ライフサイエンスコーパス: autoxidation

1 nt toxic effects of RCS derived from glucose autoxidation.

2 the design of the PEGylated Hb with minimal autoxidation.

3 urnover is curtailed by the side reaction of autoxidation.

4 lammation, on nitrosation observed during NO autoxidation.

5 lar and electronic structure, and aspects of autoxidation.

6 can be initiated but they must compete with autoxidation.

7 o dopamine neurons, possibly due to catechol-autoxidation.

8 ction, preventing the initiation of catechol autoxidation.

9 endogenous catecholamines are protected from autoxidation.

10 O(2) binding while simultaneously inhibiting autoxidation.

11 s any HOOH produced in the initial stages of autoxidation.

12 believed to be relevant to room-temperature autoxidation.

13 orresponding monocation radical, followed by autoxidation.

14 n stabilizing bound dioxygen with respect to autoxidation.

15 o their ability to protect omega-3 oils from autoxidation.

16 n extensive conjugated system, vulnerable to autoxidation.

17 verdin were susceptible to light-accelerated autoxidation.

18 iprotein, was subjected to light-accelerated autoxidation.

19 adicals that play a key role in benzaldehyde autoxidation.

20 concentrations in benzaldehyde, inhibits the autoxidation.

21 compounds to the bilayer protects them from autoxidation.

22 d to protect petroleum-derived products from autoxidation.

23 effective chain carriers in the lipid chain autoxidation.

24 sis revealed two separate phases of liposome autoxidation.

25 that are generated enzymatically or through autoxidation.

26 open problem in the kinetics of liquid-phase autoxidation.

27 site that is known to bind O(2) and undergo autoxidation.

28 sis evidenced the advanced stages of the oil autoxidation.

29 or monitoring reaction progress in inhibited autoxidations.

30 ical under the typical settings of inhibited autoxidations.

31 pproximately 1.2 microM H(2)O(2) min(-1) via autoxidation, a level sufficient to kill serially dilute

32 eroxide radical expected to be formed during autoxidation, an isotropic free radical is produced with

33 ears to result from a high susceptibility to autoxidation and a low capacity of the cell to reduce it

34 alphaV96W, betaN108K) is stabilized against autoxidation and azide-induced oxidation compared to the

35 These E11 mutations do not slow down the autoxidation and azide-induced oxidation rates of the re

36 alphaL29F) has equivalent or slower rates of autoxidation and azide-induced oxidation than does Hb A,

37 yunsaturated fatty acids, which are prone to autoxidation and breakdown into toxic products.

38 lently cross-linked network through the slow autoxidation and cross-linking of catechol moieties.

39 xicity, indicating the participation of both autoxidation and D1 receptor stimulation.

40 rophore formation involves an intramolecular autoxidation and does not require exogenous co-factors.

41 Cyanoglobin also shows high rates of autoxidation and hemin loss, indicating that the prosthe

42 mutants known to exhibit different rates of autoxidation and hemin loss.

43 ng that they are likely to arise simply from autoxidation and not from reactions with O3 or (1)O2.

44 fatty acids when looking at models involving autoxidation and oxidation by lipoxygenases.

45 alpha-dicarbonyl products of monosaccharide autoxidation and primary metabolism.

46 med using pyridoxamine which blocked glucose autoxidation and RCS production, thus protecting protein

47 rovides a protein of comparable stability to autoxidation and similar oxygen dissociation rate.

48 eurons occurs through two distinct pathways: autoxidation and the D1 dopamine receptor-linked signali

49 ate electron transfer and to minimize flavin autoxidation and the generation of reactive oxygen speci

50 However, the PEG chains enhance the autoxidation and the H 2O 2 mediated oxidation of Hb.

51 The ability of excess succinate to block autoxidation and the inhibitory effect of lowering the f

52 K-trait mice that are more susceptible to Hb autoxidation and to hypoxia-induced superoxide productio

53 differs significantly from those for organic autoxidations and for the recently reported examples of

54 ude explanations of some observed effects in autoxidations and polymerizations.

