ライフサイエンスコーパス: awake

1 y for both feature types declined over a day awake.

2 reated with a single fraction of 25 Gy while awake.

3 ge as a function of vigilance state and time awake.

4 visual and auditory stimuli while asleep and awake.

5 f care with IS use 10 times every hour while awake.

6 primarily outdoors and often when people are awake.

7 on Scale = -5, -4), "sedated" (-3, -2, -1), "awake" (0), "agitated" (+1, +2, +3, +4).

8 modulate sensory signal processing, even in awake active animals.

9 ecorded bilaterally from auditory neurons in awake adult male zebra finches with multiple microelectr

10 individual neurons in the auditory cortex of awake adult mice and is associated with long-term improv

11 , sleep onset latency, sleep efficiency, and awake after sleep onset, derived from sleep diaries; pol

12 After that the nova awakes again-with accretion returning to the pre-eruptio

13 amus [medial geniculate body (MGB)] of young awake, aged awake, young anesthetized, and aged anesthet

14 all night in laboratory bedrooms or remained awake all night.

15 independent of changes in mean clinic BP or awake ambulatory BP.

16 ent of four drugs in the bloodstream of even awake, ambulatory rats, achieving precise molecular meas

17 ke and sleep durations, reaching up to 106-h awake and 48-h asleep.

18 ive differences in VNS heart control between awake and anaesthetized states, the physiological expres

19 pport that resting-state hemodynamics in the awake and anesthetized brain are coupled to underlying p

20 In both awake and anesthetized mice, we imaged an 8 x 8 mm field

21 Using in vivo two-photon imaging of both awake and anesthetized mice, we recorded spontaneous, on

22 olfactory bulb using multiphoton imaging in awake and anesthetized mice.

23 unication in the midbrain dopamine system of awake and anesthetized rats.

24 h spatial frequency tuning was found in both awake and anesthetized recordings.

25 into the ongoing spontaneous activity in the awake and anesthetized state, and the role of cholinergi

26 ortant to compare neuronal responses between awake and anesthetized state.

27 information is processed by the brain during awake and anesthetized states and, crucially, during the

28 simultaneously over the bilateral cortex of awake and anesthetized Thy1-GCaMP mice using wide-field

29 urs to accurately derive individualized mean awake and asleep BP.

30 le strength testing as soon as patients were awake and attentive.

31 y to be recorded with cellular resolution in awake and behaving animals.

32 f HA neuron activity on sleep-wake states in awake and behaving mice, we examined the effects of opto

33 ant analysis method was employed to classify awake and drowsy states.

34 iving task, in which subjects underwent both awake and drowsy states.

35 was greatest during maintenance, compared to awake and emergence in infants at 4-6 months.

36 activity in vivo in the V1 cortical area in awake and freely moving mice using two-photon microscopy

37 bility of delirium onset in patients who are awake and not delirious in the ICU.

38 The median time awake and number of prolonged disruptions were 3 hours (

39 ) activity during NREM states was lower than Awake and rapid eye movement (REM).

40 memory consolidation processes, but whether awake and sleep reactivation are suited to play similar

41 sults demonstrate significant differences in awake and sleep reactivation in the hippocampal-prefront

42 Awake and sleep SWRs are associated with memory reactiva

43 Awake and sleep SWRs both contribute to spatial learning

44 ate difference: prefrontal modulation during awake and sleep SWRs was surprisingly distinct, with dif

45 in hippocampal-cortical reactivation during awake and sleep SWRs, with key implications for their ro

46 zation of their large-scale coherence in the awake and sleeping brain.

47 rge-scale recordings of neuronal activity in awake and unrestrained animals is needed to provide new

48 tion and expressed no dyspnea, despite being awake and vigilant.

49 These findings suggest that, in the awake animal, the diameters of dural vessels are regulat

50 animal remain a good model for those in the awake animal.

51 Increasingly, awake animals are being used in physiological studies, s

52 ermore, they provide experimental support in awake animals for the "Stabilized Supralinear Network,"

53 ts show that auditory forebrain responses in awake animals in the passive hearing state are modulated

54 cs underlying its emergence in the cortex of awake animals remain unclear.

