ライフサイエンスコーパス: aversive

1 , and those leading to punishments were more aversive.

2 can be rewarding and social isolation can be aversive.

3 ls' ability to recognize auditory stimuli as aversive.

4 Cannabis can be rewarding or aversive.

5 la and showed that high levels of Ca(2+) are aversive.

6 mbic pathway may thus function in processing aversive acoustic signals.

7 nd BLA while rats learned the location of an aversive air puff on a linear track, as well as during s

8 ells as conditioned stimuli (CS+/CS-) and an aversive alarm noise as the unconditioned stimulus.

9 ns of ghrelin signaling and examined several aversive and appetitive behaviors.

10 muli come normally associated with competing aversive and appetitive consequences and that interactio

11 to various subcortical sites that can drive aversive and appetitive CRs.

12 to motor circuits is oppositely regulated by aversive and appetitive learning.

13 lacebo hypoalgesia.SIGNIFICANCE STATEMENT In aversive and appetitive reinforcement learning, learned

14 to thrive, animals must be able to recognize aversive and appetitive stimuli within the environment a

15 Aversive and appetitive trace conditioning procedures we

16 opioid tone in the differential response to aversive and rewarding social stimuli in G-allele carrie

17 most researchers agree that mental effort is aversive and stems from limitations in our capacity to e

18 This stimulation was aversive, and instrumentally pausing stimulation could r

19 everal types of stimuli including rewarding, aversive, and neutral stimuli whereas VS dopamine showed

20 show that the Hb encodes both rewarding and aversive aspects of external stimuli, thus driving motiv

21 ne brain responses and habituation to mildly aversive auditory and tactile stimuli in 19 high-functio

22 outside the CNS, we used CGRP-induced light-aversive behavior in mice as a measure of migraine-assoc

23 itoneal) injection of CGRP resulted in light-aversive behavior in wild-type CD1 mice similar to avers

24 roles in motor coordination, appetitive, and aversive behavior, as well as neuropsychiatric disorders

25 gic (LC-NE) neurons induces anxiety-like and aversive behavior.

26 al projections that mediate these acute risk aversive behavioral states via the LC-NE system remain u

27 ironmental variables to ultimately fine tune aversive behaviors.

28 ted regions implicated in reward-seeking and aversive behaviors.

29 this CRF(BNST) inhibitory circuit underlies aversive behaviour following acute exposure to selective

30 biogenic amines, which suggest it is not an aversive behaviour.

31 the intake of food when it was offered in an aversive, bright compartment of a light/dark conflict te

32 ons including AIA is acutely required during aversive, but not appetitive, learning.

33 Both regions are sensitive to a range of aversive challenges, including uncertain or temporally r

34 courtship memory elicited in the absence of aversive chemical mating cues also is dependent on ETH-J

35 ng when the palatable diet was offered in an aversive compartment of a light/dark conflict box, and b

36 ium-depleted animals develop an appetite for aversive concentrations of sodium.

37 Increased sensitivity to aversive conditioned cues in cocaine users might be a ri

38 ich fear is first acquired through Pavlovian aversive conditioning (so-called fear conditioning), and

39 abnormalities in the neural underpinnings of aversive conditioning and extinction learning, as these

40 d retention of both contextual memory during aversive conditioning and spatial memory during spontane

41 sults support the postulated role of altered aversive conditioning in cocaine use disorder and may be

42 question, we trained rats on appetitive and aversive conditioning in different contexts.

43 sion starting from 30 days after the initial aversive conditioning normalized remote memories.

44 We designed a human parallel aversive conditioning paradigm in which different Pavlov

45 Pavlovian aversive conditioning requires learning of the associati

46 We use classical aversive conditioning to associate one out of a series o

47 ion with fear extinction training (a form of aversive conditioning) and response-outcome conditioning

48 mic pituitary-adrenal (HPA) axis activation, aversive conditioning, or insulin secretion.

49 d (phasic) habenula responses during primary aversive conditioning.

50 ble roles during both encoding and recall of aversive consequences of behavior.

51 t after a mix experience with appetitive and aversive consequences, parallel memories are established

52 emotional state; and (3) overeating despite aversive consequences.

53 s a brake to reward signaling in response to aversive costs.

54 sed activity during appetitive (CS-R) versus aversive (CS-S) conditioned stimuli (R cells and S cells

55 Perception of an aversive cue causes changes in behavior and physiology,

56 al on neural responses to both rewarding and aversive cues has not been examined.

57 nistration behavior, the presentation of the aversive delay cue reinstated drug seeking.

