ライフサイエンスコーパス: axon guidance

1 o ADAM10 substrates previously implicated in axon guidance.

2 specific neuronal connections via selective axon guidance.

3 ed forms of LON-2/glypican are functional in axon guidance.

4 have complementary roles during commissural axon guidance.

5 rning and adhesion distinct from its role in axon guidance.

6 a previously unidentified effector of Shh in axon guidance.

7 filopodial stability during netrin-dependent axon guidance.

8 n)cell-autonomous roles for Frizzled3 in MSN axon guidance.

9 adhesive molecules direct eve-dependent dMN axon guidance.

10 is known of its importance in the control of axon guidance.

11 ulation limits endocannabinoid modulation of axon guidance.

12 igand-receptor pair that is central to motor axon guidance.

13 axon populations during reciprocal cortical axon guidance.

14 py-18 acts from multiple tissues to regulate axon guidance.

15 ilitates Sema-1a-PlexA/Gyc76C-mediated motor axon guidance.

16 assembly, cellular remodeling, and repulsive axon guidance.

17 y identifies a novel role of this pathway in axon guidance.

18 ins are key regulators of cell migration and axon guidance.

19 e mechanistic link between Fz3 and Celsr3 in axon guidance.

20 ng neurite outgrowth, neuronal polarity, and axon guidance.

21 roles in axonogenesis, dendritogenesis, and axon guidance.

22 ovel function of Notum 2 in regulating motor axon guidance.

23 known about the roles of mechanical cues in axon guidance.

24 g, DNA damage, apoptosis, RAS signaling, and axon guidance.

25 ent of its intracellular domain in mediating axon guidance.

26 luding factors best known for their roles in axon guidance.

27 ion, cooperate with glia to mediate follower-axon guidance.

28 s contribute to cue-directed steering during axon guidance.

29 strongly suppress Sema-1a-mediated repulsive axon guidance.

30 lly acts as a co-receptor for DCC to mediate axon guidance.

31 eceptor complex mediating netrin-1-dependent axon guidance.

32 ing protein that we find to be necessary for axon guidance.

33 ferentiation, including subtype identity and axon guidance.

34 moting and chemoattractant during oculomotor axon guidance.

35 3 have been shown to cause primary errors in axon guidance.

36 rs that regulate neuronal cell migration and axon guidance.

37 horin (Sema3) family members, functioning in axon guidance.

38 elopmental steps such as differentiation and axon guidance.

39 n the growth cone plays an important role in axon guidance.

40 ion of contralateral RGC differentiation and axon guidance.

41 red to be soluble can promote LAD-2-mediated axon guidance.

42 es a role for the C. elegans ephrin EFN-4 in axon guidance.

43 g molecule, is important for thalamocortical axon guidance.

44 ediate a specific aspect of neuronal growth: axon guidance.

45 ntially acting downstream of Frizzled to aid axon guidance.

46 anonical ephrin receptor to EFN-4 to promote axon guidance.

47 olved in cell migration, cell signaling, and axon guidance.

48 e in neuronal migration, axon outgrowth, and axon guidance.

49 highly enriched for mRNA targets related to axon guidance.

50 ct effect of MYO9A on neuronal branching and axon guidance.

51 ects both cortical neuronal migration and CT axon guidance.

52 DPY-18 regulates ephrin expression to direct axon guidance, a role for P4Hs that may be conserved in

53 nstrate an instructive role for serotonin in axon guidance acting through ephrinB2a and reveal a nove

54 The involvement of PPFIA4 and SH3PXD2A in axon guidance also suggested a role in disease pathogene

55 ay roles in cell adhesion, ion transport and axon guidance, among other biological pathways, suggesti

56 reveal a novel sigma1 activity in modulating axon guidance and a 5-HT independent action of a widely

57 Our results reveal a developmental switch in axon guidance and a mechanism of circuit integration of

58 the microarray dataset showed enrichment in axon guidance and actin cytoskeleton signalling pathways

59 o link between semaphorin-mediated repulsive axon guidance and alteration of intracellular neuronal c

60 ne receptors that regulate processes such as axon guidance and angiogenesis.

