ライフサイエンスコーパス: autosomal dominant polycystic kidney

1 gene responsible for the most common form of autosomal dominant polycystic kidney disease ( PKD1 ) is

2 Autosomal dominant polycystic kidney disease (AD-PKD) is

3 and those with inherited co-deletions of the autosomal dominant polycystic kidney disease (ADPKD) 1 g

4 Autosomal dominant polycystic kidney disease (ADPKD) aff

5 Nine patients with autosomal dominant polycystic kidney disease (ADPKD) and

6 Hypertension develops early in patients with autosomal dominant polycystic kidney disease (ADPKD) and

7 comparator groups, and comparing with IgAN, autosomal dominant polycystic kidney disease (ADPKD) and

8 Hypertension is common in autosomal dominant polycystic kidney disease (ADPKD) and

9 The mechanisms of cystogenesis in autosomal dominant polycystic kidney disease (ADPKD) are

10 Patients with autosomal dominant polycystic kidney disease (ADPKD) are

11 Most cases of autosomal dominant polycystic kidney disease (ADPKD) are

12 Prenatal forms of autosomal dominant polycystic kidney disease (ADPKD) are

13 Bardet-Biedl syndrome (BBS) and autosomal dominant polycystic kidney disease (ADPKD) are

14 not only as a novel epigenetic regulator of autosomal dominant polycystic kidney disease (ADPKD) but

15 of the PKD1 gene mutated in the majority of autosomal dominant polycystic kidney disease (ADPKD) cas

16 ancreatic cysts in a cohort of patients with autosomal dominant polycystic kidney disease (ADPKD) com

17 Autosomal dominant polycystic kidney disease (ADPKD) con

18 In autosomal dominant polycystic kidney disease (ADPKD) cys

19 Autosomal dominant polycystic kidney disease (ADPKD) cys

20 Autosomal dominant polycystic kidney disease (ADPKD) des

21 cation channel homologous to the human Pkd2 autosomal dominant polycystic kidney disease (ADPKD) gen

22 human genomic fragment containing the entire autosomal dominant polycystic kidney disease (ADPKD) gen

23 In C. elegans and mammals, the autosomal dominant polycystic kidney disease (ADPKD) gen

24 Patients with autosomal dominant polycystic kidney disease (ADPKD) hav

25 ated that approximately 15% of families with autosomal dominant polycystic kidney disease (ADPKD) hav

26 sms of disease causation and modification in autosomal dominant polycystic kidney disease (ADPKD) hav

27 mparable to published US criteria for type 1 autosomal dominant polycystic kidney disease (ADPKD) if

28 Mutations in the PKD2 gene cause autosomal dominant polycystic kidney disease (ADPKD) in

29 tility of ultrasonography (US) in diagnosing autosomal dominant polycystic kidney disease (ADPKD) in

30 similar in many respects to that seen in the autosomal dominant polycystic kidney disease (ADPKD) in

