ライフサイエンスコーパス: axon guidance molecule

1 Semaphorins are members of these axon guidance molecules.

2 Wnts are morphogens that also function as axon guidance molecules.

3 Slits are large, secreted repulsive axon guidance molecules.

4 regulated by co-impinging signals from other axon guidance molecules.

5 gens in specifying cell fate can function as axon guidance molecules.

6 structurally related to the netrin family of axon guidance molecules.

7 bundant in the developing brain and binds to axon guidance molecules.

8 and reveal the existence of a new family of axon guidance molecules.

9 ely by controlling the expression of retinal axon guidance molecules.

10 the retinotopic map depends on the action of axon guidance molecules, activity-dependent mechanisms a

11 e that site-directed genetic manipulation of axon guidance molecules after complete spinal cord injur

12 Here, we evaluate whether axon guidance molecules also regulate regenerative growt

13 grating neurons in the mammalian brain by an axon guidance molecule and the chemotactic responsivenes

14 ssion of two members of the Netrin family of axon guidance molecules and the signalling protein Sonic

15 We provide evidence that the Slit family of axon guidance molecules and their Robo receptors contrib

16 tion cascades, transcriptional regulation of axon guidance molecules, and alterations in neural netwo

17 Myelin-associated molecules, repulsive axon guidance molecules, and extracellular matrix molecu

18 ge our previous notions about morphogens and axon guidance molecules, and suggest that these proteins

19 is less clear which of the more conventional axon guidance molecules are involved.

20 that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of

21 and temporal cAMP and calcium codes used by axon guidance molecules are unknown.

22 cell-surface receptors, previously known as axon guidance molecules, are also responsible for the di

23 Our data describe a known vertebrate axon guidance molecule as a myelin-based inhibitor of ne

24 t Slit and Robo proteins are candidate motor axon guidance molecules, as Robo proteins are expressed

25 aturation and plasticity, besides serving as axon guidance molecules, but the relevance of such synap

26 as functional diversification within related axon guidance molecules contributed to the evolution of

27 Axon guidance molecules, critical for neurodevelopment,

28 Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 th

29 lorectal Cancer (DCC), which functions as an axon guidance molecule during development of the nervous

30 To explore the role of axon guidance molecules during regeneration in the lampr

31 Although we observed that a classical axon guidance molecule, EphA4, was cleaved by BACE1 when

32 n of transcription factor paired box gene 6, axon guidance molecule Ephrin A5, and the receptor NMDA

33 unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum.

34 It is unknown whether the same repulsive axon guidance molecules expressed by glia and their prec

35 in both odor detection and the regulation of axon guidance molecule expression.

36 pha1 (GFRalpha1) can also act in trans as an axon guidance molecule for neurons.

37 During development, EphB proteins serve as axon guidance molecules for retinal ganglion cell axon p

38 ules that specify cell identity, also act as axon guidance molecules has raised the possibility that

39 factors' produced by neurons themselves, and axon guidance molecules have also been implicated in dev

40 Since axon guidance molecules have also been linked to neural

41 ptor sequence, G-protein cAMP signaling, and axon guidance molecules have been shown to direct axons

42 Gradients of axon guidance molecules have long been postulated to con

43 the psychostimulant cocaine markedly alters axon guidance molecules in adult brain of cocaine-treate

44 ge, conserved semaphorin gene family encodes axon guidance molecules in both invertebrates and verteb

45 ports a previously unrecognized function for axon guidance molecules in regulation of blood vessel de

46 are one of the best characterized inhibitory axon guidance molecules in the CNS and are widely expres

47 ngly, new functions are being identified for axon guidance molecules in the dynamic processes that oc

48 zed the role of the Slit family of repellent axon guidance molecules in the patterning of the axonal

49 erase chain reaction, we identified 17 of 26 axon guidance molecules in these cells, with varying lev

50 articipation of one of the major families of axon guidance molecules in this process, the Semaphorins

51 es have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates

52 neurons, implying that laminins may serve as axon guidance molecules in vivo.

53 ts is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive

54 Gradients of axon guidance molecules instruct the formation of contin

55 Although this axon guidance molecule is not by itself necessary for ap

56 utant mice lacking genes for one or more RGC axon guidance molecules is the presence of topographical

57 In addition to these archetypal axon guidance molecules, it is becoming apparent that mo

58 he optic nerve involves the growth promoting axon guidance molecules L1, laminin and netrin 1, each o

59 hown that semaphorin3A (Sema3A), a repulsive axon guidance molecule, localizes to the PNNs and is rem

60 henotype is due to ectopic expression of the axon guidance molecule netrin 1 (Ntn1), which regulates

61 We show that the secreted axon guidance molecule netrin-1 acts in vitro as an attr

62 arteries is facilitated by secretion of the axon guidance molecule netrin-1 by arterial VSMCs.

63 eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neur

64 Here, we show that at least two of these axon guidance molecules, NETRIN and SLIT, act through th

65 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to

66 eved through the use of a gradient of shared axon guidance molecules, or through a retinal-matching m

67 e, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal map

68 ion pathways may regulate gene expression of axon guidance molecules, potentially linking monoamine r

69 with the expression of two putative retinal axon-guidance molecules, RAGS and ELF-1, which are Eph-l

70 Netrin-1 is an attractive axon guidance molecule required for the proper navigatio

71 al BMP controls the graded expression of RGC axon guidance molecules, resulting in some dorsal RGCs p

72 Additionally, we show that the axon guidance molecules roundabout2 and roundabout3 (rob

73 emic stroke, we show that signaling from the axon guidance molecule Sema3A via eicosanoid second mess

74 Of interest, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among

75 We investigated if the repulsive axon guidance molecule Semaphorin3A (Sema3A) plays a rol

76 Here we have examined the involvement of the axon guidance molecules Semaphorin3A and Slit2, and thei

77 1) was first described as a receptor for the axon guidance molecule, Semaphorin3A, regulating the dev

78 ins are neuronal receptors for the repulsive axon guidance molecule Semaphorins.

79 e-pass transmembrane receptors that bind the axon guidance molecules semaphorins.

80 pamine receptors) affects gene expression of axon guidance molecules (semaphorins, ephrins, netrins,

81 respond to the class 3 semaphorin family of axon guidance molecules (SEMAs) and to members of the va

82 magnitude, duration, and spatial activity of axon guidance molecule signaling are precisely regulated

83 es and consider mechanisms by which abnormal axon-guidance-molecule signaling can cause loss of conne

84 ether, our studies reveal that the repulsive axon guidance molecule Slit3 is a novel and potent angio

85 Axon guidance molecules such as netrins, semaphorins, Sl

86 the other side of the cord is controlled by axon guidance molecules, such as Netrin-1 and DCC.

87 that was first identified 20 years ago as an axon guidance molecule that regulates midline crossing i

88 Semaphorins are a large family of axon guidance molecules that are known primarily as liga

89 ned new cohorts of transcription factors and axon guidance molecules that are uniquely expressed in S

90 Wnts are a large family of axon guidance molecules that can attract ascending axons

91 Lola is thus the examplar of a class of axon guidance molecules that control axon patterning by

92 Semaphorins are axon guidance molecules that signal through the plexin f

93 ucleus (dLGN) is established by gradients of axon guidance molecules, to allow initial coarse connect

94 -coupled receptors (GPCRs) and modulation of axon guidance molecules, we investigated whether GPCR ac

95 ceptors and their ephrin ligands function as axon guidance molecules while, in adults, these molecule

96 ssion of extracellular matrix components and axon guidance molecules, with these transcripts being en