58 l responses that can be either appetitive or aversive, depending on an animal's age, prior experience

59 Conversely, scopolamine increased aversive 'disgust' reactions elicited by bitter quinine

60 for memory retention in both appetitive and aversive domains.

61 This early aversive effect is mediated via the corticotrophin-relea

62 shrimp by the memory recall of postingestive aversive effects (vomiting), evoked by repeatedly touchi

63 ems to promote nicotine avoidance before its aversive effects are encountered.

64 n on affective state are biphasic: immediate aversive effects are followed by delayed increases in re

65 work suggests that sensitivity to ethanol's aversive effects negatively modulates voluntary alcohol

66 th the MAGL inhibitor, MJN110, prevented the aversive effects of acute MWD by a CB1 receptor-dependen

67 We hypothesize that the initial aversive effects of KOR activation increase, whereas the

68 d is likely attenuated by sensitivity to the aversive effects of MA.

69 dulating affective states, are necessary for aversive effects of morphine withdrawal.

70 inistered MJN110 and AM251 in regulating the aversive effects of MWD.

71 Interestingly, both the rewarding and aversive effects of nicotine are probably critical for s

72 identified as major players in mediating the aversive effects of nicotine.

73 ve-like behavior and plays a key role in the aversive effects of stress.

74 VgluT2-expressing glutamate neurons produces aversive effects that might explain why cannabinoid is n

75 erformed a concurrent appetitive (money) and aversive (effort) learning task.

76 e amygdala-independent mechanisms leading to aversive emotional experiences, we retested two of these

77 ing may control the salience of rewarding or aversive emotional memory formation and social interacti

78 ms from impaired discrimination of safe from aversive environments or discernment of unlikely threats

79 brain regions that promote recovery from an aversive event [2].

80 is during retrieval renders the memory of an aversive event more labile and suggest a strategy to mod

81 A sudden aversive event produces escape behaviors, an innate resp

82 st to characterize USV responses to the same aversive event throughout development.

83 within the first month after a traumatic or aversive event to prevent PTSD or ASD compared with no p

84 ongly depend on its temporal relation to the aversive event.

85 al" role for the RMTg during encoding of the aversive event.

86 habenula (LHb) are transiently activated by aversive events and have been implicated in associative

87 al ventral tegmental area of mice respond to aversive events in different conditions.

88 colimbic structures that supports processing aversive events in humans.

89 Activation of the lateral habenula by aversive events inhibits dopamine neurons transiently, p

90 of psychiatric disorders, particularly when aversive events occur unpredictably.

91 In contrast, neural responses to aversive events remain an under-studied area.

92 urons acquired a short-latency excitation to aversive events that masked their VPE signaling.

93 ated whether these regions process different aversive events through a common modality-independent co

94 We examined neural responses to unexpected, aversive events using methods specialized for imaging th

95 pamine neurons were exclusively inhibited by aversive events, and expectation reduced dopamine neuron

96 vioral inhibition in the context of internal aversive events, but electrophysiological correlates of

97 Hb mediates negative feedback in response to aversive events.

98 ability to inhibit the mental exploration of aversive events.

99 ght to regulate learning from appetitive and aversive events.

100 an disrupt cortical circuitry to enhance the aversive experience in a generalized anatomically nonspe

101 Being bullied is an aversive experience with short-term and long-term conseq

102 Aversive experiences can lead to complex behavioral adap

103 rehensive role of this network in processing aversive experiences for self and others.

104 dults, early-life events, such as neglect or aversive experiences, can greatly impact adult behavior

105 n DA neurons while an organism is engaged in aversive experiences.

106 ribute to the behavioral consequences of the aversive experiences.

107 act as a protective buffer against otherwise aversive experiences.

108 d a linear increase in visuocortical bias to aversive expressions for all but the most severely impai

109 , a non-specific "preparatory" system learns aversive facial expressions and autonomic responses such

110 ts between covert vigilance and avoidance of aversive facial expressions, social anxiety appears to c

111 owed sustained visuocortical facilitation to aversive facial expressions.

112 riatal regions, corresponding to the classic aversive (fear) learning circuit.

113 y EAA deprivation is also linked to an acute aversive feeding response.

114 , and medial temporal areas dissociated risk-aversive from risk-taking individuals.

115 This effect on appetitive and aversive goal-directed behaviour is likely mediated by a

116 Here we establish whether non-aversive handling, brief prior familiarisation with the

117 s to reflect on feelings elicited by viewing aversive images (Study 1) and recalling negative autobio

118 Here we examined whether suppressing aversive images might also alter emotional responses to

119 otential) within the first second of viewing aversive images without enhancing an ERP marker of cogni

120 are established in a way that appetitive and aversive information is stored to be retrieved in an opp

121 d behavior and the spatial representation of aversive information within the mPFC.