61 ular endothelial growth factors, involved in axon guidance and angiogenesis.

62 aphorins and VEGF family members to regulate axon guidance and angiogenesis.

63 rocesses, including cell fate specification, axon guidance and anteroposterior neuronal polarization.

64 ns to be enriched in PDA pathways, including axon guidance and cell adhesion, and newly identified pr

65 showed that overexpression of this repulsive axon guidance and cell patterning cue models the behavio

66 ment, including neural crest cell migration, axon guidance and cerebellar development.

67 ification of the core genes that orchestrate axon guidance and circadian rhythms in the 1990s.

68 pathway genes, but also in genes involved in axon guidance and cytoskeletal remodeling.

69 y in multiple model systems, with a focus on axon guidance and dendrite morphogenesis.

70 ditional mechanism for ephrins in regulating axon guidance and expands the repertoire of receptors by

71 d repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) si

72 phrinA attractive reverse signaling in motor axon guidance and in vivo evidence of in-parallel forwar

73 twork was enriched for genes associated with axon guidance and interneuron differentiation, consisten

74 s, which support underlying abnormalities in axon guidance and maintenance.

75 tion on the role of miRNAs in the control of axon guidance and more broadly in nervous system develop

76 o a family of cytosolic proteins involved in axon guidance and neurite outgrowth signaling during neu

77 tem development and plasticity, ranging from axon guidance and neuron migration to synaptic organizat

78 Netrins are secreted proteins that regulate axon guidance and neuronal migration.

79 ment, semaphorin-plexin signalling instructs axon guidance and neuronal morphogenesis.

80 nd transduce signals for regulating neuronal axon guidance and other processes.

81 cell non-autonomously for intraspinal motor axon guidance and peripheral branch formation.

82 what they have taught us about mechanisms of axon guidance and selective vulnerability.

83 on between the Hh and chemokine pathways for axon guidance and show that cxcl12a functions downstream

84 ngs identify a dual function of NRP1 in both axon guidance and subcellular target recognition in the

85 Although Wnt7a has been implicated in axon guidance and synapse formation, investigations of i

86 g Notch signaling, neuronal differentiation, axon guidance and synapse formation.

87 proliferation and migration, neuritogenesis, axon guidance and synapse formation.

88 erse neurodevelopmental functions, including axon guidance and synaptic adhesion, as well as self-rec

89 gether, our data indicate that EphBs control axon guidance and synaptogenesis by distinct mechanisms

90 ment, local mRNA translation is required for axon guidance and synaptogenesis, and dysregulation of t

91 rent understanding of the factors regulating axon guidance and target engagement in regenerating axon

92 in many neuronal growth mechanisms including axon guidance and the modulation of repair processes fol

93 oreover, we demonstrate that Lhx2 influences axon guidance and the topographical sorting of axons by

94 Ps) are trans-membrane receptors involved in axon guidance and vascular development.

95 developmental genes that regulate apoptosis, axon guidance and vesicle transport.

96 l development function in synapse formation, axon guidance, and axon termination.

97 pecific human pathways, such as cell growth, axon guidance, and cell differentiation.

98 -activated protein kinase signaling pathway, axon guidance, and cell-cycle regulation were among the

99 he precise regulation of neuronal migration, axon guidance, and dendritic arborization.

100 glycan is critical for the proper migration, axon guidance, and dendritic stratification of neurons i

101 pression of genes involved in cell adhesion, axon guidance, and gliogenesis upon silencing of FoxO6 W

102 M degeneration leads to defective migration, axon guidance, and mosaic spacing of neurons and a loss

103 psychosis, including synaptic cell adhesion, axon guidance, and neurogenesis.

104 ent, insect coagulation and innate immunity, axon guidance, and signaling in extracellular matrices.

105 lated factors are involved in cell adhesion, axon guidance, and signaling of Notch and GABA receptor

106 otentiation, PKA, immune response signaling, axon guidance, and synaptogenesis that significantly inf

107 ocesses, including survival, axon outgrowth, axon guidance, and synaptogenesis.

