ライフサイエンスコーパス: axonal growth

1 terminus to the two functions of Shot during axonal growth.

2 microtubule mass to levels more conducive to axonal growth.

3 central nervous system is limited by lack of axonal growth.

4 f KLF7 in cortical neurons in vitro promotes axonal growth.

5 ring the processes of myelination and radial axonal growth.

6 ed have an increased ability to initiate new axonal growth.

7 odulate the functions of the NgR1 complex in axonal growth.

8 , which display defects in dendritic but not axonal growth.

9 rt of short MTs, and also limits the rate of axonal growth.

10 olonged denervation rather than a failure of axonal growth.

11 nating neurotrophin receptor endocytosis and axonal growth.

12 xonal conduction, in addition to stimulating axonal growth.

13 TM helices, Nogo-66, is active in preventing axonal growth.

14 ave functional consequences for dendrite and axonal growth.

15 ed molecules that facilitated contralesional axonal growth.

16 nd suppresses the ability of SnoN to promote axonal growth.

17 enhancing exogenous remyelination and neuron/axonal growth.

18 F-M KSP repeats as an essential component of axonal growth.

19 in-dependent "outside-in" trigger for radial axonal growth.

20 tional M85 peptide) is deleterious to normal axonal growth.

21 stance of axonal extension and the timing of axonal growth.

22 ared pathway with Cdh1-APC in the control of axonal growth.

23 ding genetic knock-down of Smad2, stimulates axonal growth.

24 s the ability of adult rat myelin to inhibit axonal growth.

25 ition zone may bundle these filaments during axonal growth.

26 with bHLH target genes for the inhibition of axonal growth.

27 , it may have a role in myelin inhibition of axonal growth.

28 ey target of neuronal Cdh1-APC that promotes axonal growth.

29 Cdh1-APC operates in the nucleus to inhibit axonal growth.

30 owth and suppresses Cdh1 RNAi enhancement of axonal growth.

31 tin dynamics in growth cones and facilitates axonal growth.

32 and HuD affect levels of an mRNA involved in axonal growth.

33 X) complex, promote neuronal development and axonal growth.

34 T regulates mechanisms of sensory neuron and axonal growth.

35 ibose) in the cell body and axon and limited axonal growth.

36 hin-mediated signaling pathways and enhanced axonal growth.

37 ctor 3 (ATF3) promotes neuronal survival and axonal growth.

38 endocannabinoid and Slit/Robo signalling in axonal growth.

39 otubule mass of the axon, thereby increasing axonal growth.

40 diated knockdown of vinculin also attenuated axonal growth.

41 regulators dedicated to either dendritic or axonal growth.

42 is both necessary and sufficient to inhibit axonal growth.

43 pithelia, function in the dynamic context of axonal growth.

44 inases prevented the NMDA receptor-dependent axonal growth acceleration, whereas AMPA/kainate-induced

45 d ngr1 play a modulated role in limiting CNS axonal growth across a spectrum of different tracts in v

46 and GAP43, which may account for the marked axonal growth across the lesion epicenter.

47 the effects of Eph receptor misexpression on axonal growth across the midline.

48 s primer will address issues in the study of axonal growth after central nervous system injury in an

49 Myelin-derived Nogo-A protein limits axonal growth after CNS injury.

50 There are multiple barriers to axonal growth after CNS injury.

51 onstrate that the ROCKII gene product limits axonal growth after CNS trauma.

52 ay hold therapeutic potential in stimulating axonal growth after injury in the CNS.

53 and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro

54 is not required for injury signaling or new axonal growth after injury.

55 reated with MSC, suggesting that MSC support axonal growth after spinal cord injury (SCI).

56 y described that Galectin-1 (Gal-1) promotes axonal growth after spinal cord injury.

57 ning injuries have two components, increased axonal growth and a reduced response to inhibitory myeli

58 unctions autonomously in neurons to regulate axonal growth and advances a novel hypothesis that this

59 tal ARH neuronal explants to ghrelin blunted axonal growth and blocked the neurotrophic effect of the

60 Ninein in turn influences the rate of axonal growth and branching by affecting microtubule sta

61 nstrate that Nedd4-family E3 ligases promote axonal growth and branching in the developing mammalian

62 tages of neuronal differentiation, including axonal growth and branching, or dendritic development.

