ライフサイエンスコーパス: avidity

1 ficiency are characterized by high (18)F-FDG avidity.

2 into a potent one through cooperativity and avidity.

3 ent to tune its circulatory half-life or its avidity.

4 multiple ZipAs bound to a surface with high avidity.

5 that bind their cognate receptors with high avidity.

6 m was developed from predictors of (18)F-FDG avidity.

7 lanoma antigenic epitope but differ in their avidity.

8 IgGs for longevity but not for magnitude and avidity.

9 g cells, and increased anti-gp120 functional avidity.

10 t T cells with similar specificity but lower avidity.

11 on, particularly in combination with CMV IgG avidity.

12 ary disease, and no significant residual PET avidity.

13 or memory CD8 T cells, regardless of epitope avidity.

14 ve and low or moderate HCMV immunoglobulin G avidity.

15 ) are essential for antibody recognition and avidity.

16 rimeric nature of hemagglutinin for improved avidity.

17 vaccine Ab responses, including blockade Ab avidity.

18 corrected for background (18)F-fluciclovine avidity.

19 Low CMV IgG avidity (25%) alone correlated with a probability of con

20 and immunoglobulin G (IgG), (3) anti-VP1 IgG avidity, (4) anti-VP-2 epitope type specificity (ETS), a

21 aging for nodules without fluorodeoxyglucose avidity (68% vs 22%, respectively; P < .001).

22 flexibility and support a low-affinity, high-avidity adhesion mechanism that mediates bacteria-surfac

23 To explore how avidity affects regulatory strength, we generated a dupl

24 NCT01864083), changes in (18)F-fluciclovine avidity after neoadjuvant therapy were compared to breas

25 for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus

26 Type-specific antibody concentrations and avidity against HPV-16/18/31/33/45/52/58 were assessed.

27 CD8(+) T cells and inhibits their functional avidity against tumors.

28 mposite avidity/spatial metrics outperformed avidity alone.

29 Similarly, CMI and avidity analyses showed minimal qualitative improvements

30 CMV immunoglobulin G (IgG) avidity and CMV enzyme-linked immunospot (ELISpot) assay

31 between different HA configurations through avidity and establish a new mechanistic basis for the fu

32 subjects exhibited a higher T-cell receptor avidity and expression of CD25 and predominantly produce

33 dent FcRn binding that can be manipulated by avidity and Fc-engineering, factors that should inspire

34 the affinity of the individual arms, overall avidity and format valence.

35 (18)F-FDG avidity and gadolinium chelate enhancement were concorda

36 evaluated the concordance between (18)F-FDG avidity and gadolinium chelate enhancement.

37 sponses with significantly increased binding avidity and improved neutralizing breadth and potency to

38 a-CRIg dimer with increased iC3b/C3b binding avidity and MAC inhibitory activity.

39 While we did not find major differences in avidity and maturation between the pathogenic and nonpat

40 Neutralization titers and the avidity and maturation of immune responses did not diffe

41 Monovalent binding reduces avidity and potency, thus expanding the range of mutatio

42 All 6 twice-vaccinated cases had high avidity and PRN titers.

43 High avidity and selective binding of [M2pep]2-Biotin to M2 m

44 al polysaccharides revealed highly diverging avidity and selectivity for larger and more complex glyc

45 ical devices, which exploit the high binding avidity and selectivity of biospecific binding molecules

46 d transport adaptors seem to provide complex avidity and shield synaptic interaction surfaces of pre-

47 ctional dose increases CSP-specific antibody avidity and somatic hypermutation frequency in CSP-speci

48 ence cell surface expression, as well as the avidity and specificity for HLA-C ligands.

49 Class II MHC products and CD11b, showed high avidity and specificity.

50 increased antibody somatic hypermutation and avidity and sustained high protection upon rechallenge.

51 onship between changes in (18)F-fluciclovine avidity and the percentage of reduction of tumor on path

52 or avidity (SUVmax/mean/peak), composites of avidity and volume (including metabolic tumor volume), n

53 e all subunits simultaneously to attain high avidity and/or lock subunits together.