55 rostatic stabilization of bound O2, promotes autoxidation, and enhances hemin dissociation by inhibit

56 tly increased the NADP+ release rate, flavin autoxidation, and NADPH oxidase activity, and caused hyp

57 ate constant for propagation of free radical autoxidation, and the carbon[bond]oxygen BDEs of peroxyl

58 chiff reaction during glycation, via glucose autoxidation, and via hexosamine metabolism under suprap

59 While carboxylic acids produced during the autoxidation are shown to deactivate these more basic RT

60 In an effort to make inhibited autoxidations as simple as the most popular "antioxidant

61 tate (AscPH), were studied during bulk lipid autoxidation at 80 degrees C.

62 Ferroxidation is progressively overcome by autoxidation at Fe(II)/mYfh1p ratios of >0.5.

63 by the concerted process inhibit hexadecane autoxidations at 160 degrees C to the same extent as the

64 e chemistry is shown to occur in hydrocarbon autoxidations at elevated temperatures without added aci

65 We conclude that in hypoxia, increased Hb autoxidation augments superoxide production in RBCs.

66 eraction with the products of monosaccharide autoxidation (autoxidative glycosylation).

67 sly been directly detected during hemoglobin autoxidation because of its rapid dismutation.

68 Apoptosis seems to be produced by dopamine autoxidation, because intracellular peroxides increase a

69 pherical oligomers that depended on dopamine autoxidation but not alpha-syn oxidation, because mutage

70 eroxide dismutase (SOD) may protect QH2 form autoxidation by acting either directly as a superoxide-s

71 in the hydration layer of Hb and enhance the autoxidation by promoting the nucleophilic attack of hem

72 were positively identified among the FAMEs' autoxidation byproducts.

73 osurfactant-like pair of the FAMEs and their autoxidation byproducts.

74 These results suggest that the dopamine autoxidation can prevent alpha-syn fibrillization in dop

75 Because hemoglobin (Hb) autoxidation causes RBC superoxide formation that readil

76 t methyl hydroperoxide can be produced by an autoxidation chain reaction when ultrasonicating polar a

77 cals that result are highly persistent under autoxidation conditions and undergo very rapid dimerizat

78 ich forms lysine-based pyrroles that lead to autoxidation-dependent protein cross-linking, 3-TFMHD fo

79 examples of sonochemically initiated solvent autoxidation destabilizing single-walled carbon nanotube

80 The spontaneous autoxidation distinguishes curcumin among natural polyph

81 ns of oxidative nitrosylation rather than NO autoxidation, explaining why S-nitrosation can compete e

82 mental approaches to investigate the rate of autoxidation for organic peroxy radicals (RO2) produced

83 o coincide with enhanced rates of hemoglobin autoxidation for partially oxygenated intermediates.

84 n of the thiyl radical decreases the rate of autoxidation for the beta-chain and reduces heme degrada

85 e longstanding dogma that cholesterol (chol) autoxidation gives chol 7-hydroperoxide (7-OOH) as the s

86 The rate of AxPDEA1 autoxidation (half-life > 12 h) is the slowest observed

87 t on NADP+ release, flavin reduction, flavin autoxidation, heme reduction, reductase activity, or NO

88 of these secondary oxidative reactions over autoxidation in evaluating the toxicity of HBOCs.

89 esent study, we examined the role of glucose autoxidation in functional protein damage using lysozyme

90 Free radical-initiated lipid autoxidation in low density lipoprotein (LDL) has been i

91 cine at position 29 of myoglobin can inhibit autoxidation in myoglobin and at position 29 of the alph

92 The rate of autoxidation in the presence of testosterone was signifi

93 an alpha-tocopherol (alpha-TOH) in inhibited autoxidations in benzene.

94 ion of their kinetic parameters by inhibited autoxidations in the presence of a very strong H-bonding

95 n addition, the spatial propagation of lipid autoxidation increased with the degree of oil unsaturati

96 e formation of oxyferrylHb, like the rate of autoxidation, increases for all modified Hbs.

