ライフサイエンスコーパス: axonal degeneration

1 ropagation of membrane polarity asymmetry in axonal degeneration.

2 paraplegia (HSP), a disease characterized by axonal degeneration.

3 ent of drugs to prevent chemotherapy-induced axonal degeneration.

4 o we propose this phenotype is important for axonal degeneration.

5 the caspase6 apoptotic cascade that fosters axonal degeneration.

6 ligodendrocyte apoptosis, demyelination, and axonal degeneration.

7 sis in the injurious cascade associated with axonal degeneration.

8 ow that ACs are released from SCs and induce axonal degeneration.

9 rs, in which prolonged inflammation leads to axonal degeneration.

10 while sparing transport, and did not induce axonal degeneration.

11 in vivo does not affect guidance but causes axonal degeneration.

12 s and provide a target for new therapies for axonal degeneration.

13 rovides trophic support for axons to prevent axonal degeneration.

14 a conserved mechanism, in the initiation of axonal degeneration.

15 sis pathway implicated in protection against axonal degeneration.

16 Peripheral nerves showed axonal degeneration.

17 y promotes mitochondrial movement and delays axonal degeneration.

18 B3, protects against excitotoxicity-induced axonal degeneration.

19 tion mechanism connecting hyperlipidemia and axonal degeneration.

20 e of Bcl-w and of mitochondria in preventing axonal degeneration.

21 orticospinal tract, consistent with a distal axonal degeneration.

22 es are consistent with structural changes of axonal degeneration.

23 an adaptive mechanism that protects against axonal degeneration.

24 ecreased nuclear CREB activation and induced axonal degeneration.

25 onally distinct, into a unifying pathway for axonal degeneration.

26 assess the aberrant activity responsible for axonal degeneration.

27 tant in specific types of disease-associated axonal degeneration.

28 been proposed as a major contributor to this axonal degeneration.

29 echanism by which MAPK signaling facilitates axonal degeneration.

30 r optic nerve cross-sections were graded for axonal degeneration.

31 red axons via virus-like particles prevented axonal degeneration.

32 vo as well as in vitro hyperglycemia-induced axonal degeneration.

33 oreactivity within axon tracts suggestive of axonal degeneration.

34 n automated quantitative assay for assessing axonal degeneration.

35 and define a model for the steps leading to axonal degeneration.

36 ncies can be informative about the status of axonal degeneration.

37 induced neurodegeneration and injury-induced axonal degeneration.

38 a neuroinflammatory disease associated with axonal degeneration.

39 2A, a peripheral neuropathy characterized by axonal degeneration.

40 sis of axon terminals and protection against axonal degeneration.

41 ld) mice, which carry a mutation that delays axonal degeneration.

42 ccumulation of these ions is associated with axonal degeneration.

43 mide mononucleotide, and NmR, can also delay axonal degeneration.

44 P in CNS myelin had a normal lifespan and no axonal degeneration.

45 ciated peripheral neuropathies by preventing axonal degeneration.

46 ions may be useful in preventing or delaying axonal degeneration.

47 hy with minimal demyelination but pronounced axonal degeneration.

48 tion as causes of axonal ovoid formation and axonal degeneration.

49 human degenerative diseases characterized by axonal degeneration.

50 abolic changes preceded any demyelination or axonal degeneration.

51 NEDD4L, and of TNFRSF21, a key regulator of axonal degeneration.

52 coln1(-/-) mice, which indicates progressive axonal degeneration.

53 lay a critical role in mediating progressive axonal degeneration.

54 ant mitochondrial energy metabolism precedes axonal degeneration.

55 f Fig4 in motor neurons display neuronal and axonal degeneration.

56 tion, and full reversal of spongy myelin and axonal degeneration.

57 nt is both necessary and sufficient to delay axonal degeneration.

58 n this interaction causes dysmyelination and axonal degeneration.

59 tic receptors may alleviate synapse loss and axonal degeneration.

60 f demyelination with no evident white matter axonal degeneration.

61 tion, mitochondrial function, apoptosis, and axonal degeneration.

