ライフサイエンスコーパス: axonal

1 f the odorant into the asymmetry between the axonal activities.

2 dominant, inflammatory neuropathy with mixed axonal and demyelinating electrophysiology.

3 Peripheral neuropathies included axonal and demyelinating polyradiculoneuropathies (n = 2

4 rosophila motoneurons different functions of axonal and dendritic L-type like calcium channels likely

5 In contrast, axonal and glial nodal adhesion molecules [neurofascin-1

6 ormone deficiency (GHD) after TBI may impair axonal and neuropsychological recovery, and serum insuli

7 ith reduced dendritic pathology and improved axonal and synaptic plasticity on ventral horn motor neu

8 r absence in mice suggest an optimization of axonal and synaptic properties to the specific demands o

9 interdependence between the position of the axonal and the glial proteins.

10 phorins (SEMA3s), a group of neuron-secreted axonal and vascular guidance factors, suppress pathologi

11 may shape the structure and function of the axonal arbor in mature sensory neurons in the main olfac

12 aintain successful AP propagation across the axonal arbor.

13 usters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance.

14 unmyelinated axons: (1) branches of a single axonal arborization have variable AP waveforms independe

15 erogeneity exists in AP waveforms across the axonal arborization independent of axon morphology.

16 xons may play a role in synaptic plasticity, axonal arborization, or functional diversity of the circ

17 n and what molecules shape it throughout the axonal arborization?

18 y, deletion of Snapin in mice causes AD-like axonal autophagic stress, whereas overexpressing Snapin

19 ontrols synaptic APP processing by enhancing axonal BACE1 trafficking, thereby advancing our fundamen

20 Inhibition of axonal beta-actin mRNA translation disrupts arbor dynami

21 ion and measurement of structural changes in axonal boutons imaged with time-lapse two-photon laser s

22 dosis to restore normal pH and PCO2Tac1-Pet1 axonal boutons were found localized to brainstem areas i

23 fragmented, and do not aggregate normally at axonal branch points.

24 D in motoneurons in vivo during formation of axonal branches and dendrites.

25 the long-term multisite recording from pure axonal branches in a microscopy-compatible environment.

26 gation was severely compromised with >40% of axonal branches no longer responding to AP-stimulation.

27 communicate with multiple targets by forming axonal branches.

28 Axonal branching and terminal arborization are fundament

29 ulation included 20% of neurons with profuse axonal branching inside the nucleus and a dendritic arbo

30 mice were unaltered regarding axon numbers, axonal calibers, and myelin sheath thickness by electron

31 MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellul

32 e looming-evoked defensive responses through axonal collaterals to the dorsal raphe nucleus (DRN) and

33 e functional prominence of NaV1.8 within the axonal compartment immediately proximal to its terminati

34 A expression differs between the somatic and axonal compartments of the neuron, for both mRNA and mic

35 e thought to primarily reside in somatic and axonal compartments, but there is little understanding o

36 to action potential conduction in different axonal compartments, we investigated the effects of TTX

37 as to perform a quantitative analysis of the axonal components of human upper limb nerves based on hi

38 Consequently, most knowledge about axonal conductance derives from modeling studies or indi

39 Here, we investigate (1) how axonal conduction times of corticogeniculate (CG) neuron

40 ro (DIV) showed an age-dependent increase of axonal conduction velocity, which was positively correla

41 The axonal connections from the OSNs expressing about 1000 d

42 plete remyelination will irreversibly damage axonal connections, treatments effectively promoting rem

43 significantly rescued the torsion phenotype, axonal connectivity defects, and abnormal contractions i

44 anding neuron-glia signaling at synaptic and axonal contacts, but how glia support neuronal cell bodi

45 ectal Cancer (DCC), is a master regulator of axonal crossing throughout the neuraxis.

46 of Ranvier.SIGNIFICANCE STATEMENT A periodic axonal cytoskeleton consisting of actin and spectrin has

47 resulting in a reduction in the capacity of axonal D-type current to limit glutamate release, thus c

48 urofilament light chain (NFL), reflective of axonal damage and sCD27, known to best predict the prese

49 We find that demyelination and axonal damage are not directly initiated by M. leprae bu

50 se 1 (HDAC1) was shown previously to precede axonal damage in culture, but the in vivo relevance of t

51 c1(fl/fl)), we show significantly diminished axonal damage in response to neurotoxic stimuli.

