ライフサイエンスコーパス: avascular

1 t at 1-month posttransplantation were almost avascular.

2 ivity recording instrumentation; and a small avascular (123 microns) field.

3 64(165)), was studied in the transparent and avascular adult mouse cornea.

4 Because cartilage is generally avascular, all nutrients, oxygen, signaling molecules, a

5 that sflt-1 is essential for preserving the avascular ambit of the cornea can rationally guide its u

6 Early cancers are avascular and hence, profoundly acidic.

7 C.HA might explain why AM is developmentally avascular and how AM might exert an antiangiogenic actio

8 15-LOX and ALX are highly expressed in the avascular and immune-privileged cornea.

9 Regenerated cartilage was avascular and integrated with regenerated subchondral bo

10 conducted to measure the retinal function in avascular and isolated perfused retinas to separate vasc

11 Stage 1 metastases were avascular and lacked mitotic activity.

12 The myocardium of most vertebrates is avascular and obtains oxygen from luminal blood.

13 lar areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stim

14 Cartilage is an avascular and relatively tumor-resistant tissue.

15 The avascular and transparent cornea serves as a good in viv

16 (HIF-1alpha) expression and activity in both avascular and vascular growth phases of the tumor.

17 tatistical data, (2) mechanistic modeling of avascular and vascular tumor growth, and (3) modeling of

18 t change the Po(2) at the border between the avascular and vascularized retina; hyperoxia significant

19 66%) maintained a completely epithelialized, avascular, and clinically stable corneal surface.

20 ion, defined as a completely epithelialized, avascular, and clinically stable corneal surface.

21 ic features of osseous sclerosis, sequestra, avascular, and radiopaque alveolar bone in the jaw that

22 gns (successful: restoration of transparent, avascular, and stable corneal epithelium without neovasc

23 (46.7%) achieved completely epithelialized, avascular, and stable ocular surfaces.

24 , giving the bulbar conjunctiva a "blanched" avascular appearance in most but not all SCD patients du

25 Avascular area analysis with an automated algorithm usin

26 wed greater revascularization of the central avascular area and developed equal or fewer neovascular

27 Total avascular area and foveal avascular zone area were great

28 The central avascular area and neovascular tufts were measured after

29 ndary measures included the agreement of the avascular area between the OCT angiogram and FA.

30 atistically significant reduction of retinal avascular area compared with control eyes.

31 Total avascular area in the central 5.5-mm-diameter area disti

32 ls by dietary or genetic means decreased the avascular area of the retina by increasing vessel regrow

33 a statistically significant decrease in the avascular area of the retinas.

34 Moreover, vessel regrowth into the avascular area was reduced in TIMP3-injected mice, but n

35 o have abnormalities at the periphery (large avascular area, abnormal branching, shunt) or the poster

36 orescein retinal angiography, measurement of avascular area, and count of preretinal vascular cells.

37 afoveal and perifoveal vessel density, total avascular area, and foveal avascular zone as detected wi

38 ing neovascular tuft formation and increased avascular area, in a dose-dependent manner.

39 ss and quantitatively for measures of foveal avascular area, parafoveal flow, and vascular density.

40 , all showed abnormalities at the periphery (avascular area, vessel leakage, shunts, abnormal vessel

41 Retinal neovascularization was scored, and avascular areas (AVAs) were measured in ADPase stained r

42 Documentation of peripheral avascular areas on intravenous fluorescein angiography w

43 Although larger avascular areas or higher severity scores were associate

44 Neovascularization (NV) and avascular areas were assessed on retinal flat-mounts by

45 , Ntn-4(-/-) mice initially displayed larger avascular areas which recovered faster to revascularizat

46 uctures; and (5) cell process extension into avascular areas, resulting in new links within the plexu

47 at 2 weeks, whereas control L/M tumors were avascular at 2 weeks and exhibited blood lakes in lieu o

48 In only 1 of the 40 eyes did a cystic avascular bleb develop, with all the other eyes being no

49 Six (30%) cystic thin avascular blebs without oozing were recorded in the MMC

50 Limbus-based procedures produce higher, more avascular blebs, with a greater risk of infection.

51 The cornea is avascular but the tumour promotes vascularisation from t

52 dogenous cells, as exemplified by stratified avascular cartilage and vascularised bone.