31 Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) inv

32 The principal extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD) inv

33 Autosomal Dominant Polycystic Kidney Disease (ADPKD) is

34 The course of autosomal dominant polycystic kidney disease (ADPKD) is

35 Autosomal dominant polycystic kidney disease (ADPKD) is

36 Autosomal dominant polycystic kidney disease (ADPKD) is

37 Autosomal dominant polycystic kidney disease (ADPKD) is

38 Autosomal dominant polycystic kidney disease (ADPKD) is

39 Autosomal dominant polycystic kidney disease (ADPKD) is

40 Autosomal dominant polycystic kidney disease (ADPKD) is

41 Autosomal dominant polycystic kidney disease (ADPKD) is

42 Mutation-based molecular diagnostics of autosomal dominant polycystic kidney disease (ADPKD) is

43 Diagnosis and treatment of autosomal dominant polycystic kidney disease (ADPKD) is

44 Autosomal dominant polycystic kidney disease (ADPKD) is

45 Autosomal dominant polycystic kidney disease (ADPKD) is

46 Autosomal dominant polycystic kidney disease (ADPKD) is

47 Autosomal dominant polycystic kidney disease (ADPKD) is

48 Autosomal dominant polycystic kidney disease (ADPKD) is

49 Autosomal dominant polycystic kidney disease (ADPKD) is

50 Autosomal dominant polycystic kidney disease (ADPKD) is

51 Autosomal dominant polycystic kidney disease (ADPKD) is

52 Autosomal dominant polycystic kidney disease (ADPKD) is

53 Autosomal dominant polycystic kidney disease (ADPKD) is

54 Autosomal dominant polycystic kidney disease (ADPKD) is

55 The leading cause of death in autosomal dominant polycystic kidney disease (ADPKD) is

56 Autosomal dominant polycystic kidney disease (ADPKD) is

57 Autosomal dominant polycystic kidney disease (ADPKD) is

58 Autosomal dominant polycystic kidney disease (ADPKD) is

59 Autosomal dominant polycystic kidney disease (ADPKD) is

60 Autosomal dominant polycystic kidney disease (ADPKD) is

61 Cystogenesis associated with autosomal dominant polycystic kidney disease (ADPKD) is

62 Autosomal dominant polycystic kidney disease (ADPKD) is

63 Autosomal dominant polycystic kidney disease (ADPKD) is

64 Autosomal dominant polycystic kidney disease (ADPKD) is

65 Autosomal dominant polycystic kidney disease (ADPKD) is

66 Autosomal dominant polycystic kidney disease (ADPKD) is

67 Autosomal dominant polycystic kidney disease (ADPKD) is

68 Autosomal dominant polycystic kidney disease (ADPKD) is

69 Autosomal dominant polycystic kidney disease (ADPKD) is

70 Autosomal dominant polycystic kidney disease (ADPKD) is

71 Autosomal dominant polycystic kidney disease (ADPKD) is

72 Autosomal dominant polycystic kidney disease (ADPKD) is

73 Autosomal dominant polycystic kidney disease (ADPKD) is

74 Autosomal dominant polycystic kidney disease (ADPKD) is

75 Autosomal dominant polycystic kidney disease (ADPKD) is

76 Autosomal dominant polycystic kidney disease (ADPKD) is

77 Autosomal dominant polycystic kidney disease (ADPKD) is

78 Autosomal dominant polycystic kidney disease (ADPKD) is

79 Autosomal dominant polycystic kidney disease (ADPKD) is

80 Autosomal dominant polycystic kidney disease (ADPKD) is

81 Autosomal dominant polycystic kidney disease (ADPKD) is

82 Autosomal dominant polycystic kidney disease (ADPKD) is

83 Mutation screening of the major autosomal dominant polycystic kidney disease (ADPKD) loc

84 hip between renal volume and hypertension in autosomal dominant polycystic kidney disease (ADPKD) occ

85 Autosomal dominant polycystic kidney disease (ADPKD) occ

86 Patients with autosomal dominant polycystic kidney disease (ADPKD) oft

87 Autosomal dominant polycystic kidney disease (ADPKD) oft

88 Autosomal dominant polycystic kidney disease (ADPKD) pro

89 sequence similarity between a region of the autosomal dominant polycystic kidney disease (ADPKD) pro

90 ty with disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) rem

91 Autosomal dominant polycystic kidney disease (ADPKD) res

92 The major form of autosomal dominant polycystic kidney disease (ADPKD) res

93 Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) sig

94 Autosomal dominant polycystic kidney disease (ADPKD) str

95 Patients with autosomal dominant polycystic kidney disease (ADPKD) typ

96 The course of autosomal dominant polycystic kidney disease (ADPKD) var

97 Adults with autosomal dominant polycystic kidney disease (ADPKD) who

98 disease, mark a population of patients with autosomal dominant polycystic kidney disease (ADPKD) who

99 Polycystic liver disease may complicate autosomal dominant polycystic kidney disease (ADPKD), a

100 embrane proteins, which, when mutated, cause autosomal dominant polycystic kidney disease (ADPKD), a

101 Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney disease (ADPKD), a

102 g the cilia-localized Pkd1 protein result in autosomal dominant polycystic kidney disease (ADPKD), a

103 family (polycystin-1 and -2) are mutated in autosomal dominant polycystic kidney disease (ADPKD), an

104 Many renal cystic diseases, including autosomal dominant polycystic kidney disease (ADPKD), ar

105 gene product of PKD2, whose mutations cause autosomal dominant polycystic kidney disease (ADPKD), be