52 licated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other

53 dult mammalian central nervous system (CNS), axonal damage often triggers neuronal cell death and gli

54 ction, via the Wallenda (Wnd)/DLK MAP kinase axonal damage signaling pathway.

55 of degenerative events including cell death, axonal damage, and the upregulation of inhibitory molecu

56 As a marker of axonal damage, neurofilament light chain (NfL) has been

57 lamina has been associated with glaucomatous axonal death, our results suggest that the CRVT in the L

58 for reporter activation and phagocytosis of axonal debris.

59 axons to promote axonal NAD(+) depletion and axonal degeneration after injury.

60 The pathological findings suggest axonal degeneration and repair.

61 red for transmission of sensory information; axonal degeneration causes impaired tactile sensation an

62 b delayed chemotherapy-induced and Wallerian axonal degeneration in culture by preventing axotomy-ind

63 (Wld(S)) mutation, which results in reduced axonal degeneration in the central and peripheral nervou

64 ycans and exhibited abnormal myelination and axonal degeneration in the PNS.

65 dies target the nodal axolemma, induce acute axonal degeneration in the presence of complement, and i

66 Injury-induced (Wallerian) axonal degeneration is regulated via the opposing action

67 Axonal degeneration is the major cause of permanent neur

68 erative disease characterized by progressive axonal degeneration mainly affecting motor neurons.

69 SARM1 is the central executioner of the axonal degeneration pathway that culminates in depletion

70 tent with a linear molecular pathway for the axonal degeneration program.

71 significant motoneurons loss, accompanied by axonal degeneration, astrogliosis and microglial activat

72 tic receptors may alleviate synapse loss and axonal degeneration.

73 paraplegia (HSP), a disease characterized by axonal degeneration.

74 ropagation of membrane polarity asymmetry in axonal degeneration.

75 Our data thus suggest that axonal delays dominate ITD tuning.SIGNIFICANCE STATEMENT

76 validate and refine the relationship between axonal-dendritic colocations and synaptic circuits, clar

77 This approach allowed us to evaluate axonal development, including the number of fibers, fluo

78 In order to characterize axonal development, we used a novel combination of 3-DIS

79 Circumferential tension thus can regulate axonal diameter and volume, as well as potentially micro

80 Therefore, axonal diameter increased when actin/myosin disrupting d

81 ions that neuronal activity can rapidly tune axonal diameter, promote re-entry of oligodendrocyte pro

82 cell bodies; this phenotype is indicative of axonal dieback that progresses to neuronal death.

83 correlated with increased mitotic activity, axonal disruption, vascular neoplasia, and with several

84 this phenotype could be reproduced by intra-axonal disulfide reduction in wild-type axons and revers

85 estigate the functional significance of this axonal diversity, and the effects of shifting alert/nona

86 These signals converge on two axonal domains of an interneuron RIA, where the sensory-

87 y, we assessed in rats and mice the speed of axonal dye transport from the application site to the tr

88 rder multiple sclerosis (MS), contributes to axonal dysfunction and neurodegeneration.

89 ty Ca(2+) indicators optimized for examining axonal ER Ca(2+).

90 reticulum (ER) extends throughout axons and axonal ER dysfunction is implicated in numerous neurolog

91 s are required for shaping and continuity of axonal ER, thus suggesting roles for ER modeling in axon

92 tor axons, and occasional discontinuities in axonal ER.

93 erefore, Navbeta2 is a critical regulator of axonal excitability and synaptic function in unmyelinate

94 and Vegfa(188/188) mutants caused additional axonal exclusion zones within the chiasm.

95 ntly, we demonstrated roles for CHL1 in both axonal extension and repulsion, selectively of DA neuron

96 chosis, we found that processes compromising axonal fiber number, density, and myelination, rather th

97 in trigeminal nociceptive neurons and their axonal fibers, including the nociceptive nerve fibers pr

98 on is important for growth cone assembly and axonal formation.