108 pmental processes, including cell migration, axon guidance, and synaptogenesis.

109 cells during the early stages of commissural axon guidance, and that over-expression of Robo2 can res

110 e, suggesting they cooperate in longitudinal axon guidance, and through biochemical approaches, we fo

111 egulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses.

112 In particular, genes involved in axon guidance are enriched among the genes with altered

113 at modulate the strength of Wnt signaling in axon guidance are largely unknown.

114 ch as cell division, neuronal migration, and axon guidance are still prominent at P5, their expressio

115 Fc gamma receptor-mediated phagocytosis and axon guidance AS genes were also highly represented.

116 neural differentiation processes, including axon guidance as supported by in vivo functional studies

117 served Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite dev

118 odevelopment and highlighted genes linked to axon guidance (associated with SEMA6D), synapse formatio

119 The mechanisms regulating PMN axon guidance at the MPs are not fully understood.

120 issural neurons suggested a receptor role in axon guidance at the spinal cord midline.

121 as these axons are selectively deficient in axon guidance, but not elongation.

122 s independent of its role in netrin-mediated axon guidance, but requires its association with the RGM

123 d as the main attractive cue for commissural axon guidance by acting through its receptor DCC.

124 elated to cardiomyopathy, calcium signaling, axon guidance, cell adhesion, and extracellular matrix s

125 uding signaling, transcriptional regulation, axon guidance, cell adhesion, cellular stress responses,

126 p = 5.8 x 10(-4) - 1.6 x 10(-2)), as well as axon guidance, cell adhesion, nervous system development

127 leased guidance molecule that is involved in axon guidance, cell patterning, and cell survival.

128 evelopment defects in stereotyped left/right axon guidance choices within the GABAergic motor neuron

129 glutamate signaling, synaptic potentiation, axon guidance, clathrin-mediated endocytosis and 14-3-3

130 ions in zebrafish embryos induced defects in axon guidance, confirming a dominant-negative mode of ac

131 endent angiogenesis and semaphorin-dependent axon guidance, controlling signaling and cross-talk betw

132 These findings identify NELL2 as an axon guidance cue and establish Robo3 as a multifunction

133 netrin-1 is both an attractive and repulsive axon guidance cue and mediates its attractive function t

134 sylated dystroglycan as a key determinant of axon guidance cue distribution and function in the mamma

135 (deleted in colorectal cancer), serves as an axon guidance cue during neural development and also con

136 terfering with the function of this specific axon guidance cue may be beneficial to the survival of D

137 Here, we identified the axon guidance cue netrin-1 as an essential factor requir

138 n guidance defects found in mice lacking the axon guidance cue Slit and its receptor Robo.

139 UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and r

140 Netrin is a key axon guidance cue that orients axon growth during neural

141 Although Ntn1 is best known for acting as an axon guidance cue through Dcc and neogenin receptors, it

142 ns in hypodermal seam cells that secrete the axon guidance cue UNC-129/BMP, and our data revealed tha

143 GC axon pathfinding indirectly by regulating axon guidance cues at the optic disc through patterning

144 hich interactions between limited numbers of axon guidance cues can multiply the responses in develop

145 Semaphorins, originally discovered as axon guidance cues in neural development, have been show

146 cal endocytic events involving receptors for axon guidance cues play a central role in controlling gr

147 h the precise spatiotemporal effects of most axon guidance cues remain poorly characterized, a prevai

148 ated with chemoattractive and chemorepulsive axon guidance cues that influence point contact adhesion

149 mprise one of the four canonical families of axon guidance cues that steer the growth cone in the dev

150 Axon guidance cues, cell adhesion molecules, and OR indu

151 Following their description as axon guidance cues, semaphorins have been implicated in

152 racellular matrix (ECM) proteins and soluble axon guidance cues, suggesting that it may regulate axon

153 In addition to the archetypal axon guidance cues, the extracellular matrix provides lo

154 axon guidance on ECM proteins downstream of axon guidance cues.

