ライフサイエンスコーパス: autolysin

1 es suggested as being involved in triggering autolysin.

2 P60, an established SecA2-dependent secreted autolysin.

3 hTSP-1 and Vn, respectively, and a bacterial autolysin.

4 s accelerated by the addition of lysozyme or autolysin.

5 r/stationary-phase survival (Rpf/Sps) family autolysin.

6 ng AmiC's purported function as a gonococcal autolysin.

7 of S. mitis known to possess pneumolysin and autolysin.

8 ffects chain length through activation of an autolysin.

9 ease (MF-1), a putative nuclease (MF-3), and autolysin.

10 lmuramyl-L-alanine amidase, the pneumococcal autolysin.

11 specialized functions of essential cell wall autolysins.

12 can O-acetylation and repression of cellular autolysins.

13 pholipid (PL) degradation, and activation of autolysins.

14 ypeptidases and the cell wall degradation by autolysins.

15 ions in peptidoglycan structure or levels of autolysins.

16 o explore the binding mechanism of the major autolysin Acm2 from the probiotic bacterium Lactobacillu

17 of pneumolysin from WU2 was not dependent on autolysin action.

18 rine protease inhibitor) showed an increased autolysin activity.

19 at a pH non-permissive for other gonococcal autolysins, an autolytic activity was detectable in the

20 R, which "repurposes" SinR as a repressor of autolysin and motility genes, are discussed.

21 um and regulates the reciprocal synthesis of autolysins and autolysin inhibitors to co-ordinate growt

22 dy, we demonstrate that binding domains from autolysins and lysins can be fused to the Fc region of h

23 Autolysins and phage lysins are peptidoglycan hydrolases

24 Thus, these autolysins and phage-entry enzymes have a shared chemica

25 n TiO2 NP, limiting the activity of released autolysins and preventing further lytic activity.

26 in counteracting the deleterious effects of autolysins and reactive oxygen species in beta-lactam-tr

27 y controlling the transcription of genes for autolysins and their inhibitors.

28 Among known autolysins and their regulators, we found that arlRS rep

29 ll envelope stress decreases the activity of autolysins and thereby reduces the rate of antibiotic-de

30 ociated beta-lactamase, lipoprotein, lipase, autolysin, and an ABC transporter lipoprotein.

31 Although some factors, such as sortases, autolysin, and extracellular DNA (eDNA), have been assoc

32 the controlled secretion and proteolysis of autolysin, and this developmental program appears to be

33 r coagulase-negative staphylococci that some autolysins are able to bind polymer surfaces, these data

34 a condition which is reported to inactivate autolysin, as well as most known pneumococcal phage lysi

35 ectrometry revealed the major staphylococcal autolysin Atl as a bacterial binding protein for hTSP-1.

36 Staphylococcus aureus secretes autolysin (Atl) to complete cell division by hydrolyzing

37 ns extracellular adherence protein (Eap) and autolysin (Atl), both surface-exposed proteins containin

38 We show here that Esp cleaves autolysin (Atl)-derived murein hydrolases and prevents s

39 may function independently from several key autolysins (Atl, LytM, and LytN) and regulators (ArlRS,

40 The bifunctional major autolysin AtlA of Staphylococcus aureus cleaves the bact

41 We have identified a gene encoding an autolysin (atlA) from Neisseria gonorrhoeae.

42 ing downstream interactions with the primary autolysin, AtlA.

43 n, primary attachment, and expression of the autolysin AtlE, but lacked delta-toxin production.

44 o assess the importance of the proteinacious autolysin (AtlE) and the polysaccharide intercellular ad

45 o analysis approach, we identified the major autolysin AtlS as a natural substrate of SdbA and showed

46 ne important roles for the major E. faecalis autolysin (Atn), eDNA, and sortase A (SrtA) during the d

47 g the virulence determinants pneumolysin and autolysin classically associated with S. pneumoniae.

48 lation of the CwlO and LytE systems and that autolysins control different aspects of cell morphogenes

49 ent is not required for cell death since the autolysin-defective lytC, lytD, lytE, lytF strain fails

50 he culture medium, and the lack of effect of autolysin-deficient mutants.

51 by the coupling of massive PL degradation to autolysin-dependent killing and bacterial lysis or both.

52 The secreted Listeria monocytogenes p60 autolysin digests peptidoglycan and promotes bacterial i

53 rtate phosphatase (RapD), and a regulator of autolysin expression (LytR).

54 Further characterization revealed normal autolysin expression, localization, and triggering by de

55 al-PCR protocol (targeted at pneumolysin and autolysin) for EDTA blood samples.

56 A gene, designated atlS, encoding a major autolysin from Streptococcus gordonii, was identified an

57 Here we report that autolysins from Gram-positive pathogenic bacteria, enzym

58 ontaining walls are similar, indicating that autolysin function is similar and suggesting that modula

59 We tested blood by PCR for the pneumococcal autolysin gene in children aged 1-59 months in the Pneum

60 rulence factor of pneumococci, and the major autolysin gene lytA, also considered an important virule

61 , but none of them showed translation of the autolysin gene, which is located downstream of recA.