54 uated the magnitudes, epitope specificities, avidities, and functions of systemic and mucosal immune

55 assay (ELISA) to determine cross-reactivity, avidity, and competition for epitope binding; Western bl

56 T cells enhances their expansion, functional avidity, and cytokine polyfunctionality, resulting in pr

57 Anti-B19V IgM and IgG, avidity, and ETS assays were used to categorize individu

58 ed for anti-RUBV immunoglobulin G (IgG), IgG avidity, and IgG response to the 3 viral structural prot

59 measles immunoglobulin M, immunoglobulin G, avidity, and plaque reduction neutralization (PRN).

60 readth, cross-reactivity, polyfunctionality, avidity, and specificity are correlated with HIV control

61 ation and postchallenge; IgG subtypes and Ab avidity; and regulatory B (Breg) cell frequency and func

62 irectly contribute to the generation of high-avidity antibodies after TIV vaccinations by selectively

63 cell activation by low-avidity, but not high-avidity, antigens.

64 s, tumor burden, rather than CTL affinity or avidity, appears to be the main determinant of ACT outco

65 the type of peptide impacted on TCR/CD8:pMHC avidity, as tumor-reactive T cell clones derived from pa

66 for responses associated with protection, an avidity assay based on chemical disruption is often used

67 loped an HCV immunoglobulin G (IgG) antibody avidity assay by modifying the Ortho 3.0 HCV enzyme-link

68 As a result, the avidity assay is biased toward the detection of some ant

69 e feasibility and usefulness of TCR/CD8:pMHC avidity assessment by NTA-His tag-containing multimers o

70 Low-avidity autoreactive CD8 T cells (CTLs) escape from thym

71 Avidity-based algorithms have the capacity to accurately

72 interaction of MYC with WDR5 could create an avidity-based chromatin recognition mechanism that allow

73 Avidity-based testing algorithms were evaluated by their

74 directly, superantigens potently enhance the avidity between B7-2 and CD28, inducing thereby T-cell h

75 n cell surface glycoproteins results in high-avidity binding that can reversibly scaffold or cluster

76 tiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects co

77 er recognition of a wide variety of, or high avidity binding to, receptors.

78 cretor-positive participants maintained high avidity blockade Ab to GI.1 at day 180.

79 Development of high avidity, broadly neutralizing antibodies (Abs) is a prio

80 TFH cell responses favor Ab persistence and avidity but may predispose to higher acute viremia in th

81 d the threshold for B-cell activation by low-avidity, but not high-avidity, antigens.

82 ated branches have the potential to increase avidity by simultaneously binding to two subunits of a s

83 Changes in FDG avidity can provide an earlier evaluation of response to

84 T cells with high functional avidity can sense and respond to low levels of cognate A

85 as death receptor) compared with their lower-avidity CD4 counterparts.

86 ion of Francisella epitopes that elicit high-avidity CD4(+) T cell responses, specifically in humans,

87 at inclusion of an epitope that elicits high-avidity CD4(+) T cells converted a poorly protective vac

88 (+) T cell help preferentially augments high-avidity CD8(+) T cells and provide important insight for

89 nd others have previously reported that high-avidity CD8(+) T cells are more susceptible to tolerance

90 olyclonal line revealed that 94% of the high-avidity cells expressed the same TCRB gene as the high-a

91 immunosequencing of high-, medium-, and low-avidity cells sorted from a severe HA polyclonal line re

92 on-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to

93 the severe HA subject revealed that all high-avidity clones expressed the same TCRB gene.

94 lls expressed the same TCRB gene as the high-avidity clones.

95 one marrow chimeras and show that higher TCR avidity correlates with higher PLZF and reduced T-bet ex

96 hazard analysis was used to examine time to avidity cutoff.

97 ers are effective tools to isolate rare high-avidity cytotoxic T cells from patients for use in adopt

98 f LYVE-1 to bind HA is strictly dependent on avidity, demanding appropriate receptor self-association

99 ccess destruction complexes through enabling avidity-dependent AXIN binding.

100 MeV IgG avidity did not correlate with findings of neutralizatio

101 ree with literature values and show a strong avidity effect associated with the STV-NPs.

102 pecificity of the displayed octapeptides and avidity effect of their multicopy display on the phage s

103 to a solid-phase THP, most likely due to an avidity effect.

104 inity to m4-1BBL with an unexpectedly strong avidity effect.

105 the weak motifs enable processivity through avidity effects and by providing steric access to lysine

106 high affinity of fVIII for LRP1 results from avidity effects mediated by the interactions of two site

107 high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interaction

108 M), which mediate oligomerization and create avidity effects.

109 an cooperate to recruit binding partners via avidity effects.

