ライフサイエンスコーパス: axonal outgrowth

1 e of its target mRNAs, Gap43, is involved in axonal outgrowth.

2 dramatic defects in neuronal development and axonal outgrowth.

3 teins initiate signaling cascades that repel axonal outgrowth.

4 to neurotrophins or netrin-1 with efficient axonal outgrowth.

5 ing is unnecessary for retinal ganglion cell axonal outgrowth.

6 rons, reduction of SPRR1A function restricts axonal outgrowth.

7 S white matter is selectively inhibitory for axonal outgrowth.

8 s play a special role during early phases of axonal outgrowth.

9 hese components function together to control axonal outgrowth.

10 y regulate target genes that are involved in axonal outgrowth.

11 oping motor neurons when these cells undergo axonal outgrowth.

12 hat potentially mediates signals involved in axonal outgrowth.

13 in permissiveness of dorsal myotome for CaP axonal outgrowth.

14 8-mutated MAG retains the ability to inhibit axonal outgrowth.

15 generated but exhibits patterns of abnormal axonal outgrowth.

16 ns, suggesting that it, like UNC-76, acts in axonal outgrowth.

17 s (but not laminin 1) may promote peripheral axonal outgrowth.

18 tic fibers and that it functions to regulate axonal outgrowth.

19 tween the integrity of the Golgi complex and axonal outgrowth.

20 second messenger cAMP overcomes this blocked axonal outgrowth.

21 genesis, neurotransmitter specification, and axonal outgrowth.

22 n, which affects both neuronal migration and axonal outgrowth.

23 y neurons lacking OGT also exhibit decreased axonal outgrowth.

24 that this regulation is required for normal axonal outgrowth.

25 with the miRNA hairpin inhibitor suppressed axonal outgrowth.

26 levels by miR-19a likely contributes to the axonal outgrowth.

27 he establishment of dendritic complexity and axonal outgrowth.

28 cilitating a more permissive environment for axonal outgrowth.

29 ing functions in both neuronal migration and axonal outgrowth.

30 arity of neurons, as well as ensuring proper axonal outgrowth.

31 o differ with respect to the timing of their axonal outgrowth.

32 ntrosomal localization, leading to misplaced axonal outgrowth.

33 expression of GAP-43, a crucial component of axonal outgrowth.

34 eover, been demonstrated to regulate neurite/axonal outgrowth.

35 is critical for neuronal differentiation and axonal outgrowth.

36 urface targeting, synaptic transmission, and axonal outgrowth.

37 trin-1, but most DCC-mutant samples lack VCN axonal outgrowth.

38 for their role in patterning can also direct axonal outgrowth.

39 nes and regulates growth cone morphology and axonal outgrowth.

40 oneurons express scn8a and displayed delayed axonal outgrowth.

41 binds to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth.

42 neurotransmission, synaptic plasticity, and axonal outgrowth.

43 amino acids does not alter cell spreading or axonal outgrowth.

44 delay and/or increasing the initial rate of axonal outgrowth.

45 se it is involved in synaptic plasticity and axonal outgrowth.

46 otubules converging into the laminin-induced axonal outgrowths.

47 rain injury and into potential mechanisms of axonal outgrowth after injury.

48 Wnt proteins regulate axonal outgrowth along the anterior-posterior axis, but

49 n (Crmp-2), a neuronal protein implicated in axonal outgrowth and a component of the semaphorin 3A pa

50 uring development and suggest that it limits axonal outgrowth and branching in a DRG-autonomous manne

51 II or nuclear CaMKIV, dramatically decreases axonal outgrowth and branching in cultured neonatal hipp

52 tured PTPRO(-/-) TG neurons display enhanced axonal outgrowth and branching in response to BDNF and G

53 knockdown is sufficient to redrive defective axonal outgrowth and branching related to Tau-P301L expr

54 hereas a second domain, Amino-Nogo, inhibits axonal outgrowth and cell adhesion through unknown mecha

55 domain of NogoA, called amino-Nogo, inhibits axonal outgrowth and cell spreading via a largely unknow

56 tracellular signaling proteins that regulate axonal outgrowth and extension, most were conducted in t

57 ed on embryonic axons and may play a role in axonal outgrowth and fasciculation.

58 Overexpression of sAC results in axonal outgrowth and growth cone elaboration, whereas in

59 of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous

60 ggesting that Cdk5 has no obvious effects on axonal outgrowth and guidance mechanisms of these two ne

61 anterograde syd vesicles may play a role in axonal outgrowth and guidance.

