase anchoring protein-

22 preexisting plexin dimers that could act as autoinhibitory complexes.

23 ntral stalk's epsilon subunit in an extended autoinhibitory conformation in all three states.

24 In its native state, vinculin is in an autoinhibitory conformation in which domain 1 prevents i

25 The autoinhibitory conformation is common to three Neks and

26 ndicates that this mutation destabilizes the autoinhibitory conformation of MET and abrogates an impo

27 g the allosteric site and in stabilizing the autoinhibitory conformation of the DH-PH unit.

28 ap70 mutation, W131A, which destabilizes the autoinhibitory conformation of Zap70, rendering the kina

29 al data suggest that alpha-catenin adopts an autoinhibitory conformation, in the absence of junctiona

30 ts in the chaperones and to counteract their autoinhibitory conformation.

31 inase domain and latches the protein into an autoinhibitory conformation.

32 ructural determinant of the stability of the autoinhibitory conformation.

33 istent with Frq1 binding simply relieving an autoinhibitory constraint.

34 kinase domain fragment (deltaKD) freed from autoinhibitory constraints imposed by the regulatory dom

35 sting that Thr(141) phosphorylation relieves autoinhibitory constraints that limit PKCdelta activity.

36 intramolecular tether provides only limited autoinhibitory control of EGFR activity and that the low

37 indicate that the N-terminal peptide exerts autoinhibitory control over rat GTPCH and is required fo

38 re-engagement of the active site zinc by the autoinhibitory Csn5 glutamate-104 diminish affinity for

39 Unlike TnrA, GlnR sensors mediate an autoinhibitory dimer-destabilizing interaction alleviate

40 erminus contains two regulatory domains, the autoinhibitory domain (AID) and calmodulin-binding domai

41 ng a conformational change that displaces an autoinhibitory domain (AID) from the active site, result

42 exon 4A, and the other is equivalent to the autoinhibitory domain (AID) of L-WNK1.

43 th minor changes in the glycine loop and the autoinhibitory domain (AID).

44 nucleation was identified for the Diaphanous autoinhibitory domain (DAD), which is C-terminal to the

45 An autoinhibitory domain (ID) at the extreme C terminus int

46 inactivation (VDI) due to the presence of an autoinhibitory domain (inhibitor of CDI) in the distal C

47 phorylation at Ser-617 and Ser-635 within an autoinhibitory domain (residues 595-639) in bovine endot

48 tiple Lysine residues including those in its autoinhibitory domain (SAID), leading to endocytosis and

49 Deletion of the autoinhibitory domain also doubles the maximum calmoduli

50 s the intramolecular interaction between the autoinhibitory domain and a not well defined region of t

51 challenge the previous identification of an autoinhibitory domain and show instead that Hsl1p activa

52 amino acid sequence similarity to the CaMKII autoinhibitory domain and to a CaMKII binding domain in

53 addition of phosphomimetic mutations in the autoinhibitory domain and was more sensitive to inhibiti

54 f a construct of S6K1 lacking the C-terminal autoinhibitory domain as well as full-length S6K1, revea

55 Our results suggest that an autoinhibitory domain ensures the motor activity of Mfd

56 However, we found that removal of the autoinhibitory domain from Toxoplasma gondii CDPK1 is no

57 2-7 recruitment by ORC/Cdc6 is blocked by an autoinhibitory domain in the C terminus of Mcm6.

58 tion is not conserved; instead, a C-terminal autoinhibitory domain is responsible for dimerization of

59 ugh a direct interaction with the regulatory autoinhibitory domain of AMPK.

60 Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-st

61 he amino-terminal SAM domain functions as an autoinhibitory domain of intrinsic RhoGAP activity.

62 n mechanical pulling forces that disrupt the autoinhibitory domain of Notch, we hypothesized that, in

63 We show that Yck2p binds to the autoinhibitory domain of Sec2p, adjacent to the PI(4)P b

64 A somatic mutation in the JH2 autoinhibitory domain of the Janus kinase 2 (JAK2) tyros

65 eneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamyc

66 We now report cleavage of the autoinhibitory domain of the protein phosphatase calcine

67 we report the solution NMR structure of the autoinhibitory domain of WNK1 (WNK1-AI), a small regulat

68 of activated JNK as well as enhanced p70S6K1 autoinhibitory domain phosphorylation.

