ライフサイエンスコーパス: avermectin

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1 ts to be a target of the antiparasitic agent avermectin.

2 channel that is gated by both glutamate and avermectin.

3 of potentiation of the glutamate response by avermectin.

4 -chain acid starter units typical of natural avermectins.

5 abamectin and emamectin benzoate-both potent avermectins-abolished spontaneous activity in the absenc

6 In contrast, the avermectins activate both ligand- and voltage-gated chlo

7 Doramectin is a commercial antiparasitic avermectin analog produced by fermenting a bkd mutant of

8 l Committee described as 'The discoveries of Avermectin and Artemisinin have revolutionized therapy f

9 Avermectin and beta-cypermethrin are commonly used insec

10 observed in C. elegans GluCl: dual gating by avermectin and glutamate, a rapidly desensitizing glutam

11 encoding chloride channels that are gated by avermectin and glutamate, respectively, were isolated fr

12 ::Tc1 strain mRNA elicited reduced amplitude avermectin and glutamate-dependent chloride currents.

13 shi Omura for their role in the discovery of avermectin and Professor Youyou Tu for her work on the d

14 Erythromycin, avermectin and rapamycin are clinically useful polyketid

15 eric channels that are gated irreversibly by avermectin and reversibly by glutamate.

16 ents suggest that GluClalpha is a target for avermectin and that additional glutamate-gated and averm

17 hi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies tha

18 Avermectins are a class of macrocyclic lactones that is

19 , but genes conferring natural resistance to avermectins are unknown.

20 The method is suitable for the analysis of avermectins at concentration as low as 2.5 mug kg(-1), a

21 cyclopentylmethyl radical on the skeleton of avermectin B1 has been investigated using density functi

22 OB binding, including midazolam, flurazepam, avermectin Ba1, baclofen, isoguvacine, and propofol, at

23 Avermectin binding assays in GluClalpha::Tc1 strain memb

24 In addition, the detection of avermectins by high resolution mass spectrometry using a

25 annel subunits that represent targets of the avermectin class of antiparasitic compounds, have recent

26 target site involvement in resistance to the avermectin class of compounds.

27 d H-receptor and an important target for the avermectin class of insecticides.

28 We present a simple method for extracting avermectines from meat, based on a QuEChERS approach fol

29 ible for the production of the anthelminthic avermectins, harbors a 13.4 kb gene cluster containing 1

30 stance of nematodes to anthelmintics such as avermectins has emerged as a major global health and agr

31 ated chloride channel, confers resistance to avermectins in the model nematode Caenorhabditis elegans

32 Following application of avermectin or beta-cypermethrin, F. occidentalis became

33 Because the avermectin polyketide synthase is known to accept more t

34 t the same variant confers resistance to the avermectin-producing bacterium Streptomyces avermitilis.

35 The wide-specificity loading module for the avermectin-producing polyketide synthase was grafted ont

36 lated to the alpha-subunit of the C. elegans avermectin receptor.

37 tion in glutamate-gated chloride channels in avermectin resistance and provide a mechanism by which s

38 ctin and that additional glutamate-gated and avermectin-sensitive chloride channel subunits exist in

39 udy the role of these subunits in conferring avermectin sensitivity we isolated a mutant C. elegans s

40 exhibit a normal phenotype including typical avermectin sensitivity.

41 zone), the glutamate-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolit

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