ライフサイエンスコーパス: axon outgrowth

1 ern consistent with a role in regulating RGC axon outgrowth.

2 through Cav channels and thus permits normal axon outgrowth.

3 dance cues along these tracts at the time of axon outgrowth.

4 Smad1 is critical for the regulation of dI1 axon outgrowth.

5 ance of unmyelinated axon debris facilitates axon outgrowth.

6 t centrosome disruption inhibited peripheral axon outgrowth.

7 , Smad6 most potently functions to block dI1 axon outgrowth.

8 thway through which trophic factors regulate axon outgrowth.

9 n newborn cortical neurons preceding initial axon outgrowth.

10 rosome and the Golgi may predict the site of axon outgrowth.

11 ta(1)-autoreceptors that negatively regulate axon outgrowth.

12 signals through the PirB receptor to inhibit axon outgrowth.

13 bx in motoneurons dramatically hinders motor axon outgrowth.

14 nced FAK activation is necessary for optimal axon outgrowth.

15 , we found that bath-applied Wnt5a increased axon outgrowth.

16 essed in myotomes during the period of motor axon outgrowth.

17 ig-10 and ced-10 function together to orient axon outgrowth.

18 fold protein Plenty of SH3s (POSH) regulates axon outgrowth.

19 of a Fyn kinase siRNA abolished NAP-mediated axon outgrowth.

20 ranching of cortical axons without affecting axon outgrowth.

21 cells, suggesting POSH negatively regulates axon outgrowth.

22 bundling within the axon and more efficient axon outgrowth.

23 in SMN exon 7, QNQKE, is critical for motor axon outgrowth.

24 cess critical to both neuronal migration and axon outgrowth.

25 alamus of a soluble factor inhibitory to RGC axon outgrowth.

26 required for robust, properly directed motor axon outgrowth.

27 enhances branching and arborization, but not axon outgrowth.

28 g of the yeast kinase Ste20, is critical for axon outgrowth.

29 ction (by a dominant-negative mutant) blocks axon outgrowth.

30 se stabilization rather than actin-dependent axon outgrowth.

31 st that axon branching occurs independent of axon outgrowth.

32 imizing the levels of molecules that promote axon outgrowth.

33 CaMKII, but not MAPK, is also involved in axon outgrowth.

34 ation of head neurons, and can cause ectopic axon outgrowth.

35 threonine kinase that functions generally in axon outgrowth.

36 ibit defects in neuronal cell migrations and axon outgrowth.

37 rates that mediate the function of UNC-51 in axon outgrowth.

38 pment, particularly neuroblast migration and axon outgrowth.

39 chick hindlimb at various times during early axon outgrowth.

40 teracts physically with UNC-51, disrupts CAN axon outgrowth.

41 tions in axon fascicles after termination of axon outgrowth.

42 s required autonomously in neurons to affect axon outgrowth.

43 ric ORs and ORs with minor mutations perturb axon outgrowth.

44 , firmly establishing the role of sliding in axon outgrowth.

45 transients are inversely related to rates of axon outgrowth.

46 odel for cytoskeletal regulation of directed axon outgrowth.

47 us mutant for both ama and Abl show abnormal axon outgrowth.

48 ilencing them with channel blockers promotes axon outgrowth.

49 ro, an R-cadherin substrate promoted pioneer axon outgrowth.

50 rn3c in regulating the retinal ganglion cell axon outgrowth.

51 MII) is required for NGF to stimulate faster axon outgrowth.

52 significant fraction of myelin inhibition of axon outgrowth.

53 in determining the directionality of R cell axon outgrowth.

54 are required for axon branching and directed axon outgrowth.

55 owever, these treatments do cause undirected axon outgrowth.

56 olumn formation through stages of motoneuron axon outgrowth.

57 nts, which control the rate and direction of axon outgrowth.

58 ns revealed CD2AP as a positive regulator of axon outgrowth.

59 ip between decreased SCG10 levels and failed axon outgrowth.

60 ces our understanding of this process during axon outgrowth.

61 , but only during the period of robust motor axon outgrowth.

62 nals transduced in dendrites may also affect axon outgrowth.

63 -actinin 1 did not affect smn morphant motor axon outgrowth.