97 We demonstrated that glucose autoxidation induced inhibition of lysozyme activity as

98 Linoleic acid autoxidation inhibitions on all fractions were higher th

99 The mechanism of product autoxidation is also considered.

100 Because sugar or sugar-adduct autoxidation is critical for AGE formation in vitro, we

101 old decrease in O2 affinity, and the rate of autoxidation is increased by 2 orders of magnitude.

102 ntial nitrosating species produced during NO autoxidation is N(2)O(3).

103 activity evidence suggests that free radical autoxidation is not involved.

104 result of ongoing NO x emission reductions, autoxidation is now competing with bimolecular chemistry

105 er than for HbA(0)), even though its rate of autoxidation is relatively low.

106 hat increased oxidative stress, due to BH(4) autoxidation, is responsible for the observed BH(4) effe

107 hydrogen peroxide potentially formed by its autoxidation, is the causative agent.

108 Additionally, GLB-6 exhibits rapid two-state autoxidation kinetics in the presence of physiological O

109 present within protein active sites, glucose autoxidation may be a common mechanism contributing to E

110 Glucose autoxidation may cause protein damage in vivo since incr

111 nolysis of alpha-cedrene was explained by an autoxidation mechanism initiated by ozone attack at the

112 Inhibited autoxidations-monitored either by O2 consumption or hydr

113 concentrations (100 mM), Cu(2+) accelerates autoxidation more than 1500-fold.

114 lavin potential indicate that all detectable autoxidation occurs from its FAD site, rather than from

115 The mechanism for the autoxidation of 1 is more closely related to that found

116 id-containing phospholipids were produced by autoxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-

117 ty of this reaction, the copper(II)-mediated autoxidation of 4-tert-butylresorcinol and 4,6-di-tert-b

118 ctivity was investigated using the inhibited autoxidation of a standard model substrate.

119 e (Cu/Zn-SOD) has been shown to modulate the autoxidation of a variety of phenoic compounds, includin

120 f the respiratory chain, occurs primarily by autoxidation of an exposed flavin cofactor.

121 ysts, but it suppresses superoxide-releasing autoxidation of an O(2)-catalyst adduct.

122 of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-st

123 as measured by inhibition of metal-catalyzed autoxidation of ascorbate.

124 % inhibition of the rate of copper-catalyzed autoxidation of ascorbic acid in phosphate buffer.

125 cs and regio-/stereochemical outcomes of the autoxidation of both polyunsaturated fatty acids and ste

126 eactive carbonyl compounds are formed during autoxidation of carbohydrates and peroxidation of lipids

127 rations of adrenochromes, the product of the autoxidation of catecholamines initiated by O(2).

128 ard and was implicated previously in aqueous autoxidation of catechols to give ultimately hydroxyquin

129 ic endoperoxides have been detected from the autoxidation of cholesteryl arachidonate by LC-MS and GC

130 in the product mixture formed from in vitro autoxidation of cholesteryl arachidonate.

131 Autoxidation of cholesteryl-15-HpETE under free radical

132 coli these oxidants arise primarily from the autoxidation of components of its respiratory chain.

133 In the inhibited autoxidation of cumene and styrene at 303 K, magnolol tr

134 A mechanism for the autoxidation of curcumin is proposed that accounts for t

135 rivative spectroscopy to monitor kinetics of autoxidation of cytochromes P450 and applied it to study

136 We infer that the adventitious autoxidation of dihydromenaquinone in the cytoplasmic me

137 The autoxidation of dihydropyoverdine at alkaline pH and the

138 Analogously, autoxidation of docosahexaenoic acid (DHA, C22.6 omega-3

139 In a separate paper, autoxidation of DTBC to the corresponding benzoquinone a

140 insight into the factors that influence the autoxidation of fatty acids.

141 ducts (AGEs) together with free radicals via autoxidation of glucose and Amadori products.

142 may therefore underlie the increased rate of autoxidation of Hb S under aerobic conditions, the incre

143 rotetramer interaction sites in assembly and autoxidation of hemoglobin is not clear.

