ライフサイエンスコーパス: axon pathfinding

1 echanical signals as important regulators of axon pathfinding.

2 he extracellular matrix collagen XV in motor axon pathfinding.

3 ed, neuropilin-2 is required for precrossing axon pathfinding.

4 r ephrin ligands regulate cell migration and axon pathfinding.

5 als involved in cardiac valve maturation and axon pathfinding.

6 mediates the behavior of growth cones during axon pathfinding.

7 enhances the Abl mutant phenotype, affecting axon pathfinding.

8 nce the Abl mutant phenotype, also affecting axon pathfinding.

9 in vivo, but, unexpectedly, does not disrupt axon pathfinding.

10 synapse function, receptor trafficking, and axon pathfinding.

11 lly in the context of subtype-specific motor axon pathfinding.

12 am cytoskeletal effector of Rac signaling in axon pathfinding.

13 M/limatin, has previously been implicated in axon pathfinding.

14 ein that acts downstream of Rac signaling in axon pathfinding.

15 events to cytoskeletal changes required for axon pathfinding.

16 ional downstream genes that are required for axon pathfinding.

17 multiple guidance cues is integrated during axon pathfinding.

18 th cone, suggesting that they play a role in axon pathfinding.

19 ocytosis, acted with MIG-2 but not CED-10 in axon pathfinding.

20 F-21 collaboratively regulate SAX-3-mediated axon pathfinding.

21 lar mechanisms are used for neural crest and axon pathfinding.

22 ories within the CNS, suggesting a defect in axon pathfinding.

23 g axons rely on guidance molecules to direct axon pathfinding.

24 guidance molecule receptor in regulation of axon pathfinding.

25 ioneer axons and play important roles during axon pathfinding.

26 together to regulate synapse development and axon pathfinding.

27 rical activity of pioneer axons and regulate axon pathfinding.

28 and Robo class proteins and participates in axon pathfinding.

29 s known effect on neuron survival, regulates axon pathfinding.

30 formation, transducing signals required for axon pathfinding.

31 tion in wiring events that follow successful axon pathfinding.

32 ificity of Slit function during intraretinal axon pathfinding.

33 e axon, promoting its outgrowth, and guiding axon pathfinding.

34 of reactive oxygen species that also affects axon pathfinding.

35 tical developmental function in ocular motor axon pathfinding.

36 but increased VAB-1 levels elicited aberrant axon pathfinding.

37 a Caenorhabditis elegans L1CAM, functions in axon pathfinding.

38 ositioning of the cell bodies and peripheral axon pathfinding.

39 loping CNS and is required for motor and CNS axon pathfinding.

40 sruption in synapse formation rather than in axon pathfinding.

41 ation in the lateral CNS and also, later, in axon pathfinding.

42 hat are locally translated and have roles in axon pathfinding.

43 neurons, possibly in the growth cone during axon pathfinding.

44 acts in parallel to Rac/MIG-15 signaling in axon pathfinding.

45 In the Bax and type III Nrg1 double mutants, axon pathfinding abnormalities were seen for TrkA(+) neu

46 egulates Fmrf expression by controlling both axon pathfinding and BMP signaling, but cannot trigger F

47 exchange factor affected all Rac pathways in axon pathfinding and cell migration but did not affect c

48 Many genes that affect axon pathfinding and cell migration have been identified

49 ith CED-10 Rac, RAC-2 Rac, and UNC-34 Ena in axon pathfinding and cell migration, also acts with MIG-

50 inase have all been implicated in regulating axon pathfinding and cell migration.

51 h, but prenatally displayed major defects in axon pathfinding and cortical interneuron migration.

52 n sulfate proteoglycans (HSPGs and CSPGs) in axon pathfinding and have linked HSPGs to specific signa

53 on events, including those that occur during axon pathfinding and hindbrain segmentation.