64 tously expressed kinase capable of enhancing axon outgrowth.

65 ation of IGF-1 gradient sequentially directs axon outgrowth.

66 ly identified regulator of HSN migration and axon outgrowth.

67 d eIF4G2 mRNA and protein levels, as well as axon outgrowth.

68 two isoforms of Myo10 have opposing roles in axon outgrowth.

69 mice is associated with reduced commissural axon outgrowth.

70 hereas knockdown of headless Myo10 increases axon outgrowth.

71 order with defects in neuronal migration and axon outgrowth.

72 decreased bound actin levels and can inhibit axon outgrowth.

73 inges produce BMP7, an inhibitor of callosal axon outgrowth.

74 e BMPs to direct cell fate specification and axon outgrowth.

75 tail specifically impairs dendrite, but not axon, outgrowth.

76 Inosine, a purine nucleoside that stimulates axon outgrowth, activates Mst3b kinase activity, whereas

77 e in promoting synapse assembly and refining axon outgrowth activity.

78 The neural adhesion molecule L1 mediates the axon outgrowth, adhesion, and fasciculation that are nec

79 er, the results suggest that RPM-1 regulates axon outgrowth affecting axon guidance and termination b

80 Distal myelinated axon outgrowth after 4 weeks was quantified using histom

81 cell differentiation, neuronal excitability, axon outgrowth after nervous system injury, and protein

82 Caudal primary motoneurons, CaPs, pioneer axon outgrowth along ventral myotomes; whereas, middle p

83 th in vitro assays that Wnt-5a increases OSN axon outgrowth and alters growth cone morphology.

84 ly kinases inhibited FAK phosphorylation and axon outgrowth and attraction by netrin.

85 Axon outgrowth and attraction induced by netrin-1 were s

86 Both axon outgrowth and axon attraction induced by netrin wer

87 During development axon outgrowth and branching are independently regulated

88 SPP1 and SPARC; and other genes involved in axon outgrowth and cell matrix interactions.

89 Inhibition of axon outgrowth and cell spreading by a second Nogo domai

90 intracellular domain inhibits netrin-induced axon outgrowth and commissural axon turning in vitro.

91 I dominant repressor in CGN cultures blocked axon outgrowth and dendrite formation and decreased CGN

92 -deficient dissociated neurons show abnormal axon outgrowth and dendritic structure, with defects in

93 Although axon outgrowth and elongation appear normal, antisense m

94 -neuronal signaling pathway that accelerates axon outgrowth and enhances glutamate release from presy

95 report that ephexin1 is required for normal axon outgrowth and ephrin-dependent axon repulsion.

96 in somitic muscle during the period of motor axon outgrowth and found specific perturbations in the p

97 ially regulated differences in the timing of axon outgrowth and functions in parallel with spatial po

98 as inhibition of sAC blocks netrin-1-induced axon outgrowth and growth cone elaboration.

99 rtantly, we found that tau knockdown reduced axon outgrowth and growth cone turning in Wnt5a gradient

100 Importantly tau knockdown reduced axon outgrowth and growth cone turning, due to disorgani

101 Because Ca2+ signaling regulates the rate of axon outgrowth and growth cone turning, we investigated

102 ell fate decisions, polarity, migration, and axon outgrowth and guidance are influenced by five endos

103 that positively regulates netrin-1-mediated axon outgrowth and guidance in embryonic cortical neuron

104 not required for Netrin-induced commissural axon outgrowth and guidance in mice.

105 strate here that Ca(2+)-dependent inhibition axon outgrowth and guidance is mediated by calpain prote

106 rate that filopodial Ca(2+) signals regulate axon outgrowth and guidance through calpain regulation o

107 nto Ena/VASP function in neurite initiation, axon outgrowth and guidance.

108 Ena/VASP proteins play important roles in axon outgrowth and guidance.

109 42 have been implicated in the regulation of axon outgrowth and guidance.

110 P to tightly regulate netrin-1/DCC-dependent axon outgrowth and guidance.

111 nactivating two or more genes perturbed both axon outgrowth and guidance.

112 ther similar F-actin-clutching forces affect axon outgrowth and guidance.

113 ng platform to recruit proteins that promote axon outgrowth and guidance.