144 I) nor FE(III) was capable of modulating the autoxidation of HG.

145 The acceleration of autoxidation of HQ by Cu/Zn-SOD results in the productio

146 echanism involved in the Cu/Zn-SOD-catalyzed autoxidation of HQ may be occur through either its conve

147 Rather, the autoxidation of HQ to SQ-. is a prerequisite for the enh

148 s are key primary products that arise in the autoxidation of hydrocarbons.

149 d approximately 130 H2O2 and 15 O-2 min-1 by autoxidation of its reduced FAD cofactor.

150 ntity of this product that is generated upon autoxidation of linoleic acid and by decomposition of 13

151 nds were equally effective in inhibiting the autoxidation of linoleic acid in aqueous micelles, with

152 e induction temperature of linoleic acid and autoxidation of linoleic acid in Tween 20 micellar mediu

153 ere confirmed by HPLC to be generated in the autoxidation of linoleic acid promoted by Fe(II)/ascorbi

154 nt activity (radical scavenging activity and autoxidation of linoleic acid) was higher in JE than in

155 tridec-11-enoic acid (HOT), is produced upon autoxidation of linoleic acid.

156 s more closely related to that found for the autoxidation of main group and early transition metal al

157 vity of nitrogen oxide species formed during autoxidation of nano- to micromolar levels of NO were ex

158 The autoxidation of nitric oxide (NO.) forms the nitrosating

159 m the generation of nitrogen dioxide via the autoxidation of nitric oxide, a product of HU metabolism

160 stinct from the process that occurred during autoxidation of NO in aqueous media.

161 measurement of oxygen consumption during the autoxidation of oils rich in omega-3 fatty acids.

162 analysis of the product mixture derived from autoxidation of optically pure Ch-15-HpETE by atmospheri

163 s tunnel is proposed to facilitate the rapid autoxidation of oxy-DcrH-Hr and suggests that sensing is

164 Further, although the rate of autoxidation of oxy-DHP is somewhat enhanced by the pres

165 nge heme from methemoglobin (metHb) and that autoxidation of oxyhemoglobin to metHb must occur prior

166 Autoxidation of polyunsaturated fatty acids and esters l

167 Autoxidation of polyunsaturated fatty acids and esters l

168 Hence, the autoxidation of QH2 is a competing reaction that reduces

169 These results indicate that the autoxidation of QH2 is independent of SOD.

170 that this H2O2 is primarily generated by the autoxidation of redox enzymes within the respiratory cha

171 /s intracellular H2O2 through the accidental autoxidation of redox enzymes.

172 Thus the autoxidation of sulfite reductase, like that of the resp

173 The primary KIE for autoxidation of tetralin was determined to be 15.9 +/- 1

174 Autoxidation of the biodiesel constituents was found to

175 the o-quinones of H(2)O(2) generated during autoxidation of the catechols.

176 owly desaturated acyl-ACPs was attributed to autoxidation of the electron-transfer chain.

177 However, as in the solution experiments, autoxidation of the Hb mutant crystals leads to electron

178 ty, enhanced Bohr effect, and slower rate of autoxidation of the heme iron atoms from the Fe(2+) to t

179 nity and high cooperativity and also ease of autoxidation of the heme iron atoms from the Fe2+ state

180 tation), e.g. , Leu --> Phe, can inhibit the autoxidation of the heme iron of myoglobin.

181 sion to Met and Asp enhanced the spontaneous autoxidation of the mutants relative to wild-type HbA an

182 ing in CYP3A4, we documented the kinetics of autoxidation of the oxy-ferrous intermediate of CYP3A4 a

183 ion of the PEGylated Hb, we have studied the autoxidation of the PEGylated Hb site-specifically modif

184 In an attempt to understand the autoxidation of the PEGylated Hb, we have studied the au

185 correlation between the in vitro and in vivo autoxidation of the PEGylated Hb.

186 The autoxidation of the PEGylated Hbs is attenuated signific

187 litate the analysis of degradation products, autoxidation of the three methine bridges in biliverdin

188 photolysis experiments designed to minimize autoxidation of the unstable apolar E7 mutants.