122 ntegrate different sources of appetitive and aversive information.

123 rons establishes a scalable, persistent, and aversive internal state that dynamically controls thirst

124 ypically determined by whether appetitive or aversive interneuron populations are activated.

125 Aversive learning and appetitive motivation therefore to

126 esearch suggests that early adversity alters aversive learning and associated neurocircuitry, no prio

127 However, they are dispensable for aversive learning and innate behavior toward the odors a

128 reased anxiety-related behavior and impaired aversive learning as well as markedly affected motor fun

129 , early adversity alters the neurobiology of aversive learning by engaging a broader prefrontal-subco

130 Here we show that aversive learning causes a persistent depression of the

131 is administered either immediately after an aversive learning event or following a delay.

132 important step in understanding the role of aversive learning in the pathology of cocaine use disord

133 of a distributed set of brain regions during aversive learning may serve a protective function.

134 vantage of two well-described appetitive and aversive learning paradigms and combining them in a sing

135 ons make different contributions to a single aversive learning process or represent independent learn

136 Aversive learning requires nuclear translocation of the

137 We tested this using an aversive learning task manipulating environmental volati

138 For the PI youth, better aversive learning was associated with higher concurrent

139 titutionalization, individual differences in aversive learning were associated with worse current anx

140 -episode acute stressor on generalization of aversive learning when stress is administered either imm

141 Although pain is the main driver of aversive learning, the mechanism that transmits pain sig

142 An amygdala-projecting ensemble promoted aversive learning, while an independent medial prefronta

143 gdala circuits in resolving ambiguity during aversive learning.

144 arison youth, recruit the hippocampus during aversive learning.

145 prefrontal cortex development and associated aversive learning.

146 o prevent acute SSRI-induced enhancements in aversive learning.

147 1 males; age range, 7-16 years) completed an aversive-learning paradigm while undergoing functional n

148 Like in previous studies, aversive LTAM is also CREB dependent, and CREB activity

149 ciative memory and may specifically regulate aversive LTAM.

150 resentational patterns in the suppression of aversive memories after consolidation.

151 aminergic ligands might reduce dysfunctional aversive memories and improve the efficacy of exposure p

152 ical processes underlying the suppression of aversive memories before and after overnight consolidati

153 This evidence suggests that extinction of aversive memories engages reward-related circuits, but a

154 and in preserving episodic content of remote aversive memories in hippocampal-cortical networks.

155 Here we report that consolidated aversive memories retain their emotional reactivity and

156 und that crabs build separate appetitive and aversive memories that compete during retrieval but not

157 us normally acts to inhibit consolidation of aversive memories via the hippocampus and this system is

158 nterference and maintain precision of remote aversive memories.

159 ta-adrenergic receptors (betaARs), modulates aversive memory formation following PTC through two mole

160 eral cortical regions before retrieval of an aversive memory in choice-based versus no-choice-based c

161 Extinction of taste aversive memory led to the reduced insular synaptic effi

162 hat a retrieval cue can return a conditioned aversive memory to a labile state.

163 DAN cell type can either write or reduce an aversive memory, or write an appetitive memory, dependin

164 opiate-withdrawal-induced physical signs and aversive memory.

165 only essential for expression of short-term aversive memory.

166 reas adult exposure generates only transient aversive memory.

167 creased the retrieval-induced lability of an aversive memory.

168 ing task with appetitive (monetary gain) and aversive (monetary loss and electric shock) outcomes dur

169 patients, the human studies suggest that the aversive nature of light is more complex than its associ

170 hat releases both food odor and the innately aversive odor CO2.

171 eptors are known to contribute to Drosophila aversive odor learning per se, we here show that D2 rece

172 generated at birth disrupts responses to an aversive odor.

173 Second, when combined, some attractive and aversive odorants neutralize one another's behavioral ef

174 or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odor

175 od or a potential mate predict reward, while aversive odors of pathogen-laced food or a predator pred

176 attractive odors and reduced sensitivity to aversive odors.

177 ance responses when anticipating an upcoming aversive odour.

178 bditis elegans gene expression changes using aversive olfactory associative long-term memory (LTAM) a

179 Moreover, appetitive and aversive olfactory conditioning bidirectionally alters t

180 In the fruit fly, Drosophila melanogaster, aversive olfactory learning forms several phases of labi

181 airing odor with food deprivation results in aversive olfactory learning, and pairing odor with food

182 has been mainly studied by focusing on pure aversive or appetitive experiences.