62 ble neuroprotective effect of lamotrigine on axonal degeneration.

63 enerative clusters (50%), increased rates of axonal degeneration (91%) and increased numbers of empty

64 However, late onset of progressive axonal degeneration, accompanied by astrogliosis, microg

65 axons to promote axonal NAD(+) depletion and axonal degeneration after injury.

66 otected oligodendrocytes but did not prevent axonal degeneration after OGD.

67 thways that contribute to early and subacute axonal degeneration after stroke.

68 primary cultured mouse motor neurons showed axonal degeneration after transient expression of the TT

69 Axonal degeneration after traumatic brain injury and ner

70 We found that although Nmnat blocks axonal degeneration after trophic factor withdrawal, it

71 ascular insult to the sixth nerve trunk with axonal degeneration, allowing for substitutive innervati

72 The loss of MOCA in mice leads to axonal degeneration and causes sensorimotor impairments

73 t is not known how mitofusin mutations cause axonal degeneration and CMT2A disease.

74 axons followed by examination of progressive axonal degeneration and debris clearance alongside uninj

75 crostructural changes suggest trauma-related axonal degeneration and demyelination, which are related

76 009) was observed, suggesting co-presence of axonal degeneration and demyelination.

77 Wld(s) mice also have slower axonal degeneration and disease progression in numerous

78 indings have important implications for both axonal degeneration and dysfunction during the progressi

79 d in a significant increase in the extent of axonal degeneration and loss compared to non-irradiated

80 on of nodes and paranodes is associated with axonal degeneration and may lead to impaired conduction

81 mice that develop forebrain tau inclusions, axonal degeneration and MT deficits.

82 ie-Tooth type 4B (CMT4B) is characterized by axonal degeneration and myelin outfoldings.

83 ochemical studies support the involvement of axonal degeneration and neuroinflammation--ubiquitous co

84 Intestinal inflammation causes initial axonal degeneration and neuronal death but subsequent ax

85 aline-2,3-dione (NBQX) decreased OGD-induced axonal degeneration and oligodendrocyte loss at P10 and

86 vidence for spinal motor neuron loss, distal axonal degeneration and p75 neurotrophin receptor (p75(N

87 ategy designed to treat patients at risk for axonal degeneration and persistent visual loss from opti

88 symptoms likely reflect combined effects of axonal degeneration and plasticity, inappropriate firing

89 osphorous compounds which cause a paralyzing axonal degeneration and recently mutations in NTE have b

90 available data suggest that it results from axonal degeneration and reduced regenerative capacity.

91 ansmission, postsynaptic receptor abundance, axonal degeneration and regeneration.

92 The pathological findings suggest axonal degeneration and repair.

93 o be multifactorial including causes such as axonal degeneration and retrograde degeneration.

94 Electron microscopy confirmed the cell and axonal degeneration and revealed cytoplasmic inclusions

95 uggest an ON-limited infarct with subsequent axonal degeneration and selective neuronal loss similar

96 to be recognized as regulators of selective axonal degeneration and synaptic function, thus playing

97 be useful in examining mechanisms of distal axonal degeneration and testing potential neuroprotectiv

98 impaired rotarod performance and widespread axonal degeneration and was more pronounced in shiverer

99 system, and the cerebellum, which result in axonal degeneration and WM loss.

100 uron death and neurotoxin-induced retrograde axonal degeneration, and axon regeneration.

101 wed the PAI-1 treatment reduced brain edema, axonal degeneration, and cortical cell death at 24-48 h

102 reased lesion size, PhMN loss, phrenic nerve axonal degeneration, and diaphragm neuromuscular junctio

103 e of tissue responses leading to cell death, axonal degeneration, and glial scar formation, exacerbat

104 osis (MS) is characterized by demyelination, axonal degeneration, and inflammation.

105 an result in tissue disruption, neuronal and axonal degeneration, and neurological dysfunction.

106 erve biopsies identified mild demyelination, axonal degeneration, and perivascular inflammation.

