ライフサイエンスコーパス: autoproteolysis

1 64A conferred significant protection against autoproteolysis.

2 ining an affinity tag and modified to resist autoproteolysis.

3 proceed via mechanisms which do not involve autoproteolysis.

4 te binding pocket undergo rearrangement upon autoproteolysis.

5 RO(FUR) when compared to PRO(PC1) to enhance autoproteolysis.

6 ), we proposed a mechanism of intramolecular autoproteolysis.

7 inhibitor or ligand and is poised to undergo autoproteolysis.

8 odule with traits matching those ascribed to autoproteolysis.

9 iated aggregation is above the threshold for autoproteolysis.

10 he bacterial cell surface via intermolecular autoproteolysis.

11 was enhanced substantially by inhibition of autoproteolysis.

12 hereas the C-terminal domain is required for autoproteolysis.

13 vation of amidase activity by intramolecular autoproteolysis.

14 l effect on the LDL receptor, PCSK9 requires autoproteolysis.

15 iated adherence is enhanced by inhibition of autoproteolysis.

16 reserved during the folding of GA to trigger autoproteolysis.

17 chelation, suggesting that release involves autoproteolysis.

18 ought to further define the mechanism of Hap autoproteolysis.

19 ominantly a nuclear protease which undergoes autoproteolysis.

20 of respiratory secretions that inhibits Hap autoproteolysis.

21 uggesting a His-Thr-Thr active triad for the autoproteolysis.

22 human enzyme to be a prerequisite to trigger autoproteolysis.

23 is decrease was found to be due, in part, to autoproteolysis.

24 d the enzyme activity presumably by reducing autoproteolysis.

25 ered agonist of the receptor, but not on its autoproteolysis, a characteristic biochemical feature of

26 port here a 1.9-A-resolution structure of an autoproteolysis-active precursor (a T152C mutant) that i

27 The p52 fragment has a low level of autoproteolysis activity that possibly increases the aut

28 In vitro autoproteolysis allowed the mutant enzymes to be activat

29 This upregulation resulted in limited autoproteolysis and activation of HtrA1.

30 These results highlight the critical role of autoproteolysis and an intermolecular mechanism of cleav

31 ostatin4.5 (AS4.5) is the product of plasmin autoproteolysis and consists of kringles 1 to 4 and appr

32 ted signaling of a GPR56 mutant defective in autoproteolysis and hence, in Stachel peptide exposure.

33 In contrast, ASC is critical for caspase-1 autoproteolysis and IL-1beta secretion by the NLRC4, NLR

34 hreonine, which plays a central role in both autoproteolysis and in its amidase activity.

35 that overproduction of BofC inhibits SpoIVB autoproteolysis and leads to a delay in proteolytic clea

36 ke serine protease domain that mediates SltB autoproteolysis and proteolytic cleavage of SltA.

37 nthrax lethal toxin (LeTx)-induced caspase-1 autoproteolysis and speck formation.

38 threshold of Hap precursor was required for autoproteolysis and that this threshold approximated exp

39 This constraint is released upon autoproteolysis and we propose a molecular basis for the

40 p26 segment is generated from p67 due to its autoproteolysis and whether p26 is required for the prot

41 ceptor binding, endocytosis, pore formation, autoproteolysis, and glucosyltransferase-mediated modifi

42 ude of Hap expression, the efficiency of Hap autoproteolysis, and the level of Hap-mediated adherence

43 n cytomegalovirus (CMV), assemblin undergoes autoproteolysis at an internal (I) site located near the

44 Capsids undergo autoproteolysis at residue 570, generating the 74-residu

45 trast to other caspases, we demonstrate that autoproteolysis at the second cleavage site, Asp316, is

46 IV protease (PR), we noted that it underwent autoproteolysis (autolysis) to give discrete cleavage pr

47 t and to presumably form the active site for autoproteolysis but not for the chemistry of cleavage.

48 These nucleoli lacked significant autoproteolysis, but many nucleolar proteins and autoant

49 bstrate with positive cooperativity, and its autoproteolysis can be stimulated with exogenous substra

50 nt proteins released from the large toxin by autoproteolysis catalyzed by an embedded cysteine protea

51 of the nucleoli may attribute to their poor autoproteolysis, causing autologous immune stimulation u

52 ike proprotein convertases, TIMPs, shedding, autoproteolysis, dimerization, exocytosis, endocytosis,

53 ivation requires a RecA-stimulated repressor autoproteolysis event, with cleavage occurring precisely

54 First, autoproteolysis generating intermediate products, at lea

55 Kinetic analysis of Hap autoproteolysis in bacteria expressing Hap under control

56 48 cleavage and the functional importance of autoproteolysis in the context of hypovirus replication

57 nts for p29 and p48 cleavage and the role of autoproteolysis in the context of hypovirus replication.