114 (GEF) Trio is essential for netrin-1-induced axon outgrowth and guidance.

115 is function underlies netrin-1/DCC-dependent axon outgrowth and guidance.

116 e findings place Mst3b as a key regulator of axon outgrowth and help explain the purine sensitivity o

117 ynapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle

118 ys, Wnt5a gradients simultaneously increased axon outgrowth and induced repulsive turning, a potentia

119 hibits the effects of MS channel blockers on axon outgrowth and local Ca(2+) transients.

120 ion of CCK (10(-7) m) reduced both olfactory axon outgrowth and migration of GnRH-1 cells.

121 tic studies in mice, we show here that motor axon outgrowth and neuromuscular junction (NMJ) formatio

122 onal mRNA localization pathway that enhances axon outgrowth and neurotransmitter release.

123 aneous activity and synaptic transmission in axon outgrowth and olfactory neuron survival.

124 plasmic reticulum chaperone BiP/GRP78 during axon outgrowth and pathfinding in the developing mammali

125 on remodeling in the growth cone (GC) during axon outgrowth and pathfinding.

126 ear transcription that is crucial for normal axon outgrowth and peripheral innervation offers a cruci

127 Myelin-derived inhibitors limit axon outgrowth and plasticity during development and in

128 as a potential therapeutic target to enhance axon outgrowth and plasticity in the injured CNS.

129 itive transducer of growth cone motility and axon outgrowth and provide a new physiological role for

130 cortical circuitry by parallel processes of axon outgrowth and pruning, but the mechanisms that cont

131 MSC produce factors important for mediating axon outgrowth and recovery after SCI but that MSC lots

132 Netrin-1, a secreted molecule that promotes axon outgrowth and regulates axon pathfinding, elevates

133 Here we show that TACC3 promotes axon outgrowth and regulates microtubule dynamics by inc

134 al cord injury (SCI) may result in part from axon outgrowth and related plasticity through coordinate

135 which regulates genes required for neuronal axon outgrowth and repair.

136 lar calcium, which is required for increased axon outgrowth and repulsion by Wnt5a.

137 ignaling mechanisms underlying Wnt5a-induced axon outgrowth and repulsive guidance.

138 blastoma cells and mesencephalic neurons and axon outgrowth and sprouting of striatal terminals in de

139 programs of gene expression, correlated with axon outgrowth and synapse formation, can be decoupled a

140 ates in neuronal differentiation, migration, axon outgrowth and synaptogenesis.

141 isual system glia in orienting photoreceptor axon outgrowth and target selection has also been uncove

142 as a process that can be differentiated from axon outgrowth and targeting.

143 opographic mapping without affecting time of axon outgrowth and that time of axon outgrowth directs t

144 functional receptor for netrin and mediates axon outgrowth and the steering response.

145 K inhibition and hnRNP K knockdown inhibited axon outgrowth and translation of hnRNP K-regulated cyto

146 Netrins promote axon outgrowth and turning through DCC/UNC-40 receptors.

147 tions are known to shape corticospinal tract axon outgrowth and withdrawal during development.

148 ns, CNP stimulates branch formation, induces axon outgrowth, and attracts growth cones.

149 RBPs play a key role in neuronal migration, axon outgrowth, and axon guidance.

150 In vitro, EphB3 supported adult RGC axon outgrowth, and axons turned toward a source of this

151 ing of vessels, impaired spinal motor neuron axon outgrowth, and early death.

152 play crucial roles in growth cone motility, axon outgrowth, and guidance.

153 myelin binds to receptors on axons, inhibits axon outgrowth, and limits functional recovery.

154 to neuronal precursor cells, associated with axon outgrowth, and regulated in response to contact wit

155 l trophic roles in neuronal differentiation, axon outgrowth, and synapse development and plasticity i

156 Early steps in neuronal migration, axon outgrowth, and synapse formation proceed in mutant

157 12-13) pre-tongue explants repel trigeminal axon outgrowth, and this is mediated by Sema3A.