107 has been implicated in mechanisms leading to axonal degeneration, and several studies have shown that

108 evolutionarily conserved genes that promote axonal degeneration, and so could identify candidate the

109 es cannot distinguish neuroinflammation from axonal degeneration, and therefore provide little specif

110 However, mechanisms of axonal degeneration are developmentally regulated.

111 the underlying molecular pathways leading to axonal degeneration are incompletely understood, accumul

112 Inflammation, demyelination, gliosis and axonal degeneration are pathological hallmarks of multip

113 of myelin gene expression and development of axonal degeneration as the mice aged.

114 ency in the brain, produce both neuronal and axonal degeneration as well as more moderate and potenti

115 vo, p75(NTR-/-) mice exhibited resistance to axonal degeneration associated with oxidative injury fol

116 ent with an intra-axonal redox mechanism for axonal degeneration associated with the initiation and p

117 significant motoneurons loss, accompanied by axonal degeneration, astrogliosis and microglial activat

118 sion of extracellular NR delays NMDA-induced axonal degeneration (AxD) much more strongly than extrac

119 = 0.75, P = 0.0015) and to a lesser extent, axonal degeneration (beta = -0.48, P = 0.043).

120 tes resistance to axonal injury and prevents axonal degeneration both in cell culture and in vivo.

121 neuron (MN)-selective protein inclusions and axonal degeneration but the underlying mechanisms of suc

122 on of JNK activity during this period delays axonal degeneration, but critical JNK substrates that fa

123 tinjury during which the course of Wallerian axonal degeneration can be halted.

124 er time, and that once a threshold is passed axonal degeneration can become functionally apparent in

125 Nmnat also prevented axonal degeneration caused by exposure to exogenous oxid

126 at augmenting expression of MFN1 rescued the axonal degeneration caused by MFN2 mutants, suggesting a

127 of these proteins resulted in prevention of axonal degeneration caused by paclitaxel.

128 e tested whether this pathway is involved in axonal degeneration caused by withdrawal of other trophi

129 red for transmission of sensory information; axonal degeneration causes impaired tactile sensation an

130 hanism of its involvement in the progressive axonal degeneration characteristic of these diseases is

131 sure [IOP], retinal ganglion cell death, and axonal degeneration) closely resembling those seen in pa

132 arkedly reduced clinical deficit and reduced axonal degeneration compared to wild-type mice.

133 ose that even after completed remyelination, axonal degeneration continues to progress at a low level

134 The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD

135 Axonal degeneration contributes to permanent neurologica

136 This suggests that axonal degeneration contributes to the recruitment of in

137 We tested whether a delay in axonal degeneration could affect the disease severity in

138 Molecules that promote axonal degeneration could represent potential targets fo

139 mic insult but go on to experience a delayed axonal degeneration driven in part by changes in axoglia

140 of mitochondrial volume and distribution in axonal degeneration following acute CNS demyelination.

141 ilure of prompt remyelination contributes to axonal degeneration following demyelination.

142 e of intra-axonal Ca(2+) stores in secondary axonal degeneration following spinal cord injury.

143 Progressive axonal degeneration follows demyelination in many neurol

144 ion slow (WldS) protein significantly delays axonal degeneration from various nerve injuries and in m

145 Axonal degeneration has been proposed to be mediated by

146 is APP/DR6/caspase 6 pathway and resulted in axonal degeneration, however, APP cleavage and caspase 6

147 is known to regulate neuronal apoptosis and axonal degeneration; however, the contribution of microg

148 s in neuronal apoptotic death and subsequent axonal degeneration; (ii) a direct, local toxicity exert

149 Intraepidermal nerve fiber loss, axonal degeneration, immune cell infiltration, alteratio

150 luate if genetic deletion of SARM1 decreases axonal degeneration in a mouse model of neuropathy induc

151 ta indicate N-APP is not the sole culprit in axonal degeneration in adult nerves.

152 lies mutant SOD1-mediated NF aggregation and axonal degeneration in ALS MNs.

153 esults in amelioration of acrylamide-induced axonal degeneration in an EPO-dependent manner.