110 avidity, whereas targeted disruption of TCR avidity enhancement eliminated GUCY2C-specific antitumor

111 Together, TCR avidity enhancement may be leveraged by prime-boost immu

112 Ad5 maximized antitumor efficacy through TCR avidity enhancement, it produced no autoimmunity, reflec

113 was determined through the limiting antigen avidity enzyme immunoassay.

114 ersely, robust and early expression of a low-avidity epitope compensated its weak intrinsic antigenic

115 In this study we tested the low-avidity epitope KCSRNRQYL, and show that a mouse CMV (MC

116 ressing a single MHC class I-restricted high-avidity epitope provided strong, T cell-dependent protec

117 n, although MCMV vectors expressing the high-avidity epitope SSIEFARL induced protective immunity irr

118 s in Ag competition, where responses to high-avidity epitopes outcompeted weaker ones expressed later

119 ence eventual clinical outcomes and lung FDG avidity, even before infection.

120 l defects with regard to isotype, functional avidity, expansion after boosting immunization, or the c

121 and organization influence its affinity and avidity following cell stimulation with chemokines and/o

122 clones and polyclonal lines having different avidities for the peptide-loaded tetramer were isolated

123 Unexpectedly, a substantially increased avidity for complement opsonins, as seen in midiFH, did

124 li, and iii) the impact of relative antibody avidity for dsDNA, chromatin fragments, or cross-reactin

125 T cells have sufficiently high TCR/CD8:pMHC avidity for efficient Ag recognition and consequently st

126 2-restricted T-cell receptor (TCR) with high avidity for human TERT from vaccinated HLA-A*0201 transg

127 a bipartite NLS in trans, which ensures high avidity for importin alpha7 while preventing non-specifi

128 context of the full length NP to confer high avidity for importin alpha7, explaining why the virus ef

129 uences of precursor frequency, affinity, and avidity for interclonal GC competition and indicate that

130 modified polyglucose nanoparticle with high avidity for macrophages.

131 e KIR locus and selective attenuation of KIR avidity for MHC class I are the functionally distinctive

132 AIT cell ligand displays the same functional avidity for MR1 as does the microbial compound.

133 ed to weaken its affinity for EPO-R, but its avidity for RBC precursors was rescued via tethering to

134 sion of T cell receptor of higher functional avidity for self-antigen by Treg cells than Tconv cells,

135 cell surface CD5, a surrogate marker for TCR avidity for self-pMHC, as compared with their adult coun

136 thin the apoptosome, markedly increasing its avidity for the complex and inducing selective intramole

137 s-reactive T cells, with variable functional avidity for the self-peptide, including some T cells tha

138 enfeebled dephosphorylation, suggesting that avidity for the substrate plays an important role in imp

139 ss subfamilies displayed a higher functional avidity for their cognate antigen than Vss subfamilies n

140 However, antibody avidity for these types showed noninferiority, independe

141 ain targeting by Listerin is imparted by the avidity gained from a multivalent network of context-spe

142 T, 82 [95% CI, 73-92]); and exhibited higher avidity (geometric mean avidity index [GMAI], 60%) than

143 Notably, increased functional CD4 T cell avidity improved antiviral efficacy of CD8 T cells.

144 mprehensive characterization of TCR/CD8:pMHC avidity in clinically relevant situations has remained e

145 macrophages and T cells drive [(64)Cu]-LLP2A avidity in granulomas.

146 water adjuvant induced the highest titer and avidity in IgG antibodies, measured using alga-produced

147 se-positron emission tomography demonstrated avidity in inguinal and internal iliac nodes, with lymph

148 (18)F-FDG avidity in the index malignancy, an advanced stage for t

149 absence of metastatic disease with expected avidity in two separate breast masses and multiple congl

150 s in the RBS 220-loop and can be buffered by avidity in viral receptor binding.

151 tive compound, CM11, dimerizes VHL with high avidity in vitro and induces potent, rapid and proteasom

152 immunoglobulin G antibody titers with a high avidity index (>/= 55%), absent or low titers of serum a

153 and exhibited higher avidity (geometric mean avidity index [GMAI], 60%) than in Typbar recipients (GM

154 primary HCMV infection, in association with avidity index and DNAemia may help to assess the risk of

155 aternary-structural dependence) and that the avidity index has no simple relationship to antibody aff

156 As a result of such biases, the avidity index may at best be a mere surrogate for undefi

157 what does the assay measure and what does an avidity index mean?