58 A and other S24 peptidases, NG1427 undergoes autoproteolysis in vitro, which is facilitated by either

59 l of an inducible promoter demonstrated that autoproteolysis increases as the density of Hap precurso

60 GPS to be part of a larger domain named GPCR autoproteolysis inducing (GAIN) domain.

61 ately 320-residue domain that we termed GPCR-Autoproteolysis INducing (GAIN) domain.

62 mone-binding, and G-protein-coupled receptor autoproteolysis-inducing (GAIN) domains).

63 in-like (PLL) and G protein-coupled receptor autoproteolysis-inducing (GAIN)] in its ECR.

64 n inverse-agonist monobody, revealing a GPCR-Autoproteolysis-Inducing domain and a previously unident

65 cis-Autoproteolysis is a post-translational modification nec

66 and HMGB1 in circulation, although caspase-1 autoproteolysis is abolished.

67 Hap autoproteolysis is mediated by Ser(243) and occurs at LN

68 A two-step dimerization mechanism to trigger autoproteolysis is proposed to accommodate the data pres

69 An obstacle to our understanding of GA autoproteolysis is the uncertainty concerning its quater

70 at the P1 position in the NS3-NS4A (NS3-4A) autoproteolysis junction, while a cysteine is maintained

71 However, after autoproteolysis, many enzymes, like ThnT, are observed t

72 orms are processed into two peptides through autoproteolysis mediated by the C-terminal domain of hNu

73 s we show that CwpV undergoes intramolecular autoproteolysis, most likely facilitated by a N-O acyl s

74 volved in cell adhesion has a characteristic autoproteolysis motif of HLT/S known as the GPCR proteol

75 In intact cells, caspase-12 autoproteolysis occurred in the inhibitory complex conta

76 d site-directed mutagenesis established that autoproteolysis occurs at LT1046-7, FA1077-8, and FS1067

77 olytic activity (HapS243A) demonstrated that autoproteolysis occurs by an intermolecular mechanism.

78 Autoproteolysis of caspase-8 may be a mechanism for incr

79 eolysis activity that possibly increases the autoproteolysis of full-length p67.

80 Autoproteolysis of SpoIVB is tightly linked to the initi

81 cteriophage usually involves RecA-stimulated autoproteolysis of the bacteriophage repressor protein.

82 aspase-8 and is followed by specific limited autoproteolysis of the linker which separates the two su

83 present as a dimer, how can RecA-stimulated autoproteolysis play a role in bacteriophage induction?

84 This cis-autoproteolysis possesses unique kinetics characterized

85 proteinase, HTLV-1 proteinase also undergoes autoproteolysis rapidly upon renaturation to produce two

86 est that the model for calpain activation by autoproteolysis requires re-investigation.

87 cal or E. coli RecA proteins or high pH, and autoproteolysis requires the active and cleavage site re

88 Thr/Ser/Cys-152 in activation suggests that autoproteolysis resembles proteolysis by serine/cysteine

89 PKD) proteins constitutes a highly conserved autoproteolysis sequence, but its catalytic mechanism re

90 based on a precursor structure paused at pre-autoproteolysis stage by a reversible inhibitor (glycine

91 domain is both necessary and sufficient for autoproteolysis, suggesting an autoproteolytic mechanism

92 The YscP-mediated inhibition of YscU autoproteolysis suggests that the cleavage event may act

93 g temperatures of GA dimers before and after autoproteolysis suggests two states of dimerization in t

94 was hypothesized to be critical for driving autoproteolysis through an N-O acyl shift.

95 imerization of GA plays an essential role in autoproteolysis to activate the amidase activity.

96 surface globular beta-actin mediates plasmin autoproteolysis to AS4.5.

97 iate plasmin binding to the cell surface and autoproteolysis to AS4.5.

98 sid and digests the delta domain followed by autoproteolysis to produce the metastable Prohead-II.

99 m a single chain precursor by intramolecular autoproteolysis to yield the N-terminal nucleophile.

100 tivity, and purified Cpl appeared to undergo autoproteolysis upon transfer to inhibitor-free buffer.

101 A mechanism of autoproteolysis via an N-O acyl shift was proposed to re

102 t to promote bacterial aggregation only when autoproteolysis was inhibited, indicating that the thres

103 However, the role of this autoproteolysis, which directly activates executioner ca

104 Then plasmin undergoes autoproteolysis within the inner loop of kringle 5, whic