154 V can use axons to disseminate in the brain, axonal degeneration in B6 mice might be a beneficial mec

155 Thus, a decrease in axonal degeneration in Bim deficient DBA/2J mice may not

156 ovides new insights into the pathogenesis of axonal degeneration in Charcot-Marie-Tooth disease type

157 ted model thus mimics some of the aspects of axonal degeneration in chronic progressive MS.

158 genic precursors preceding demyelination and axonal degeneration in CMT1C patients.

159 type specificity and molecular mechanisms of axonal degeneration in CMT2A and dominant optic atrophy.

160 b delayed chemotherapy-induced and Wallerian axonal degeneration in culture by preventing axotomy-ind

161 e Nmnat alone is clearly sufficient to delay axonal degeneration in cultured neurons, we sought to de

162 Rotenone induced profound axonal degeneration in DRG neurons; however, this degene

163 Taxol-induced axonal degeneration in Drosophila shares molecular execu

164 protection against neurological deficit and axonal degeneration in experimental autoimmune encephalo

165 ed microglia converge on the initial site of axonal degeneration in human glaucoma, yet their part in

166 ted the hypothesis that ASIC1 contributes to axonal degeneration in inflammatory lesions of the centr

167 However, there are no signs of axonal degeneration in les rats up to 9 months.

168 e, we investigated oxidative stress-mediated axonal degeneration in mice lacking the antioxidant enzy

169 ther characterization of plt mice identified axonal degeneration in motor and sensory neurons, limite

170 t the mouse ortholog of rtp, MORN4, promotes axonal degeneration in mouse sensory axons following axo

171 Axonal degeneration in multiple sclerosis is related to

172 f bclw mRNA to the axon, and thereby prevent axonal degeneration in rat and mouse sensory neurons.

173 ysis revealed that CMT2B Rab7 mutants caused axonal degeneration in rat E15.5 DRG neurons.

174 Na(+) and Ca(2+) currents that contribute to axonal degeneration in response to inflammatory conditio

175 Here we show that Mtmr13 loss leads to axonal degeneration in sciatic nerves of older mice.

176 onfocal microscopy has been used to identify axonal degeneration in several peripheral neuropathies.

177 Knockdown of rtp also delays axonal degeneration in severed olfactory axons.

178 (Wld(S)) mutation, which results in reduced axonal degeneration in the central and peripheral nervou

179 ing acute demyelination and protects against axonal degeneration in the CNS.

180 nt significantly attenuated the PBBI-induced axonal degeneration in the corpus callosum and ipsilater

181 oteins, especially mutant M1, contributes to axonal degeneration in the corticospinal tracts.

182 hat neuroinflammation is more prominent than axonal degeneration in the early stage of schizophrenia,

183 This mutation leads to axonal degeneration in the in vitro neuronal cell line.

184 n cells (RGCs) in the peripheral retina, and axonal degeneration in the optic nerve.

185 retina was determined by fundus imaging, and axonal degeneration in the optic nerves was determined b

186 ycans and exhibited abnormal myelination and axonal degeneration in the PNS.

187 dies target the nodal axolemma, induce acute axonal degeneration in the presence of complement, and i

188 RGCs in the peripheral retina, and exhibited axonal degeneration in the retina and optic nerve as com

189 Axonal degeneration in the spinal cord and muscle atroph

190 sequences, is all that is required to delay axonal degeneration in vivo.

191 m that limits the virus spread, whereas slow axonal degeneration in Wld mice could favor virus spread

192 om other neurodegenerative diseases suggests axonal degeneration, in the absence of neuronal loss, ca

193 imary dorsal root ganglion cultures prevents axonal degeneration induced by acrylamide in a dose-depe

194 nd caspase 6 activation were observed during axonal degeneration induced by dynactin 1(Dctn1) dysfunc

195 nd caspase 6 activation were not involved in axonal degeneration induced by mechanical or toxic insul

196 the effects of increased Nmnat expression on axonal degeneration induced by mitochondrial dysfunction

197 degeneration slow (Wld(s)) protein can delay axonal degeneration initiated via axotomy, chemotherapeu

