ライフサイエンスコーパス: autophagy

1 show that the VAPB-PTPIP51 tethers regulate autophagy.

2 t was given, seemingly due to suppression of autophagy.

3 nt in autophagic flux and further stimulated autophagy.

4 volved in cell proliferation, apoptosis, and autophagy.

5 olded proteins and are ultimately removed by autophagy.

6 lated to proteasome dysfunction and impaired autophagy.

7 ls by increasing betaCTF degradation through autophagy.

8 ylceramide, protein aggregate clearance, and autophagy.

9 is a critical negative regulator of general autophagy.

10 ls by increasing betaCTF degradation through autophagy.

11 ysosomal compartment for degradation through autophagy.

12 torin 1-induced, but not starvation-induced, autophagy.

13 cts as a master transcriptional regulator of autophagy.

14 degradation through p62-dependent selective autophagy.

15 ancer cells by inducing apoptosis as well as autophagy.

16 eal a new molecular mechanism for regulating autophagy.

17 97, in the clearance of damaged lysosomes by autophagy.

18 ked to inhibition of both the proteasome and autophagy.

19 ecroptosis, which can be counterregulated by autophagy.

20 which promotes starvation-independent, basal autophagy.

21 e known to promote cellular survival through autophagy.

22 of the master metabolic kinase AMPK enhances autophagy.

23 egulate anabolic processes and down-regulate autophagy.

24 ze in Physiology or Medicine for research in autophagy.

25 reductions: apoptosis, oxidative stress and autophagy.

26 ome-mediated degradation and thereby enables autophagy.

27 Golgi in addition to its established role in autophagy.

28 litated HNSCC progression after blocking CAF autophagy.

29 Beclin 1 (BECN1) is a key regulator of autophagy, a critical catabolic homeostasis pathway that

30 Here, we aim to establish autophagy, a downstream pathway of mTOR, as a new therap

31 Drosophila melanogaster Cdk5 regulates basal autophagy, a key mechanism suppressing neurodegeneration

32 s due, in part, to the compromise of hepatic autophagy, a process that leads to lysosomal degradation

33 logical forms of TDP-43 typically cleared by autophagy accumulate more rapidly in PGRN-deficient neur

34 Autophagy activated after DNA damage or other stresses m

35 se (Ampk) at tyrosine 172 and of unc-51 like autophagy activating kinase 1 (Ulk1) at serine 555.

36 to initiate autophagy: the ULK1 (unc51-like autophagy activating kinase 1) protein kinase complex an

37 , we have demonstrated beneficial effects of autophagy-activating digitalislike compounds (DLCs) on r

38 ed expression of the kinase-dead unc-51-like autophagy-activating kinase (ULK1) mutant K46N increased

39 NET formation, reactive oxygen species, autophagy activation and intracellular signaling pathway

40 ogical characterization of a novel series of autophagy activators involving fatty acid cysteamine con

41 In addition to the robust autophagy activity of the Kalpha2-helix peptide, the pre

42 uitin, the proteasome, the ubiquitin-binding autophagy adaptor NBR1, the autophagy protein LC3, and t

43 ost proteins with essential functions during autophagy also bind.

44 Deficiency in endothelial autophagy also increased TNF-alpha-induced inflammation

45 Autophagy also modulated the phosphorylation of p38 and

46 nfection, lysozyme is rerouted via secretory autophagy, an autophagy-based alternative secretion path

47 lates cell-to-cell adhesion, AMPK signaling, autophagy and apoptosis in different cell types.

48 to palbociclib, and that the combination of autophagy and CDK4/6 inhibitors induces irreversible gro

49 d upregulating PSMB6, which together induces autophagy and cell cycle arrest and benefits virus repli

50 role of vitamin D and the VDR in modulating autophagy and cell death in both the normal mammary glan

51 hibition of mitochondrial function increased autophagy and decreased the aberrant proliferation signa

52 embrane fusion mediates the last step of the autophagy and endocytosis pathways and supports organell

53 noncanonical function of ErbB2 in modulating autophagy and establishes ErbB2 as a therapeutic target

54 ss talk of LX-2 cells and B. abortus induces autophagy and fibrosis with concomitant apoptosis of LX-

55 ite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons an

56 synthetic ion transporters can disrupt both autophagy and induce apoptosis.