69 C-terminal region that is different from the autoinhibitory domain present in all other CnA isoforms.

70 protein-protein interactions, domain 4 is an autoinhibitory domain regulating the DNA binding and ATP

71 ID mutations in DLBCL and reveal an unusual autoinhibitory domain structure and strategy for prevent

72 deletion mutants, we show that the HD is an autoinhibitory domain that blocks productive NAD(+) bind

73 the region immediately upstream of CBD is an autoinhibitory domain that maintains the closed state th

74 ated, this N-terminal region functions as an autoinhibitory domain that places DLC1 in a closed, inac

75 hat the C-terminal region of GlnR acts as an autoinhibitory domain that prevents GlnR dimerization an

76 inal domain in the wild-type enzyme being an autoinhibitory domain that upon binding the effector HPA

77 st that the COOH-terminal tail can act as an autoinhibitory domain to control both PTEN membrane recr

78 cation of PMCA reduced the propensity of the autoinhibitory domain to dissociate from binding sites n

79 initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimula

80 which probes the tightness of binding of the autoinhibitory domain to sites near the catalytic core o

81 se domain and partial loss of the N-terminal autoinhibitory domain was identified in fibroblasts from

82 Also, a central autoinhibitory domain was identified that opposes RRM fu

83 2, provided evidence that the amino-terminal autoinhibitory domain was not essential for direct redox

84 of Arg114 [me-Arg114]) within an N-terminal autoinhibitory domain were important for Ras-induced C/E

85 re the Mre11 RBD and linker domain act as an autoinhibitory domain when not in complex with Rad50.

86 ons in BTK (Cys481) and/or PLCG2 (within the autoinhibitory domain) were found in 9 patients (10.7%),

87 ing of beta-catenin exon 3, which encodes an autoinhibitory domain, induces partial skipping of the i

88 letions, located within a region encoding an autoinhibitory domain, result in protein products with c

89 Thus, rather than being an autoinhibitory domain, the C-terminus of Chk1 also conta

90 mimicking the sequence of the phosphatase's autoinhibitory domain-interfere with normal CDI.

91 horylation of S344 in the calmodulin-binding/autoinhibitory domain.

92 rminal amino acids of NBCe1-B function as an autoinhibitory domain.

93 and motifs, or this domain together with the autoinhibitory domain.

94 ermeable peptide corresponding to the CaMKII autoinhibitory domain.

95 ts N-terminal C2 domain that functions as an autoinhibitory domain.

96 er-617 partially reverses suppression by the autoinhibitory domain.

97 nsistent with its lack of the NH(2)-terminal autoinhibitory domain.

98 ated alpha(1) subunit and serves as a potent autoinhibitory domain.

99 he transactivation domain that behaves as an autoinhibitory domain.

100 pling between the ATP binding domain and the autoinhibitory domain.

101 promoting phosphorylation of the C-terminal autoinhibitory domain.

102 Capu does not contain conserved autoinhibitory domains and can be regulated by a second

103 l unfolding and tension-dependent removal of autoinhibitory domains are common features in force-sens

104 st, N-terminal truncated CRAF (CatC) lacking autoinhibitory domains forms constitutive dimers and occ

105 is allosteric Ras-binding site is blocked by autoinhibitory domains of SOS.

106 ese data indicate that JAK pseudokinases are autoinhibitory domains that hold the kinase domain inact

107 everal classes of signaling proteins contain autoinhibitory domains that prevent unwarranted signalin

108 integrates opposing inputs from the RRM and autoinhibitory domains to link properly H3K4 methylation

109 thermore, CEP290 activity was regulated by 2 autoinhibitory domains within its N and C termini, both

110 imited to Purkinje cells, it lacks classical autoinhibitory domains, and its FH1 domain has minimal p

111 at the post-translation level by cis-acting autoinhibitory domains, which can be relieved by protein

112 thin its negative regulatory DNA-binding and autoinhibitory domains.

