ライフサイエンスコーパス: axial element

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1 ted sister chromatids are organized along an axial element.

2 mbly of a transverse element between the two axial elements.

3 show that SWI1 is required for formation of axial elements.

4 and Hop1, two meiotic specific components of axial elements.

5 is required for homolog pairing, as well as axial element (AE) and synaptonemal complex (SC) formati

6 utation that prevents DSB formation enhances axial element (AE) formation for rad50-4, an allele pred

7 t HTP-3, a known component of the C. elegans axial element (AE), molecularly links these meiotic inno

8 ops, which are anchored to the proteinaceous axial element (AE).

9 eases in the percentage of nuclei containing axial elements (AE) only or no structures.

10 t Rec8 are defective in the formation of the axial elements (AEs) of the SC, suggesting that, in mamm

11 The proper assembly of axial elements (AEs), lateral components of the SC, duri

12 higher for SC segments than for (asynapsed) axial elements (AEs).

13 d for formation of cytologically discernible axial elements and SC and maximal levels of recombinatio

14 normal in ndj1Delta cells, but formation of axial elements and synapsis were delayed.

15 Functional axial elements are essential for wild-type levels of rec

16 Axial elements are fully developed, but synapsis of any

17 During meiosis, axial elements are generated by the condensation of sist

18 model whereby Mek1 kinase activity controls axial element assembly by regulating the affinity with w

19 Using the immunostaining of the axial element component (ASY1/HOP1) to find unsynapsed r

20 lating mechanism that requires the conserved axial-element component Hop1 biases axis protein binding

21 We show that axial element components HTP-1 and HTP-2 are removed dur

22 roper assembly of Rad51 onto the chromosomal axial elements during meiosis.

23 genes, HOP1, RED1 and MEK1, are involved in axial element formation in the yeast Saccharomyces cerev

24 sister chromatid cohesion, recombination and axial element formation.

25 zygonema-like shortening of their chromosome axial elements/lateral elements, partial loss of centrom

26 otic chromatin regions, including unsynapsed axial elements linked to chromatin inactivation, and med

27 hese experiments lead us to hypothesize that axial elements mediate the activities of recombination p

28 undergo proper chromosome synapsis; neither axial elements nor mature synaptonemal complexes are com

29 lear foci in somatic cells as well as on the axial elements of developing synaptonemal complexes in m

30 subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes.

31 In the synaptonemal complex (SC), axial elements of each homologue connect through molecul

32 revealed localization of SMC1beta along the axial elements of synaptonemal complexes in prophase I.

33 by linear elements (LinEs) analogous to the axial elements of the synaptonemal complex (SC) in other

34 1 and Rad51 were both detected on asynapsed (axial) elements of human synaptonemal complexes.

35 (SC) morphogenesis, we explored the role of axial elements--precursors to the lateral element in the

36 Red1 also localizes to the unsynapsed axial elements present in a zip1 mutant, suggesting that

37 interhomolog recombination by targeting the axial element protein Hop1.

38 Female mice lacking the SC axial element protein SYCP3 produce viable, but often an

39 We found that the axial element proteins of budding yeast are flexibly anc

40 Assembly of Rad51 foci on axial elements remained defective, and gametogenesis pro

41 es fail to synapse, despite the formation of axial elements that are the precursor to the SC.

42 ription, we investigated the assembly of the axial element, the proteinaceous structure that compacts

43 LinEs are related to axial elements, the synaptonemal complex precursors of o

44 uch robust but flexible tethering allows the axial element to promote recombination while easily adap

45 OP1 and RED1 encode structural components of axial elements while MEK1 encodes a putative protein kin

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