57 Dysregulation of autophagy and inflammasome activity contributes to the d

58 signals to the actin cytoskeleton, modulates autophagy and inflammasome function.

59 We discuss the roles of autophagy and inflammation in pancreatitis, mechanisms o

60 ed alterations in several proteins linked to autophagy and lysosomal catabolism reflecting vesicular

61 We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of

62 We conclude that mTORC1 actively suppresses autophagy and maintains endosomal recycling, thereby pre

63 T) is required for glucagon-stimulated liver autophagy and metabolic adaptation to starvation.

64 target whose inhibition enhances productive autophagy and mHtt proteolysis, revealing a useful pharm

65 We investigated the possibility that autophagy and polyploidization might also affect the ant

66 We conclude that autophagy and polyploidy increase the immunogenicity of

67 The autophagy and proteasome pathways were activated in both

68 s through two membrane trafficking pathways: autophagy and rerouting of endosomes to lysosomes.

69 Evidence from research on both autophagy and synaptic function suggests that there are

70 well known hypertrophic agonist, suppresses autophagy and that activation of focal adhesion kinase (

71 s, or chromatin and has an essential role in autophagy and the ubiquitin proteasome system (UPS).

72 ne signaling, the unfolded protein response, autophagy, and cellular metabolism and exploit these pat

73 al cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated

74 hat NRF2 and HSF1 have opposing roles during autophagy, and illustrate the existence of tight mechani

75 by mitochondrial depolarization, disordered autophagy, and pathological endoplasmic reticulum stress

76 c pathways, increases cell death, diminishes autophagy, and reduces cancer formation.

77 These findings indicate that induction of autophagy, and removal of ataxin-3 protein, plays an imp

78 t with Atg5, an E3-like ligase essential for autophagy, and to inhibit the induction of autophagy in

79 ), the ubiquitin-proteasome system (UPS) and autophagy, appear indispensable for longevity in many lo

80 effects of VAPB and PTPIP51 manipulation on autophagy are a consequence of their ER-mitochondria tet

81 Interferon effector functions and autophagy are evolutionarily conserved arms of cell-auto

82 own, the mechanisms that promote and sustain autophagy are less well defined.

83 ur results, we propose direct stimulation of autophagy as a novel mechanism for IL-6-mediated protect

84 We identified autophagy as a pivotal cell response determining the eff

85 We demonstrated IBDV induction of autophagy as a significant increase in puncta of LC3(+)

86 Here, we review the significance of autophagy as an anoikis resistance pathway, focusing on

87 ependent; hyperosmolarity did not upregulate autophagy as previously reported.

88 e control can be facilitated by induction of autophagy, as well as by polyploidization of cancer cell

89 autophagy, demonstrating a role for SDHD in autophagy-associated pathogenesis of differentiated thyr

90 and is able to up-regulate the expression of autophagy-associated proteins, including p62/SQSTM1.

91 In Drosophila, we demonstrate that blocking autophagy at any step of the pathway enhances Ras(V12)-d

92 These peptides induce autophagy at micromolar concentrations in vitro, have ag

93 zyme is rerouted via secretory autophagy, an autophagy-based alternative secretion pathway.

94 Chronic autophagy blockage in several conditions, including DRPL

95 Cleavage of syntaxin 17 inhibits not only autophagy but also staurosporine-induced apoptosis occur

96 podocyte apoptosis, while the inhibition of autophagy by chloroquine (CQ) enhanced palmitic acid-ind

97 we assessed the interplay between Wnt5A and autophagy by combining expression studies in human clini

98 This suggests that the regulation of autophagy by ER-mitochondria signaling is at least partl

99 somes, grows in the host cytosol, and avoids autophagy by expressing three determinants of pathogenes

100 We found that inhibition of autophagy by knocking down the core autophagy protein At

101 ATG4B stimulates autophagy by promoting autophagosome formation through r

102 eased ROS generation, and the stimulation of autophagy by rapamycin (Rap) remarkably suppressed palmi

103 ostprandial epigenetic repression of hepatic autophagy by recruiting histone demethylase LSD1 in resp

104 However, little is known about whether autophagy can regulate NSCs through cell-extrinsic mecha

105 at targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistan

106 Chaperone-mediated autophagy (CMA) serves as quality control during stress

107 markers of mitochondrial damage and impaired autophagy, compared with normal pancreas.