158 A multiassay algorithm (defined as an avidity index of <30%, followed by HCV viremia detection

159 The anti-Hib avidity index postvaccination strongly correlated with t

160 Based on that assay, an avidity index was devised for assessing the affinity mat

161 Only immunoglobulin G avidity index was higher in nontransmitting mothers, who

162 Since a high avidity index was linked to protection in animal models

163 s-protective types (HPV-16/18/31/33/45), the avidity index was noninferior for the 2-dose compared wi

164 The measles virus antibody avidity indexes were high for all children.

165 induced antigen specific endpoint titers and avidity indices of IgG in sera and IgA in tracheal, lung

166 Males had higher IgG Ab titers and avidity indices than females.

167 mportantly, CD4 T cells of higher functional avidity induced by low-dose vaccinations showed higher c

168 y regardless of antigen exposure; and 5) low-avidity insulin-reactive CD8(+) T cells are less affecte

169 serum, displaying a calcium-dependent, high-avidity interaction and ability to form large complexes.

170 proteins simultaneously, resulting in a high-avidity interaction that may confer specific binding to

171 lls, as is the ability of LFA-1 to form high-avidity interactions with ICAM-1.

172 onse to the Gag293 epitope with a functional avidity intermediate between that of controllers and tre

173 antigen-specific CD8(+) T cells is that this avidity is low.

174 gold nanoparticles can be conjugated to high-avidity ligands for a variety of cellular targets.

175 activation inside LNs leading to functional avidity maturation and uncover a role for low-affinity e

176 How functional avidity maturation is orchestrated in lymphoid tissue an

177 gned to TFV gel demonstrated slower antibody avidity maturation, as determined by the Bio-Rad (P = .0

178 jugate vaccines" efficiently induce antibody avidity maturation, isotype switching, and immunological

179 TFV but became infected had slower antibody avidity maturation, with potential implications for diag

180 further demonstrate that differences in TCR avidity may contribute to decreased expansion of the end

181 of protein specificity, including functional avidity, may carry greater weight in mediating effective

182 mation (lung [(18)F]fluorodeoxyglucose [FDG] avidity) measured by positron emission tomography and co

183 SUVmax, 6.8; range, 3.6-9.9) than (18)F-FDG avidity (median SUVmax, 10; range, 3.3-43.5).

184 6.1; range, 4.5-10.9) greater than (18)F-FDG avidity (median SUVmax, 3.7; range, 1.8-6.0).

185 ILCs (n = 4) demonstrated (18)F-fluciclovine avidity (median SUVmax, 6.1; range, 4.5-10.9) greater th

186 IDCs (n = 10) had a lower (18)F-fluciclovine avidity (median SUVmax, 6.8; range, 3.6-9.9) than (18)F-

187 py, our work describes the emergence of high-avidity Melan-A-specific clonotypes as a surrogate marke

188 proved antitumor immunity mediated by higher avidity, melanoma-specific CD8(+) T cells, but not T cel

189 critical for Cdc15 oligomerization and high-avidity membrane binding, stabilization of contractile r

190 e basis of these observations, we propose an avidity model of how JNJ-61186372 engages EGFR and c-MET

191 hat selective enhancement of C1q binding via avidity modulation is superior to the unattended increas

192 evel of viremia, showed lower quantities and avidities of IgG and lower frequencies of memory B cells

193 In addition, we measured the quantities and avidities of plasma Abs against various Ags by ELISA.

194 Moreover, the functional avidities of the immunodominant M1(58-66)/HLA-A*02:01-sp

195 We also assessed conditions where the avidity of Ag recognition varied because the lymphoma ce

196 Neutralizing antibodies and the avidity of antibodies were measured for measles virus.

197 strongly correlated with the increase in the avidity of antibodies, particularly in subjects who did

198 g nanoparticle, which markedly increased the avidity of antibody binding.

199 Improving the functional avidity of effector T cells is critical in overcoming in

200 ls as well as to enhance the affinity and/or avidity of Env-specific antibodies.