106 protein mutated in the majority of cases of autosomal dominant polycystic kidney disease (ADPKD), bu

107 latory protein polycystin-1 (PC1) results in autosomal dominant polycystic kidney disease (ADPKD), ch

108 Autosomal dominant polycystic kidney disease (ADPKD), ch

109 In autosomal dominant polycystic kidney disease (ADPKD), cy

110 In autosomal dominant polycystic kidney disease (ADPKD), cy

111 PKD2, the second gene for the autosomal dominant polycystic kidney disease (ADPKD), en

112 PKD2, mutations in which cause autosomal dominant polycystic kidney disease (ADPKD), en

113 seases such as mucolipidosis type IV (MLIV), autosomal dominant polycystic kidney disease (ADPKD), fa

114 D2, the gene defective in the second form of autosomal dominant polycystic kidney disease (ADPKD), ha

115 merulonephritis and compared with those with autosomal dominant polycystic kidney disease (ADPKD), in

116 hich is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is

117 rogression varies widely among patients with autosomal dominant polycystic kidney disease (ADPKD), ne

118 Autosomal dominant polycystic kidney disease (ADPKD), of

119 Autosomal dominant polycystic kidney disease (ADPKD), on

120 c Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant polycystic kidney disease (ADPKD), on

121 or almost all clinically identified cases of autosomal dominant polycystic kidney disease (ADPKD), on

122 A second gene for autosomal dominant polycystic kidney disease (ADPKD), PK

123 The PKD1 gene accounts for 85% of autosomal dominant polycystic kidney disease (ADPKD), th

124 Autosomal dominant polycystic kidney disease (ADPKD), th

125 Autosomal dominant polycystic kidney disease (ADPKD), Ty

126 ure of the polycystic liver that accompanies autosomal dominant polycystic kidney disease (ADPKD), we

127 progression in an orthologous mouse model of autosomal dominant polycystic kidney disease (ADPKD).

128 large multi-exon genes, PKD1 and PKD2, cause autosomal dominant polycystic kidney disease (ADPKD).

129 disease is a well described manifestation of autosomal dominant polycystic kidney disease (ADPKD).

130 tations in PKD1 are the most common cause of autosomal dominant polycystic kidney disease (ADPKD).

131 stin-1 (PC1), contribute to >85% of cases of autosomal dominant polycystic kidney disease (ADPKD).

132 on are a continuous concern in patients with autosomal dominant polycystic kidney disease (ADPKD).

133 D1 and TRPP2 account for nearly all cases of autosomal dominant polycystic kidney disease (ADPKD).

134 f Src has been linked to the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD).

135 the focal nature for renal cyst formation in autosomal dominant polycystic kidney disease (ADPKD).

136 ics of sensory behavior, cilia function, and autosomal dominant polycystic kidney disease (ADPKD).

137 mplicated in mediating disease escalation in autosomal dominant polycystic kidney disease (ADPKD).

138 nction, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD).

139 werful model to study the molecular basis of autosomal dominant polycystic kidney disease (ADPKD).

140 tic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD).

141 the disease as it manifests in patients with autosomal dominant polycystic kidney disease (ADPKD).

142 d fluid secretion by the cystic epithelia in autosomal dominant polycystic kidney disease (ADPKD).

143 is detected in kidneys of all patients with autosomal dominant polycystic kidney disease (ADPKD).

144 luid filled cysts in MDCK cells and in human autosomal dominant polycystic kidney disease (ADPKD).

145 of unknown function that is responsible for autosomal dominant polycystic kidney disease (ADPKD).

146 umulation are responsible for cyst growth in autosomal dominant polycystic kidney disease (ADPKD).

147 Mutations in polycystin-2 (PC2) lead to autosomal dominant polycystic kidney disease (ADPKD).

148 in infants with a family history of classic, autosomal dominant polycystic kidney disease (ADPKD).

149 he progressive enlargement of renal cysts in autosomal dominant polycystic kidney disease (ADPKD).

150 elopment of hypertension and cystogenesis in autosomal dominant polycystic kidney disease (ADPKD).

151 ion in the PKD1 or PKD2 gene, which leads to autosomal dominant polycystic kidney disease (ADPKD).

152 t growth and progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD).