108 s, leading to decreased transcription of the autophagy component microtubule-associated protein 1 lig

109 RTN3-mediated ER-phagy requires conventional autophagy components, but is independent of FAM134B.

110 Autophagy comprises the processes of autophagosome synth

111 vivo Collectively, our results indicate that autophagy contributes to macrophage resistance to L. maj

112 of lysosomal and melanosomal biogenesis and autophagy-control mTORC1 lysosomal recruitment and activ

113 Autophagy coordinates lysosomal destruction of cytosolic

114 Muscle autophagy deficiency did not affect glucose clearance an

115 Unexpectedly, we also detected autophagy deficiency.

116 Furthermore, TBC1D5 depletion in autophagy-deficient cells rescues retromer recruitment t

117 drial respiration rescued differentiation in autophagy-deficient neutrophil precursors.

118 and -H50R variants cause down-regulation of autophagy, demonstrating a role for SDHD in autophagy-as

119 Cells surviving ischemia were autophagy dependent.

120 this could represent a targetable pathway in autophagy-dependent cancers.

121 Thus, we hypothesized that autophagy-dependent secretion of tumor-promoting factors

122 lle acidification but not those defective in autophagy displayed augmented APOL1 toxicity with all is

123 gly, TuMV seems to antagonize NBR1-dependent autophagy during infection by the activity of distinct v

124 ter (GC) cells exhibited the highest rate of autophagy during viral infection.

125 In contrast, autophagy enhancement by means of hepatic gene transfer

126 th a natural disaccharide trehalose, a known autophagy enhancer, delays SG assembly and facilitates t

127 Here we identify AUTEN-99 (autophagy enhancer-99), which activates autophagy in cel

128 anscription factor EB or treatments with the autophagy enhancers rapamycin and Tat-Beclin-1 increased

129 Here, we report that induction of neuronal autophagy enhances BACE1 turnover, which is suppressed b

130 The present study demonstrated that autophagy enhances viral replication at the late stage o

131 screened a small molecule library for novel autophagy-enhancing factors that inhibit the myotubulari

132 ers of pancreatitis, mitochondrial function, autophagy, ER stress, and lipid metabolism were measured

133 MPA treatment of Huh7 cells could suppress autophagy, evidenced by decreased LC3B-II level and conv

134 r, impaired protein synthesis, and increased autophagy flux in response to hyperammonemia, which were

135 d in atheroprone areas, in which endothelial autophagy flux is already blocked.

136 t of rapamycin complex 1-dependent canonical autophagy, GC B cell autophagy occurred predominantly th

137 A variant of the autophagy gene ATG16L1 is associated with Crohn's diseas

138 The cellular degradative pathway of autophagy has a fundamental role in immunity.

139 al and starvation response, we now know that autophagy has a much broader role in biology, including

140 Autophagy has a protective effect on acute liver injury.

141 Specifically, autophagy has been shown to be involved in modulating tu

142 encodes PKCalpha, reverses diabetes-induced autophagy impairment, cellular organelle stress and apop

143 et of rapamycin complex 1, and deficiency of autophagy impairs ammonia detoxification.

144 s (IBDV) was used to investigate the role of autophagy in avibirnavirus replication.

145 tophagy slowed disease, the combined loss of autophagy in both cell types resulted in a lethal sepsis

146 d that both trehalose and rapamycin activate autophagy in BV2 microglial cells and down-regulate the

147 CD4+ T cells on protein quality control and autophagy in cardiomyocytes.

148 -99 (autophagy enhancer-99), which activates autophagy in cell cultures and animal models.

149 ance its nuclear expression induces profound autophagy in cultured renal epithelial cells.

150 ociated with the regulation and operation of autophagy in F. graminearum.

151 Here, we describe a function for autophagy in germline stem cell proliferation.

152 r autophagy, and to inhibit the induction of autophagy in heterologous cells.

153 ses an alternative pathway to mTOR to induce autophagy in host macrophages.

154 cell-cycle arrest, apoptosis, senescence and autophagy in many cancer cells.