113 e disparate Drp1 isoforms and alleviates the autoinhibitory effect imposed by these sequences on Drp1

114 enes induced by Treg cells that bolstered an autoinhibitory effect in Teff cells, and this induction

115 This autoinhibitory effect may play an important role in prev

116 In the context of ABL, these domains have an autoinhibitory effect on kinase activity, and mutations

117 biquitin-associated domain revealed a modest autoinhibitory effect.

118 activated state of CDC42, EspF(U) mimics an autoinhibitory element found within N-WASP.

119 t more complex and may involve an additional autoinhibitory element in the form of a molten globule r

120 cal and cellular analyses of the five-domain autoinhibitory element of Vav1.

121 ding to an allosteric site that includes the autoinhibitory elements in addition to the PH domain.

122 relieved by competitive sequestration of the autoinhibitory elements in grooves at the Arf6/PH domain

123 l evidence has revealed regulatory roles for autoinhibitory elements within PLCbeta, Gbetagamma, smal

124 cardiac-specific amino terminus acted in an autoinhibitory fashion to bind MYOCD via specific negati

125 ; SA biosynthesis is negatively regulated by autoinhibitory feedback at ICS1.

126 ffect of ex9-39 on PYY secretion supports an autoinhibitory feedback mechanism that controls L cell s

127 This particular mechanism for autoinhibitory feedback reveals strategies and challenge

128 roplast and inhibits its own accumulation by autoinhibitory feedback.

129 in solution, suggesting that it exists in an autoinhibitory form.

130 We identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)L

131 Thus, this pathogen has used a simple autoinhibitory fragment as a component to build a highly

132 We show that the disordered region has an autoinhibitory function and a dimerization interface, wh

133 by promoting a closed conformation, plays an autoinhibitory function and decreases SNARE complex form

134 nylalanine residues known to be critical for autoinhibitory function of AID abolish the ability of th

135 activates the MAPK pathway by disrupting an autoinhibitory function of the Dbl domain on Ras activat

136 .3 CT strongly suppresses VDF, signifying an autoinhibitory function of this part of the channel.

137 factor regulatory region, serve an essential autoinhibitory function.

138 the release of this domain and relief of its autoinhibitory function.

139 Here we show that EspF(U) binds to the autoinhibitory GTPase binding domain (GBD) in WASP prote

140 Here, we tested the extent to which the autoinhibitory head-tail interaction (HTI) in vinculin r

141 nally linked to the interactions between the autoinhibitory helix and the DH domain.

142 upted by mutation of Tyr633 within the Mint1 autoinhibitory helix leading to enhanced APP binding and

143 homodimerization, and that RIM disrupts the autoinhibitory homodimerization forming monomeric primin

144 rystal structure of EspG in complex with the autoinhibitory Ialpha3-helix of PAK2 defines a previousl

145 tric-oxide synthase (nNOS) contains a unique autoinhibitory insert (AI) in its FMN subdomain that rep

146 ind that mutations predicted to disrupt this autoinhibitory interaction (including several that have

147 SMURF2, is antagonized by an intramolecular, autoinhibitory interaction between its C2 and Hect domai

148 An intramolecular autoinhibitory interaction between the FERM and catalyti

149 ral and biochemical data indicating that the autoinhibitory interaction between the N-SH2 and protein

150 tic actin nucleation factors regulated by an autoinhibitory interaction between the N-terminal RhoGTP

151 is missing in cten, and thereby releases an autoinhibitory interaction between the sterile alpha mot

152 lipid transport by releasing a charge-based autoinhibitory interaction between this domain and the S

153 ulation of FAK activity is an intramolecular autoinhibitory interaction between two of its domains--t

154 mmalian myosin V suggest that a head-to-tail autoinhibitory interaction is a primary means of regulat

155 Altogether, the results suggest that the autoinhibitory interaction of the extreme C-terminal seg

156 2-DAD is also predicted to participate in an autoinhibitory interaction with the N-terminal diaphanou

157 ough two levels of regulation, an allosteric autoinhibitory interaction, in which the VCA is sequeste

158 pe IGF1R, consistent with a disruption of an autoinhibitory interaction.