153 C2) cause the common genetic kidney disorder autosomal dominant polycystic kidney disease (ADPKD).

154 ciliary function causes ciliopathies such as autosomal dominant polycystic kidney disease (ADPKD).

155 r PKD2 (15%) account for almost all cases of autosomal dominant polycystic kidney disease (ADPKD).

156 entified as one of the genes responsible for autosomal dominant polycystic kidney disease (ADPKD).

157 a variety of diseases, including cancer and autosomal dominant polycystic kidney disease (ADPKD).

158 PCLD is most often associated with autosomal dominant polycystic kidney disease (ADPKD); ho

159 previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; est

160 sial in patients with refractory symptoms of autosomal dominant polycystic kidney disease (APKD) in n

161 ers of patients with autosomal recessive and autosomal dominant polycystic kidney disease (ARPKD and

162 identification of the genes responsible for autosomal dominant polycystic kidney disease (PKD) and a

163 Autosomal dominant polycystic kidney disease (PKD) is ca

164 Autosomal dominant polycystic kidney disease (PKD) is th

165 m of Radiologic Imaging Study of PKD (CRISP) autosomal dominant polycystic kidney disease (PKD) popul

166 icking defects may be an underlying cause of autosomal dominant polycystic kidney disease (PKD), and

167 signaling in in vitro and in vivo models of autosomal dominant polycystic kidney disease (PKD).

168 of renal cystic disease in the major form of autosomal dominant polycystic kidney disease (PKD1) is h

169 function and its role in the development of autosomal dominant polycystic kidney disease (PKD1) requ

170 ncluding the gene most frequently mutated in autosomal dominant polycystic kidney disease (PKD1).

171 A cohort of 234 patients with autosomal dominant polycystic kidney disease and baselin

172 quaretics are promising for the treatment of autosomal dominant polycystic kidney disease and have be

173 lvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Out

174 hibit hepatorenal pathology resembling human autosomal dominant polycystic kidney disease and represe

175 Most cases of autosomal dominant polycystic kidney disease are caused

176 Patients with autosomal dominant polycystic kidney disease are increas

177 attern is unchanged in orthologous models of autosomal dominant polycystic kidney disease due to muta

178 Autosomal dominant polycystic kidney disease has been li

179 Autosomal dominant polycystic kidney disease is a geneti

180 Autosomal dominant polycystic kidney disease is an impor

181 Autosomal dominant polycystic kidney disease is caused b

182 Autosomal dominant polycystic kidney disease is caused b

183 Autosomal dominant polycystic kidney disease is characte

184 Autosomal dominant polycystic kidney disease is largely

185 Autosomal dominant polycystic kidney disease is the most

186 Autosomal dominant polycystic kidney disease is the most

187 Although autosomal dominant polycystic kidney disease is transmit

188 D2) responsible for the majority of cases of autosomal dominant polycystic kidney disease is unknown.

189 ysregulation of these or similar channels in autosomal dominant polycystic kidney disease may contrib

190 The most severe form of autosomal dominant polycystic kidney disease occurs in p

191 ogues is equally effective for patients with autosomal dominant polycystic kidney disease or polycyst

192 a control mechanism that may play a role in autosomal dominant polycystic kidney disease pathogenesi

193 uates factors that may predict and/or effect autosomal dominant polycystic kidney disease progression

194 2 forms a calcium-sensitive complex with the autosomal dominant polycystic kidney disease protein pol

195 A common inherited cause of renal failure, autosomal dominant polycystic kidney disease results fro

196 For patients with autosomal dominant polycystic kidney disease that progre

197 s a genetic modifier for disease severity in autosomal dominant polycystic kidney disease that result

198 ast 85% of the mutations present in affected autosomal dominant polycystic kidney disease type 1 pedi

199 Although autosomal dominant polycystic kidney disease type 2 (PKD

200 an with end-stage renal disease secondary to autosomal dominant polycystic kidney disease was referre

201 nd others may help to identify patients with autosomal dominant polycystic kidney disease who are mos

202 polycystin-1 family (the protein mutated in autosomal dominant polycystic kidney disease).