155 The requirement of autophagy in Mincle-mediated NET formation was further s

156 017) find that tumors trigger non-autonomous autophagy in neighboring cells and distant organs, thus

157 Loss-of-function studies showed that autophagy in NP cells was not TonEBP-dependent; hyperosm

158 role of TonEBP in hyperosmolarity-dependent autophagy in NP.

159 as associated with the palmitic acid-induced autophagy in podocytes.

160 we report that breast cancer cells activate autophagy in response to palbociclib, and that the combi

161 aimed to understand the role of endothelial autophagy in the atheroprotective effect of high SS.

162 Todoric et al. discover a role for impaired autophagy in the development of PDAC through p62-mediate

163 her, these data unveil a role for mTORC1 and autophagy in the pathogenesis of skeletal disorders and

164 Our results demonstrate a novel role for autophagy in the regulation of microglial cell activatio

165 nfection, and identify an intrinsic role for autophagy in the T. gondii parasite and its close relati

166 ar model of Huntington's disease, and induce autophagy in vivo.

167 or the induction of lipophagy, but not basal autophagy, in DENV-infected cells.

168 nced Mtb survival, whereas rapamycin-induced autophagy increased intracellular killing of Mtb.

169 lesterolemic mice, deficiency in endothelial autophagy increased plaque burden only in the atheroresi

170 eliminated the excessive ROS and suppressed autophagy, indicating that the increased generation of R

171 urther supported by exogenous treatment with autophagy inducer tamoxifen, which rescued the NET forma

172 Importantly, the autophagy-inducing bioactivity was reduced by interferen

173 We aimed to examine HO-1-mediated autophagy induction in human OLT and in a murine OLT mod

174 omponents LKB1 and AMPKalpha, which regulate autophagy induction through their kinase activities.

175 vity of ATG4B to control LC3 processing.Upon autophagy induction, LC3 is cleaved by the protease ATG4

176 se (AMPK) activation, mTORC1 inhibition, and autophagy induction.

177 iminished HO-1-mediated hepatoprotection and autophagy induction.

178 ects of several biological processes such as autophagy, inflammation, proliferation and differentiati

179 gocytosis of the pathogen activates the host autophagy initiation complex (AIC) and the upstream regu

180 gic intermediate membranes and show that the autophagy-initiation complex containing ULK and FIP200 f

181 These findings suggest that the autophagy-initiation complex, the PIS-enriched ER subdom

182 SiRNA knockdown of autophagy initiator beclin-1 enhanced Mtb survival, wher

183 The authors show that the autophagy initiator ULK1 phosphorylates beta1-Ser108 on

184 We identify the autophagy initiator Unc-51-like kinase 1 (ULK1) as a bet

185 nk between the pluripotency factor NANOG and autophagy involved in resistance to CTL under hypoxia.

186 Autophagy is a conserved intracellular degradation pathw

187 Autophagy is a highly conserved degradation process that

188 Autophagy is a lysosomal pathway involved in degradation

189 Autophagy is a ubiquitous pathway that degrades cytosoli

190 Autophagy is activated in response to stress, but its re

191 Autophagy is an evolutionarily conserved intracellular d

192 Autophagy is essential for maintaining cellular homeosta

193 Autophagy is important in a variety of cellular and path

194 Here we show that autophagy is induced in multiple tissues of Caenorhabdit

195 ar fidelity, and while the core machinery of autophagy is known, the mechanisms that promote and sust

196 to advanced melanoma because it ensures that autophagy is maintained at a homeostatic level that prom

197 Our data demonstrate that mTORC1-regulated autophagy is necessary and sufficient for starvation-ind

198 munity, Riffelmacher et al. (2017) show that autophagy is necessary for the release of free fatty aci

199 While previous studies show that autophagy is required for differentiation of other blood

200 Hepatic autophagy is triggered in vivo by hyperammonemia through

201 al via the key lysosomal-mediated process of autophagy is unknown.

202 Here, we report that autophagy is upregulated in HNSCC-associated CAFs, where

203 ys a role in both canonical and noncanonical autophagy, key processes that control the presentation o

204 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the plasma drug co

205 plies neurons with key factors for executing autophagy-lysosomal function.