198 Since it is unknown whether the axonal degeneration is a consequence of neuronal death o

199 Axonal degeneration is a critical, early event in many a

200 Axonal degeneration is a hallmark of many debilitating n

201 Axonal degeneration is a hallmark of many neurological d

202 Axonal degeneration is a hallmark of many neuropathies,

203 Axonal degeneration is a key component of a variety of n

204 Axonal degeneration is a major cause of permanent disabi

205 Axonal degeneration is a major contributor to non-remitt

206 Axonal degeneration is a molecular self-destruction casc

207 ization after axotomy.SIGNIFICANCE STATEMENT Axonal degeneration is a neuronal process independent of

208 Axonal degeneration is a pathophysiological mechanism co

209 Axonal degeneration is a primary cause of permanent neur

210 Axonal degeneration is a prominent feature of many neuro

211 n in response to axonal injury, suggest that axonal degeneration is an active process.

212 Axonal degeneration is an early and important component

213 Axonal degeneration is an early and prominent feature of

214 of neurodegenerative diseases indicate that axonal degeneration is an early event in the disease pro

215 Axonal degeneration is an important determinant of progr

216 Significantly, axonal degeneration is associated with significant atrop

217 Therefore, understanding the mechanisms of axonal degeneration is critical for developing new thera

218 , it has been recognized that the process of axonal degeneration is distinct from somal degeneration

219 portance in other conditions in which distal axonal degeneration is found.

220 (ER), but the relevance of this function to axonal degeneration is not understood.

221 lic, and toxic insults, but the mechanism of axonal degeneration is poorly understood.

222 Injury-induced (Wallerian) axonal degeneration is regulated via the opposing action

223 Axonal degeneration is the major cause of permanent neur

224 Although axonal degeneration is thought to be a predominant featu

225 the GTPase Rab7 cause a dominantly inherited axonal degeneration known as Charcot-Marie-Tooth type 2B

226 zed by retinal ganglion cell (RGC) death and axonal degeneration leading to irreversible blindness.

227 s with MS eventually experience results from axonal degeneration, little is known about the mechanism

228 , deletion of PrP(C) expression rescues 5-HT axonal degeneration, loss of synaptic markers, and early

229 erative disease characterized by progressive axonal degeneration mainly affecting motor neurons.

230 o control levels, and both soluble Abeta and axonal degeneration markers decreased in parallel.

231 In conclusion, we propose a novel pathway of axonal degeneration mediated by gp120 that is dependent

232 sruption might, over time, contribute to the axonal degeneration observed in peripheral demyelinating

233 otein complexes, which may contribute to the axonal degeneration observed in SMA.

234 However, a late onset of demyelination and axonal degeneration occurred at hyperelevated, but not m

235 explored the relationship between markers of axonal degeneration occurring after the stroke and visua

236 Axonal degeneration occurs in multiple neurodegenerative

237 Neuro-axonal degeneration occurs progressively from the onset

238 The mechanisms by which axonal degeneration occurs, even in the presence of appa

239 ized by spasticity of the leg muscles due to axonal degeneration of corticospinal neurons.

240 However, the selective vulnerability and axonal degeneration of motor neurons in ALS pose the que

241 2 expression in zebrafish is associated with axonal degeneration of motor neurons that can be rescued

242 ection, is characterized by length-dependent axonal degeneration of sensory fibres.

243 ower limbs, and pathologically by retrograde axonal degeneration of the corticospinal tracts and post

244 Axonal degeneration of the CST in the atrophic cervical

245 Here, we asked whether axonal degeneration or axonal regeneration in adult nerv

246 tically induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth.

247 whether this defect plays a critical role in axonal degeneration or simply reflects sequelae of gener

248 SARM1 is the central executioner of the axonal degeneration pathway that culminates in depletion

249 as the central determinant of a fundamental axonal degeneration pathway that is activated by diverse

250 Therefore, axonal degeneration plays contrasting roles (beneficial

251 but whether such changes play a role in the axonal degeneration process is not clear.

252 tent with a linear molecular pathway for the axonal degeneration program.

253 rmissive for execution of the injury-induced axonal degeneration program.