53 initially inhibit angiogenesis to allow for avascular cartilage formation.

54 penetration and distribution of TAA into the avascular cartilage is not well understood.

55 Endochondral ossification depends on an avascular cartilage template that completely remodels in

56 cal step in bone formation is to replace the avascular cartilage template with vascularized bone.

57 c agents to the resident chondrocytes in the avascular cartilage.

58 fferentiate in the perichondrium surrounding avascular cartilaginous rudiments; the source of trabecu

59 We demonstrate here that in the avascular chicken retina, vascular endothelial growth fa

60 d histologic examination revealed only small avascular clusters of tumor cells.

61 Molecular transport in avascular collagenous tissues such as articular cartilag

62 or their capacity to grow expansively within avascular compartments of transplanted tumors.

63 HRM, OCTA distinguished between vascular and avascular components.

64 neal micropocket angiogenesis assay uses the avascular cornea as a canvas to study angiogenesis in vi

65 genesis of lymphatic vessels in the normally avascular cornea in response to HSV-1 infection.

66 Neovascularization of the avascular cornea is a significant problem associated wit

67 The avascular cornea is a uniquely-isolated organ, with its

68 Angiogenesis into the normally avascular cornea is incompatible with good vision and, t

69 enesis is neovascularization of the normally avascular cornea, a process that involves the vascular e

70 n the chick chorioallantoic membrane, in the avascular cornea, and in a variety of primary tumors.

71 In the normally avascular cornea, however, pathological lymphangiogenesi

72 lood and lymphatic vessels into the normally avascular cornea.

73 hemangiogenesis are induced in the normally avascular cornea.

74 role for resident stromal keratocytes in the avascular cornea: one of cornea maintenance, which invol

75 the wound-healing process, especially in the avascular corneal environment.

76 y of peripheral nerves after injury using an avascular corneal nerve injury model.

77 l emigration through limbal vessels into the avascular corneal stroma, peaking within 12 to 18 hours

78 outcome was graded as a success if a smooth, avascular corneal surface was restored, a partial succes

79 ion of a completely epithelized, stable, and avascular corneal surface.

80 corneas, do not express sflt-1, whereas the avascular corneas of dugongs, also members of the order

81 h a distinct biological advantage over their avascular counterparts by conferring upon them the abili

82 changes that decrease nutrient supply to the avascular disc.

83 of invasive carcinomas, whereas necrotic and avascular ductal carcinomas in situ display significantl

84 e, we demonstrated efficient regeneration of avascular elastic cartilage from in vitro-grown mesenchy

85 humor play a direct part in maintaining the avascular environment of the cornea.

86 e in vitro, but glomeruli do not form in the avascular environment.

87 study is to evaluate the reliability of the avascular exposed root surface area (AERSA) as a prognos

88 ned, and flatmounted to determine peripheral avascular extent and NV incidence and severity.

89 ion and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix

90 In the avascular fibrous stromal core of all specimens, the pre

91 more likely to be graded as higher and to be avascular (GEE model, both P < 0.0001).

92 uires rapid restoration of blood flow to the avascular graft.

93 tion before gonadotoxic chemotherapy and its avascular grafting after cancer healing permitted fertil

94 mour growth, linking the relatively harmless avascular growth phase and the potentially fatal vascula

95 ug therapy in ACH is targeting agents to the avascular growth plate.

96 hereas Tie-1 was expressed in EC surrounding avascular hepatic islands.

97 C) proliferation is initiating, resulting in avascular hepatocyte islands.

98 These studies suggest that the normal avascular human cornea contains and synthesizes the comp

99 , and differentiation of chondrocytes in the avascular hypoxic fetal growth plate, which is rich in e

100 Avascular, hypoxic retina has been postulated to be a so

101 Sema6A expression increases in avascular inner retina and colocalizes with Nrf2 in huma

102 istochemistry showed deposition of HP in the avascular inner retina but not in areas underlying prere

103 M showed an anatomic preference for vascular-avascular junctions.

104 ounding the retina and were separated by the avascular layer in between.