55 However, recordings from visual cortex in awake animals show that a large fraction of neural activ

56 recent studies of V1 have been performed in awake animals to examine links between vision and behavi

57 The largest age-related differences from awake animals were found for mid-to-high fms in MGB unit

58 oscillations have been described in inactive awake animals, but it is unclear whether they shape sens

59 uld thus demonstrate the existence of HRR in awake animals, namely, a respiration-entrained slow rhyt

60 For recordings from the visual cortex of awake animals, small "fixational" eye movements (FEMs) i

61 l posterior nucleus of both anesthetized and awake animals, using a common set of stimuli: drifting s

62 CN neuron activity and electrocorticogram in awake animals, we investigated to what extent pharmacolo

63 How responses adapt in awake animals, when stimuli may be behaviorally relevant

64 vity and hemodynamics was robust and fast in awake animals, whereas coupling in urethane-anesthetized

65 ortex are poorly understood, particularly in awake animals.

66 single-unit recordings with iontophoresis in awake animals.

67 and raised thermal withdrawal thresholds in awake animals.

68 ormation is processed in sensory cortices of awake animals.

69 processing and whether they occur in aroused awake animals.

70 d inhibitory neurons in the visual cortex of awake behaving animals, we found visually evoked stereot

71 l processing in the primary visual cortex of awake behaving macaque monkeys.

72 dynamics of large-scale neuronal circuits in awake behaving mammals at high speed and resolution has

73 Using local field potential recording in awake behaving mice and concomitant field potential and

74 rols mouse behavior, we used optogenetics in awake behaving mice and found that activation of choline

75 calcium transients in NAc D1- and D2-MSNs in awake behaving mice and found that D1-MSN activity is a

76 Ca(2+) dynamics of large neural ensembles in awake behaving mice and tracked the responses of MeA neu

77 ng to monitor the activity of young abGCs in awake behaving mice.

78 dendrites of neocortical pyramidal cells in awake behaving mice.

79 ss cortical layers and in the hippocampus of awake behaving mice.

80 ntrol food intake, AgRP and POMC neurons, in awake behaving mice.

81 m up to 37 cortical and subcortical areas in awake behaving monkeys for up to 9 months.

82 This oscillatory activity can be recorded in awake behaving rats with unilateral dopamine cell lesion

83 ecent advances in the use of optogenetics in awake behaving rodents has added an additional valuable

84 ificially imprinting neuronal ensembles into awake, behaving animals and of later recalling those ens

85 ent investigations of rapid state changes in awake, behaving animals have provided insight into the m

86 ation of the VGat-Cre(CeMA-vmPFC) circuit in awake, behaving animals produced a positive, reward-like

87 model that mimics natural input patterns in awake, behaving animals.

88 ncurrent hippocampal microdialysis in young, awake, behaving APPswe/PS1dE9 transgenic mice.

89 rded intracellularly from hippocampal CA1 of awake, behaving male mice to examine both subthreshold a

90 found that physiological hyperinsulinemia in awake, behaving mice does not increase CNS insulin to an

91 al imaging of dentate gyrus granule cells in awake, behaving mice in an intact hippocampal circuitry

92 Optical recordings in awake, behaving mice reveal that these neurons are selec

93 subthreshold patterns of activity in CA1 of awake, behaving mice.

94 ly inhibits hunger-promoting AgRP neurons in awake, behaving mice.

95 ng to monitor the activity of mossy cells in awake, behaving mice.

96 tentials (EPs) in the sensorimotor cortex of awake, behaving monkeys.

97 ity in recordings of neuronal populations in awake, behaving nonhuman primates induced by paired elec

98 dopamine release from deep brain circuits of awake, behaving primates in a longitudinally reproducibl

99 etry measurements in the ventral striatum in awake, behaving rats reveal reward-related tissue oxygen

100 nsory and motor functions is demonstrated in awake, behaving rats, in which natural activation of the

101 holinergic terminal fields within the BLA in awake-behaving mice during training in a cued fear-condi

102 ivo two-photon microscopy in anesthetized or awake-behaving mice, we document for the first time that

103 recise activation of vestibular afferents in awake-behaving monkeys to link plasticity at different n

104 g low-vigilance states but also occur during awake behavior.