155 nge can map to neural circuit patterning and axon guidance decisions during development.

156 role for localized translational control in axon guidance decisions in vivo.

157 This pathway may also be important in axon guidance decisions since asymmetric inhibition of M

158 rin signaling is required for key oculomotor axon guidance decisions, and provide a zebrafish model f

159 dystroglycan mutants resemble several of the axon guidance defects found in mice lacking the axon gui

160 , we have reported that BACE1 null mice have axon guidance defects in olfactory sensory neuron projec

161 Trim9 deletion induces axon guidance defects in vitro and in vivo, whereas a gr

162 Slit-mediated repulsion and produces severe axon guidance defects in vivo.

163 function results in stereotypical oculomotor axon guidance defects, which are reminiscent of DRS, whe

164 olymicrogyria, pachygyria, microcephaly, and axon guidance defects.

165 for axon growth, and reveal the aetiology of axon-guidance defects in sax-3/Robo and vab-1/EphR mutan

166 ic neurons in the intestines, and have motor axon guidance deficits, similar to Gfralpha1(-/-) mice.

167 many neurodevelopmental processes including axon guidance, dendrite arborization, and synapse format

168 e brain at developmental stages relevant for axon guidance, dendrite formation, and synaptogenesis.

169 Commissural axon guidance depends on a myriad of cues expressed by i

170 only beginning to be applied in the field of axon guidance due to specific requirements of neuronal c

171 Ligand receptor interactions instruct axon guidance during development.

172 s a secreted protein that directs long-range axon guidance during early stages of neural circuit form

173 lpain regulation of growth cone motility and axon guidance during neuronal development.

174 o in mouse and chick resulted in commissural axon guidance errors.

175 es to date, and deepens our understanding of axon guidance events both in vitro and in vivo.

176 Compared to axon guidance, far less is understood about how individu

177 ap is unclear, as is the impact of embryonic axon guidance fidelity on adult nervous system function.

178 A prevailing concept that has emerged in the axon guidance field is the importance of repulsion as a

179 An important concept to have emerged in the axon guidance field is the importance of repulsion as a

180 e of the embryo, thereby contributing to the axon guidance function of the floor plate.

181 on start sites of upregulated genes, notably axon guidance genes and ion channel genes.

182 The role of electrical activity in axon guidance has been extensively studied in vitro.

183 How PTEN functions in axon guidance has remained unknown.

184 contain guidance receptors and contribute to axon guidance; however, the mechanism by which the guida

185 trate that ZBP1 is required for Shh-mediated axon guidance, identifying a new member of the noncanoni

186 tify a gene that provides anterior-posterior axon guidance in a large brain nucleus and link Frizzled

187 lt stem cell maintenance, cell migration and axon guidance in a wide range of organisms.

188 or genes that contribute to Netrin-dependent axon guidance in midline-crossing (commissural) neurons.

189 fibroblasts and drive neurite outgrowth and axon guidance in neurons.

190 rates suggests that Nogo-A may contribute to axon guidance in the lizard visual system.

191 nter, known to direct ventral cell fates and axon guidance in the neural tube.

192 Loss of Megf8 disrupts axon guidance in the peripheral nervous system and leads

193 During commissural axon guidance in the spinal cord, chemorepulsion by Sema

194 pathway formation (i.e., anterior-posterior axon guidance in the striatum and axon entry into the gl

195 o examine the role of G-protein signaling in axon guidance in vivo, we used the GAL4/UAS system to dr

196 egulating Gyc76C activity in vitro and motor axon guidance in vivo.

197 ly, the absence of FLRT3 produces defects in axon guidance in vivo.

198 ne kinase activity of EphBs was required for axon guidance in vivo.

199 idance cues, suggesting that it may regulate axon guidance in vivo.

200 we identified several oncogenes involved in axon guidance, including Sema4d and Sema6d, which we fun

201 ing all electrical activity had no effect on axon guidance, indicating that an activity-based competi

202 lly synthesized for functional roles such as axon guidance, injury signaling and regeneration.