105 s is important for tissue homeostasis in the avascular lens, and extensive areas of gap junctions for

106 delayed CT, indicating that they represented avascular lesions consistent with high-density cysts.

107 Avascular lesions were defined as benign.

108 Transformation of small avascular masses of tumor cells into rapidly progressive

109 nancies and metastases generally initiate as avascular masses that only belatedly induce vascular sup

110 iew that most tumors and metastases begin as avascular masses, evidence is presented here that a subs

111 Although tumors may arise as avascular masses, there is increasing evidence that some

112 nd pathologic angiogenesis into the normally avascular, mature (secondary) vitreous.

113 In contrast, the avascular media is often spared by immune-mediated disor

114 ctant for the developing kidney vasculature, avascular metanephric kidneys from rat embryos (E14) wer

115 le for the generation and maintenance of the avascular midline and that BMP antagonists expressed by

116 hesive aortic vessels because of loss of the avascular midline, yet maintain lateral avascular zones.

117 nched aortic plexus with a markedly narrowed avascular midline.

118 and continues to be broadly used as a unique avascular model, the isolation of the cloche gene has be

119 Because cartilage is avascular, molecular transport occurs primarily via diff

120 egions far from blood vessels, they exhibit 'avascular motility', defined by high speed and less conf

121 growth factor to induce angiogenesis in the avascular mouse cornea.

122 ould be involved in the establishment of the avascular nature of seminiferous tubules and after puber

123 Owing to the avascular nature of the IVD and lack of understanding th

124 with a 1.2-fold increase in the risk of both avascular necrosis (95% CI 1.1, 1.4) and stroke (95% CI

125 Avascular necrosis (AVN) after renal transplantation has

126 xperience a high rate of fracturing and some avascular necrosis (AVN), but little is known about the

127 as well as other bone complications, such as avascular necrosis (AVN).

128 ), posttransplant diabetes (P < 0.0001), and avascular necrosis (P = 0.0003).

129 n syndromes are associated with or accompany avascular necrosis and leg ulcers.

130 Glucocorticoid-related avascular necrosis can incur morbidity affecting employm

131 Avascular necrosis developed in 18 (13%) of the 142 pati

132 Avascular necrosis of bone (AVN) developed in 9% of pati

133 both have led to a reduction in the rate of avascular necrosis of the femoral head.

134 Avascular necrosis of the femur head (AVNFH) is a debili

135 ered from long bone fractures (n = 4) and/or avascular necrosis of the hip (n = 4).

136 Avascular necrosis of the lunate bone (Kienbock's diseas

137 recognized acute complication of treatment, avascular necrosis of weight-bearing bones, is still not

138 egenerative arthrosis, chondral injuries, or avascular necrosis required MR arthrography.

139 s suppression resulted in severe hypoxia and avascular necrosis that are incompatible with progressiv

140 History of bone pain, fractures, and avascular necrosis was found in 22, 12, and 7 patients,

141 gesics and physical therapy for treatment of avascular necrosis, and use of angiotensin-converting en

142 recipients had significantly lower rates of avascular necrosis, cytomegalovirus, cataracts, new-onse

143 suffer from chronic pain syndromes including avascular necrosis, leg ulcers, and intractable pain.

144 d HIV act as common risk factors for stroke, avascular necrosis, severe splenic dysfunction, pulmonar

145 ine patients had MR findings consistent with avascular necrosis.

146 ataracts; 1%, posttransplant diabetes; 0.2%, avascular necrosis; 0.2%, posttransplant lymphoprolifera

147 n contrast, bFGF levels were not elevated in avascular nodules but rather were detected at levels app

148 Recipient beds were either avascular (normal risk) or neovascularized (high risk).

149 tumor cell death was localized to relatively avascular or hypoxic areas, coupled with the fact that n

150 ditionally, possible confounders specific to avascular organ culture were investigated.

