ライフサイエンスコーパス: axial mesoderm

1 omplete failure of the anterior extension of axial mesoderm.

2 ge embryo, and does not share a lineage with axial mesoderm.

3 neath, lateral to and ahead of the ingressed axial mesoderm.

4 from the paraxial mesoderm (PM) and not from axial mesoderm.

5 os, cells at this position form endoderm and axial mesoderm.

6 ecify prechordal mesoderm character in chick axial mesoderm.

7 oly even before making vertical contact with axial mesoderm.

8 differentiation and forms in the absence of axial mesoderm.

9 ly in response to differential signalling by axial mesoderm.

10 tion of Shh transcription within the CNS and axial mesoderm.

11 ion of RDVM cells under the influence of the axial mesoderm.

12 d in the organizer region and transiently in axial mesoderm.

13 or proper development of the neural tube and axial mesoderm.

14 se to paraxial mesoderm, at the exclusion of axial mesoderm.

15 ed Vg1, mature zDVR-1 is a potent inducer of axial mesoderm.

16 ate gastrulation, regulating BMP activity in axial mesoderm.

17 Chick posterior non-axial mesoderm also induces Pax-3, provided that the ani

18 le mutants display a progressive loss of non-axial mesoderm and a concomitant expansion of axial meso

19 s in association with impaired maturation of axial mesoderm and failed specification of paraxial meso

20 xpressed at high levels in the organizer and axial mesoderm and is required for establishing left/rig

21 per Shh expression in the underlying rostral axial mesoderm and localized changes of neural marker ex

22 s the ortholog of mammalian HNF3beta in both axial mesoderm and neurectoderm; the role of Xenopus HNF

23 ealed defective convergent extension in both axial mesoderm and neuroepithelium, before the onset of

24 tor, is expressed in the limb bud as well as axial mesoderm and primitive streak.

25 The extension of axial mesoderm and the continuation of ingression throug

26 e sources responsible for this activity, the axial mesoderm and the ventral midline of the neural tub

27 nsistently lack the anterior neural tube and axial mesoderm, and ventral fates are markedly expanded.

28 Chordin is expressed throughout the axial mesoderm as it extends, but is downregulated in pr

29 f the developing neural tube and surrounding axial mesoderm as well as in developing forelimb and hin

30 ng domains in the developing neural tube and axial mesoderm as well as in developing limbs.

31 hord, but not in notochord precursors in the axial mesoderm at early gastrula stage.

32 not account for early patterning defects of axial mesoderm, but likely contributes to overall reduct

33 he prime meridian also gives rise to dorsal, axial mesoderm, but not uniquely, as specification tests

34 of prechordal mesoderm identity in extending axial mesoderm by repressing notochord characteristics,

35 The primary defect is a failure of axial mesoderm cell migration toward the posterior porti

36 ing experiments, reveal that early extending axial mesoderm cells are labile and that their character

37 that oep is required in prospective anterior axial mesoderm cells before gastrulation.

38 Two populations of axial mesoderm cells can be recognised in the chick embr

39 At the beginning of gastrulation anterior axial mesoderm cells form the prechordal plate and expre

40 results indicate that a shared lineage with axial mesoderm cells is not a pre-requisite for floor pl

41 We therefore conjectured that axial mesoderm cells might display the GPI-linked protei

42 rlapping roles in regulating the motility of axial mesoderm cells.

43 Important gene expressions within axial mesoderm (chordin, Shh and BMP7) appear unaffected

44 a possible molecular mechanism for blocking axial mesoderm-derived Hh ligands from the prepancreatic

45 arising from Hensen's node and posterior non-axial mesoderm do not strictly depend on FGF or retinoic

46 between presumptive pharyngeal endoderm and axial mesoderm during gastrulation indicate that signals

47 xial mesoderm and a concomitant expansion of axial mesoderm during gastrulation.

48 hoA and Rac1 control convergent extension of axial mesoderm during Xenopus gastrulation.

49 ) is essential for the formation of anterior axial mesoderm, endoderm and ventral neuroectoderm.

50 In axial mesoderm explants, inhibition of this apoptosis ca

51 ion, in which cells directly adjacent to the axial mesoderm express the gene.

52 , we demonstrate that Bon is required in the axial mesoderm for anterior neural development.

53 results, bon-mutant embryos show defects in axial mesoderm gene expression starting at mid-gastrulat

54 preceded by ectopic expression of Foxa2, an axial mesoderm gene involved in node specification, with

55 the mesoderm requires the maintenance of non-axial mesoderm identity by Wnt8 and BMP2b at the onset o

56 nsistent with Wnt8 and BMP2b maintaining non-axial mesoderm identity during gastrulation through the

57 rm, suggesting that the establishment of non-axial mesoderm identity requires continual repression of

58 As shown previously, axial mesoderm in floating head mutant gastrulae fails t

59 d-type cells are capable of forming anterior axial mesoderm in oep embryos, suggesting that oep is re

60 been controversy concerning the role of the axial mesoderm in the induction and rostrocaudal pattern

61 sion of surface cells into both paraxial and axial mesoderm (including hypochord), in similar pattern

62 esodermal gene expression, and an absence of axial mesoderm, indicating that transcriptional repressi

63 trulation followed by subdivision of the non-axial mesoderm into different functional domains during

64 Although the subsequent subdivision of non-axial mesoderm into multiple D/V fate domains is known t

65 expanded posteriorly, Shh expression in the axial mesoderm is reduced, and Bmp2 and Bmp7 are abnorma

66 el genes (Ch-TbxT) becomes restricted to the axial mesoderm lineage and is a potential candidate for

67 ectopic pMesogenin1 also actively suppressed axial mesoderm markers and disrupted normal formation of

68 tive, and show that AP patterning of the non-axial mesoderm occurs across the classic gastrula stage

69 of various molecular markers reveal that the axial mesoderm of epiboly stage embryos is abnormally wi

70 g, FoxD3, Zic5 and Sox9), whereas the future axial mesoderm only induces a subset of these genes.

71 e evidence that the signalling properties of axial mesoderm over this period are regulated by the BMP

72 In contrast, axial mesoderm persists and T and nodal appear to be app

73 e it does not also activate a dorsal (future axial) mesoderm phenotype, suggesting that pMesogenin1 i

74 t they develop expanded and often duplicated axial mesoderm structures, including nodes and notochord

75 r development of chordamesoderm, a subset of axial mesoderm that gives rise to the notochord, but not

76 ural tube, whereas the notochord is a rod of axial mesoderm that lies directly beneath the floor plat

77 ring gastrulation indicate that signals from axial mesoderm (the notochord and prechordal mesoderm) s

78 n the presence of sonic hedgehog in gastrula axial mesoderm, the tissue that will give rise to the no

79 e influences of Hensen's node and ingressing axial mesoderm - tissues that are able to induce Ganf, t

80 e floating head homeobox gene is required in axial mesoderm to repress the expression of both spadeta

81 unction is required for floating head mutant axial mesoderm to transfate to muscle.

82 with BMP antagonism to induce prechordal and axial mesoderm when expressed as an independent protein

83 eobox gene Xlim-1 is expressed in the entire axial mesoderm, whereas the distinct transcription facto

84 ural tissue is thought to be directed by the axial mesoderm which is functionally divided into head a

85 Second, Hensen's node and posterior non-axial mesoderm which underlies the neural plate induce P

86 nterior and posterior territories in the non-axial mesoderm while retinoic acid (RA) functions later,