54 an essential role for lactosamine in sensory axon pathfinding and in the formation of OB synaptic con

55 askin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physicall

56 gation of molecular mechanisms that underlie axon pathfinding and map formation.

57 t, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

58 somites suggests their possible function in axon pathfinding and neural crest cell migration.

59 Moreover, by linking axon pathfinding and neural progenitor behaviors, our re

60 cted and novel role for collagen XV in motor axon pathfinding and neuromuscular development.

61 Initially identified as regulators of axon pathfinding and neuronal cell migration, Ephs and e

62 We found that hypoxia caused specific axon pathfinding and neuronal migration defects in C. el

63 secreted guidance factors are known to guide axon pathfinding and neuronal migration.

64 ds that regulate axon branching, commissural axon pathfinding and neuronal migration.

65 lent factors released from myelin may impair axon pathfinding and neuroregeneration after injury.

66 for Hedgehog (Hh) signaling for intraretinal axon pathfinding and show that Shh acts to pattern the o

67 In hiw mutants, the specificity of motor axon pathfinding and synapse formation appears normal.

68 transcription factor Engrailed (En) controls axon pathfinding and synaptic target choice in an identi

69 Axon pathfinding and target choice are governed by cell

70 uncover a novel role for Brn3a in regulating axon pathfinding and target field innervation by spiral

71 fasciculate from other axons is critical for axon pathfinding and target innervation.

72 Axon pathfinding and target recognition are highly dynam

73 organelles of developing neurons that enable axon pathfinding and target recognition for precise wiri

74 tially by an activity-independent process of axon pathfinding and target selection and subsequently r

75 ed to identify genes responsible for precise axon pathfinding and targeting in the retinotectal syste

76 regulating larval and adult locomotion, and axon pathfinding and targeting of embryonic motoneurons.

77 ad, loss of islet function causes defects in axon pathfinding and targeting plus loss of dopamine and

78 s suggest that in vivo the Slits control RGC axon pathfinding and targeting within the diencephalon b

79 undant expression is closely correlated with axon pathfinding and targeting, and with certain aspects

80 nd p35 are essential for neuronal migration, axon pathfinding and the laminar configuration of the ce

81 hese ap neurons can be subdivided based upon axon pathfinding and their expression of neuropeptidergi

82 pellents throughout development to influence axon pathfinding and topographic mapping, as well as res

83 lia may contain decision points for thalamic axons' pathfinding and topographic organization.

84 uding neurite outgrowth and differentiation, axon pathfinding, and dendritic spine formation and main

85 iding trophic support to neurons, modulating axon pathfinding, and driving nerve fasciculation.

86 e three redundant pathways that each control axon pathfinding, and that the NIK kinase MIG-15 acts in

87 owever, the RNA-binding proteins involved in axon pathfinding, and their corresponding mRNA targets,

88 cal events, dorsal closure and photoreceptor axon pathfinding, and thus provide the first evidence th

89 he Abl substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila embryonic CNS midline

90 ovide evidence for transcriptional coding of axon pathfinding at the midline.

91 Hypoxia exerted its effect on axon pathfinding, at least in part, through HIF-1-depend

92 During the period of commissural axon pathfinding, B-class ephrin protein is expressed at

93 phosphatases (RPTPs) as key determinants of axon pathfinding behavior.

94 essed abundantly in most fiber tracts during axon pathfinding but were downregulated beginning in syn

95 morphogenic proteins (BMPs) are involved in axon pathfinding, but how they guide growth cones remain

96 e shown that type III RPTPs are important in axon pathfinding, but nothing is known about their funct

97 downstream of Rac in Caenorhabditis elegans axon pathfinding, but the cellular role of UNC-115 in th

98 s have receptor-like roles in the control of axon pathfinding by repulsion, although it is largely un

99 Intermediate targets play important roles in axon pathfinding by supplying growing axons with long- a

100 ice and found that muscle development, motor axon pathfinding, clustering of postsynaptic proteins, a

101 mbomeres and, by analogy with their roles in axon pathfinding, could mediate cell repulsion at bounda

102 iprotein complexes that receive and transmit axon pathfinding cues during development are essential t

103 quired for the correct execution of an early axon pathfinding decision.