254 critical and early ER-dependent step during axonal degeneration, providing novel targets for axonal

255 he molecular mechanisms responsible for this axonal degeneration remain to be elucidated, dysfunction

256 excitability, peripheral polyneuropathy, and axonal degeneration reminiscent of CMT and HSP.

257 Axonal degeneration represents an early pathological eve

258 osis, which requires caspase 3, we show that axonal degeneration requires caspase 6, which is activat

259 ructural loss of retinal ganglion cells, and axonal degeneration, resembling glucocorticoid-induced g

260 Neuronal and axonal degeneration results in irreversible neurological

261 The JNK pathway promotes axonal degeneration shortly after axonal injury, hours b

262 mutant mice have demonstrated that delaying axonal degeneration slows disease course and prolongs su

263 rgo selective motor and sensory neuronal and axonal degeneration specific to the spinal cord and peri

264 Seventeen biopsies had increased axonal degeneration suggesting active neuropathy.

265 ssed to generate a fragment that can trigger axonal degeneration, suggesting a vital role for BACE1 i

266 not only halted neuronal loss, but prevented axonal degeneration, symptom onset, weight loss, and par

267 that lead to ischemia, amyloid accumulation, axonal degeneration, synaptic loss, and eventually irrev

268 EphB3 null mutant mice exhibited more severe axonal degeneration than wild type littermates after tre

269 eparated out to reveal abnormalities such as axonal degeneration that affect diffusion characteristic

270 s one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accru

271 ollowing demyelination may contribute to the axonal degeneration that occurs in peripheral demyelinat

272 Our findings reveal focal axonal degeneration that occurs in the ventral side of t

273 euronal processes and is linked to Wallerian axonal degeneration, though the ubiquitin ligases that c

274 f OPTN led to progressive dysmyelination and axonal degeneration through engagement of necroptotic ma

275 how that gp120 causes neuronal apoptosis and axonal degeneration through two, independent and spatial

276 meability transition pore and contributes to axonal degeneration triggered by both mechanical and tox

277 igated the reaction of fibrous astrocytes to axonal degeneration using a transgenic mouse strain expr

278 in-3, kif1b, or its adaptor kbp, exacerbates axonal degeneration via a nonmitochondrial cargo common

279 results indicate that diverse insults induce axonal degeneration via multiple pathways and that these

280 Axonal degeneration was evident in brain stem, spinal co

281 Three weeks after TMEV infection, axonal degeneration was induced in the posterior funicul

282 Distal Wallerian axonal degeneration was observed 14 days after ablation.

283 Axonal degeneration was observed at the periphery of the

284 ify where WldS activity is required to delay axonal degeneration, we adopted a method to alter the te

285 tion is a major contributor to Ca2+-mediated axonal degeneration, we focused on changes in oxidative

286 iosynthetic pathways are capable of delaying axonal degeneration, we overexpressed each of the enzyme

287 over agents that suppress neuronal death and axonal degeneration, we performed drug screens on primar

288 Utilizing an in vitro model of axonal degeneration, we studied a subset of mouse periph

289 In contrast, significant signs of axonal degeneration were limited to focal areas in the f

290 ested to cause axonal swellings that lead to axonal degeneration, which is known as "diffuse axonal i

291 igate the effect of a conditioning lesion on axonal degeneration, which occurs in the distal stump af

292 ins abolishes the ability of SARM to promote axonal degeneration, while a SARM mutant containing only

293 Optic nerves displayed axonal degeneration with a modest axon loss of 6% and in

294 disease is characterized by length-dependent axonal degeneration with distal sensory loss and weaknes

295 TNF-alpha causes axonal degeneration with probable delayed loss of retina

296 We studied early molecular events in axonal degeneration with single-axon laser axotomy and t

297 , whereas the adult-onset phenotype reflects axonal degeneration without antecedent demyelination.

298 , and produced classic features of segmental axonal degeneration without cell body death, including n

299 es endogenous remyelination and/or minimizes axonal degeneration would reduce the rate and degree of

300 such neuropathies are characterized by early axonal degeneration, yet therapies that inhibit this axo