183 specific to a particular type of procedure (aversive or appetitive).

184 rons and those that suppress activity during aversive or non-rewarding events.

185 o learning about, or responding to, the same aversive outcome, precisely the goals of therapeutic int

186 evant stimuli; blunted neural activation for aversive outcomes and aversive prediction errors; reduce

187 o an associative learning task by presenting aversive outcomes both in the presence and in the absenc

188 nt reward seeking despite highly negative or aversive outcomes, but the neural mechanisms underlying

189 a brain nucleus activated in anticipation of aversive outcomes.

190 d responses to CSs that predict rewarding or aversive outcomes.

191 ask with auditory cues for appetitive versus aversive outcomes.

192 entral tegmental area neurons exhibit longer aversive pauses relative to SNc neurons.

193 egmental area neurons tend to exhibit longer aversive pauses relative to SNc neurons.SIGNIFICANCE STA

194 ateral amygdala (LA) during consolidation of aversive pavlovian conditioning and that this memory req

195 rutabaga (rut) and dunce (dnc) mutants using aversive phototaxic suppression and courtship conditioni

196 The outcomes evaluated were the aversive, pleasurable, and stimulatory ratings of nicoti

197 ere modulated in a manner consistent with an aversive prediction error in individuals who learned pre

198 neural activation for aversive outcomes and aversive prediction errors; reduced willingness to expen

199 wever, scopolamine was without effect in the aversive procedure, revealing the importance of procedur

200 ggesting that 5-HT mediates the link between aversive processing and inhibition.

201 brain structure that plays a central role in aversive processing and is hypothesised to be hyperactiv

202 However, habenula responses during aversive processing have yet to be reported in individua

203 ngs about the role of the hormone ghrelin in aversive processing, with studies suggesting that ghreli

204 lutamatergic inputs to mediate rewarding and aversive properties of opiates.

205 other drugs of abuse, has both rewarding and aversive properties.

206 other drugs of abuse, has both rewarding and aversive properties.

207 Individual variations in aversive pruning levels related to subclinical anxiety l

208 found that individual variation in levels of aversive pruning was associated with the responses of in

209 ce and ubiquity of one such shortcut, namely aversive pruning, a reflexive Pavlovian process that inv

210 One pervasive and powerful heuristic is aversive pruning, in which potential decision-making ave

211 we show that when planning was influenced by aversive pruning, the subgenual cingulate cortex was rob

212 d by our task but which are complementary to aversive pruning.

213 ging (fMRI) to determine the neural basis of aversive pruning.

214 es associated with appetitive sucrose versus aversive quinine, indicating that they behave like rewar

215 pus' involvement in the contextual aspect of aversive reinforced tasks.

216 th dorsal raphe serotonergic activity during aversive reinforcement and amygdala serotonin 2C recepto

217 inhibition of BLA neurons around moments of aversive reinforcement or nonreinforcement causes reduct

218 Stress bolsters the consequences of aversive reinforcement, not by simply enhancing the neur

219 Robust activation to aversive relative to neutral events was observed in the

220 is not unique to TAARs and can extend to an aversive response of potential importance to survival.

221 ronic pain in one limb in rats increased the aversive response to acute pain stimuli in the opposite

222 neurons showed bidirectional control of the aversive response to acute pain.

223 We postulate that the delayed aversive response to detrimental microbes may provide su

224 n facilitating the extinction of conditioned aversive response to nicotine.

225 eralized site-nonspecific enhancement in the aversive response to nociceptive inputs.

226 ty representation in the ACC to increase the aversive response to noxious stimuli at anatomically unr

227 Bitter compounds elicit an aversive response.

228 terneurons contribute to both attractive and aversive responses through modulation of sensory neuron

229 elegans can alternate between attractive or aversive responses to carbon dioxide (CO2), depending on

230 ntal cortex-projecting ensemble extinguished aversive responses to enable flexible behavior.

231 that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons exp

232 and subjective stimulatory, pleasurable and aversive responses were monitored.

233 t activation of the caudal shell exacerbated aversive responses.

234 ion of involuntary tetanus was reported, and aversive sensations were restricted to the affected limb

235 conditions included one in which predictable aversive shocks were signaled by a cue, a second during

236 by exposure to the threat of unpredictable, aversive shocks while undergoing magnetoencephalography.

237 tive experiences and is involved in encoding aversive signals.

238 vocalizations (USV) when confronted with an aversive situation.