62 tch and exists in a SlrR(LOW) state in which autolysin genes are on, and a SlrR(HIGH) state in which

63 enes are on, and a SlrR(HIGH) state in which autolysin genes are repressed by SinR-SlrR.

64 d, rat appears to be a negative regulator of autolysin genes including lytM and lytN.

65 d expression in the stp1 mutant and included autolysin genes.

66 ion conditions, mutations in pneumolysin and autolysin had different effects on virulence.

67 A, a protective antigen, and LytA, the major autolysin) have been well characterized.

68 l studies of lysostaphin, a PG lytic enzyme (autolysin), have suggested that residues in the active s

69 To elucidate the function of this putative autolysin, here named IsdP, we investigated its contribu

70 which [the p60 and N-acetylmuramidase (NamA) autolysins] hydrolyze bacterial peptidoglycan (PGN) and

71 The role played by pneumolysin and autolysin in pneumococcal meningitis is poorly understoo

72 Downregulation of the major autolysin in Streptococcus pneumoniae leads to penicilli

73 The lack of active autolysin in the mutant cells became apparent by impaire

74 d to bacteriophage endolysins and acts as an autolysin in the stationary phase.

75 and by wild-type cells after treatment with autolysin, indicating that they are localized to the per

76 s the reciprocal synthesis of autolysins and autolysin inhibitors to co-ordinate growth and division

77 that the amidase LytA, the main pneumococcal autolysin, inhibits complement-mediated immunity indepen

78 by a multimodular LysM domain from AtlA, an autolysin involved in cell division in the opportunistic

79 The activity of autolysins is not restricted to the producer cells but c

80 Accordingly, the expression of autolysins is tightly regulated by several endogenous re

81 dunensis contains a gene encoding a putative autolysin located adjacent to the Isd operon.

82 of dividing cells from cleavage by the major autolysin LytA and occurs at the septal site.

83 The pneumococcal autolysin LytA is a key virulence factor involved in sev

84 The pneumococcal autolysin LytA is a virulence factor involved in autolys

85 pneumolysin but depended on the pneumococcal autolysin LytA.

86 a process dependent on the suicidal amidase autolysin LytA.

87 hat do not express pneumolysin (DeltaPly) or autolysin (LytA(-)) caused very mild or no disease.

88 Immunodetection studies revealed that the autolysin (LytA), normally located on the cell wall, was

89 pneumolysin (Pln), pyruvate oxidase (SpxB), autolysin (LytA), pneumococcal surface protein A, or neu

90 the genetic determinant of the pneumococcal autolysin (N-acetylmuramic acid-L-alanine amidase).

91 The lytA-encoded autolysin (N-acetylmuramoyl-L-alanine amidase) of Strept

92 were resistant to hydrolysis by pneumococcal autolysin (N-acetylmuramyl-L-alanine amidase) but were c

93 umolysin-negative derivative (P-1), and into autolysin-negative derivative (A-1).

94 Acm2, the major autolysin of Lactobacillus plantarum, is a tripartite pr

95 e strain by adding purified recombinant AtlA autolysin of S. mutans but was only partially restored b

96 The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence

97 ; and (ii) indirectly, through adsorption of autolysins on TiO2 NP, limiting the activity of released

98 s type I, also shows reduced secretion of an autolysin, p60.

99 On the basis of LCA models, sensitivity of autolysin PCR and pneumolysin PCR was 82% and 89%, respe

100 strong in vivo evidence that pneumolysin and autolysin play crucial roles in the pathogenesis of pneu

101 transcript levels of lytA, which encodes an autolysin previously implicated in biofilms, and also th

102 competence-stimulating peptide (CSP) induced autolysin production and cell lysis of its own non-compe

103 ption of genes that function in motility and autolysin production.

104 that appeared to be mainly due to decreased autolysin production.

105 he Streptococcus mutans atlA gene encodes an autolysin required for biofilm maturation and biogenesis

106 s for ligand restriction by the pneumococcal autolysin, revealing for the first time an importance of

107 It was previously proposed that autolysin's primary role in the virulence of pneumococci

108 A mutant lacking autolysin showed the same pattern of pneumolysin release

109 e mother cell, a process that depends on the autolysin SpoIID and two proteins of unknown function, S

110 h aids in bacterial survival, as it prevents autolysins such as lysozyme from cleaving the PG.

111 These studies establish IsdP as an autolysin that functions in heme acquisition and describ

112 e we present evidence that SpoIIP is also an autolysin, that it acts in tandem with SpoIID, and that

113 wall protein extract containing concentrated autolysin to exponentially growing TA-containing and TUA

114 We show that autolysins trim the outermost peptidoglycan fragments an

115 emonstrate that the peptidoglycan-remodeling autolysins under sigma(D) control, LytC, LytD, and LytF,

116 herefore the probability of being cleaved by autolysins varies with orientation of the chain on the c

117 were derived from PGN remodeled by bacterial autolysins, was recognized.

118 ClpB, lysozyme, and autolysin were detected in the culture supernatant of th

119 Cell separation is mediated by autolysins, whose genes are under the negative control o

120 As such, FlgJ represents the first autolysin with this activity to be characterized from a

121 n hydrolase activity and biofilm maturation, autolysin zymography was performed, which revealed an al