63 ced palmitoylation of proteins that regulate axonal growth and branching.

64 rvival or cell death, can promote or inhibit axonal growth and can facilitate or attenuate proliferat

65 oosting morphogenetic activity to facilitate axonal growth and collateral branching.

66 cular modification was shown to be vital for axonal growth and dendritic branching.

67 The extent of axonal growth and functional recovery after transplantat

68 r signaling of RhoA and promotes significant axonal growth and functional recovery following spinal c

69 Axonal growth and functional recovery following the sust

70 Several interventions promote axonal growth and functional recovery when initiated sho

71 cal environmental cues are indispensable for axonal growth and guidance during brain circuit formatio

72 that dDAAM also plays a pivotal role during axonal growth and guidance in the adult Drosophila mushr

73 (Fz6) have been shown previously to control axonal growth and guidance in the CNS and hair patternin

74 ions for endothelins as general mediators of axonal growth and guidance in the developing nervous sys

75 monophosphate (cAMP) plays a pivotal role in axonal growth and guidance, but its downstream mechanism

76 kinases and among other functions regulates axonal growth and guidance.

77 Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cell

78 f specific Cdk5 targets, leading to aberrant axonal growth and impaired dendritic spine and synapse f

79 The triple-mutant mice exhibit greater axonal growth and improved locomotion, consistent with a

80 of Sip1 in the neocortex reveals defects in axonal growth and in ipsilateral intracortical-collatera

81 ntal switch that permits the transition from axonal growth and incipient synapse formation to synapti

82 hic factor signal directs sexually dimorphic axonal growth and maintenance, resulting in generation o

83 ong functional links between Shot and EB1 in axonal growth and microtubule organization.

84 ed precursors (GDAs(BMP)) promotes extensive axonal growth and motor function recovery in a rodent sp

85 chanisms include phospholipid production for axonal growth and myelination, acetylcholine enhancement

86 Loss of Usp9x causes reduction in both axonal growth and neuronal cell migration.

87 Axonal growth and neuronal rewiring facilitate functiona

88 ectrical stimulation to promote regenerative axonal growth and new insights on the recovery of sensor

89 regrowth, yet signaling pathways employed in axonal growth and pathfinding are similar to those in ma

90 All treatments resulted in aberrant axonal growth and pathfinding errors, suggesting that lo

91 ned novel roles for APC in the regulation of axonal growth and patterning, as well as in synaptic dev

92 l analysis of mitochondrial transport during axonal growth and pauses.

93 ediated sleep-wake regulation via control of axonal growth and PDF levels within the sLNv-encompassin

94 istances of the primate CNS, promoting local axonal growth and preventing lesion-induced neuronal deg

95 Whisker plucking induces axonal growth and pruning of horizontal projecting axons

96 t about by the formation of new circuits via axonal growth and pruning.

97 te glycosaminoglycans significantly enhances axonal growth and recovery in rodents following spinal c

98 ere, we identify KIF3C as a key regulator of axonal growth and regeneration by controlling microtubul

99 -specific kinesin that is a key regulator of axonal growth and regeneration by promoting microtubule

100 sent a novel therapeutic strategy to promote axonal growth and regeneration.

101 decorin as a potential therapy for promoting axonal growth and repair in the injured adult mammalian

102 herapeutic benefit appears to be mediated by axonal growth and repair, and is not attributable to cha

103 he importance of local protein synthesis for axonal growth and responses to axotomy, yet there is lit

104 to the lesion site secrete factors promoting axonal growth and serve as an axonal substrate, yet whet

105 y laminin, and if so, how CaMK-II influences axonal growth and stability.

106 ntral nervous system including neurogenesis, axonal growth and structural plasticity.

107 own of SnoN in neurons significantly reduces axonal growth and suppresses Cdh1 RNAi enhancement of ax

108 conditioning in adult mice can induce robust axonal growth and synapse formation in the cerebellar nu

109 extensively investigated, its regulation of axonal growth and target innervation are just being eluc

110 ot required for proliferation, migration, or axonal growth and targeting of developing PFN neurons.