151 The eye lens is an encapsulated avascular organ whose function is to focus light on the

152 sient bone marrow edema syndrome (TBMES) and avascular osteonecrosis.

153 plus the embedded retinal vessels, (ii) the avascular outer nuclear (photoreceptor) layer and its ph

154 ular layers bounding the retina, but not the avascular outer nuclear layer and the vitreous.

155 h or without treatment with Mn2+, 1/T1rho of avascular outer retina (64% to 72% depth) was significan

156 in mistargeting of the HSCs to the normally avascular outer retina.

157 in a single patient showed a subepithelial, avascular pannus.

158 her the vascular midperipheral retina or the avascular periphery in the ROP group, theoretically this

159 the optic nerve, was as low as that from the avascular periphery, 2 to 3 mm from the optic nerve.

160 But the molecular underpinnings of the avascular phenotype have until now remained obscure and

161 ntrols blood vessel growth into the normally avascular photoreceptor layer through the inflammatory s

162 logical neovessels growing into the normally avascular photoreceptors cause vision loss in many eye d

163 he Vldlr(-/-) retinas, which invade normally avascular photoreceptors, are reminiscent of the vascula

164 tional characterization of UAS homologs from avascular plants (mosses, liverwort, and hornwort), from

165 kweed cell walls but not in the walls of the avascular plants and algae.

166 m Api distinguishes vascular plants from the avascular plants and green algae.

167 n characterized; however, it is not known if avascular plants or green algae produce this enzyme.

168 ich these signals regulate the disruption of avascular privilege in photoreceptors are unknown.

169 -risk keratoplasty within the preoperatively avascular recipient bed.

170 topoietic lineage cells were observed in the avascular region around the dorsal midline of the develo

171 ntained at the inner and outer border of the avascular region during hyperoxia, Q(av) was not restore

172 improved the morphology of astrocytes in the avascular region of the retina.

173 ArntDeltaEC mice had a significant volume of avascular region.

174 ts, EECs in the vascularized, but not in the avascular, region efficiently produce and secrete lipopr

175 derived myeloid progenitor cells migrated to avascular regions of the retina, differentiated into mic

176 ted C. novyi-NT spores germinated within the avascular regions of tumors in mice and destroyed surrou

177 from intact blood vessels quickly infiltrate avascular regions via vascular sprouting.

178 cally evident, subdividing the gonad into 10 avascular regions where testis cords form.

179 vessel, demonstrating the ability to target avascular regions.

180 lial tubes form in a region that is normally avascular, resulting in aberrant connections.

181 ent intravitreous neovascularization (IVNV), avascular retina (AVA), and retinal detachment in preter

182 as DMOG-treated wild-type mice have 50% less avascular retina (P < 0.0001).

183 Inhibition of STAT3 reduced avascular retina and increased retinal erythropoietin (E

184 Areas of avascular retina and neovascular tufts in injected (trea

185 w that increased retinal VEGF contributes to avascular retina by regulating retinal Epo expression th

186 k of MMP-12 accelerated revascularization of avascular retina in OIR.

187 Epo administered exogenously also reduced avascular retina in the model.

188 F has on other factors in the development of avascular retina is important to prevent aberrant angiog

189 Laser treatment of the avascular retina may have helped prevent complications f

190 retinal neovascularization and/or peripheral avascular retina on fluorescein angiography and were tre

191 ice are returned to room air and the hypoxic avascular retina triggers both normal vessel regrowth an

192 at occurred in cultured Muller cells from an avascular retina were similar but not identical to the c

193 ed for clock hours of NV, percent peripheral avascular retina, capillary density, apoptosis, and VEGF

194 IOH to the junction between vascularized and avascular retina.

195 oxia found at the border of the vascular and avascular retina.

196 vation of astrocytes and Muller cells in the avascular retina.

197 for neuronal Nrf2 in vascular regrowth into avascular retina.

198 this model, inhibition of creatine kinase in avascular retinas blocks synaptic transmission without i

199 In avascular retinas, aerobic production of energy occurs o

200 ) and to compare the predictive value of the avascular root surface area calculation and Miller class

201 al portion naturally created to survive over avascular root surfaces.