99 ssays and fluorescent reporters to show that axonal fusion enables full recovery of function after ax

100 spontaneous regenerative mechanism known as axonal fusion provides a highly efficient means of achie

101 ch, where mGluR2/3 have been shown to reduce axonal glutamate release and increase glial glutamate up

102 and GAP43, which may account for the marked axonal growth across the lesion epicenter.

103 cular modification was shown to be vital for axonal growth and dendritic branching.

104 -specific kinesin that is a key regulator of axonal growth and regeneration by promoting microtubule

105 show that Kv3.4, the major Kv channel in the axonal growth cones of embryonic dorsal spinal neurons,

106 Membrane excitability in the axonal growth cones of embryonic neurons influences axon

107 re, we report that Kv3.4 is expressed in the axonal growth cones of embryonic spinal commissural neur

108 Kv3.4, which is transiently expressed in the axonal growth cones of many types of embryonic neurons,

109 LCN stimulations significantly increased the axonal growth protein GAP43 in the ipsilesional somatose

110 Here, we demonstrate that axonal growth triggered by neurotrophin-3 remotely inhib

111 alized, there was a significant reduction in axonal growth when incubated in HUVEC-conditioned medium

112 conditioned medium was sufficient to enhance axonal growth, demonstrating that direct cell-cell conta

113 h, migration, differentiation, dendritic and axonal growth, synaptogenesis, and synaptic pruning, all

114 is transport is essential for maintenance of axonal growth-cone dynamics and autophagosome turnover.

115 otubule mass of the axon, thereby increasing axonal growth.

116 microtubule mass to levels more conducive to axonal growth.

117 and HuD affect levels of an mRNA involved in axonal growth.

118 ive renewed perspective on the mechanisms of axonal guidance in the spinal cord that provide for a di

119 inal ganglion cell (RGC) differentiation and axonal guidance is required for a functional visual syst

120 Semaphorin 3B (SEMA3B) is a secreted axonal guidance molecule that is expressed during develo

121 demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial role in B cell

122 analysis also indicated an upregulation of "Axonal Guidance Signaling" pathway.

123 igodendrocytes and is a critical receptor in axonal guidance.

124 target by corridor (Co) neurons that act as axonal guideposts.

125 interplay of dendritic excitatory inputs and axonal inhibitory inputs.

126 er understanding of the underlying nature of axonal injury and its long-term processes is needed as c

127 g diffusion tensor imaging (DTI) to identify axonal injury distant from contusions.

128 growth cones from axons re-emerging from an axonal injury express uPAR and that binding of uPA to th

129 idylserine externalization immediately after axonal injury in purified retinal ganglion cells.

130 Functional regeneration after axonal injury requires transected axons to regrow and re

131 NCV and amplitude might provide measures of axonal injury to guide clinical practice.Significance: T

132 , we used in vitro and in vivo models of CNS axonal injury to test the hypothesis that uPA binding to

133 llowing TBI compared to controls, indicating axonal injury, with longitudinal increases indicating ax

134 occur in the mature nervous system following axonal injury.

135 ctivation of transcriptional reporters after axonal injury.

136 synapse maturation and the stabilization of axonal inputs and reveal a potential role for d-serine a

137 es contain the specialized domains formed by axonal interaction with myelinating Schwann cells, such

138 ponding to the Bclw BH4 domain interact with axonal IP3R1 and prevent paclitaxel-induced degeneration

139 , we studied the functional relationships of axonal kinesins to dense core vesicles (DCVs) that were

140 uidance receptor PlexinA4 did not change its axonal localization in the absence of Gal-1.

141 ight into this question, we investigated the axonal localization of translational regulators and asso

142 hat corneal confocal microscopy demonstrates axonal loss and increased DC density in patients with MS

143 n Schwann cells thus promotes post-traumatic axonal loss and neuropathic pain.

144 CMT1A is characterized by demyelination and axonal loss, which underlie slowed motor nerve conductio

145 ta production is amplified by plaque-induced axonal lysosome transport defects.

146 stablish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic am

147 portance of the JIP3-dependent regulation of axonal lysosomes was revealed by the worsening of the am

148 onstrate that OGT is important in regulating axonal maintenance in the periphery and the overall heal

149 at VRCs provide a method to study changes of axonal membrane potential of human sympathetic nerve fib

150 athological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynapti

151 Cs with a Brn3b(Cre) knock-in allele reduced axonal midline crossing at the optic chiasm and optic tr

152 irect involvement in protease inhibition and axonal migration, respectively.