206 l of DA neurons and in the regulation of the autophagy-lysosomal pathway in the aging brain.

207 The autophagy-lysosomal system plays a key role in the maint

208 y ALS/FTD linked genes play a direct role in autophagy/lysosomal degradation, one of the most importa

209 Consequently, autophagy-lysosome flux and mitochondrial function are c

210 patient fibroblasts HSP70, ubiquitin and the autophagy-lysosome pathway proteins Lamp2 and p62 reloca

211 hway as well as the ubiquitin-proteasome and autophagy-lysosome pathways, resulting in myotube atroph

212 Here we show that a decline in the autophagy-lysosome system contributes to this as evidenc

213 on, Plasmodium parasites are targeted by the autophagy machinery of the host cell, and the PV membran

214 surface results in the translocation of the autophagy machinery to the phagosome and ultimately LC3

215 We report that high expression of the autophagy marker cleaved LC3 expression correlates with

216 Additionally, cfs1 mutants accumulate the autophagy markers ATG8 and NBR1 independently from EDS1.

217 to this as evidenced by a derangement in key autophagy markers in both mouse and human atheroscleroti

218 and hyperammonemic stress response including autophagy markers normally found in portacaval anastomos

219 embrane (PVM) becomes decorated with several autophagy markers, including LC3 (microtubule-associated

220 ron transport chain activity and accumulated autophagy markers.

221 olved measures to antagonize or even exploit autophagy mechanisms for the benefit of infection.

222 ria parasite Plasmodium is accompanied by an autophagy-mediated host response directly targeting the

223 Inhibiting autophagy-mediated lipid degradation or fatty acid oxida

224 TRIM23 was critical for autophagy-mediated restriction of multiple viruses, and

225 They also reveal that the onset of autophagy might serve as a protective mechanism against

226 ation of PI3 kinase-mTOR signaling, impaired autophagy, mitochondrial dysfunction, stem cell exhausti

227 x 1-dependent canonical autophagy, GC B cell autophagy occurred predominantly through a noncanonical

228 Thus, Smurf1 is required for selective autophagy of Mtb and host defense against tuberculosis i

229 We show that Smurf1 facilitates selective autophagy of the human pathogen Mycobacterium tuberculos

230 status that lead to apoptosis, necrosis, and autophagy of tumour cells.

231 en the endolysosomal degradation pathway and autophagy on the proteolytic processing and turnover of

232 BL/6 and Tlr3/7/9(-/-) mice, indicating that autophagy operates downstream of TLR signaling and is re

233 roteolysis of misfolded collagen X by either autophagy or proteasomal degradation, thereby reducing i

234 Inhibition of chaperone expression, autophagy or the proteasome, in addition to compromising

235 acrophages defective in a related, canonical autophagy pathway (Atg14, Ulk1, or cGAS).

236 an cells, the ER is degraded via a selective autophagy pathway (ER-phagy), mediated by two specific r

237 ificant portion of BACE1 is recruited to the autophagy pathway and co-migrates robustly with autophag

238 receptor protein DSK2 and is targeted to the autophagy pathway during stress via the interaction of D

239 tion at the late stage of infection, and the autophagy pathway facilitates IBDV replication complex f

240 ollectively, our data identify the canonical autophagy pathway in DCs as a molecular target of Foxp3+

241 letion of Atg7, a necessary component of the autophagy pathway, in beta cells by pancreatic intra-duc

242 s in control of amplitude and selectivity of autophagy pathways as well as their impact on the develo

243 The secretory and autophagy pathways can be thought of as the biosynthetic

244 R), AMP-activated protein kinase (AMPK), and autophagy pathways-processes implicated in longevity-on

245 Taken together, we conclude that autophagy plays a critical role in growth, asexual/sexua

246 Autophagy plays a paramount role in mammalian antiviral

247 Autophagy plays important roles in maintaining cellular

248 gy, the selective removal of mitochondria by autophagy, positively regulates hepatic cancer stem cell

249 We also found that NBR1-independent bulk autophagy prevents premature plant death, thus extending

250 te that, in contrast to tumor cells in which autophagy promotes caspase-independent cell death, ATG16

251 ition of autophagy by knocking down the core autophagy protein Atg5 promotes cystogenesis, while acti

252 The autophagy protein Beclin1 regulates activation of Rab5 a

253 biquitin-binding autophagy adaptor NBR1, the autophagy protein LC3, and the lysosomal marker LAMP1 to

254 e how host cells co-opt sequential action of autophagy proteins and IFN-inducible GTPases to inhibit

255 ize the existing literature concerning which autophagy proteins are capable of curvature recognition.