203 Autosomal dominant polycystic kidney disease, a common c

204 Humans heterozygous for PKD1 or PKD2 develop autosomal dominant polycystic kidney disease, a common g

205 Mutations of either PKD1 or PKD2 cause autosomal dominant polycystic kidney disease, a syndrome

206 Mutations in polycystin-1 (PC1) give rise to autosomal dominant polycystic kidney disease, an importa

207 cultured cells from patients who suffer from autosomal dominant polycystic kidney disease, and this P

208 el of HIVAN, in HIVAN biopsy samples, and in autosomal dominant polycystic kidney disease, another re

209 2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to

210 nd pathologically identical to those seen in autosomal dominant polycystic kidney disease, but withou

211 ate that Pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease, developed

212 These properties of PC2 are lost in autosomal dominant polycystic kidney disease, emphasizin

213 e for renal and systemic diseases, including autosomal dominant polycystic kidney disease, Gitelman s

214 in encoded by the principal gene involved in autosomal dominant polycystic kidney disease, has been i

215 oduct of the gene most frequently mutated in autosomal dominant polycystic kidney disease, has reveal

216 specific Pkd1(flox/-);Ksp-Cre mouse model of autosomal dominant polycystic kidney disease, in which t

217 ein defective in a majority of patients with autosomal dominant polycystic kidney disease, is a ubiqu

218 the gene responsible for the second form of autosomal dominant polycystic kidney disease, is highly

219 ients referred with a suspected diagnosis of autosomal dominant polycystic kidney disease, medullary

220 The gene responsible for the second form of autosomal dominant polycystic kidney disease, PKD2, has

221 Autosomal dominant polycystic kidney disease, the most c

222 ystin 1 and polycystin 2 are responsible for autosomal dominant polycystic kidney disease, the most c

223 Major genes for tuberous sclerosis and autosomal dominant polycystic kidney disease, TSC2 and P

224 To gain insights into autosomal dominant polycystic kidney disease, we perform

225 tations in pkd2 result in the type 2 form of autosomal dominant polycystic kidney disease, which acco

226 Here we focus on autosomal dominant polycystic kidney disease, which is a

227 Mutations in PKD1 result in autosomal dominant polycystic kidney disease, which is c

228 which are the principal proteins involved in autosomal dominant polycystic kidney disease, with polar

229 Furthermore, autosomal dominant polycystic kidney disease-associated

230 gy, with mutations in either protein causing autosomal dominant polycystic kidney disease.

231 ons are responsible for approximately 15% of autosomal dominant polycystic kidney disease.

232 of polycystin-1 (PC1) is the major cause of autosomal dominant polycystic kidney disease.

233 flow-stimulated calcium signaling and causes autosomal dominant polycystic kidney disease.

234 annel, is frequently mutated or truncated in autosomal dominant polycystic kidney disease.

235 and PC2 are membrane proteins implicated in autosomal dominant polycystic kidney disease.

236 mediating cyst formation and enlargement in autosomal dominant polycystic kidney disease.

237 thogenesis of cystic renal disorders such as autosomal dominant polycystic kidney disease.

238 mechanism for progressive cyst formation in autosomal dominant polycystic kidney disease.

239 represents a potentially novel treatment for autosomal dominant polycystic kidney disease.

240 nsible for approximately 15% of all cases of autosomal dominant polycystic kidney disease.

241 Mutations in either PKD1 or PKD2 cause autosomal dominant polycystic kidney disease.

242 leading cause of morbidity and mortality in autosomal dominant polycystic kidney disease.

243 Mutations in polycystin-2 (PC2) cause autosomal dominant polycystic kidney disease.

244 of its function causes cystogenesis in human autosomal dominant polycystic kidney disease.

245 its function causes cyst formation in human autosomal dominant polycystic kidney disease.

246 PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease.

247 sensitive channel, with defects resulting in autosomal dominant polycystic kidney disease.

248 lial cells and when mutated results in human autosomal dominant polycystic kidney disease.

249 roduct of the PKD1 gene, which is mutated in autosomal dominant polycystic kidney disease.

250 in turn could contribute to the pathology of autosomal dominant polycystic kidney disease.

251 leading cause of morbidity and mortality in autosomal dominant polycystic kidney disease.

252 pithelia are associated with mouse and human autosomal dominant polycystic kidney disease.