104 o intracellular signaling cascades to direct axon pathfinding decisions.

105 r the execution of several stereotyped motor axon pathfinding decisions.

106 Sey/Sey embryos also exhibit an axon pathfinding defect specific to the first longitudin

107 ained very low, and this was correlated with axon pathfinding defects and cell death.

108 nctionally compromised: both recruitment and axon pathfinding defects are evident.

109 migrate appropriately, the HSNs also display axon pathfinding defects in ham-3 mutants.

110 pe CAM Neuroglian result in profound sensory axon pathfinding defects in the developing Drosophila wi

111 Axon pathfinding defects included dysgenesis of the corp

112 mediated ablation of Ext1 causes commissural axon pathfinding defects that share similarities with th

113 but not with rac-2/3 Rac displayed synthetic axon pathfinding defects, and that loss of unc-115 funct

114 erentiation as well a neuronal migration and axon pathfinding defects.

115 sh roles for PlexB in central and peripheral axon pathfinding, define a functional ligand for PlexB,

116 Axon pathfinding depends on attractive and repulsive tur

117 Accurate retinotectal axon pathfinding depends upon the correct establishment

118 us) and in ipsilateral and contralateral RGC axon pathfinding, development events fundamental to bino

119 gnaling pathway in motoneurons necessary for axon pathfinding during embryogenesis.

120 secreted molecules, play important roles in axon pathfinding during nervous system development.

121 phila use PlexB and PlexA, respectively, for axon pathfinding during neural development.

122 s, and reveal that it is required for normal axon pathfinding during vertebrate development.

123 e that promotes axon outgrowth and regulates axon pathfinding, elevates cyclic AMP (cAMP) levels in g

124 Apart from their role in axon pathfinding, emerging lines of evidence suggest tha

125 orm protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points.

126 ction mechanisms that eliminate most sensory axon pathfinding errors early in development.

127 ucing SDF1 signaling in vivo rescues retinal axon pathfinding errors in zebrafish mutants that have a

128 S1 or alphaPS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying

129 n subunit in all neurons leads to no obvious axon pathfinding errors.

130 erve hypoplasia and a wide repertoire of RGC axon pathfinding errors.

131 nscription factor Nerfin-1, required for CNS axon pathfinding events, is subject to post-transcriptio

132 ished roles of ephrins and EphB receptors in axon pathfinding, expression of these molecules does not

133 Retinal axon pathfinding from the retina into the optic nerve in

134 During axon pathfinding, growth cones commonly show changes in

135 the role of L1-CAMs in neurite extension and axon pathfinding has been extensively studied, much less

136 Specification of motoneuron morphology and axon pathfinding has been studied extensively, implicati

137 While guidance cues contributing to motor axon pathfinding have been identified, the intracellular

138 en implicated in retinal ganglion cell (RGC) axon pathfinding in a number of species.

139 uired for normal sensory neuron survival and axon pathfinding in both central and peripheral targets.

140 r semaphorin signaling molecules and mediate axon pathfinding in the central nervous system.

141 ns with other axons are important in sensory axon pathfinding in the developing chick hindlimb.

142 cell surface molecules essential for proper axon pathfinding in the developing nervous system, namel

143 for a developmental role of acetylcholine in axon pathfinding in the Drosophila visual system.

144 s toward the optic disc is the first step in axon pathfinding in the visual system.

145 urbation of polarized Akt activity disrupted axon pathfinding in vitro and in vivo.

146 ested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type a

147 zebrafish primary motor neurons (PMN) during axon pathfinding in vivo.

148 ing laminin, and that it is likely to affect axon pathfinding in vivo.

149 pinal axon guidance in vitro and commissural axon pathfinding in vivo.