256 al that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate

257 nting autophagy signalling via activation of autophagy receptors (OPTN and NDP52), thereby alleviatin

258 l as to analyze the requirement for SIRT1 in autophagy regulation by HO-1.

259 Here we report the key autophagy regulators modulated by diabetes in the murine

260 consequent down-regulation of FOXO3a-target autophagy-related gene (ATG) expression.

261 Autophagy-related genes are required for the thermoresis

262 patocytes, autophagy was inhibited by 3MA or autophagy-related protein 7 (Atg7) small interfering RNA

263 and by measuring LC3B protein lipidation and autophagy-related protein expressions.

264 Autophagy-related proteins such as Beclin-1 are involved

265 , moreover, association of both Atg9 and the autophagy-related SNARE protein syntaxin17 with the auto

266 associated with integrins that modulate the autophagy response and dictate the balance between cell

267 in1 in in vitro human cells did not block an autophagy response, but attenuated the expression of sev

268 Dietary cyclocreatine tempered autophagy, restored microglial clustering around plaques

269 in B cells alone enhanced this noncanonical autophagy, resulting in changes of mitochondrial homeost

270 arance of damaged mitochondria by augmenting autophagy signalling via activation of autophagy recepto

271 Although a loss of DC autophagy slowed disease, the combined loss of autophagy

272 Overall, our findings establish a pathway of autophagy specific to the DNA damage response.

273 ine metabolism and subsequent proliferation, autophagy, stress resistance, and cancer formation.

274 We show that accumulation of the autophagy substrate p62/SQSTM1 in stressed Kras(G12D) ac

275 such as apoptosis, necrosis, paraptosis, and autophagy, suggesting that a novel mode of action may be

276 a cell death due to a major dysregulation of autophagy, suggesting that alpha-synuclein is highly ben

277 Autophagy supports cell growth and survival autonomously

278 our results indicated that hypoxia-regulated autophagy suppresses metastasis in breast cancer by prev

279 kinase (FAK) is necessary for PE-stimulated autophagy suppression and subsequent initiation of hyper

280 interactions provide more information about autophagy than all previous datasets, producing a second

281 onverge on two protein complexes to initiate autophagy: the ULK1 (unc51-like autophagy activating kin

282 rial fission factor Drp1 in fed cells and in autophagy through interaction with Atg14L and other SNAR

283 detects damaged endomembranes and activates autophagy through recruitment of the cargo receptor nucl

284 ular pathogens is the homeostatic process of autophagy, through which cells capture unwanted intracel

285 However, the contribution of autophagy to FK866-conferred hepatoprotection is still u

286 t synaptic homeostasis during aging requires autophagy to regulate protein homeostasis.

287 ns of clinical trials that aim to manipulate autophagy to treat (or prevent) disease.

288 tic gene transfer of the master regulator of autophagy transcription factor EB or treatments with the

289 cells can activate p62 and induce selective autophagy upon the accumulation of autophagic cargoes.

290 5 promotes cystogenesis, while activation of autophagy using a specific inducer Beclin-1 peptide amel

291 Suppression of autophagy via hypoxia-induced expression of the kinase-d

292 Autophagy was evaluated using electron microscopic detec

293 In primary hepatocytes, autophagy was inhibited by 3MA or autophagy-related prot

294 Autophagy was monitored biochemically and cell death was

295 Metabolic derailment and autophagy were offset in vitro through Dectin-1, a recep

296 Starvation induces liver autophagy, which is thought to provide nutrients for use

297 Indeed, MSCs exhibited intrinsic autophagy, which was up-regulated after activation with

298 tegy is based on the idea that inhibition of autophagy will increase drug sensitivity and kill more c

299 rum-free conditions, NP cells did not induce autophagy with increasing osmolarity.

300 d to as PMI), which drives mitochondria into autophagy without collapsing their membrane potential (D