ライフサイエンスコーパス: autolytic

1 sibility that the observed shedding could be autolytic.

2 kedly enhanced (>50-fold) the intermolecular autolytic activation of promatrilysin and the activity o

3 Similarly, autolytic activation of promatrilysin in vitro can take

4 hin A23187-treated cells remained capable of autolytic activation upon treatment with p-aminophenylme

5 ant revealed that CaM binding enhanced CAPN3 autolytic activation.

6 The results add major autolytic activities to the growing list of functions co

7 led altered cell morphologies and effects on autolytic activity and antibiotic susceptibilities that,

8 lucosamine, fibronectin-binding proteins, or autolytic activity and were antibiotic resistant.

9 s, changes in cell-wall cross-linking and/or autolytic activity can modulate PLA2 action either by af

10 oduct (34.4 kDa) corresponded to that of the autolytic activity detected (approximately 36 kDa) in th

11 at gene product is an important regulator of autolytic activity in S. aureus.

12 ouble mutant strain also exhibited increased autolytic activity in the presence of detergents.

13 s showed slow growth, and strongly decreased autolytic activity that appeared to be mainly due to dec

14 rmissive for other gonococcal autolysins, an autolytic activity was detectable in the wild-type strai

15 A gene encoding an autolytic activity was identified in an autolysis-defici

16 The effects of protonmotive force on autolytic activity were studied by adding cell wall prot

17 d a 70-fold increase in bovine factor X(a)'s autolytic activity, consistent with the 60-fold increase

18 within the cell envelope, severely decreased autolytic activity, resistance to lysis by S. aureus pha

19 Besides its effect on autolytic activity, we recently found alterations in the

20 al, as the first positive regulator of CAPN3 autolytic activity.

21 ion of a disulfide bond that is required for autolytic activity.

22 uman MBP, but not an MBP fragment that lacks autolytic activity.

23 the gene likely or proven to be involved in autolytic activity.

24 eins, IsaA and SceD, were both found to have autolytic activity.

25 biofilm was released extracellularly due to autolytic activity.

26 this gene rat, which stands for regulator of autolytic activity.

27 binding protein to these known repressors of autolytic activity.

28 coli clones carrying the lytM gene exhibited autolytic-activity bands of approximately 36 kDa as well

29 aureus which produces only a single band in autolytic-activity gels.

30 e LytR modulates the expression of the major autolytic amidase and CsbB may function in peptidoglycan

31 Various autolytic and cross-activation relationships identified

32 The GH25 is non-autolytic and exhibits lysozyme-mediated lytic activity

33 , thereby preventing relief of repression of autolytic and other cell death functions in response to

34 Despite possible autolytic artifacts due to technical and experimental co

35 This truncation was autolytic as illustrated by its R199A/R200A or E346A mut

36 long chains by the cells, markedly decreased autolytic capacity, poor biofilm formation, diminished t

37 veral nonenveloped animal viruses possess an autolytic capsid protein that is cleaved as a maturation

38 e show that NLRP1 activity is dependent upon autolytic cleavage at Ser(1213) within the FIIND.

39 -barrel head domains in the mu1 trimer, (ii) autolytic cleavage at the mu1N/C junction, associated wi

40 Autolytic cleavage divides Mu1 into myristoylated Mu1N a

41 Previous evidence has suggested that an autolytic cleavage in mu1 allows the release of its N-te

42 , coupling exposure of the fatty acid chain, autolytic cleavage of Mu1N, and long-range molecular rea

43 Thiol oxidation was associated with autolytic cleavage of pro-MMP-7, strongly suggesting tha

44 Autolytic cleavage of the helicase site was insensitive

45 Autolytic cleavage reactions also occurred in NS2B-NS3 r

46 alytic domain to the hinge region and to the autolytic cleavage site and protects MT1-MMP from autoly

47 s of CTRC cleavage sites Leu-81 and Leu-148, autolytic cleavage site Arg-122, and restoration of the

48 Autolytic cleavage to form micro1N is required for hemol

49 Autolytic cleavage within the caspase-12 proenzyme was m

50 tion could render cathepsin G susceptible to autolytic cleavage.

51 With these materials, the autolytic cleavages were found to be intramolecular only

52 The protease catalyzed two autolytic cleavages.

53 m in the presence or absence of oxidant, and autolytic conversion of both the 80- and 30-kDa subunits

54 In addition, autolytic conversion of either the 80- or 30-kDa subunit

55 Autolytic conversion of the 80-kDa subunit of calpain I

56 The rate of autolytic conversion of the large subunit of calpain I f

57 restingly, whereas oxidation did not inhibit autolytic conversion, the presence of high substrate con

58 Insignificant autolytic degradation is characteristic for naturally ex

59 he common carp alpha1-PI effectively reduced autolytic degradation of bigeye snapper surimi at the co

60 ssociation at low enzyme concentrations, and autolytic degradation of the p10 subunit at high concent

61 was stabilized greater than 80-fold against autolytic degradation relative to wild-type N-His ICE.