158 Estrogen also prevented axon outgrowth, and this was reversed by exogenous BMP4.

159 Neurogenesis and axon outgrowth are features shared by normal nervous sys

160 maintenance of pyramidal neurons and initial axon outgrowth are grossly normal, suggesting that these

161 Induced membrane expansion and axon outgrowth are inhibited after axon-specific knockdo

162 Cargos of particular importance for axon outgrowth are microtubule modifiers, such as SCG10

163 Specific features, such as soma size and axon outgrowth, are graded along the spiral contour of t

164 ctin-like domains, regulates UNC-40-mediated axon outgrowth as well as the organization of presynapti

165 lts to show that Nrp2 patterns initial motor axon outgrowth as well.

166 that ephrin-A5 functions to restrict initial axon outgrowth at E11.

167 Independent of axon outgrowth, axon branching in response to guidance c

168 tiple aspects of axon development, including axon outgrowth, axon guidance and axon branching.

169 us biological processes, including survival, axon outgrowth, axon guidance, and synaptogenesis.

170 the central nervous system (CNS), including axon outgrowth, axon guidance, fasciculation, and neuron

171 the brain, is required for netrin-1-mediated axon outgrowth, branching, and attraction.

172 defective peripheral innervation or central axon outgrowth but is attributable to the misprojection

173 mmunoglobulin domain, has no consequence for axon outgrowth but leads to a failure to postembryonical

174 A3 to prevent hyperexcitability and aberrant axon outgrowth but limit MF synaptic transmission and so

175 s, both propranolol and metoprolol increased axon outgrowth but the beta(2)-blocker ICI 118551 did no

176 (JNK) mediates cell signaling essential for axon outgrowth, but the associated substrates and underl

177 of the neurotrophic factor used to stimulate axon outgrowth, but the minimum level of Sema3A required

178 in II activity provides the motile force for axon outgrowth, but to achieve directional movement duri

179 Extracellular cues guide axon outgrowth by activating intracellular signaling cas

180 Despite the ability to revamp axon outgrowth by altering an increasing number of extra

181 xons but instead promotes ventrally directed axon outgrowth by haptotaxis, i.e., directed growth alon

182 fic gene expression and posteriorly directed axon outgrowth by preventing UNC-4 repression of DB diff

183 ut it is unclear whether Kv channels control axon outgrowth by regulating Ca(2+) influx.

184 phrin-A1 reduces retinal ganglion cell (RGC) axon outgrowth by stabilizing existing adhesions and inh

185 idline exit also requires the stimulation of axon outgrowth by Stem Cell Factor (SCF, also known as S

186 tebrate neurons, riluzole treatment restored axon outgrowth caused by diminished SMN.

187 imb buds rostrally in chick embryos prior to axon outgrowth, causing DRGs to innervate novel skin reg

188 nd in their environment for the promotion of axon outgrowth, consistent with a homotypic mode of acti

189 pe IIa and type III RPTPs can regulate motor axon outgrowth, consistent with findings in Drosophila.

190 as it modulates neurofilament metabolism in axon outgrowth, cytoskeletal stabilization and radial gr

191 peractivation of Pak itself does not lead to axon outgrowth defects as when Rac1 is constitutively ac

192 d protein levels in growth cones and rescues axon outgrowth defects in SMA neurons.

193 er recent studies, our findings suggest that axon outgrowth defects may be a common feature of childh

194 EEA1 function causes missorting of L1/NgCAM, axon outgrowth defects on the L1 substrate, and disturba

195 Here, we report that axon outgrowth defects within specific subsets of motone

196 sms of topographic map formation and a novel axon outgrowth-dependent temporal mechanism in which tim

197 study growth factor-dependent cell survival, axon outgrowth, differentiation and basic mechanisms of

198 ting time of axon outgrowth and that time of axon outgrowth directs topographic mapping without affec

199 es of known effectors of UNC-40 signaling in axon outgrowth during AC invasion.

200 N, indicate a distinct role of IGF-I in CSMN axon outgrowth during development, and might enable cont

201 utonomously for presynaptic assembly and for axon outgrowth dynamics in specific neurons.