153 mechanistic insights into the maintenance of axonal mitochondrial quality through SNPH-mediated coord

154 Here we investigate axonal mitochondrial response to mild stress in wild-typ

155 insights into microtubule regulation during axonal morphogenesis and may shed light on MAP7 function

156 TRN dendritic and axonal morphologies are inconsistent with visual stream-

157 vices for the long-term in vitro tracking of axonal morphology and activity with high spatiotemporal

158 Kinesin-1, a robust axonal motor, moves cargo less efficiently in dendrites.

159 ice varied depending on activity levels, and axonal myelination and conduction velocity exhibited no

160 ma-axon patch-clamp recordings combined with axonal Na(+) imaging and immunocytochemistry revealed th

161 length SARM1 is required in axons to promote axonal NAD(+) depletion and axonal degeneration after in

162 tion pathway that culminates in depletion of axonal NAD(+), yet the identity of the underlying NAD(+)

163 Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive.

164 MFN2 mutations cause axonal neuropathy, with associated lipodystrophy only oc

165 We have previously proposed that axonal NMNAT2 primarily promotes axon survival by mainta

166 lgn1 or inhibition of ectodomain shedding in axonal Nrxn1-beta increases presynaptic release at indiv

167 the ER immediately beneath somatic, but not axonal or dendritic, plasma membrane.

168 Remarkably, NMN deamidase also rescues axonal outgrowth and perinatal lethality in a dose-depen

169 e of its target mRNAs, Gap43, is involved in axonal outgrowth.

170 functions, including neuronal migration and axonal pathfinding in the brain.

171 s establishing a foundation for ameliorating axonal pathology in AD.

172 e normal-appearing white matter reveal early axonal pathology outside inflammatory demyelinating lesi

173 gro-striatal axonal terminals leads to early axonal pathology, synaptic disruption, dysfunction of do

174 ompaction, which is associated with worsened axonal pathology.

175 ipheral nervous system-most commonly causing axonal peripheral neuropathy-and usually manifest later

176 work revealed upregulation of chemokines and axonal permissive factors including FGF2, BDNF, and NGF.

177 are distinct from dynein and dynactin mutant axonal phenotypes.

178 Microtubule-associated protein tau is an axonal phosphoprotein.

179 ynapses triggers insertion of GLUT4 into the axonal plasma membrane driven by activation of the metab

180 ming the role of M1R in tonic suppression of axonal plasticity.

181 he importance of this mechanism for critical axonal processes.

182 ction of neuropeptide expression, changes in axonal projection morphology, and a switch in neuronal f

183 vealed that somata associated with different axonal projection pathways were not completely spatially

184 e soma position, dendritic architecture, and axonal projections determine their roles in functional c

185 Moreover, the intra-V1 laminar patterns of axonal projections identify two distinct neuron classes

186 Here, we examined axonal projections of SL and SP cells using a combinatio

187 iled anatomical description of the extensive axonal projections of the hypocretin/orexin neurons.

188 ere we report that ErbB4 in midbrain DAergic axonal projections regulates extracellular DA levels and

189 lization to the caudal medulla primarily and axonal projections to brainstem motor nuclei most promin

190 D3-receptor-expressing neurons send axonal projections to intratelencephalic (IT) targets, i

191 eling SL cells showed that they send profuse axonal projections to olfactory cortical areas, but not

192 ma-aminobutyric acid (GABA) neurons or their axonal projections to paraventricular thalamus (PVT) exc

193 dopamine neurons grouped according to their axonal projections to the nucleus accumbens or dorsal st

194 hort-axon cell interneurons with superficial axonal projections to the sensory input layer of the MOB

195 derstanding the mechanisms that wire retinal axonal projections to their appropriate central targets.

196 ortex - pyramidal tract neurons (PTs) - send axonal projections to various subcortical areas.

197 ted, results in ectopic, anteriorly directed axonal projections.

198 result in the disorganization of topographic axonal projections.

199 er than on the synapses formed by interareal axonal projections.