111 l the 22q11.2 deletion, revealed deficits in axonal growth and terminal arborization, which can be pr

112 ion sites to provide permissive matrices for axonal growth, and brain-derived neurotrophic factor gra

113 rotrophic factors that significantly enhance axonal growth, and can inform future in vivo studies to

114 mechanical integrity of the axon, promoting axonal growth, and facilitating cargo transport.

115 trocytes inhibited GAP43 phosphorylation and axonal growth, and increased neuronal damage in cultured

116 has been implicated in synaptic plasticity, axonal growth, and neuronal survival.

117 Da Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelia

118 ound both local effects of growth factors on axonal growth, and remote effects of growth factors refl

119 otor neuron connectivity, column-specific on axonal growth, and subtype-specific on survival.

120 uggest a role of TDP-43 in the regulation of axonal growth, and suggest that impairment in the post-t

121 g Smad1 by RNA interference in vitro impairs axonal growth, and the continued presence of Smad1 is re

122 trinsic factors, a number of proteins termed axonal growth associated proteins (GAPs) are strongly in

123 us, following SCI, Ch'ase ABC may facilitate axonal growth at the spinal level, enhance adaptive feat

124 se data provide evidence that miR16 mediates axonal growth, at least in part, by regulating the local

125 Inactivation of Tsc1/Tsc2 promotes axonal growth, at least in part, via up-regulation of ne

126 lpting the nervous system through control of axonal growth, axonal and dendritic pruning, and regulat

127 This was not due to a failure of axonal growth, because injured motor axons eventually fu

128 re, we show that SRF mediates NGF signaling, axonal growth, branching, and target innervation by embr

129 ily conserved E3 ubiquitin ligase, restrains axonal growth but acts as a positive regulator for dendr

130 gnaling pathways and it functions to promote axonal growth but inhibit dendritic growth via activatio

131 nstitutively active (ca) Rit mutant promoted axonal growth but inhibited dendritic growth.

132 Rit mutant in hippocampal neurons inhibited axonal growth but potentiated dendritic growth.

133 d its activator Cdh1 (APC/C(Cdh1)) restrains axonal growth but the targets of APC/C(Cdh1) in neurons

134 nfluence neural progenitor proliferation and axonal growth, but its involvement in neuronal different

135 r work suggests that NOX-derived ROS promote axonal growth by regulating Rac1 activity, a molecular d

136 ex 2 (TSC2) in DRGs is sufficient to enhance axonal growth capacity in vitro and in vivo.

137 4, which activates Smad1, markedly enhances axonal growth capacity, mimicking the effect of a condit

138 owing damage and that this activity enhances axonal growth capacity.

139 s, all three USP9X variants failed to rescue axonal growth, caused reduced USP9X protein localization

140 ich injury unlocks mature neurons' intrinsic axonal growth competence are not well understood.

141 function for p53 as a critical regulator of axonal growth cone behavior by suppressing ROCK activity

142 p53 inhibition-induced axonal growth cone collapse was significantly reduced by

143 RNAs, or by dominant-negative forms, induced axonal growth cone collapse, whereas p53 overexpression

144 tau in the organization and dynamics of the axonal growth cone cytoskeleton.

145 a4D), a protein originally shown to regulate axonal growth cone guidance in the developing central ne

146 ss 3 semaphorins were initially described as axonal growth cone guidance molecules that signal throug

147 Recruitment of HRas to the axonal growth cone is paralleled by a decrease in HRas c

148 Whereas many molecules that promote cell and axonal growth cone migrations have been identified, few

149 r of PI3K, markedly increases in the nascent axonal growth cone upon symmetry breaking.

150 Transplanted hMDSPCs surrounded the axonal growth cone, while hMDSPCs infiltrating the regen

151 forced by vesicular transport of HRas to the axonal growth cone.

152 is transport is essential for maintenance of axonal growth-cone dynamics and autophagosome turnover.

153 It is enriched in axonal growth cones (GCs) and has been implicated in cel

154 nctions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brain.

155 t actively participate in synapse formation: axonal growth cones and dendritic filopodia.