159 the WH2 motif likely doubles as a DAD in an autoinhibitory interaction.

160 riphosphatases to the IS domain disrupts the autoinhibitory interactions and exposes the IS domain bi

161 utively active, truncated myoV, in which the autoinhibitory interactions between the globular tail an

162 ysin/Rvs167 (F-BAR) proteins is regulated by autoinhibitory interactions between their SRC homology 3

163 iphosphate, presumably due to release of the autoinhibitory interactions in WASP.

164 ar juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for t

165 nduces a conformational change that relieves autoinhibitory interactions with the ATPase motor, which

166 The tail domain of vinculin (Vt) forms tight autoinhibitory interactions with the head domain and dow

167 In the absence of stress, autoinhibitory interactions, mediated by the L3 loop, st

168 To understand these autoinhibitory interactions, we generated mutations at t

169 altering the number and affinity of modular autoinhibitory interactions, we show that we can predict

170 talytic activity by relieving intramolecular autoinhibitory interactions.

171 al rearrangement of the loop and breaking of autoinhibitory interactions.

172 However, PI(4,5)P2 does not release autoinhibitory interactions; rather, Src phosphorylation

173 substrate these activities are repressed by autoinhibitory interdomain contacts.

174 Instead, a distinct set of autoinhibitory interdomain interactions hold unliganded

175 Here we validate the significance of this autoinhibitory interface for the regulation of ZAP-70 ca

176 tations that disrupted the predicted p30-p20 autoinhibitory interface resulted in GSDMD aggregation,

177 ults directly correlate the stability of the autoinhibitory interface with the activation of these ke

178 All our PlxnA ectodomain structures show autoinhibitory, intermolecular "head-to-stalk" (domain 1

179 These results suggest that disruption of the autoinhibitory JM domain is an alternative, dimerization

180 CDPKs contain an autoinhibitory junction (J) region whose calcium-depende

181 red to a calmodulin-like domain (CLD) via an autoinhibitory junction (J).

182 Deleting the autoinhibitory L(1)-alpha(2) motif (or just the loop L(1

183 C-terminal 86 residues of Zuo1 fold into an autoinhibitory left-handed four-helix bundle.

184 ears to activate the enzyme by displacing an autoinhibitory loop from the iodothyronine binding site.

185 f CDC20 to APC/C is normally prevented by an autoinhibitory loop in APC1 and that its mitotic phospho

186 ll-like receptor (TLR) agonists, creating an autoinhibitory loop that may contribute to the pathogene

187 number of structural features, including an autoinhibitory loop, the C-terminal tail of the enzyme,

188 ng that IL-1beta might be involved in a like autoinhibitory loop, we determined that (1) TLR activati

189 Interestingly, NTD functions in an autoinhibitory manner during initiation, and its partial

190 Fis1 arm, suggesting that the arm acts in an autoinhibitory manner to restrict access to the Dnm1 bin

191 al hydrophobic domain 1 (HD1) of GDAP1 in an autoinhibitory manner.

192 This reveals an autoinhibitory mechanism aimed at reducing dopamine cell

193 us to re-evaluate the current model for the autoinhibitory mechanism and the structural basis for co

194 full activation of the enzyme, suggesting an autoinhibitory mechanism for self-preservation.

195 region of MyoGEF to its DH domain acts as an autoinhibitory mechanism for the regulation of MyoGEF ac

196 Here we identified an autoinhibitory mechanism in alpha2-chimaerin that restri

197 Our findings suggest that an autoinhibitory mechanism in Mint1 is important for regul

198 mplex formation may represent an alternative autoinhibitory mechanism in the ETS family at the protei

199 rized cell growth, is regulated by a similar autoinhibitory mechanism in vivo.

200 These data support an autoinhibitory mechanism in which competition between th

201 hought to be controlled by an intramolecular autoinhibitory mechanism involving an N-terminal extensi

202 how that PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal

203 Many formins are controlled through an autoinhibitory mechanism involving the interaction of a

204 ks, Plk4 possesses a previously unidentified autoinhibitory mechanism mediated by a linker (L1) near

205 The structure reveals that the autoinhibitory mechanism mediated by the importin-beta b

206 regulated by the same Rho-GTPase-controlled autoinhibitory mechanism modulating formin-mediated acti

207 h is inconsistent with a previously proposed autoinhibitory mechanism of regulation.