62 We show that kbp is required for axonal outgrowth and maintenance.

63 factor (EGF) ligand neuregulin required for axonal outgrowth and myelination, are indeed posttransla

64 ny aspects of neuronal development including axonal outgrowth and neuronal migration.

65 RP promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presy

66 variety of developmental processes, such as axonal outgrowth and pathfinding, synaptogenesis, and th

67 eurons are studied intensively as a model of axonal outgrowth and pathfinding, yet the neurotransmitt

68 de have identified many molecules underlying axonal outgrowth and pathfinding.

69 dies have revealed many molecules underlying axonal outgrowth and pathfinding.

70 Remarkably, NMN deamidase also rescues axonal outgrowth and perinatal lethality in a dose-depen

71 e protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS.

72 upregulation of Tuj1 and SV2 is required for axonal outgrowth and search for appropriate targets, whe

73 monstrate that G protein activation inhibits axonal outgrowth and suggest that there may be a G prote

74 retinal ganglion cell (RGC) differentiation, axonal outgrowth and survival.

75 Thy-1 has been implicated in regulating axonal outgrowth and synaptic function, but little is kn

76 were found to be highest during periods when axonal outgrowth and synaptogenesis predominate.

77 ation through postmitotic differentiation to axonal outgrowth and synaptogenesis.

78 cell bodies to synaptic terminals following axonal outgrowth and synaptogenesis.

79 After termination of axonal outgrowth and target recognition, axons in the ve

80 ting that there is an increased capacity for axonal outgrowth and targeting, and increased support fo

81 ing 5-HT axons, is necessary for normal 5-HT axonal outgrowth and terminal arborization during the pe

82 on of miR-17-92 cluster expression regulates axonal outgrowth and that local modulation of PTEN prote

83 -sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-a

84 f the quaternary CRMP2 complex that controls axonal outgrowth and thus neuronal development.

85 Previous work has identified axonal outgrowth and/or guidance defects in the brain an

86 Many of these regions are known to display axonal outgrowth and/or synaptic rearrangement in adulth

87 We measured GC adhesion, initial axonal outgrowth, and substrate preference on alternatin

88 including neuronal migration, dendritic and axonal outgrowth, and synaptogenesis.

89 rial traffic in axons responds to changes in axonal outgrowth, and that the mechanism by which sortin

90 Collapsin-1 or semaphorin III(D) inhibits axonal outgrowth by collapsing the lamellipodial and fil

91 the C-terminal tail of the protein, displays axonal outgrowth defects similar to those observed in nu

92 ice had agenesis of the corpus callosum, and axonal outgrowth defects specific to ventral motoneuron

93 loproteinases (MMPs) have been implicated in axonal outgrowth during CNS development and show increas

94 hem (i.e., class II) correlates closely with axonal outgrowth during development and regeneration.

95 critical requirement for spastin to promote axonal outgrowth during embryonic development, and they

96 Axonal outgrowth during peripheral nerve regeneration re

97 , or rapamycin, an mTOR inhibitor, abolished axonal outgrowth enhanced by overexpression of the miR-1

98 tand how leptin could simultaneously promote axonal outgrowth from and inhibit the activity of NAG ne

99 l development in the rodent, leptin promotes axonal outgrowth from ARH neurons, and preautonomic NAG

100 In addition, axonal outgrowth from cerebellar granule neurons is incr

101 n this study, the time course and pattern of axonal outgrowth from different populations of pregangli

102 utralizing antibodies to BDNF eliminated the axonal outgrowth from spinal organotypics observed with

103 I nIF protein expression and early phases of axonal outgrowth has changed during evolution, the autho

104 survival of motoneurons, but its effects on axonal outgrowth have not been examined in detail.

105 related strongly with the earliest phases of axonal outgrowth in fishes but less so in mammals.

106 o laminin and APP-binding peptide as well as axonal outgrowth in Itgb1- independent manner; and APP d

107 d impairment of FAT in squid axoplasm and of axonal outgrowth in mammalian primary motor neurons invo

108 T STXBP5L, but not variant STXBP5L, promoted axonal outgrowth in manipulated mouse primary hippocampa

109 irements for plasticity and stability during axonal outgrowth in neurons that project long axons.