202 hy angiography can distinguish vascular from avascular SHRM components.

203 OCTA artifacts may distinguish certain avascular SHRM components.

204 al role for lymphangiogenesis in a primarily avascular site such as the cornea has not been described

205 l lymphangiogenesis also occurs in primarily avascular sites.

206 racterize macrophage infiltration into early avascular solid tumours, and extensions to study the int

207 ot directly injure the limbal vessels or the avascular stroma of the cornea.

208 ial layer, a thick basement membrane, and an avascular stroma.

209 metabolic rate of lumbar discs (the largest avascular structures in the body) prevents them from kee

210 vessels are permitted to grow into normally avascular structures, such as the articular cartilage an

211 P > .05) when considering total vascular and avascular surfaces.

212 ne (FAZ) features and the total vascular and avascular surfaces.

213 By being avascular, those zones lack endogenous retinoids as indi

214 ty settings alter the detected percentage of avascular tissue and the blood flow measurements in tiss

215 nd penetration of therapeutic agents through avascular tissue are critically important processes if s

216 he brain and in tumours requires invasion of avascular tissue by endothelial cells, we examined the I

217 Articular cartilage is an avascular tissue that functions at a lower oxygen tensio

218 Articular cartilage is an avascular tissue with precise polarity and organization

219 Articular cartilage is an avascular tissue with precise polarity and organization

220 he percentage of pixels with values of zero (avascular tissue) increased with increasing photodetecto

221 Since the cornea is an avascular tissue, recruitment of granulocytes such as ne

222 ins several vascular beds sandwiched between avascular tissue.

223 pecific targeting to delete HIF-1alpha in an avascular tissue: the cartilaginous growth plate of deve

224 mounts were analyzed for percent of areas of avascular/total retina (AVA) and of intravitreal neovasc

225 es were intravitreous neovascularization and avascular/total retinal areas, vascular endothelial grow

226 viral infection and LN reconstruction after avascular transplantation.

227 tigated the signals attracting leukocytes to avascular transplanted pancreatic islets and leukocyte a

228 instead regresses, leading to a secondarily avascular tumor and massive tumor cell loss.

229 tumor-associated macrophage (TAM) entry into avascular tumor areas is regulated by Semaphorin 3A/Neur

230 We present a new mathematical model for avascular tumor growth and development that spans three

231 st paper, we present simulations of unstable avascular tumor growth in two and three dimensions and d

232 higher level of VEGF protein was detected in avascular tumor nodules compared with vascular nodules.

233 higher in vascular nodules compared with the avascular tumor nodules.

234 on of HIF-1alpha was detected exclusively in avascular tumor nodules.

235 on of such molecules into poorly perfused or avascular tumor regions remains problematic.

236 a single tumor cell, this model produces an avascular tumor that quantitatively mimics experimental

237 As avascular tumors became vascularized, VEGF levels decrea

238 role of hypoxia in incipient angiogenesis in avascular tumors during their early stages of growth.

239 ctor (VEGF) expression and resulted in small avascular tumors in mice.

240 ule and antibody therapies into microscopic, avascular tumors typical of patients with ascites.

241 hereas the low producer generated relatively avascular tumors, as determined by immunohistologic stai

242 or progression, particularly in slow-growing avascular tumors.

243 ading to dormancy of a substantial number of avascular tumors.

244 mature DC population than respective dormant avascular tumors.

245 , resulting in stunted and almost completely avascular tumors.

246 Whilst an avascular tumour always proceeds to a benign steady stat

247 Both vascular and avascular tumour dynamics are investigated, and a number

248 The outcome of the avascular tumour growth model suggested that tumour micr

249 mour implants, or whether this characterises avascular tumour growth more generally.