208 The autoinhibitory mechanism of ZAP-70 is, however, distinct

209 This autoinhibitory mechanism plays a nonessential role in th

210 This autoinhibitory mechanism presumably evolved to prevent b

211 Our findings suggest that an autoinhibitory mechanism prevents clathrin recruitment b

212 hange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like

213 Our studies identify an autoinhibitory mechanism, in which unmethylated CpG dinu

214 N lobe of the catalytic domain disrupted an autoinhibitory mechanism, producing a weakly hyperactive

215 as limited our further understanding of this autoinhibitory mechanism.

216 tly binding and disrupting an intramolecular autoinhibitory mechanism.

217 molecularly, thereby forming the basis of an autoinhibitory mechanism.

218 involved in regulation of RopGEF through an autoinhibitory mechanism.

219 ta establish how a combination of active and autoinhibitory mechanisms ensures the high fidelity of D

220 s known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biolog

221 iven the widespread regulation of kinases by autoinhibitory mechanisms, the approach described herein

222 tes the simultaneous suppression of multiple autoinhibitory mechanisms, which in turn confers added s

223 The core autoinhibitory module of Vav1 consists of the catalytic

224 tail of Asef2, allowing it to function as an autoinhibitory module within the protein.

225 h regulatory mechanism is the presence of an autoinhibitory module, which in Ets-1 allosterically inh

226 phosphorylated pathogenic mutants reveals an autoinhibitory "molecular brake" mediated by a triad of

227 ent microtubule-binding sequence and the IAK autoinhibitory motif - are essential for development and

228 ngly, there were no indications that the IAK autoinhibitory motif acts as a general downregulator of

229 An autoinhibitory motif restrains Hsl1p activity when it is

230 identify a physical interaction between the autoinhibitory N terminus and the TIR domain of SARM1, r

231 t mechanism that could serve to override the autoinhibitory negative feedback regulation of ARF2 on i

232 R from IL-6R and downregulation of the SOCS3 autoinhibitory pathway.

233 application of okadaic acid (10 nM) and CaN-autoinhibitory peptide (50 microM) did not potentiate th

234 with the calcineurin antagonist calcineurin autoinhibitory peptide (CAIP) significantly reduced peri

235 istinct calcineurin antagonists (calcineurin autoinhibitory peptide and cyclosporine/cyclophilin comp

236 Displacement of the autoinhibitory peptide provides a molecular mechanism fo

237 vents that remove the C1 domain (but not the autoinhibitory PH domain) limit maximal PKD1 activity to

238 m in which the tyrosine is released from its autoinhibitory position.

239 in which the latency is maintained by their autoinhibitory pro-domains.

240 e than full-length vti1a, suggesting that an autoinhibitory process regulates vti1a function.

241 letes the removal and the degradation of the autoinhibitory prodomain and the liberation of the funct

242 ALIX activation requires dissociation of the autoinhibitory PRR and opening of the V domain arms.

243 A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical

244 type II PAKs are regulated by an N-terminal autoinhibitory pseudosubstrate motif centered on a criti

245 We have previously shown that the autoinhibitory pseudosubstrate must be removed from the

246 H-bonds that link the C-terminal tail to the autoinhibitory region (AIR) and the tandem Src homology

247 ansporters are activated when the N-terminal autoinhibitory region is deleted, to give an N-terminall

248 Our data suggest that dismantling this autoinhibitory region via deletion or proteolysis is the

249 stepwise fashion, first an unwinding of the autoinhibitory region, followed by a two-step unfolding

250 n demonstrated that the FLAP is a functional autoinhibitory region.

251 nlike other IRF members, IRF4 has a flexible autoinhibitory region.

252 We propose that SCF may be subject to autoinhibitory regulation, in which Nedd8 conjugation ac

253 in-frame FAM73A-BRAF fusion lacking the BRAF autoinhibitory regulatory domain but retaining an intact

254 The autoinhibitory regulatory domain of AHA2 reduced the int

255 urring between the kinase catalytic core and autoinhibitory/regulatory region.