105 neurons and whether they occur during active awake behavioral states.

106 ingle Vg units in both anesthetized rats and awake, body restrained rats.

107 thalamus, and (2) how alert versus nonalert awake brain states affect visual processing across the s

108 We also show that transitions between awake brain states powerfully affect corticogeniculate p

109 Awake bronchoscopic intubation supported with a noninvas

110 intubation with a novel technique combining awake bronchoscopic intubation supported with nasally de

111 e to sleep increases the longer that we stay awake, but this process is poorly understood at the cell

112 firing (6 h) in cortex by: (1) keeping mice awake by exposure to novel objects to promote plasticity

113 Finally, awake CA1-PFC reactivation was enhanced most prominently

114 corded from the posterior lobe hemisphere in awake cats.

115 an animated ICU filled with patients who are awake, cognitively engaged, and mobile with family membe

116 the rate-coding neurons are only observed in awake conditions, it is especially challenging to probe

117 5.8 coughs; P < 0.0001), but not spontaneous awake cough frequency (mean change from baseline, XEN-D0

118 1 (oral, 4 mg twice daily) versus placebo on awake cough frequency (primary outcome), capsaicin-evoke

119 ong males), and can be affected by the sleep-awake cycle.

120 Awake DBS cohorts had a significantly greater decrease i

121 ay lead to lower complication rates overall, awake DBS may lead to less treatment-induced side effect

122 ients who are not candidates for traditional awake DBS or prefer the asleep alternative.

123 tive comparative studies of the efficacy of 'awake' deep brain stimulation (DBS) for Parkinson's dise

124 called ripples-both during sleep [9, 10] and awake deliberative periods [11-13].

125 Here we established an awake electrophysiological recording system, combined wi

126 In awake female Dutch-Belted rabbits, we found 58% of CG ne

127 ing individual MLIs in the Crus II region of awake female mice during two types of oromotor activity,

128 ve phase and either left undisturbed or kept awake for 90 min after which their brains were collected

129 cularly defined populations of LH neurons in awake freely moving mice, we show that MCH neurons gener

130 ivery of fluids and light into the brains of awake, freely behaving animals.

131 ction of irradiance in both anesthetized and awake, freely moving mice and at the level of the retina

132 Among them, 27 awoke from coma, resulting in a positive predictive valu

133 l activity parcellation in head-fixed, quiet awake GCaMP6 mice from both sexes by using mesoscopic ca

134 area), display distinct visual properties in awake head-fixed mice.

135 orded from primary mechanosensory neurons of awake, head-fixed mice as they explored a pole with thei

136 volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and d

137 ance in any region of the visual field of an awake, head-fixed mouse.

138 S placement, we found measurements of PPG in awake, hemodynamically stable patients at least 24 hours

139 During a self-paced spatial task, awake hippocampal replay occurring either immediately be

140 n appear in various cortical regions in both awake humans [2] and rodents [3-5].

141 ortical substrate to hypocapnic breathing in awake humans and fuels the notion of corticosubcortical

142 and spontaneous arterial CO2 fluctuations in awake humans at rest.

143 clamped the behavior of the animal to either awake immobility or treadmill running by using a head-fi

144 In contrast, during awake immobility, the hippocampus is thought to be domin

145 ess during sleep, but SWRs also occur during awake immobility, where their role remains unclear.

146 Meanwhile, staying awake in the second half of the night led to an increase

147 t enriched wake, more than simply time spent awake, induces DSBs, and their repair in mice is delayed

148 Novel methods were developed to scan awake infants with fMRI, while they viewed multiple cate

149 STG, and the patient subsequently underwent awake intraoperative mapping using direct electrical sti

150 he brain sleeps while the other half remains awake, is seen in some aquatic mammals and birds, partic

151 neutral stimuli during recall, while staying awake led to a recovery of discrimination between exting

152 transmission in olfactory neurons in intact, awake locusts (Schistocerca americana) while pharmacolog

153 that visually induced gamma-band activity in awake macaque area V4 rhythmically modulates responses t

154 of two-photon imaging with genetic tools in awake macaque monkeys will enable fundamental advances i

155 chniques for long-term two-photon imaging in awake macaque monkeys.