150 ontractions are necessary for proper sensory axon pathfinding in vivo.

151 ng in vitro, suggesting that FAK may control axon pathfinding in vivo.

152 t ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effec

153 lts support a model in which Shh acts in RGC axon pathfinding indirectly by regulating axon guidance

154 initial step of retinal ganglion cell (RGC) axon pathfinding involves directed growth of RGC axons t

155 Olfactory axon pathfinding is also necessary for establishment of

156 The current understanding of axon pathfinding is based mainly on chemical signaling.

157 Precise axon pathfinding is crucial for establishment of the ini

158 Strikingly, in hda-1(cw2) mutants, axon pathfinding is defective; specific axons often appe

159 Appropriate olfactory axon pathfinding is essential for functional chemorecept

160 Axon pathfinding is essential for the establishment of p

161 Axon pathfinding is orchestrated by numerous guidance cu

162 ndings suggest that early events in cortical axon pathfinding may be controlled by a soluble activity

163 olecules in dorsal closure and photoreceptor axon pathfinding may provide the flexibility that allows

164 al for cancer cells, and by inactivating the axon pathfinding molecule L1CAM, which metastatic cells

165 oposterior and dorsoventral regionalization, axon pathfinding, neuronal differentiation and survival,

166 t LIM domains are not interchangeable during axon pathfinding of the Ap neurons.

167 ranial nerve) motor neuron migration and for axon pathfinding of trigeminal (Vth cranial nerve) motor

168 relatively little is known about commissural axon pathfinding on the contralateral side of the floor

169 ing the mechanisms that regulate commissural axon pathfinding on the contralateral side of the floor

170 ptic sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolys

171 not affect neuronal identity specification, axon pathfinding, or EphA/ephrinA signaling during the d

172 xons, is involved in many cell migration and axon pathfinding processes in the CNS.

173 The fmi-1 mutants exhibit defective axon pathfinding, reduced synapse number, aberrant synap

174 Thus ray axon pathfinding relies on a variety of general and more

175 Axon pathfinding relies on cellular signaling mediated b

176 Axon pathfinding relies on the ability of the growth con

177 It is clear that axon pathfinding requires a growth cone to sample and in

178 Successful axon pathfinding requires both correct patterning of tis

179 ction of many extracellular guidance cues on axon pathfinding requires Ca2+ influx at the growth cone

180 Axon pathfinding requires directional responses of growt

181 Proper axon pathfinding requires that growth cones execute appr

182 dence that abLIM plays a crucial role in RGC axon pathfinding, sharing functional similarity with its

183 m the CNS is an indispensable phase of motor axon pathfinding, the underlying molecular mechanisms re

184 Abl also regulates motor axon pathfinding through a non-overlapping set of functi

185 eze acts in Tv cells to promote their unique axon pathfinding to a peripheral target.

186 t locally during a late phase of commissural axon pathfinding to specify the dorsoventral position at

187 s were found that affect either: (1) retinal axon pathfinding to the contralateral tectal lobe; or (2

188 In netrin-1- and DCC-deficient embryos, RGC axon pathfinding to the disc was unaffected; however, ax

189 ence that EphB receptors are involved in RGC axon pathfinding to the optic disc.

190 guidance molecules for retinal ganglion cell axon pathfinding toward the optic nerve head and in midb

191 To further characterize their role in axon pathfinding, we developed a two-dimensional cocultu

192 dingly, to elucidate how CAMs affect sensory axon pathfinding, we injected antibodies that block the

193 volved in RGC axon mapping in the brain, RGC axon pathfinding within the retina is partially mediated

194 of EphB mutant mice, however, has shown that axon pathfinding within the retina to the optic disc is

195 requires precise retinal ganglion cell (RGC) axon pathfinding within the retina to the optic disc, th

196 molecules and diffusible cues both regulate axon pathfinding, yet how these two modes of signaling i