203 o contains glutamatergic interneurons, whose axon guidance involves the EphA4 receptor.

204 Axon guidance is a key process during nervous system dev

205 lt, indicating that accurate embryonic motor axon guidance is critical for optimal neuromuscular func

206 repulsion is still present but longitudinal axon guidance is disrupted, particularly across segment

207 Axon guidance is driven by changes in the growth cone in

208 e demonstrate that this novel role of Mud in axon guidance is independent of its previously described

209 Axon guidance is proposed to act through a combination o

210 Semaphorin family proteins are well-known axon guidance ligands.

211 pattern also extended to associated cues of axon guidance like neuropilin-1 and F-actin.

212 as a sympathetic guidance cue, and show how axon guidance mechanisms are coordinated with endorgan m

213 surprising regional diversity in commissural axon guidance mechanisms.

214 ing on juxtacrine signaling systems, such as axon guidance mediated by Ephrins and developmental patt

215 yelination in the central nervous system and axon guidance might be significant contributors to the g

216 n of transcription factor paired box gene 6, axon guidance molecule Ephrin A5, and the receptor NMDA

217 unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum.

218 arteries is facilitated by secretion of the axon guidance molecule netrin-1 by arterial VSMCs.

219 emic stroke, we show that signaling from the axon guidance molecule Sema3A via eicosanoid second mess

220 that was first identified 20 years ago as an axon guidance molecule that regulates midline crossing i

221 Although we observed that a classical axon guidance molecule, EphA4, was cleaved by BACE1 when

222 hown that semaphorin3A (Sema3A), a repulsive axon guidance molecule, localizes to the PNNs and is rem

223 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to

224 Of interest, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among

225 that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of

226 Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 th

227 factors' produced by neurons themselves, and axon guidance molecules have also been implicated in dev

228 articipation of one of the major families of axon guidance molecules in this process, the Semaphorins

229 e-pass transmembrane receptors that bind the axon guidance molecules semaphorins.

230 Semaphorins are a large family of axon guidance molecules that are known primarily as liga

231 the retinotopic map depends on the action of axon guidance molecules, activity-dependent mechanisms a

232 Myelin-associated molecules, repulsive axon guidance molecules, and extracellular matrix molecu

233 ts is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive

234 the other side of the cord is controlled by axon guidance molecules, such as Netrin-1 and DCC.

235 ucleus (dLGN) is established by gradients of axon guidance molecules, to allow initial coarse connect

236 ssion of extracellular matrix components and axon guidance molecules, with these transcripts being en

237 on in a well-defined in vivo model system of axon guidance, mouse olfactory sensory neurons (OSNs).

238 fy several cohesive gene networks related to axon guidance, neuronal cell mobility, synaptic function

239 n factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic

240 P1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF121 can

241 ggest that local clutching of RF can control axon guidance on ECM proteins downstream of axon guidanc

242 different isoforms, like an association with axon guidance or neuron differentiation during early dev

243 a multifunctional kinase can trigger diverse axon guidance outcomes through the use of distinct struc

244 iquitin ligase region, respectively) exhibit axon guidance/outgrowth defects and striking defects of

245 components in cortical, brainstem and spinal axon guidance/outgrowth pathways during neural different

246 By using the Slit-Robo axon guidance pathway to target neuronal midline crossin

247 plays a crucial role in multiple Drosophila axon guidance pathways during development, though the me

248 tion of these two functions well explain the axon guidance phenotype observed in Sfrp1 and Sfrp2 sing

249 Axon guidance plays a key role in establishing neuronal

250 and Robo2, Lhx2 differentially regulates the axon guidance program of distinct populations of thalami

251 -124 regulates Smed-slit-1, which encodes an axon guidance protein, either by targeting slit-1 mRNA o