202 lular matrix proteins has been implicated in axon outgrowth, fasciculation and neuronal cell migratio

203 repair strategies have been shown to promote axon outgrowth following neuronal injury in the mammalia

204 bility to reverse MAG-mediated inhibition of axon outgrowth from rat cerebellar granule neurons in vi

205 generation and neuronal death but subsequent axon outgrowth from surviving neurons restores innervati

206 as a key developmental signal that promotes axon outgrowth from the arcuate nucleus (ARH) during a d

207 The axon outgrowth from the ARH to PVH occurs during a criti

208 present on muscle fibers in advance of motor axon outgrowth from the spinal cord.

209 f netrin-1 to the substrate was required for axon outgrowth, growth cone expansion, axon attraction a

210 development requires the precise control of axon outgrowth, guidance, and arborization.

211 teins in the regulation of cell motility and axon outgrowth has been controversial.

212 ressed in the hippocampus, but their role in axon outgrowth has not been extensively studied in the C

213 These genes also act in cell migration and axon outgrowth; however, many proteins that function in

214 localized to growth cones, and essential for axon outgrowth; however, the mechanisms of SCG10 transpo

215 d after social drinking blocked NAP-mediated axon outgrowth (IC(50) = 17 mM) by inhibiting NAP activa

216 guidance, mig-10 stimulates netrin-dependent axon outgrowth in a process that requires the age-1 phos

217 is characterized by abnormal termination of axon outgrowth in a subset of several distinct neuron cl

218 previously implicated in synaptogenesis and axon outgrowth in C. elegans and other animals.

219 potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activati

220 ter release, we observed a specific delay in axon outgrowth in cultured hippocampal neurons from syna

221 ct modes of steady-state accumulation during axon outgrowth in cultured hippocampal neurons.

222 A) neurons using this chimeric motor rescued axon outgrowth in cultured neurons and in vivo, firmly e

223 axonally targeted amphoterin mRNA increases axon outgrowth in cultured sensory neurons, but axon gro

224 POSH-dependent mechanism operates to inhibit axon outgrowth in different types of CNS neurons.

225 function by RNA interference (RNAi) enhances axon outgrowth in differentiating mouse primary cortical

226 nase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture,

227 phorylated and activated by GSK-3 to promote axon outgrowth in mouse hippocampal neurons.

228 ing form of axon growth but had no impact on axon outgrowth in naive neurons.

229 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons.

230 is sufficient to restore netrin-1-dependent axon outgrowth in p120RasGAP-deficient neurons.

231 MAG inhibition of axon outgrowth in some neurons is reversed by treatment

232 or treatment with the MT drug Taxol reduced axon outgrowth in spinal cord neurons.

233 owth, demonstrating that Brn3c could promote axon outgrowth in the absence of Brn3b.

234 specifically expressed during the period of axon outgrowth in the chick brain; cPTPRO is expressed i

235 ting, ckn and dock have overlapping roles in axon outgrowth in the CNS.

236 s, driven by PEDF-R activation, that fosters axon outgrowth in the cornea.

237 orm of endogenous activity-dependent ectopic axon outgrowth in the same neuron type.

238 endent competition shapes corticospinal (CS) axon outgrowth in the spinal cord during development.

239 eaves a different ARI (CSPGs), also enhanced axon outgrowth in this model.

240 isolated based on their potent inhibition of axon outgrowth in vitro.

241 that CSPGs caused inhibition of sympathetic axon outgrowth in vitro.

242 anscriptional gene control, is essential for axon outgrowth in Xenopus.

243 otor neurons and important for correct motor axon outgrowth in zebrafish.

244 ly identified to play a role in motor neuron axon outgrowth, including chondrolectin.

245 cultures of inferior olive explants, olivary axon outgrowth increased significantly in the presence o

246 glycan mimetics as blockers of MAG-mediated axon outgrowth inhibition.

247 The myelin-derived axon outgrowth inhibitors Nogo, oligodendrocyte-myelin g

248 Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for

249 CNS myelin contains axon outgrowth inhibitors, such as Nogo, that restrict r

250 lin-associated glycoprotein, enhances spinal axon outgrowth into implanted peripheral nerve grafts in

251 edial fast muscle and is essential for motor axon outgrowth into the ventral myotome.

252 However, whereas increased axon outgrowth involves calcium release from stores thro

253 We found that axon outgrowth is mediated by Ryk, whereas axon repulsio

254 thways with cytoskeletal components to drive axon outgrowth is not well understood.