62 Glu was added to eliminate the major site of autolytic degradation while maintaining catalytic activi

63 In turn, extensive autolytic degradation, which leads to the inactivation o

64 pancreatitis by stabilizing trypsin against autolytic degradation, while the mechanism of action of

65 Autolytic DNA breakdown, detected as smears in electroph

66 Similar repression of autolytic enzymatic activity and transcription was also

67 ked the in vitro hydrolysis of cell walls by autolytic enzyme extracts, lysostaphin and mutanolysin.

68 mbination between DNA encoding bacteriophage autolytic enzymes and chromosomally encoded lytA might b

69 wever, it is not known how these potentially autolytic enzymes are regulated to prevent lethal breach

70 creased in vitro hydrolysis of cell walls by autolytic enzymes due to hypo-cross-linked peptidoglycan

71 hubs coordinating the activities of multiple autolytic enzymes during cell constriction and fission r

72 The aim of this study was to inactivate autolytic enzymes in C. finmarchicus by applying heat (7

73 Therefore, the expression and activity of autolytic enzymes must be tightly regulated in growing c

74 inappropriately upregulating the activity of autolytic enzymes that weaken the cell wall.

75 ope-dependent processes, such as activity of autolytic enzymes, binding of divalent cations, and susc

76 on and enzymatic activities of several major autolytic enzymes.

77 during growth may be one means of regulating autolytic enzymes.

78 vitro hydrolysis of resistant cell walls by autolytic extracts prepared from either susceptible or r

79 However, the enterococcal autolytic factors GelE and Atn (also known as AtlA), whi

80 Sequencing of the autolytic fragments showed loss of three amino acids fro

81 is similar and suggesting that modulation of autolytic function may be similar.

82 imers generated from gene sequences of known autolytic genes of S. aureus clearly indicate that the l

83 M gene is distinct from other staphylococcal autolytic genes reported to date.

84 is LasA, an M23 metallopeptidase related to autolytic glycylglycine endopeptidases such as Staphyloc

85 Also, the cleavage pattern and kinetics in autolytic inactivation of both KLK2 variants can be expl

86 le when compared to the rate of the internal autolytic inactivation or to the ability of other protea

87 The autolytic Lys-Lys-Gln(59) downward arrow Gln(60)-Phe-His

88 Here, we comprehensively analyze the autolytic machinery of the alphaproteobacterial model or

89 upport a role for VncRS in the regulation of autolytic or other putative cell death loci.

90 s also shed efficiently, thus ruling out the autolytic pathway.

91 Also, the autolytic phenotype in the arlRS mutant of MSSA strain N

92 We describe an autolytic postmortem histologic artifact of eosinophilic

93 te the active amino terminal fragment, by an autolytic process.

94 oss of bacterial viability, indicative of an autolytic process.

95 nmarchicus rapidly changes postmortem due to autolytic processes; in particular phospholipids rapidly

96 Although the autolytic processing and interstitial collagenase activi

97 t lacking exon 14 differentially affect this autolytic processing and subsequent NLRP1 activity.

98 to perform common functions as catalysts of autolytic processing following cell death due to program

99 Rather, APMA inhibited the autolytic processing in these mutants, further confirmin

100 Three sequential autolytic processing steps at the N and C terminus are r

101 synchrotron small-angle X-ray scattering, 3' autolytic processing, and hydroxyl radical protection.

102 e to the organomercurial APMA by accelerated autolytic processing.

103 3,3'-Diindolylmethane (DIM), a natural autolytic product in plants of the Brassica genus, inclu

104 The identical autolytic profile was obtained using a sortase mutant (S

105 trypsin enables the proteolytic activity and autolytic properties of the enzyme to be studied.

106 structural change in the capsid that induces autolytic protease activity.

107 gical markers and the expression of putative autolytic proteases.

108 mutant was linked to an observed increase in autolytic rate compared to the parental strain.

109 otonated, and proton-motive force influences autolytic regulation in both TUA-containing and TA-conta

110 at resulted in decreased expression of known autolytic regulators lytSR, lrgAB and arlRS.

111 The results thus show that the primary autolytic regulatory mechanism of KLK6 is negative feedb

112 of KLK6 toward its pro-sequence and internal autolytic sequence is characterized.

113 er subsegment containing a potential calpain autolytic site severely disturbs gametophore development

114 n-cysteine, cellular proteases acting on the autolytic sites of CAPN3, rather than autolysis.

115 Two of the major autolytic sites were Leu(49)-Thr(50) and Ala(75)-Leu(76)

116 it has no effect on catalytic properties or autolytic stability of trypsin.

117 elE-expressing E. faecalis strains were more autolytic, suggesting that GelE affects chain length thr

118 f S. aureus induces strong repression of the autolytic system and provide evidence for transcriptiona

119 of cell wall synthesis on the status of the autolytic system in Staphylococcus aureus.

120 arA double mutants of both strains were more autolytic than the single mutants in vitro.

121 as viable and grew normally, but it was less autolytic than the wild-type strain in stationary-phase

122 s, we documented that BlaR1 fragmentation is autolytic, that it occurs in the absence of antibiotics,