189 uperoxide anion generation during subsequent autoxidation of these glucose adducts, and non-glycative

190 gene encoding NADH dehydrogenase II averted autoxidation of vesicles, and its overproduction acceler

191 mechanism initiated by radicals generated by autoxidation of Zr-R and/or Al-R species.

192 roplate reader) in samples from 24 inhibited autoxidations of a lubricating oil, which were carried o

193 Autoxidations of cis,cis, cis,trans, and trans,trans non

194 y sequential O2 addition steps, that is, RO2 autoxidation, on a time scale of seconds.

195 . L-1 . min-1) produced either by pyrogallol autoxidation or a hypoxanthine/xanthine oxidase system i

196 e was mostly governed by lipid oxidation via autoxidation or induced by lipoxygenase.

197 learly reveals the relative contributions of autoxidation pathways.

198 onditions (25 and 40 degrees C) to mimic the autoxidation process during real storage conditions.

199 e beta-93 cysteine residue in the hemoglobin autoxidation process has been delineated by electron par

200 eased oxygen consumption associated with the autoxidation process in this case.

201 ation products accumulated in VOO during the autoxidation process, thus they may be used as early eva

202 mechanism reveal a radical pathway for this autoxidation process.

203 roved to be a more potent inhibitor of model autoxidation processes in a polar solvent (acetonitrile)

204 ow here that reaction of nitrite (NO2-), the autoxidation product of nitric oxide (.NO), with hypochl

205 undergo rapid autoxidation, suggesting that autoxidation product(s) acts directly or indirectly on A

206 f beta-carotene-5,6-epoxide, a ROS-catalyzed autoxidation product, and inhibiting accumulation of ant

207 The resulting novel concept is that of an autoxidation-product-initiated dioxygenase.

208 mes were associated with increased levels of autoxidation products (octane, hexanal, C10 hydrocarbons

209 cumin, but it is not known how many and what autoxidation products are formed, nor their mechanism of

210 The identities of enzyme autoxidation products are significant because O2*- and H

211 The isoprostanes are a class of autoxidation products generated from arachidonic acid (o

212 NO* and its autoxidation products have an extensive biochemical reac

213 A1 may participate in the removal of harmful autoxidation products in these tissues, while providing

214 The interaction of the primary autoxidation products of cholesterol, namely 25- and 20x

215 Q-deficient yeast are hypersensitive to the autoxidation products of linolenic acid and other polyun

216 The results indicate that autoxidation products of polyunsaturated fatty acids med

217 To assess the autoxidation products, a simplified model system was use

218 ng [(14)C2]curcumin as a tracer, seven novel autoxidation products, including two reaction intermedia

219 nt and was attributed to the accumulation of autoxidation products.

220 Rate constants for autoxidation propagation of several unsaturated lipids i

221 s lipid bilayer radical clock gives relative autoxidation propagation rate constants of arachidonate

222 operativity (n50), alkaline Bohr effect, and autoxidation rate as Hb S.

223 The myoglobin autoxidation rate increased with increasing storage time

224 ally more stable in the ferrous form with an autoxidation rate of 0.003/min at 37 degrees C.

225 tion coefficient (R(2)) of IC50versus log of autoxidation rate of 0.75.

226 The autoxidation rate of beta1(1-194) was 0.073/min, while t

227 urbed the heme environment and increased the autoxidation rate of Hb, which is at a higher level than

228 The autoxidation rate of the PEGylated Hb does not show an i

229 We have measured the dependence of autoxidation rate on oxygen concentration for Rhizobium

230 nt technique and enabling measurement of the autoxidation rate over a wide range of temperatures, yie

231 These increases in autoxidation rates are attributed to increased solvent a

232 The DevS autoxidation rates are extremely low (half-lives of >24

233 Autoxidation rates of alpha(2)beta(2)(116Asp) and alpha(

234 vel presentation of the oxygen dependence of autoxidation rates that uses heme saturation, rather tha

235 n hemoglobin was also assessed by evaluating autoxidation rates using recombinant Hb tetramers contai

236 Significant increases in autoxidation rates were observed for all of the L98X Hrs

237 Comparison of the autoxidation rates with the available data on CYP3A4 tur

238 tep (alpha --> alpha3), followed by a slower autoxidation reaction that promotes the assembly of high

239 physiological pH and rapidly degrades in an autoxidation reaction to a major bicyclopentadione produ

240 ified kinetic theory for both initiation and autoxidation reactions of Et3B and O2 is put forth, and

241 otopologues, the precursors to a sequence of autoxidation reactions that ultimately yield HOMs in the

242 med from glucose by sequential glycation and autoxidation reactions.