256 action is rendered TCR-inducible by the four autoinhibitory repressive elements in the CARD11 inhibit

257 in, but was critically dependent on a single autoinhibitory residue (Leu-919) upstream of the C-termi

258 miRNA processing through the formation of an autoinhibitory RNA conformation.

259 stream of vesicle priming, revealing a novel autoinhibitory role for the C2B.

260 The large RecA2 insert played an autoinhibitory role in suppressing DHX29's intrinsic NTP

261 of Rpn11, due in part to alleviation of the autoinhibitory role of its C terminus.

262 ased platelet binding, corroborating the key autoinhibitory role of the A2 domain within VWF multimer

263 Consistent with the postulated autoinhibitory role of the JMD Tyr-559 and its relief by

264 Consistent with an autoinhibitory role of the VD, we identified Arg-376 in

265 describe biochemical evidence suggesting an autoinhibitory role played by the human CUL1 ECTD (extre

266 In contrast, Gln-316 has an autoinhibitory role, and its mutation to lysine resulted

267 n, whereas the SH3 domain appears to have an autoinhibitory role.

268 hat instead plays an activating--rather than autoinhibitory--role.

269 We found that the autoinhibitory segment (AIS), located within the CBD, is

270 vation segment similar in conformation to an autoinhibitory segment observed in the hepatocyte growth

271 its catalytic core structure rather than an autoinhibitory segment.

272 e similarity with other MLCKs but lacking an autoinhibitory segment.

273 PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains vi

274 Binding requires deletion of an apparently autoinhibitory sequence in the Gga2p hinge.

275 nteraction with SCPL-1 required the putative autoinhibitory sequence, and immunoglobulin (Ig) and fib

276 Ca(2+)-calmodulin to the calmodulin-binding autoinhibitory sequence, which in the human PMCA is loca

277 ous mutation (R707Q) in the highly conserved autoinhibitory SH2 domain in three of 10 cases.

278 he p.Ser707Tyr substitution is located in an autoinhibitory SH2 domain that is crucial for PLCgamma2

279 Thus, leptin activates autoinhibitory signals via LRb Tyr985 to attenuate the a

280 The significance of a bipartite autoinhibitory site is evidenced by its effects on talin

281 Pin1 increases Raf-1 phosphorylation on the autoinhibitory site Ser259, leading to reduced MEK activ

282 Definition of a second autoinhibitory site, the D4-Vt interface, supports the c

283 This is mediated by disruption of an autoinhibitory Smurf1 homodimer and is independent of AP

284 st majority of Cb splice variants contain an autoinhibitory src homology 3 domain, and several synapt

285 rase, RfaH exists in a structurally distinct autoinhibitory state in which the RNA polymerase-binding

286 However, the mechanism(s) that maintains the autoinhibitory state of the DDR1 dimers is unknown.

287 Formation of the autoinhibitory state, and thus sequence-specific recruit

288 o adopt a conformation that destabilizes the autoinhibitory state.

289 This autoinhibitory strategy makes CARD11 highly susceptible

290 Re-engineering the highly conserved autoinhibitory structure of GEFs, Yeh et al. generated n

291 ults in IRF-3 dimerization and removal of an autoinhibitory structure to allow interaction with the c

292 elta364-685) containing the dimerization and autoinhibitory subdomains and two allosteric cGMP-bindin

293 ed that the variant probably destabilizes an autoinhibitory subunit interaction, sensitizing mast cel

294 eptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, sugges

295 that CHMP proteins are regulated through an autoinhibitory switch mechanism that allows tight contro

296 totic protein Bcl-xL and a BH3 peptide as an autoinhibitory switch that can be controlled with a smal

297 Here, we show that EB1 and the KIF17 autoinhibitory tail domain (KIF17-Tail) interacted compe

298 Thus, PHLPP, Akt, and Mst1 constitute an autoinhibitory triangle that controls the fine balance o

299 back-to-back dimerization that releases the autoinhibitory tyrosine residue, a mechanism conserved i

300 In contrast, removal of the autoinhibitory X/Y-linker region of the catalytic core o