110 Proteoglycans influence axonal outgrowth in several experimental paradigms, and

111 Collagen type V(SC) blocked axonal outgrowth in the presence of otherwise active sub

112 Moreover, C3 increases axonal outgrowth in the rat hippocampus, raising the pos

113 or KIF3C gene knock-out, display an impaired axonal outgrowth in vitro and a delayed regeneration aft

114 neuronal cell spreading and strongly inhibit axonal outgrowth in vitro and in vivo.

115 CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacle

116 GDF10 promotes axonal outgrowth in vitro in mouse, rat and human neuron

117 h necessary and sufficient for NGF-dependent axonal outgrowth in vitro, and NGF regulates SRF-depende

118 ) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediat

119 bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro.

120 g that NgR mediates a significant portion of axonal outgrowth inhibition by myelin.

121 Axonal outgrowth is generally thought to be controlled b

122 al development shows that the speed of early axonal outgrowth is reduced in both the peripheral and c

123 bryonic day (E) 11.5, when sensory and motor axonal outgrowth is underway.

124 fundamental processes including mitosis and axonal outgrowth, its mechanism of action is poorly unde

125 axonal proteins that have been implicated in axonal outgrowth, microtubule spacing, and microtubule b

126 It was found that during the period of axonal outgrowth, Npr2 and cGKIalpha were strongly label

127 eages, and reveals L/R asymmetric control of axonal outgrowth of bilaterally symmetric neurons.

128 These results implicate 20E in enhancing axonal outgrowth of Kenyon cells to support MB remodelin

129 ERK/MAPK signaling was dispensable for axonal outgrowth of layer 2/3 callosal neurons.

130 ene, mutations in which cause defects in the axonal outgrowth of motor neurons, as well as defects in

131 ding astrocyte-neuron metabolic coupling and axonal outgrowth of neurons.

132 on of Rac1 in VZ progenitors did not prevent axonal outgrowth of telencephalic neurons.

133 iscernible effect on either the migration or axonal outgrowth of the EP cells.

134 ith F-actin in membrane ruffles and augments axonal outgrowth on a range of substrates.

135 response because it occurs without affecting axonal outgrowth or cell survival, and it is not observe

136 ting a potential role for the DAN protein in axonal outgrowth or guidance.

137 analysis addressed the role of FGF-2 in mDA axonal outgrowth, pathway formation, and innervation of

138 a crucial role in axon guidance, but not in axonal outgrowth per se.

139 uggests that ADAM21 is involved in the final axonal outgrowth phase and/or synapse formation.

140 cetylcholinesterase (AChE) during periods of axonal outgrowth prior to synaptogenesis, suggesting tha

141 ent and inhibitory effects of the miR-19a on axonal outgrowth, respectively.

142 Timeline analysis of axonal outgrowth reveals that leg motoneurons reach thei

143 ogenous 5-HT and blunting of endogenous 5-HT axonal outgrowth specifically within the fetal forebrain

144 n DNA repair, cell cycle, cell survival, and axonal outgrowth, suggesting p53 as key modifier of axon

145 neural precursors produce grafts with richer axonal outgrowth than primary foetal grafts, and that th

146 suppressor factor, p53, in the regulation of axonal outgrowth through a nontranscriptional effect inv

147 regulates SRF-dependent gene expression and axonal outgrowth through activation of both MEK/ERK and

148 surface of oligodendrocytes and can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR

149 regulate these events, inducing and guiding axonal outgrowth through the processes they extend.

150 jury-conditioned neurons by siRNA attenuated axonal outgrowth to 48% of control injured neurons and w

151 eurons, to examine their distribution during axonal outgrowth, to determine the reliance of this dist

152 Sensory neuron formation and axonal outgrowth, two early metamorphic events, also occ

153 ssociation between XIF3 expression and early axonal outgrowth was especially strong.

154 were observed at C7, while only one surge of axonal outgrowth was found at the L4 level.

155 However, by 8 days, differences in axonal outgrowth were observed with respect to target ty

156 ain binds to the Nogo-66 receptor to inhibit axonal outgrowth, whereas a second domain, Amino-Nogo, i

157 rtical neurons, LMNB1 overexpression reduces axonal outgrowth, whereas deficiency of endogenous Lmnb1

158 in cortical neurons substantially increased axonal outgrowth, whereas distal axonal attenuation of e

159 n of the exon 41 ortholog caused deficits in axonal outgrowth, whereas suppression of other exons phe

160 urin-NFAT signaling have dramatic defects in axonal outgrowth, yet have little or no defect in neuron