239 While aversive situations activate a network of limbic forebra

240 oxytocin plays a role in both appetitive and aversive social learning.

241 erein visual cues were paired with either an aversive sound (CS+) or no sound (CS-).

242 n of Pavlovian biases; or that stress, as an aversive state, might specifically impact action product

243 hat activation of NAc neurons produces acute aversive states and raises the possibility that inhibiti

244 uits have not yet been defined through which aversive states are orchestrated by 5-HT.

245 The unconditioned effects of more prolonged aversive states on dopamine release dynamics are not wel

246 OR agonist U50,488, which induce stress-like aversive states, reinstate alcohol seeking after extinct

247 licated in promoting opposing appetitive and aversive states, respectively.

248 o the Pavlovian linkage between inaction and aversive states.

249 Picking up mice by the tail is aversive, stimulating stress and anxiety.

250 , it resulted from the administration of the aversive stimulation alone.

251 limbic dopamine neurons that were excited by aversive stimulation.

252 ct functional circuits and were inhibited by aversive stimulation.

253 e LHb, a brain region involved in processing aversive stimuli and negative reward prediction outcomes

254 levance of variability in brain responses to aversive stimuli and provide a model that leverages this

255 tal nucleus (RMTg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections

256 (KO) mice displayed more robust responses to aversive stimuli and spent less time in the open arms of

257 are necessary for normal learning involving aversive stimuli and support the contention that dysregu

258 of SSRI treatment is to alter processing of aversive stimuli and that this is linked to DRN 5-HT1A r

259 m influences its perception of attractive or aversive stimuli and thus promotes adaptive behaviors th

260 It also senses aversive stimuli but reports their physical impact rathe

261 se to chronic exposure to both rewarding and aversive stimuli by regulating largely distinct subsets

262 n the nucleus accumbens (NAc) while discrete aversive stimuli elicit pauses in dopamine neuron firing

263 First, exposure to conditioned aversive stimuli in males trained to inhibit sexual beha

264 ERK induction by exposure to the conditioned aversive stimuli in mPFC and OFC.

265 We establish a circuit for the processing of aversive stimuli in the context of an innate visual beha

266 their attractiveness to mates, as opposed to aversive stimuli like predator cues.

267 r conditions, notably with appetitive versus aversive stimuli or positive versus negative emotions, i

268 apid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well cha

269 We observe that aversive stimuli, including foot-shocks, excite LHb neur

270 , global recruitment of most cells by strong aversive stimuli.

271 diated behavior, particularly in response to aversive stimuli.

272 ent of the LHb in encoding and responding to aversive stimuli.

273 sensory processing of information related to aversive stimuli.

274 ence associated with failed expectations and aversive stimuli.

275 ir firing in response to reward omission and aversive stimuli.

276 protect against heightened fear responses to aversive stimuli.

277 ditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the ti

278 d that exercising behavioral control over an aversive stimulus can persistently diminish threat respo

279 head movement, and avoidance response to an aversive stimulus-and we found that, if individually ove

280 e, and induced stimulatory, pleasurable, and aversive subjective effects.

281 Selectively silencing this pathway abolishes aversive symptoms in two different mouse models of opiat

282 To alleviate or avoid the aversive symptoms of withdrawal, many of these individua

283 n of memories into stable representations in aversive tasks such as fear conditioning.

284 ng spontaneous tasks that are different from aversive tasks.

285 vate the MB alpha lobe and are essential for aversive taste memory.

286 ef access task, where rats avoided consuming aversive taste stimuli and consumed the palatable tastan

287 m will be produced in response to a strongly aversive taste.

288 tion of palatable tastes and the ejection of aversive tastes, and that are sourced in a multifunction

289 tegmental area, which is consistent with an aversive "teaching signal" role for the RMTg during enco

290 ral dementia rated unpleasant odours as less aversive than did controls and displayed lower skin cond

291 t-sensing GRNs switches L-canavanine from an aversive to an attractive compound.

292 ystemic scopolamine was without effect in an aversive trace conditioning procedure, but impaired appe

293 Our study shows that non-aversive tunnel handling can substantially improve mouse

294 ide of the brain can result in attractive or aversive turning behaviors depending on the cell type.

295 s between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) is often assumed to

296 of an acoustic conditioned (CS, tone) and an aversive unconditioned stimulus (US, electric shock).

297 n auditory conditioned stimulus (CS) with an aversive unconditioned stimulus.

298 The aversive valence of these new extinction memories neutra

299 discrimination task involving appetitive and aversive visual cues.

300 ted the findings of increased sensitivity to aversive visual stimuli in synaesthetes.