156 investigated Granger-causal influences among awake macaque primary visual area V1, higher visual area

157 We find that in the awake macaque the modulatory effect of serotonin is surp

158 Here, by using two-photon imaging in awake macaques and systematically characterizing V1 neur

159 , and measured visually evoked potentials in awake male and female mice before and after a 7 d monocu

160 ) to time-varying acoustic and CI signals in awake marmoset monkeys (Callithrix jacchus).

161 tic and CI stimulation in auditory cortex of awake marmoset monkeys, we discovered that neurons unres

162 stimuli, a large population of A1 neurons in awake marmosets (Callithrix jacchus) responded to rapid

163 lar recording technique that we developed in awake marmosets, we found that the two types of rate-cod

164 r cortical feedback in the olfactory bulb of awake mice and further probe its impact on the bulb outp

165 shifted toward higher values in the dLGN of awake mice and responses were more sustained.

166 tions from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontane

167 modeling study using a data set recorded in awake mice containing respiratory rate modulation.

168 yer 2/3 excitatory and inhibitory neurons in awake mice during passive visual stimulation and perform

169 Using calcium imaging in awake mice of both sexes, we show that the spatial frequ

170 In vivo imaging in awake mice revealed that L2 cells had higher bandwidth t

171 Whole-cell recordings in L2/3 of awake mice revealed that the E/I ratio systematically de

172 roscope we confirmed with calcium imaging in awake mice that hM4D activation by CNO inhibits striatop

173 aging of the indicator GCaMP6 in head-fixed, awake mice to characterize the organization of spontaneo

174 ordings in visual cortex of anesthetized and awake mice to measure intracellular activity; we then ap

175 l recording and two-photon Ca(2+) imaging in awake mice to show that lateral inhibition shapes freque

176 o-photon calcium imaging in anesthetized and awake mice to visualize both odorant-evoked excitation a

177 aging of granule cell population activity in awake mice using a cortical window implant that leaves t

178 evoked gamma activity in layers 2/3 of V1 of awake mice using targeted patch-clamp recordings and syn

179 xcitability during in vivo EEG recordings in awake mice where the effects of the proconvulsant pentyl

180 We examined this issue in brain slices, awake mice, and a computational model.

181 al seizures in primary visual cortex (V1) of awake mice, and compared their propagation to the retino

182 ike train properties of cerebellar output in awake mice, and strongly supports rate coding in the cer

183 Using large-scale population recordings in awake mice, we find distinct coding strategies facilitat

184 ing calcium imaging of cellular responses in awake mice, we find surprising asymmetries in the spatia

185 In awake mice, we found that auditory responses in entorhin

186 oton emission computed tomography imaging in awake mice, we identified brain structures activated dur

187 Using two-photon calcium imaging in awake mice, we show that the encoding of audiovisual sti

188 single-unit recordings in auditory cortex of awake mice, we show that this may not generally hold tru

189 using chronic two-photon calcium imaging in awake mice.

190 ation-entrained rhythm in the hippocampus of awake mice.

191 al respiration rhythm" (HRR), also occurs in awake mice.

192 c imaging of cortex in both anesthetized and awake mice.

193 osterior nucleus, and V1 in anesthetized and awake mice.

194 during hyperinsulinemic-euglycemic clamp in awake mice.

195 odor concentrations and in anesthetized and awake mice.

196 vation sufficient to evoke motor behavior in awake mice.

197 opulations can be achieved and maintained in awake monkeys for months.

198 sensory neocortex from anesthetized mice and awake monkeys supported these predictions, suggesting th

199 isual areas in one hemisphere in each of two awake monkeys to investigate spatial patterns of local a

200 motion processing in the auditory cortex of awake monkeys using functional magnetic resonance imagin

201 cell or single dendritic spine resolution in awake monkeys, the techniques reported can help bridge t

202 psin-containing corticothalamic terminals in awake monkeys.