243 ed from both carbohydrates and lipids during autoxidation reactions.

244 Gas-phase autoxidation-regenerative peroxy radical formation follo

245 the distal pocket and may contribute to the autoxidation resistance of this myoglobin.

246 e heme cavity of the extreme oxygen-avid and autoxidation-resistant oxy-myoglobin complex from the tr

247 nt forms a stable oxy adduct; instead, rapid autoxidation results in formation of the corresponding m

248 y, high cooperativity, and stability against autoxidation, rHb (beta N108Q) is considered a potential

249 However, enzyme ferrous heme-O(2) autoxidation showed an opposite rank order.

250 and Fe(II)-MetAP enzymes are susceptible to autoxidation, so strict care must be taken to remove all

251 be used as early evaluation index of the VOO autoxidation state before fatty acids oxidation.

252 r markers of VOO freshness to define the VOO autoxidation state.

253 be used as early evaluation index of the VOO autoxidation state.

254 be linked to their tendency to undergo rapid autoxidation, suggesting that autoxidation product(s) ac

255 oignition and are implicated in tropospheric autoxidation that can form low-volatility, highly oxygen

256 iological pH, curcumin undergoes spontaneous autoxidation that is enhanced by oxidizing agents.

257 Autoxidation, the primary oxidative reaction which initi

258 ough NO(2) was not a component of aqueous NO autoxidation, the results suggest that the intermediacy

259 amounts of oleic acid will be more prone to autoxidation, thus potentially having greater impact on

260 ercepting reactive intermediates of aldehyde autoxidation to aerobically generate hypervalent iodine

261 e-buffered saline (PSB), HQ underwent a slow autoxidation to BQ, which was accelerated by Cu/Zn-SOD,

262 Benzaldehyde readily undergoes autoxidation to form benzoic acid on exposure to air at

263 se and glucose have been reported to undergo autoxidation to generate reactive oxidative species (ROS

264 The next step was an autoxidation to hydroperoxides bearing the heteroaromati

265 assembly of the I-ring; discovery of a novel autoxidation to introduce the C(22) tertiary hydroxyl gr

266 albumin (BSA) (PBS/BSA), HQ did not undergo autoxidation to SQ-., and as such the presence of SOD wa

267 Autoxidation to the met form is very rapid, as reported

268 he nitrite-forming reaction (which may be NO autoxidation under these conditions) competes with react

269 ng the kinetics of radical-initiated styrene autoxidations under controlled conditions.

270 under anaerobic conditions, undergoing rapid autoxidation upon being exposed to air.

271 e induced by radicals generated from sulfite autoxidation using cyclic voltammetry (CV) and electroch

272 Autoxidation was inhibited by azide, suggesting involvem

273 Autoxidation was only detected at >/=1.2 mum NO/min.

274 a model vegetable oil highly susceptible to autoxidation, was determined.

275 n and dissociation rates, O(2) affinity, and autoxidation were examined.

276 ucing power, and inhibition of linoleic acid autoxidation were significantly enhanced after appropria

277 ilize the ferrous-O2 complex with respect to autoxidation, which should result in partial uncoupling

278 ced responses were lost when we inhibited Hb autoxidation with CO or nitrite, or when the H(2)O(2) in

279 The initiation of lipid autoxidation within single oil droplets in Tween-20-stab

280 dant load and ability to prevent lipid chain autoxidation, within the inner mitochondrial membrane of

281 The autoxidation/Wittig coupling reaction was employed to sy

282 However, we argue that autoxidation would not occur in vivo, leading to the con