252 We propose that BACE1 cleavage of axon guidance proteins is essential to maintain the conn

253 SRGAP2 and other axon guidance proteins likely play a role in osteosarcom

254 Recently, numerous axon guidance proteins were identified as potential subs

255 chondroitin sulfate derivatives bound to the axon guidance proteins, protein tyrosine phosphatase sig

256 and pathways associated with chemotaxis and axon guidance, providing new insights into the mechanism

257 During axon guidance, Psidin functions as an actin regulator an

258 Time-lapse imaging indicated that peripheral axon guidance, rather than outgrowth or maintenance, was

259 Humans with heterozygous mutations in the axon guidance receptor DCC display such mirror movements

260 In addition, we identify the axon guidance receptor EphB1 as a target of Fezf2 necess

261 deployed downstream of molecularly distinct axon guidance receptor families, but the scope of this o

262 ify novel (non)cell-autonomous roles for the axon guidance receptor Frizzled3 in uncharacterized aspe

263 late axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bun

264 Here we find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical

265 s revealed that the expression of Plxnc1, an axon guidance receptor, is repressed by Lmx1a/b and enha

266 ins interact with and activate an inhibitory axon guidance receptor.

267 -function mutations in the gene encoding the axon-guidance receptor 'deleted in colorectal carcinoma'

268 By regulating axon guidance receptors, such as Robo1 and Robo2, Lhx2 d

269 nuclear signaling may be a common output of axon guidance receptors.

270 xpression of specific motor pool markers and axon guidance receptors.

271 rsity within the Roundabout (Robo) family of axon guidance receptors.

272 g integrator downstream of growth factor and axon guidance receptors.

273 anism for preventing premature activation of axon guidance receptors.

274 e (Ryk), a Wnt5a-binding protein required in axon guidance, regulates PCP signaling.

275 s alternative splicing events of a series of axon guidance related genes during cortical development.

276 pression of differentiation-, apoptosis- and axon guidance-related genes was changed in BDNF mutant m

277 P2, show that it interacts with a network of axon guidance-related mRNAs, and reveal that it is requi

278 Upregulation of an axon-guidance-related gene signature was the most signif

279 wever, whether JNK activation is involved in axon guidance remains unknown.

280 trin and Semaphorin in pioneer- and follower-axon guidance, respectively, and for glial and pioneer-n

281 oss of function and subsequent disruption of axon guidance, resulting in abnormal decussation of the

282 Axon guidance signaling and many other pathway genes are

283 ew mediator of noncanonical Shh signaling in axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh

284 reviously undescribed glial roles in pioneer-axon guidance, suggesting conserved principles of brain

285 collicular development and in hindlimb motor axon guidance, suggesting that chick and mouse PTPRO hav

286 eural cell fate determination and migration, axon guidance, synaptogenesis and function, behavioral n

287 ination of a multiple-step program including axon guidance, target recognition, and synaptogenesis.

288 calcium (Ca(2+)) is an essential signal for axon guidance that mediates opposing effects on growth c

289 s within growth cone filopodia that regulate axon guidance through activation of the protease calpain

290 AX-1), a conserved BC-box protein, regulates axon guidance through PQC of the SAX-3/Robo receptor.

291 vadosomes to target protease activity during axon guidance through tissues.

292 indings demonstrate that Sema-2b couples ORN axon guidance to postsynaptic target neuron dendrite pat

293 trin-1 is dispensable for commissural neuron axon guidance to the CNS midline during development.

294 branching, but not in regulating sympathetic axon guidance to their targets.

295 We identified 52 hpf as a key axon guidance "transition," when oculomotor axons reach

296 maphorin 3E (Sema3E) plays a crucial role in axon guidance, vascular patterning, and immune regulatio

297 ing earlier developmental processes, such as axon guidance, we conditionally knocked out Celsr3 in th

298 ard genetic screen for novel determinants of axon guidance, we identified B3gnt1 and ISPD as required

299 , neuron differentiation, cell adhesion, and axon guidance, whereas CHD8-bound genes are strongly ass

300 0.05], such as KEGG FOCAL ADHESION and KEGG AXON GUIDANCE, which had been demonstrated to be involve