250 The model is based upon a growing avascular tumour spheroid, in which volume is filled by

251 lular automaton model to mimic the growth of avascular tumours, including the infusion of a bioreduct

252 by loss of endothelial cells leaving behind avascular type IV collagen-positive empty sleeves with r

253 uded extensive fibrinoid deposits, fibrosis, avascular villi, and edema, which could impair placental

254 tion of the placenta leads to development of avascular villi, edema, and hypoxia associated with symp

255 Large fibrinoids with avascular villi, edema, and inflammation were significan

256 owed visualization of the architecture of an avascular vitreous veil with localized retinal traction.

257 Analyses of the foveal avascular zone (FAZ) and vasculature surrounding the FAZ

258 To quantify foveal avascular zone (FAZ) area and macular vascular density o

259 Foveal avascular zone (FAZ) area was measured manually; vessel

260 Parameters quantified include the foveal avascular zone (FAZ) area, peripheral ischemic index, pe

261 Foveal avascular zone (FAZ) area, vessel densities, and perfusi

262 custom software used to quantify the foveal avascular zone (FAZ) area.

263 d to provide quantitative data on the foveal avascular zone (FAZ) features and the total vascular and

264 re able to quantify the size of their foveal avascular zone (FAZ) from the entoptic view, whereas onl

265 ity (VD), fractal dimension (FD), and foveal avascular zone (FAZ) of superficial and deep capillary p

266 The foveal avascular zone (FAZ) was more clearly delineated using t

267 The capillary network and foveal avascular zone (FAZ) were extracted using video and imag

268 l collateral vessels, the size of the foveal avascular zone (FAZ), and degree of vessel branching wer

269 ation of a perfusion network with the foveal avascular zone (FAZ).

270 years) with three preselected with no foveal avascular zone (FAZ).

271 ique for use in quantification of the foveal avascular zone (FAZ).

272 alized to areas of enlargement of the foveal avascular zone and macular capillary nonperfusion.

273 he SRL (0.794 [95% CI, 0.707-0.881]), foveal avascular zone area (0.472 [95% CI, 0.356-0.588]), and v

274 Parameters included: (1) foveal avascular zone area and macular leakage, (2) peripheral

275 Visual acuity correlated with foveal avascular zone area and parafoveal vascular density in t

276 Total avascular area and foveal avascular zone area were greater in eyes with DR by 0.82

277 el density, total avascular area, and foveal avascular zone as detected with 6 x 6-mm OCT angiography

278 ibitory role of the notochord in defining an avascular zone at the embryonic midline, in part via BMP

279 For foveal avascular zone grading, agreement was good for the 3 x 3

280 detected between vascular density or foveal avascular zone metrics and hemoglobin A1C or duration of

281 he area of capillary nonperfusion and foveal avascular zone morphology in patients with RVO.

282 ed the DA and increased the thickness of the avascular zone of the DA, which in turn induced the expr

283 ity was independently associated with foveal avascular zone size and central macular thickness (R(2)-

284 01), there was no association between foveal avascular zone size and peripheral ischemia (r = 0.114,

285 The size of the foveal avascular zone was also calculated automatically, and so

286 An avascular zone was not identified in the subjects with R

287 o form at Fd 135 in the center of the foveal avascular zone which is surrounded by a ring of blood ve

288 The nonflow area (foveal avascular zone) was significantly larger in sickle cell

289 (hyperfluorescent lesions, absence of foveal avascular zone).

290 (hyperfluorescent lesion, absence of foveal avascular zone).

291 hat co-localized to areas of enlarged foveal avascular zone, areas of no flow between capillaries, an

292 greatest linear dimension and area of foveal avascular zone, perifoveal capillary dropout grade, and

293 s of 2 patients had irregularities in foveal avascular zones and poor vision.

294 e findings demonstrate that Sema3E-generated avascular zones are critical regulators of mammalian car

295 We demonstrate that lateral avascular zones are directly generated by the lateral pl

296 ulpted through the generation of stereotyped avascular zones by EC-repulsive cues.

297 Four fellow eyes with normal foveal avascular zones did not show any retinal changes on SD-O

298 erning and normal revascularization into the avascular zones of the retina were augmented.

299 the avascular midline, yet maintain lateral avascular zones.

300 irculations and irregularities of the foveal avascular zones.