156 uding neural crest cells, endothelial cells, axonal growth cones and many types of adult stem cells,

157 axons but provide an adhesive substrate for axonal growth cones and promote their growth even in the

158 ghly enriched in vesicular structures within axonal growth cones and varicosities as well as at axona

159 During neural circuit assembly, axonal growth cones are exposed to multiple guidance sig

160 the nervous system, although their roles at axonal growth cones are unclear.

161 dynein, dynactin, and LIS1 were enriched in axonal growth cones at stage 3, and both growth cone org

162 During neural development, axonal growth cones depend on rapid assembly and disasse

163 xons but promoted their growth in vitro, and axonal growth cones formed extensive contacts with NG2 c

164 ghly and specifically expressed in axons and axonal growth cones in primary hippocampal neurons.

165 Axonal growth cones initiate and sustain directed growth

166 on from synaptic vesicle clusters present at axonal growth cones of developing neurons.

167 show that Kv3.4, the major Kv channel in the axonal growth cones of embryonic dorsal spinal neurons,

168 Membrane excitability in the axonal growth cones of embryonic neurons influences axon

169 re, we report that Kv3.4 is expressed in the axonal growth cones of embryonic spinal commissural neur

170 Kv3.4, which is transiently expressed in the axonal growth cones of many types of embryonic neurons,

171 t also restores beta-actin protein levels in axonal growth cones of SMN-deficient motor neurons.

172 ocess of chemotaxis in invasive tumor cells, axonal growth cones of Xenopus spinal neurons modulate t

173 examined NMDAR localization and function at axonal growth cones of young hippocampal neurons.

174 critical for axon branching and pruning once axonal growth cones reach their correct topographic posi

175 ecline during development, and concomitantly axonal growth cones switch their response to cAMP-depend

176 ckdown, we show for the first time in living axonal growth cones that tau is important for microtubul

177 eptor activation elicited calcium signals in axonal growth cones that were mediated by calcium influx

178 ioning neural network relies on responses of axonal growth cones to molecular guidance cues that are

179 into the peripheral zone of differentiating axonal growth cones was decreased dramatically by antibo

180 s results in enhanced KIF21A accumulation in axonal growth cones, aberrant axon morphology, and reduc

181 caused reduced USP9X protein localization in axonal growth cones, and (in 2/3 variants) failed to res

182 to Sema3A on local protein synthesis (PS) in axonal growth cones, but a recent study has called this

183 modeling, such as retraction of neurites and axonal growth cones, elevated neuronal rigidity, and res

184 5) channels, which are present in developing axonal growth cones, suppressed CaMKK-mediated activatio

185 tial role of PTEN in chemotactic guidance of axonal growth cones.

186 pid responses that control the navigation of axonal growth cones.

187 Kif5c560-YFP, and leads to the formation of axonal growth cones.

188 ated local translation of beta-actin mRNA in axonal growth cones.

189 d expression in adult brain and are found in axonal growth cones.

190 h general aging, there was downregulation of axonal growth, cytoskeletal assembly/transport, signalin

191 h acceleration, whereas AMPA/kainate-induced axonal growth decrease was blocked by inhibitors of calc

192 ZPR1 stimulates neurite growth and rescues axonal growth defects in SMN-deficient spinal cord neuro

193 n rescue the RNA transport deficits, but the axonal growth deficit is only rescued if the transported

194 Axonal growth deficits caused by GSK-3 inhibition could

195 ein, vinculin, is sufficient to overcome the axonal growth deficits of SRF-deficient and GSK-3-inhibi

196 conditioned medium was sufficient to enhance axonal growth, demonstrating that direct cell-cell conta

197 Axonal growth depends on axonal transport.

198 t a novel role for NG2 cells in facilitating axonal growth during development and regeneration.

199 -associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury.

200 lthough pulling forces have been observed in axonal growth for several decades, their underlying mech

201 actor (BDNF), which significantly stimulated axonal growth from chicken or rat dorsal root ganglia (D

202 identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of

203 e receptors and guidance signals that direct axonal growth have been identified, less is known about

204 Thus, active GSK3 can also markedly promote axonal growth in central nerves if CRMP2 concurrently re

205 Mutants of the Id2 D box enhance axonal growth in cerebellar granule neurons in vitro and

206 f RGS12 expression also inhibits NGF-induced axonal growth in dissociated cultures of primary dorsal

207 ing is developmentally regulated and governs axonal growth in dorsal root ganglion (DRG) neurons.