200 torted by block, they are regularized during axonal propagation.

201 reased levels of NMNAT2 are required for the axonal protection caused by loss of MAPK signaling.

202 s in Fmr1 null mice show that FMRP regulates axonal protein expression but is not required for axonal

203 Local axonal protein synthesis plays a crucial role in the for

204 h are bound to ankyrin particles, a critical axonal protein, is reduced compared to the thermal motio

205 At paranodes, both axonal proteins (betaII spectrin, Caspr) and glial prote

206 e the nanoscale organization of 12 glial and axonal proteins at the nodes of Ranvier of teased sciati

207 ll as BACE inhibition, result in the loss of axonal puncta and in the accumulation of unprocessed pro

208 ass NRGs accumulate as unprocessed proforms, axonal puncta of CRD-NRG1 and NRG3 are comprised of proc

209 nd that binding of uPA to this uPAR promotes axonal recovery by a mechanism that does not require the

210 jury, with longitudinal increases indicating axonal recovery.

211 ion in wild-type axons and reversed by extra-axonal reduction in Wld(S) axons.

212 essentially involved in RGC degeneration or axonal regeneration after acute CNS injury.SIGNIFICANCE

213 g the role of GAGs in neural development and axonal regeneration after CNS injury.

214 entral nervous system (CNS) pose barriers to axonal regeneration and functional recovery following in

215 actors in the lesion site, thereby promoting axonal regeneration and locomotor function recovery.

216 rug and therapeutic nucleic acids to promote axonal regeneration and plasticity after spinal cord inj

217 suggest a practical strategy for stimulating axonal regeneration following spinal cord injury.SIGNIFI

218 spinal lesion site is a major impediment to axonal regeneration in mammals.

219 hypothesis that uPA binding to uPAR promotes axonal regeneration in the CNS.

220 morphological repair phenotype that promotes axonal regeneration.

221 matter and motor neurons and an increase in axonal reinnervation of the lumbar motor neurons.

222 hAPP neurons facilitates the trafficking of axonal retromer toward the soma and thus enhances protea

223 and a comprehensive characterization of the axonal RNAs involved in maintaining neuronal health has

224 FXGs (Fragile X granules) are axonal RNPs present in a stereotyped subset of mature ax

225 gy, demonstrating functional requirement for axonal SFPQ.

226 nsively in axons, spanning nearly the entire axonal shaft of mature neurons.

227 However, the axonal signals, the receptors on myelin, and the integra

228 800 mum around the neuron, and propagated at axonal speed, which is consistent with their unitary nat

229 Adult-onset leukoencephalopathy with axonal spheroids, a probably underestimated disorder, is

230 A mechanism based on axonal sprouting and occupancy of the vacant synaptic sp

231 expression of GAP43 (P < 0.01), a marker of axonal sprouting and plasticity, in the peri-infarct cor

232 s, fiber length as well as the morphology of axonal sprouting, deep within the tissue.

233 ARM1 by limiting the levels of the essential axonal survival factor NMNAT2 to promote injury-dependen

234 T-1 modulates PNS myelination and myelinated axonal survival through the GlcNAc-6-O-sulfation of N-gl

235 nality are degraded in the presence of focal axonal swellings (FAS) arising from neurodegenerative di

236 Lysosomes robustly accumulate within axonal swellings at Alzheimer's disease (AD) amyloid pla

237 y cultures accumulate lysosomes within focal axonal swellings that resemble the dystrophic axons at a

238 ed the slow transport of synapsin, disrupted axonal synapsin organization, and attenuated Hsc70-synap

239 Axonal synapsin-Hsc70 coclusters are also visualized by

240 origins, ChCs display host-region-dependent axonal/synaptic organization and CR expression when tran

241 Axonal targeting of signaling receptors is essential for

242 structures allow identifying the long-range axonal targets of individual in vivo recorded PTs.

243 thological alpha-synuclein in nigro-striatal axonal terminals leads to early axonal pathology, synapt

244 Amphisomes predominantly accumulate at axonal terminals of mutant hAPP mice and AD patient brai

245 simplex virus 1 (HSV-1) to enter neurons via axonal termini.