203 ary visual cortex (V1) at eye opening in the awake mouse and identify the features of basic V1 functi

204 nges of single dural and pial vessels in the awake mouse during voluntary locomotion.

205 Two-photon calcium imaging in awake mouse models showed that nicotine can differential

206 ial (LFP) activity in both anaesthetized and awake mouse sensori-motor cortex.

207 tely 4,000 cortical neurons in layers 1-5 of awake mouse V1.

208 k, we use data from the visual cortex of the awake mouse watching naturalistic stimuli and show that

209 studies of receptive field properties in the awake mouse, especially in dLGN and lateral posterior nu

210 ultaneously from five brain structures in an awake mouse.

211 intained or even increased their activity in awake naive mice.

212 Intracranial electrical brain stimulation in awake neurosurgery patients is a powerful means to deter

213 temperature of distinct cortical regions in awake neurosurgical patients, and we relate this perturb

214 d-of-dose deterioration and had a mean total awake off-time (state of akinesia or decreased mobility)

215 rcadian phase, prior sleep, and elapsed time awake on cognition and sleep.

216 predictive values of mean clinic BP and mean awake or 48-hour ambulatory BP was not significant when

217 essive treatment-induced decrease of clinic, awake, or asleep BP are unknown.

218 ken across laminae of the midbrain SC of the awake, passively listening big brown bat, Eptesicus fusc

219 ears feasible in cardiac arrest patients and awake patients with acute myocardial infarction.

220 ld, high-speed, and long-range OCT images of awake patients' vocal folds as well as cross-sectional v

221 these rhythms can be caused by altered sleep-awake patterns or by pathological conditions and can ini

222 endogenous reactivation during post-encoding awake periods, less work has addressed whether awake tar

223 st experiments in the superior colliculus of awake primates with strabismus using a combination of si

224 In awake primates, however, small "fixational" eye movement

225 a more general problem for V1 recordings in awake primates.

226 % prednisolone acetate (PA) every hour while awake (q1hWA, Group 1) or qid (Group 2).

227 e, in the corticogeniculate visual system of awake rabbits, we investigate the functional significanc

228 ors when applied to the ocular surface of an awake rat.

229 sured as oxygen consumption) both in vivo in awake rats and ex vivo in skeletal muscle tissue, with a

230 ing in the medial prefronal cortex (mPFC) of awake rats as measured by ex vivo (1)H-[(13)C]-nuclear m

231 By juxtacellularly recording PreS neurons in awake rats during passive-rotation, we found that head-d

232 and striatal ongoing population activity in awake rats during quiet resting that intrastriatal inhib

233 l stimulation of the ipsilateral hindlimb in awake rats evoked field potentials in the C1 zone in the

234 trate that medial geniculate body units from awake rats show an age-related preference for predictabl

235 onnectivity to be measured in freely moving, awake rats, implanted carbon paste electrodes (CPEs) wer

236 release in the NAc of both anesthetized and awake rats.

237 e-neuron and electromyographic recordings in awake rats.

238 Awake reactivation is a higher-fidelity representation o

239 Our findings suggest that awake reactivation is ideally suited to support initial

240 Stronger awake reactivation was observed despite the absence of c

241 hibition of MECIII input to CA1 during quiet awake reduced ripple bursts in CA1 and restricted the sp

242 63 infants were randomly assigned to receive awake-regional anaesthesia and 359 to general anaesthesi

243 re randomly assigned (1:1) to receive either awake-regional anaesthesia or sevoflurane-based general

244 ntal outcome at 2 years of age compared with awake-regional anaesthesia.

245 data were available for 238 children in the awake-regional group and 294 in the general anaesthesia

246 ite score (mean [SD]) was 98.6 (14.2) in the awake-regional group and 98.2 (14.7) in the general anae

247 here was equivalence in mean between groups (awake-regional minus general anaesthesia 0.169, 95% CI -

248 vides strong evidence for the involvement of awake replay in fear memory retrieval.