208 t on the appearance of the growth cone or on axonal growth in either type of neuron.

209 as used to bridge a lesion cavity and induce axonal growth in experimental spinal cord injury (SCI).

210 r2 controls integrin-dependent dendritic and axonal growth in mouse hippocampal neurons.

211 Nedd4-1 and Nedd4-2 are indeed required for axonal growth in murine central nervous system neurons.

212 d tensin homolog (PTEN) and thereby regulate axonal growth in neurons.

213 ce of developing precise terms that describe axonal growth in terms of the inciting event, the distan

214 enerating myelin and astroglial scar prevent axonal growth in the adult brain and spinal cord.

215 ssociated inhibitors play a role in limiting axonal growth in the adult central nervous system.

216 Semaphorin 7A (Sema7A) promotes axonal growth in the central nervous system.

217 with rehabilitation, significantly increased axonal growth in the deafferented basilar pontine nuclei

218 e bifunctional guidance molecule netrin-1 on axonal growth in the injured adult spinal cord.

219 define a novel SnoN-Ccd1 link that promotes axonal growth in the mammalian brain, with important imp

220 the Frizzled3 (Fz3) gene leads to defects in axonal growth in the VII(th) and XII(th) cranial motor n

221 neration-associated protein that accelerates axonal growth in vitro.

222 c, is dynamic and elongates independently of axonal growth, in contrast to stretch-based mechanisms p

223 tors, Nogo, MAG, and OMgp, in injury-induced axonal growth, including compensatory sprouting of uninj

224 lso abolished the negative effects of Shh on axonal growth, including growth cone collapse and chemor

225 Thus, ephrinB3 contributes to myelin-derived axonal growth inhibition and limits recovery from adult

226 us fail to support a central role for NgR in axonal growth inhibition in vitro or in corticospinal tr

227 Here we show that axonal growth inhibition mediated by CSPGs requires intr

228 tracellularly, CSPG-LAR interaction mediates axonal growth inhibition of neurons partially via inacti

229 d synergistic role for all three proteins in axonal growth inhibition.

230 Nogo-A is an important axonal growth inhibitor in the adult and developing CNS.

231 are thought to mediate the action of several axonal growth inhibitors in the adult brain and spinal c

232 by the non-permissive environment, including axonal growth inhibitors such as the Nogo-A protein.

233 ation in primary cultured neurons exposed to axonal growth inhibitors.

234 Radial axonal growth initiates with myelination, and is depende

235 valuation included MSC survival, evidence of axonal growth into grafts, phenotypic analysis of MSC, a

236 tively growing state, the rate of peripheral axonal growth is accelerated and the injured central axo

237 This increased axonal growth is accompanied by improved locomotor perfo

238 Directed axonal growth is essential to establish neuronal network

239 Axonal growth is fundamental to the establishment of neu

240 explanation for this is that injury-induced axonal growth is too slow.

241 of axonal morphogenesis, but how SnoN drives axonal growth is unknown.

242 ration research has been like the process of axonal growth itself: there is steady progress toward re

243 ns of these motifs abolish Shot functions in axonal growth, loss of EB1 function phenocopies Shot los

244 ul to reprogramme quiescent neurons into the axonal growth mode.

245 deletion of MAG and OMgp stimulates neither axonal growth nor enhanced locomotion.

246 nterestingly, in contrast with the excessive axonal growth observed during development, mec-7 mutants

247 The increase in axonal growth occurs on both a favorable substrate and a

248 transduction, we followed the dendritic and axonal growth of adult-born neurons in the mouse dentate

249 dder hyperactivity, accompanied by increased axonal growth of calcitonin gene-related peptide-labeled

250 ing physiological levels of ROS required for axonal growth of hippocampal neurons.

