ライフサイエンスコーパス: autotaxin

1 ranscript for the major LPA-producing enzyme autotaxin.

2 r A7, angiopoetin 1, endothelial lipase, and autotaxin.

3 and a species homolog of the human cytokine autotaxin.

4 oach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular

5 phosphonate (16c) mimicked LPA in inhibiting autotaxin, a secreted lysophospholipase D that produces

6 Autotaxin activity increases locally following lung inju

7 osphatidic acid (LPA), a lipid by-product of autotaxin activity, is involved in cancer, vascular defe

8 fied mechanism by which galectin-3 regulates autotaxin and assign a novel role for NFAT1 during melan

9 Plasma levels of autotaxin and its enzymatic product, lysophosphatidic ac

10 These data indicate that elevated levels of autotaxin and soluble markers of immune activation durin

11 actor family 4-1BB ligand, ephrin B1, stra6, autotaxin, and ISLR.

12 In this study, we validate Enpp2/Autotaxin as one of the highest expressed signature gene

13 expression of the autocrine motility factor autotaxin, as determined by Affymetrix gene chip, real-t

14 Plasma autotaxin associated with platelets during aggregation a

15 The extracellular lysophospholipase D autotaxin (ATX) and its product, lysophosphatidic acid,

16 r in EOC ascites, is an enzymatic product of autotaxin (ATX) and phospholipase A(2) (PLA(2))enzymes.

17 ented here identify the extracellular factor autotaxin (ATX) as a novel upstream signal modulating HD

18 program of forming joints, we used GDF-5 and Autotaxin (Atx) as joint tissue specific markers, and So

19 Autotaxin (ATX) generates the lipid mediator lysophospha

20 r3 or inhibition of the LPA-producing enzyme autotaxin (ATX) in pregnant mice leads to HB-EGF and COX

21 We examined the role of autotaxin (ATX) in pulmonary LPA production during fibro

22 Autotaxin (ATX) is a secreted enzyme playing a major rol

23 Autotaxin (ATX) is a secreted enzyme responsible for the

24 Autotaxin (ATX) is a secreted enzyme that hydrolyzes lys

25 Autotaxin (ATX) is a secreted glycoprotein with lysophos

26 Autotaxin (ATX) is a secreted lysophospholipase D (lysoP

27 Autotaxin (ATX) is a secreted lysophospholipase D that c

28 Autotaxin (ATX) is a secreted lysophospholipase D that g

29 Autotaxin (ATX) is a secreted lysophospholipase D that g

30 Autotaxin (ATX) is a secreted lysophospholipase D that h

31 Autotaxin (ATX) is an ectoenzyme that catalyzes the conv

32 Autotaxin (ATX) is an exoenzyme that potently induces tu

33 Autotaxin (ATX) is an extracellular enzyme and an autocr

34 Autotaxin (ATX) transforms lysophosphatidylcholine into

35 Autotaxin (ATX), a lysophospholipase D, plays an importa

36 LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, from ly

37 ramatically (approximately 100-fold) encodes Autotaxin (ATX), a secreted tumor motility-promoting fac

38 udy describes the identification and role of autotaxin (ATX), a secretory protein and a major source

39 A key discovery was that autotaxin (ATX), an enzyme previously implicated in canc

40 Autotaxin (ATX), an exo-nucleotide pyrophosphatase and p

41 l evidence implicated the lysophospholipase, autotaxin (ATX), and its product, lysophosphatidic acid

42 d by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an ar

43 clear factor of activated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and beta-c

44 ial for the motility stimulating activity of autotaxin (ATX), one member of the exophosphodiesterase

45 Autotaxin (ATX), through its lysophospholipase D activit

46 Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospho

47 Autotaxin (ATX, NPP2) has recently been shown to be the

48 Autotaxin (ATX, nucleotide pyrophosphate/phosphodiestera

49 ll membrane glycoprotein 1 (PC-1, or PDNP1), autotaxin (ATX, or PDNP2), and B10/PDNP3.

50 o LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD).

51 acid (LPA), a potent neuronal activator, and autotaxin (ATX; ectonucleotide pyrophosphatase/phosphodi

52 mal models express significant quantities of autotaxin (ATX; ENPP2), a lysophospholipase D that catal

53 Autotaxin [ATX (NPP-2)], originally isolated as a tumor

54 with itch severity and, in combination with autotaxin, distinguished pregnant women with itch that w

55 profiling identified the protumorigenic gene autotaxin (ENPP2) to be downregulated after silencing ga

56 tein expression, which resulted in decreased autotaxin expression and activity.

57 Here we report that galectin-3 regulates autotaxin expression at the transcriptional level by mod

58 nd that the alpha6beta4 integrin potentiates autotaxin expression through the upregulation and activa

59 ng sites in the promoter region of the mouse autotaxin gene (ATX, ENPP2), which we were able to verif

60 noma growth and metastasis by regulating the autotaxin gene (Enpp2).

61 s including osteoprotegerin, syndecan-2, and autotaxin have been refined from the general locations p

62 Reexpression of autotaxin in galectin-3 silenced melanoma cells rescues

63 grin alpha6beta4-dependent overexpression of autotaxin in MDA-MB-435 cells is mediated by NFAT1, but

64 Structural modifications of the known autotaxin inhibitor lead compound 1, to attenuate hERG i

65 ibitors (bile salts) into potent competitive Autotaxin inhibitors that do not interact with the catal

66 h the use of siRNAs that specifically target autotaxin, integrin beta4, NFAT1 and NFAT5.

67 We evaluated plasma levels of autotaxin, interleukin 6 (IL-6), soluble CD14 (sCD14), s

68 Autotaxin is a circulating enzyme with a major role in t

69 Autotaxin levels correlated with IL-6, sCD14, sCD163, Ma

70 We observed greater plasma autotaxin levels in HCV-infected and HCV-HIV-coinfected

71 Autotaxin, LPA, and sCD14 levels normalized, while sCD16

72 A role for the autotaxin/LPA axis has been suggested in many disease ar

73 gated LPA-stimulated vascular Akt signaling, autotaxin/LPA-driven phosphorylation of Akt and cyclin D

74 The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathw

75 This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modu

76 Transgenic overexpression of autotaxin/lysophospholipase D (Enpp2), the enzyme necess

77 but not resting platelets bound recombinant autotaxin/lysoPLD in an integrin-dependent manner.

78 y a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thromb

79 s and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a m

80 ating interferon-free HCV treatment and that autotaxin may be causally linked to immune activation du

81 The exo-enzyme autotaxin/NPP2 (ATX/NPP2) is a potent stimulator of cell

82 In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC

83 Autotaxin produces the bioactive lipid lysophosphatidic

84 wo consensus NFAT binding sites found in the autotaxin promoter strongly and specifically bind NFAT1

85 We further demonstrate that increased autotaxin secretion from integrin alpha6beta4 expressing

86 ss motile to serum and 86-99% less motile to autotaxin than control vector transfectants.

87 itors of the lysophospholipase D activity of autotaxin, the dominant biosynthetic source of LPA.

88 mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible fo

89 Autotaxin transcript was present, and GFs were found to