255 During synapse formation, presynaptic axon outgrowth is terminated, presynaptic clusters of ve

256 Axon outgrowth is the first step in the formation of neu

257 The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivit

258 daptor protein talin to reduce Src-dependent axon outgrowth, likely through altered adhesion turnover

259 rhabditis elegans RPM-1 negatively regulates axon outgrowth mediated by the guidance receptors SAX-3/

260 enhances the extent and rate of murine CSMN axon outgrowth, mediated via the IGF-I receptor and down

261 We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and

262 we isolated a mutation that perturbed motor axon outgrowth, neurogenesis, and somitogenesis.

263 outgrowth) mutants, that display defects in axon outgrowth of specific neuron classes.

264 Although the development and axon outgrowth of these motoneurons has been characteriz

265 that regulate the extension and direction of axon outgrowth on rigid, but not compliant, substrata.

266 LI of ephrin-A5 did not affect the extent of axon outgrowth on the tectal surface but instead caused

267 have been implicated in cell morphology and axon outgrowth or cellular proliferation and fate determ

268 Little is known about how NGF elicits faster axon outgrowth or how growth cones integrate and transfo

269 n axons, is not required for rat commissural axon outgrowth or Xenopus spinal axon attraction to netr

270 eurons do not require APCs for polarization, axon outgrowth, or, in the latter two cases, axon target

271 eover, acute stimulation with LN accelerates axon outgrowth over a time course that correlates with p

272 Changes in axon outgrowth patterns are often associated with synapt

273 skeleton organizing proteins to modify motor axon outgrowth phenotypes in an smn morphant zebrafish m

274 These alterations in axon outgrowth probably reflect compromised inductive in

275 tension and neurite branching during sensory axon outgrowth, probably through regulating TrkA recepto

276 hanisms operating to change the direction of axon outgrowth remain unknown.

277 Unexpectedly, Sema7A enhancement of axon outgrowth requires integrin receptors and activatio

278 rpm-1 mutations cause a failure to terminate axon outgrowth, resulting in an overextension of the lon

279 e adult CNS is an inhibitory environment for axon outgrowth, severely limiting recovery from traumati

280 approaches, we show that Cad7 enhances motor axon outgrowth, suppresses the formation of multiple axo

281 egulators of axon development, with roles in axon outgrowth, target selection, and synapse formation.

282 CEH-14 appears to regulate an aspect of ALA axon outgrowth that is distinct from that of the Prd-lik

283 and chronic ischemia stimulated sympathetic axon outgrowth that was blocked by nerve growth factor a

284 te that locally generated Ca2+ signals repel axon outgrowth through calpain-dependent regulation of p

285 Our results suggest that (1) Rac1 controls axon outgrowth through downstream effector pathways dist

286 ulsive guidance cues orient MIG-10-dependant axon outgrowth to cause a directional response.

287 on of spared CS circuits induced substantial axon outgrowth to the largely denervated side of the spi

288 mig-10 and age-1 lipid signaling promote axon outgrowth; unc-34 and to a lesser extent mig-10 pro

289 Our data indicate that MAG inhibits axon outgrowth via two independent receptors, gangliosid

290 The pattern of axon outgrowth, visualized by labeling with anti-acetyla

291 branchial placodes, and when cultured alone, axon outgrowth was random over 4 days, a time period coi

292 Furthermore, pioneer axon outgrowth was rescued in vivo by selective replacem

293 To determine how Smn functions in motor axon outgrowth, we coinjected smn MO with various human

294 ress the function of SMN important for motor axon outgrowth, we determined the ability of different S

295 lation by hnRNP K of the cytoskeleton during axon outgrowth, we focused on three validated RNAs repre

296 rotein kinase Czeta, and the role of FEZ1 in axon outgrowth, we propose that UNC-76 helps integrate k

297 Knockdown of full-length Myo10 reduces axon outgrowth, whereas knockdown of headless Myo10 incr

298 motor neurons caused a severe impairment in axon outgrowth, which was dependent on the C-terminal pr

299 fine the mechanistic underpinnings of failed axon outgrowth with loss of KBP or its associated motor,

300 g4 function caused dramatic defects in motor axon outgrowth without affecting the events driving the