251 teins (CRMPs) specify axon/dendrite fate and axonal growth of neurons through protein-protein interac

252 re, we show that Tip60 HAT activity mediates axonal growth of the Drosophila pacemaker cells, termed

253 cilitate the differentiation, maturation and axonal growth of the ORN, perhaps by recycling lipids fr

254 he distinct dependence between dendritic and axonal growth on the secretory pathway helps to establis

255 yogenesis, Nmnat2 plays an important role in axonal growth or maintenance.

256 l of AP-2 from older neurons does not impair axonal growth or signaling and synaptic function.

257 temperature adaptation, Ca(2+) homeostasis, axonal growth, (para)node of Ranvier stability and synap

258 urs and whether it can be altered to enhance axonal growth potential.

259 pically considered together, these two adult axonal growth processes are fundamentally different.

260 ore provide insights into the control of the axonal growth program.

261 This study shows that adaptive axonal growth-promoting mechanisms can substantially imp

262 Here we show that axonal growth-promoting roles of Shot require interactio

263 LCN stimulations significantly increased the axonal growth protein GAP43 in the ipsilesional somatose

264 tein 2 (CRMP2) is traditionally viewed as an axonal growth protein involved in axon/dendrite specific

265 al outcome can be improved by increasing the axonal growth rate.

266 nsists of Highwire and Wallenda and controls axonal growth, regeneration, and degeneration, is also i

267 roximately 200 diverse proteins critical for axonal growth, regeneration, and synaptic function at av

268 Regenerative axonal growth requires alterations in axonal microtubule

269 To address whether this switch in axonal growth response was mediated by distinct calcium

270 Myelin-derived inhibitors contribute to axonal growth restriction, with ephrinB3 being a develop

271 njured adult spinal cord to mount remarkable axonal growth, resulting in formation of new relay circu

272 We address definitions of axonal growth, sprouting and regeneration after injury,

273 nce of achieving functional recovery through axonal growth, substantial research effort has been, and

274 emergence of NDO, together with reduction of axonal growth, suggesting that BDNF may have a crucial r

275 in maintaining central nervous system (CNS) axonal growth, synapse formation, and neurotransmitter r

276 elevate the capacity of the adult brain for axonal growth, synaptic plasticity, and cognitive functi

277 h, migration, differentiation, dendritic and axonal growth, synaptogenesis, and synaptic pruning, all

278 pathway by which extrinsic signals regulate axonal growth through activation of m-calpain and p53 tr

279 Furthermore, compensatory axonal growth through collateral sprouting, normally see

280 unocytochemical analysis demonstrated robust axonal growth through the grafts of animals treated with

281 i3 signaling pathway that ultimately affects axonal growth through the optic chiasm.

282 as OA1 to regulate melanosome biogenesis and axonal growth through the optic chiasm.

283 ng Rac1 activity, a molecular determinant of axonal growth, through a ryanodine receptor (RyR)-mediat

284 vely switch from a dormant state with little axonal growth to robust axon regeneration upon injury.

285 ons, where it could restrict ADAM21-mediated axonal growth to the glomeruli.

286 Here, we demonstrate that axonal growth triggered by neurotrophin-3 remotely inhib

287 ol, an endocannabinoid affecting directional axonal growth, triggers corpus callosum enlargement due

288 Although CSPGs may negatively regulate axonal growth via binding and altering activity of other

289 vel receptor mechanism whereby CSPGs inhibit axonal growth via interactions with neuronal transmembra

290 of the Nogo receptor complex, which inhibits axonal growth via RhoA.

291 Recovery of locomotion and of axonal growth was assessed.

292 Axonal growth was partially dependent on mammalian targe

293 alized, there was a significant reduction in axonal growth when incubated in HUVEC-conditioned medium

294 ) upregulated genes commonly associated with axonal growth, whereas axotomized neurons whose axons we

295 ive physical and biochemical environment for axonal growth, which may lead to functional recovery.

296 it2/Robo1 signalling to modulate directional axonal growth, which may provide a basis for understandi

297 e treatments face the challenge of restoring axonal growth within an injury environment where inhibit

298 cord can enhance astrocyte infiltration and axonal growth within the injury site, but the mechanisms

299 sm that differentially directs dendritic and axonal growth within the same neuron in vivo.

300 ynthesis of cytoskeletal components to allow axonal growth without marked increase in expression of g