201 ectal IgG (r = +0.6) and IgA (r = +0.6), the avidity of Env-specific serum IgG (r = +0.5), and Ab dep

202 The magnitude, longevity and avidity of IgG differed significantly among mouse strain

203 The antibody titer and avidity of immunoglobulin (Ig) G specific for diphtheria

204 of protein specificity, including functional avidity of individual responses, are also critically imp

205 The binding affinity and avidity of integrins can be regulated via inside-out sig

206 The functional TcR avidity of only a subset of epitope-specific cells corre

207 Avidity of potentially neutralizing Ab may be an importa

208 Indeed, functional TCR avidity of responding GUCY2C-specific CD8(+) T cells ind

209 We found that both the amount and the avidity of specific antibodies rapidly increased during

210 2:01 transgenic B6 mice underscores the poor avidity of T cells recognizing M1(58-66).

211 bivalency of the interactions increases the avidity of tepsin for AP-4 and may enable cross-linking

212 rcentage of TFH and, interestingly, with the avidity of the Abs that recognize the SIV gp120 envelope

213 This reflects the increased functional avidity of the Env response over Gag, substantially more

214 earlier increases of both the magnitude and avidity of the IgG binding response than those with Env

215 stigated the role played by the affinity and avidity of the interaction between the tumor and the CTL

216 after TIV vaccination in the amount and the avidity of the polyclonal antibodies specific for the HA

217 y unresponsive tumors and predict pTR, using avidity of the primary tumor alone.

218 The avidity of the T-cell receptor (TCR) for antigenic pepti

219 ially to the Golgi suggesting an exceptional avidity of this organelle for curved membranes without s

220 approach to describe and compare the oxygen avidity of wines according to their basic chemical compo

221 f precursor frequency, antigen affinity, and avidity on B cell responses following immunization.

222 ated to understand the effect of valency and avidity on delivery.

223 ned to bind to Tf receptors (TfRs) with high avidity on the blood side of the BBB, but separate from

224 other KIR2DP1(F) residues modulate receptor avidity or signaling.

225 ar recognition agent whose orthogonal use of avidity over affinity results in uniquely stable yet rev

226 EL9 also has significantly higher functional avidity (P < 0.0001) and drives stronger selection press

227 T cells bearing TCRs with high TCR/CD8:pMHC avidity (p < 0.0001).

228 ne response and produced high titers of high avidity polyclonal antibodies.

229 served intrinsic lectin activity of the CRD, avidity property of Lg-ECD is affected as shown by a mar

230 Whether changes in (18)F-fluciclovine avidity reflect changes in tumor burden resulting from t

231 and observed several nonintuitive effects of avidity related to antigen density, target ratio, and an

232 combined use of CMV ELISpot and low CMV IgG avidity resulted in a higher level of association than e

233 gen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 i

234 vary and intestinal IgA responses and higher-avidity SIV Env-specific IgG in plasma.

235 h independently predicted pTR, and composite avidity/spatial metrics outperformed avidity alone.

236 ion rates of living CD8(+) T cells on a wide avidity spectrum.

237 Conclusion: Changes in (18)F-fluciclovine avidity strongly correlated with the tumor response on p

238 Changes in (18)F-fluciclovine avidity strongly correlated with the tumor response on p

239 imaging parameters included metrics of tumor avidity (SUVmax/mean/peak), composites of avidity and vo

240 cific IgA responses in combination with high-avidity systemic Env-specific IgG in protection against

241 Attempts to induce high-avidity T cells by low-dose in vivo vaccination failed b

242 Instead, selective induction of high-avidity T cells has required in vitro culturing of speci

243 How the exquisite specificity of high-avidity T cells is achieved is unknown but essential, gi

244 s effector function to levels seen with high-avidity T cells of identical specificity.

245 R affinity will allow a large arsenal of low-avidity T cells previously thought to be therapeutically

246 Only high- and medium-avidity T cells proliferated and secreted cytokines when

247 We demonstrate here that engineering of low-avidity T cells recognizing a naturally processed and pr

248 Because thymic selection depletes high-avidity T cells recognizing CD79b-derived peptides prese

249 tumor antigens are generally weak, and high avidity T cells specific for self-antigens are deleted i

250 e and promising approach for generating high-avidity T cells through vaccination.

251 dels of ATT, PD-1:28 engineering enabled low-avidity T cells to proliferate stronger and prevented PD

252 Upgrading the function of low-avidity T cells without changing the TCR affinity will a

253 ytokine secretion and lytic capacity of high-avidity T cells, but not low-avidity T cells.