246 e common C-type Pcdh isoform is required for axonal tiling and assembly of serotonergic circuitries.

247 uster in serotonergic neurons disrupts local axonal tiling and global assembly of serotonergic circui

248 postsynaptic neuronal targets, thus allowing axonal tracing and functional manipulations of the latte

249 thereby rapidly reestablishing the original axonal tract.

250 neuromuscular junction level, but not on the axonal tracts or myelin sheath integrity.

251 We found that retrograde axonal trafficking of brain-derived neurotrophic factor

252 uronal processes, including gene expression, axonal trafficking, proteasome and mitochondrial activit

253 h axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits

254 projections were functionally similar to the axonal transcriptome of rat cortical neurons.

255 Regulation of axonal translation by FMRP may shape the structure and f

256 within individual FXGs, suggesting that the axonal translation of functionally related proteins may

257 particles (RNPs) that form the substrate for axonal translation.

258 This axonal translational machinery is associated with Fragil

259 This FXG-associated axonal translational machinery is present in adult rats,

260 Axonal translational machinery is thus a feature of adul

261 acellular trafficking events, including fast axonal transport (FAT), may contribute to HSP pathogenes

262 of let-7 overcomes this barrier by promoting axonal transport and enrichment of the EFF-1 fusogen at

263 ing to further deficits in the mitochondrial axonal transport and onset of disease.

264 Axonal transport defects are rescued by CRISPR/Cas9-medi

265 (ER)-mitochondrial overlay, and restore the axonal transport defects in patient-derived MNs.Amyotrop

266 gy, hypoexcitability, as well as progressive axonal transport defects.

267 Protein aggregation and axonal transport deficits have been implicated in the di

268 FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cel

269 iro1) is a master regulator of mitochondrial axonal transport in response to cytosolic calcium (Ca2+)

270 highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide no

271 8 phosphorylated Tau regulates inhibition of axonal transport in the disease state.

272 corrects the synaptotoxicity and deficits of axonal transport induced by Abeta.

273 Defective axonal transport is an early neuropathological feature o

274 Microtubule-based axonal transport is tightly regulated by numerous pathwa

275 is, we provide evidence that CKA facilitates axonal transport of dense core vesicles and autophagosom

276 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synap

277 Axonal transport of mitochondria and mitochondrial fissi

278 ovide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parki

279 n Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor neurons isolat

280 o identify the mechanism underlying impaired axonal transport of mitochondria in mutant SOD1-related

281 l protein expression but is not required for axonal transport of ribosomes or its target mRNAs.

282 spersin, and blos-9/MEF2BNB-cause defects in axonal transport of SVPs, leading to ectopic accumulatio

283 Thus, BORC regulates the axonal transport of synaptic materials and synapse forma

284 genous relative content of tau isoforms over axonal transport regulation.

285 n of retromer trafficking through retrograde axonal transport to fulfil its function in promoting lys

286 ignaling cascade that leads to disruption of axonal transport, a critical function for neuronal survi

287 tions such as the regulation of MT dynamics, axonal transport, and neurite outgrowth.

288 eurons to measure anterograde and retrograde axonal transport, demonstrating the usefulness of this n

289 and US9 initiate the process of anterograde axonal transport, ensuring that virus particles are tran

290 ugh Snapin-mediated dynein-driven retrograde axonal transport, thereby suggesting a potential approac

291 between tau isoform imbalance and defects in axonal transport, which induce an abnormal APP metabolis

292 lying cause of the deficits in mitochondrial axonal transport.

293 ident protein tyrosine phosphatase, prior to axonal transport.

294 t, inter-tubular spacing, and, by extension, axonal transport.

295 sphatase PTP1B is required to prime TrkA for axonal transport.

296 lay an adaptive role to stresses that impair axonal transport.

297 Ps and directly activates UNC-104/KIF1A, the axonal-transport kinesin for SVPs in C. elegans.

298 treated retinae degenerated slowly after the axonal trauma and neurons died.

299 In mice, PTP1B deletion reduces axonal TrkA levels and attenuates neuron survival and ta

300 reversible, consistent with the formation of axonal varicosities in vivo induced by mechanical impact

301 eotyped spatio-temporal control that governs axonal wiring of the zebrafish spinal cord.