249 Conflicting hypotheses implicate awake replay in learning from reward and in memory retri

250 s reactivation occurred in ripple-associated awake replay of place cell sequences encoding the paths

251 Further, awake replays can be forward, in the same order as exper

252 sive micron-scale mapping of cerebral Po2 in awake, resting mice.

253 it recordings from multiple brain regions in awake restrained mice over 4 mo.

254 activation of corticothalamic projections in awake rhesus macaques.

255 Hippocampal activity during awake sharp-wave ripple (SWR) events is important for sp

256 ficient information integration for the time awake.SIGNIFICANCE STATEMENT Lack of sleep deteriorates

257 ore suggest that behavioral markers exist in awake sleepwalkers, characterized by their ability to pe

258 ulated (SAM) tones in the auditory cortex of awake squirrel monkeys, we show that the prior presentat

259 minergic circuitry in the maintenance of the awake state and ethologically relevant sleep-related beh

260 sharp-wave ripples (SWRs) occur both in the awake state during behavior and in the sleep state after

261 place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple

262 In awake state, HRRs were determined for each combination o

263 nses under anesthesia resembled those in the awake state, indicating that the novel anesthetic combin

264 rom an anesthetized, unconscious state to an awake state, suggesting critical involvement in behavior

265 rain activity and is largely constant in the awake state.

266 t during the sleep state, but not during the awake state.

267 y during the sleep state, but not during the awake state.

268 during sleep or anesthesia compared with the awake state.

269 AR antagonists to mimic the elevation in the awake-state delta frequency EEG power that occurs in sch

270 ent's inability or unwillingness to tolerate awake surgery, or anatomic anomaly or variant that could

271 We report that awake SWR rates at the reward site are inversely related

272 ween SWRs and VTE behaviors and suggest that awake SWRs and associated planning and memory consolidat

273 d ensemble measures, was more structured for awake SWRs compared with post-task sleep SWRs.

274 Thus, awake SWRs mark times of strong coordination between hip

275 These findings suggest that awake SWRs support accurate memory storage and memory-gu

276 ple (SWR) events occur during both behavior (awake SWRs) and slow-wave sleep (sleep SWRs).

277 CA1-PFC synchronization was stronger during awake SWRs, and spatial reactivation, measured using bot

278 To measure the in vivo effects of such loss, awake symptomatic-stage ALS mice performing self-initiat

279 ake periods, less work has addressed whether awake targeted memory reactivation modulates memory.

280 liver require eating during a mouse's normal awake time and that these size changes are controlled by

281 support the notion that reactivation during awake time periods improves memory stabilization.

282 n these overlapping memories acquired during awake time.

283 pact on overlapping memories acquired during awake time.

284 Awake tissue Po2 is about half that under isoflurane ane

285 , these two parameters correspond well to an awake to drowsy state transition.

286 On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological

287 conditions, these sleeping champagne bottles awoke to tell us a chapter of the story of winemaking an

288 An awake, trained caregiver should be present at all times,

289 ive-wake behaviors, while leaving time-spent-awake unaffected.

290 d RAN SAM stimuli; significantly fewer young awake units (51%, p < 0.0001) preferred RAN SAM signals

291 ts, there was a significant increase of aged awake units preferring SEQ SAM (30%, p < 0.05).

292 Compared with young awake units, there was a significant increase of aged aw

293 sponses have not been adequately explored in awake, unrestrained animals.

294 ty and investigated a weaning strategy using awake venoarterial extracorporeal membrane oxygenation (

295 by the UPDRS IV off medication score (78.4% awake vs 59.7% asleep, p=0.022).

296 s and the mean peak ratio when patients were awake were the best predictors of faster progression.

297 M) associated stages was greater than during Awake, whereas beta (13-30 Hz) activity during NREM stat

298 and long-range replays specifically in quiet awake, whereas CA3 input is essential for both, regardle

299 geniculate body (MGB)] of young awake, aged awake, young anesthetized, and aged anesthetized rats.

300 We used calcium imaging in awake zebrafish during optokinetic behavior to record tr