254 HLA/CMV tetramers selectively detecting high-avidity T cells, we observed coappearance of CMV-CTLs wi

255 apacity of high-avidity T cells, but not low-avidity T cells.

256 Clonal expansion of lower-avidity T-cell clonotypes depends on availability of MHC

257 Cross-arm avidity targeting of antigen double-positive cancer cell

258 st time, the possibility of utilizing a high-avidity TCR specific for human TERT.

259 tion efficiency strongly correlated with TCR avidity, TCR signaling, cell-cell conjugate formation, a

260 The affinity of the remaining low-avidity TCRs can be improved to increase their antitumor

261 specific T-cell therapy and may require high-avidity TCRs that are capable of activating effector fun

262 rmed with differential-agglutination and IgG avidity tests when T. gondii IgG and IgM results were po

263 In contrast, high-avidity, Tf-containing nanoparticles with the acid-cleav

264 ed Mavs(-/-) mice exhibited lower functional avidity than those in wild-type animals, and even virus-

265 almost no interaction to the relatively high avidity that characterizes alphaIIbbeta3 is seen between

266 electively induce T cells of high functional avidity through vaccination.

267 Avidities to heterotypic genogroup I VLPs were not susta

268 DNA-based reagent platform that uses massive avidity to achieve stable, but reversible specific recog

269 Avidity to an immunologically novel GII.4 strain VLP cor

270 s RGD-like motif, altering baseline integrin avidity to ECM ligands and also facilitating preadhesion

271 ur experience and previous reports on VHL-HB avidity to somatostatin analogues suggested somatostatin

272 Blockade Ab avidity to the GI.1 vaccine component peaked at day 35 (

273 Avidity to the GII.4c vaccine component peaked at day 7,

274 zed and evaluated for improvement in binding avidity to the murine macrophages.

275 ly for immature thymocytes with intermediate avidity to the selecting ligands.

276 FcgammaRs have been associated with altered avidity toward IgG, thereby substantially impacting clin

277 S55-3 and S55-5 display similar avidity toward lipid A despite possessing a number of di

278 We use this approach to design high-avidity trimeric proteins that bind influenza A hemagglu

279 but conferred responses of lower functional avidity upon TCR transfer.

280 Belatacept, a second-generation, higher avidity variant of CTLA4Ig (abatacept), was approved by

281 affinity maturation, inter- and intraclonal avidities varied greatly, and half of GC B cells did not

282 Composite avidity/volume measures improve prediction.

283 sease, confirming that the (89)Zr-pertuzumab avidity was a true-positive result for HER2-positive mal

284 rophils LFA-1 adhesiveness was impaired, and avidity was enhanced, whereas Mac-1 adhesiveness was inc

285 Blockade Ab relative avidity was evaluated by measuring the slope of blockade

286 ional avidity, whereas CD8 T cell functional avidity was unrelated to vaccine dose in mice.

287 y (CMI), and immunoglobulin G (IgG) antibody avidity were assessed at baseline and 1 month and 1 year

288 he cell-mediated immunity and immunoglobulin avidity were evaluated as potential predictors of congen

289 obulin messenger RNA sequencing and antibody avidity were evaluated.

290 primary immune responses of low and/or high avidity were found against WT1 (15%), MUC1 (14%), PRAME

291 an, metabolic tumor volume, and total lesion avidity were obtained for the primary breast tumor, axil

292 an, metabolic tumor volume, and total lesion avidity were obtained for the primary breast tumor, axil

293 Changes in (18)F-fluciclovine avidity were strongly correlated with the percentage of

294 vely primes CD4 T cells of higher functional avidity, whereas CD8 T cell functional avidity was unrel

295 tumor efficacy associated with increased TCR avidity, whereas targeted disruption of TCR avidity enha

296 ect tumor-specific CD8(+) T cells of highest avidity, which are of the greatest interest for adoptive

297 lonotypic expansion, according to functional avidity, which correlates with self-reactivity.

298 (B-CLL) patients, but display low functional avidity, which limits their clinical utility in adoptive

299 derive from steric hindrance and diminished avidity with Nsp1p.

300 eals that Sir silencing proteins enhance the avidity with which nucleosomes assemble, endowing hetero

301 sing adjunctive therapy for restoring iodide avidity within the full spectrum from RAI-refractory ded