253 ng polycystin-1 (PC1) and polycystin-2 cause autosomal dominant polycystic kidney disease.

254 ation channel that, when mutated, results in autosomal dominant polycystic kidney disease.

255 hat can be used to study the pathogenesis of autosomal dominant polycystic kidney disease.

256 2), a Ca(2+)-permeable cation channel, cause autosomal dominant polycystic kidney disease.

257 espectively, account for almost all cases of autosomal dominant polycystic kidney disease.

258 adult kidney expression of PRKX was found in autosomal dominant polycystic kidney disease.

259 KD2, genes that are mutated in most cases of autosomal dominant polycystic kidney disease.

260 pathways, and its deletion suffices to cause autosomal dominant polycystic kidney disease.

261 ne models resembles that seen in humans with autosomal dominant polycystic kidney disease.

262 iation with ACKD and one in association with autosomal dominant polycystic kidney disease.

263 nt of large cystic kidneys that characterize autosomal dominant polycystic kidney disease.

264 KD2, genes that are mutated in most cases of autosomal dominant polycystic kidney disease.

265 Germline mutations in PKD2 cause autosomal dominant polycystic kidney disease.

266 fer from that of 273 control recipients with autosomal dominant polycystic kidney disease.

267 tion may be a new target in the treatment of autosomal dominant polycystic kidney disease.

268 the most common extrarenal manifestation in autosomal dominant polycystic kidney disease.

269 erged as a promising therapeutic strategy in autosomal dominant polycystic kidney disease.

270 nselective cation channel that is mutated in autosomal dominant polycystic kidney disease.

271 nd polycystin-2 (PC2), respectively, lead to autosomal dominant polycystic kidney disease.

272 phropathy, immunoglobulin A nephropathy, and autosomal dominant polycystic kidney disease.

273 Persons with early autosomal dominant polycystic kidney disease.

274 ntry of polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease.

275 Autosomal-dominant polycystic kidney disease (ADPKD) and

276 This adaptive response is blocked when the autosomal-dominant polycystic kidney disease (ADPKD) gen

277 Autosomal-dominant polycystic kidney disease (ADPKD) is

278 Autosomal-dominant polycystic kidney disease (ADPKD) is

279 Autosomal-dominant polycystic kidney disease (ADPKD) is

280 Autosomal-dominant polycystic kidney disease (ADPKD) is

281 Autosomal-dominant polycystic kidney disease (ADPKD) is

282 uggests that some vascular manifestations of autosomal-dominant polycystic kidney disease (ADPKD) res

283 Patients with diabetic nephropathy (DN) and autosomal-dominant polycystic kidney disease (ADPKD) ser

284 Mutations in polycystin-1 (PC1) lead to autosomal-dominant polycystic kidney disease (ADPKD), a

285 Polycystin-1 and -2 are mutated in autosomal-dominant polycystic kidney disease (ADPKD), bu

286 cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney disease (ADPKD), wh

287 of its function causes cystogenesis in human autosomal-dominant polycystic kidney disease (ADPKD).

288 ts of rigorous versus standard BP control on autosomal-dominant polycystic kidney disease (ADPKD).

289 disorders are the main cause of mortality in autosomal-dominant polycystic kidney disease (ADPKD).

290 in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD).

291 ycin (mTOR) signaling pathway is aberrant in autosomal-dominant polycystic kidney disease (ADPKD).

292 Autosomal-dominant polycystic kidney disease is a multio

293 rats, normal human beings, and patients with autosomal-dominant polycystic kidney disease or ARPKD.

294 ssion in the livers of PCK rats and ARPKD or autosomal-dominant polycystic kidney disease patients.

295 several of the most severe complications of autosomal-dominant polycystic kidney disease, such as in

296 2 patients and 9 of 11 Group 1 patients had autosomal-dominant polycystic kidney disease.

297 1 and polycystin-2 encoded by PKD2, underlie autosomal-dominant polycystic kidney disease.

298 protein encoded by PKD1, a gene involved in autosomal-dominant polycystic kidney disease.

299 mology to human polycystins, products of the autosomal dominant polycystic kidney-disease loci PKD1 a

300 , between two groups of inherited disorders, autosomal dominant polycystic kidney diseases (ADPKD), a