ライフサイエンスコーパス: axonal transport

1 g load, which is vital for robust retrograde axonal transport.

2 y, but also reaches the CNS after retrograde axonal transport.

3 his denervation results from disturbances of axonal transport.

4 filament networks associated with defects in axonal transport.

5 t HTT and Rab2, 7 or 19 move together during axonal transport.

6 nd shape of the axon as well as facilitating axonal transport.

7 called neurofilaments, which are cargoes of axonal transport.

8 esulted from local protein synthesis and not axonal transport.

9 lay an adaptive role to stresses that impair axonal transport.

10 ctural proteins into proximal axons to begin axonal transport.

11 smic proteins reaching the axon tip via slow axonal transport.

12 lase inhibitor trichostatin A (TSA) restores axonal transport.

13 etase processing of APP is impairment of APP axonal transport.

14 ing to microtubules, does not interfere with axonal transport.

15 s of non-functional GSK-3beta did not affect axonal transport.

16 ic associations with vesicles moving in fast axonal transport.

17 ubule depolymerization are known to decrease axonal transport.

18 pha-Syn aggregates with proteins involved in axonal transport.

19 ins, but only if the mRNAs were targeted for axonal transport.

20 US9(-) mutants are not absolutely blocked in axonal transport.

21 ain reverse for another round of anterograde axonal transport.

22 f second-order neurons following anterograde axonal transport.

23 euronal surface and to increased anterograde axonal transport.

24 the prospective synapse by kinesin-mediated axonal transport.

25 lying cause of the deficits in mitochondrial axonal transport.

26 ted beta-cleavage stimulates APP anterograde axonal transport.

27 ndent degradation and is replenished by fast axonal transport.

28 lizing agent that plays an important role in axonal transport.

29 u function and to maintain/restore effective axonal transport.

30 ident protein tyrosine phosphatase, prior to axonal transport.

31 t, inter-tubular spacing, and, by extension, axonal transport.

32 sphatase PTP1B is required to prime TrkA for axonal transport.

33 that perturbations in tau metabolism impair axonal transport.

34 d in the neuronal soma and conveyed via slow axonal transport.

35 sting that other factors must regulate their axonal transport.

36 s for how gE/gI and US9 initiate anterograde axonal transport.

37 icantly less effect on all microtubule-based axonal transport.

38 ive of a putative dysfunction of anterograde axonal transport.

39 he restrictive temperature of mammalian fast axonal transport.

40 ignaling cascade that leads to disruption of axonal transport, a critical function for neuronal survi

41 Retrograde axonal transport also plays a major role in neurotrophic

42 to promote dynamic microtubules required for axonal transport and activity-dependent remodeling of pr

43 involved in the loss of synapses, defective axonal transport and cognitive decline, in patients with

44 se terminals occurs with similar anterograde axonal transport and DCV half-lives.

45 we show that these Rab7 mutants dysregulated axonal transport and diminished the retrograde signaling

46 Integrins are in ARF6 vesicles during rapid axonal transport and during trafficking in the growth co

47 , both activating dynein-mediated retrograde axonal transport and enhancing microtubule stability thr

48 of let-7 overcomes this barrier by promoting axonal transport and enrichment of the EFF-1 fusogen at

49 exerts a neuroprotective role in APP-induced axonal transport and functional locomotion defects.

50 a pathogenic sphingolipid able to block fast axonal transport and is the first to provide a molecular

51 Furthermore, unambiguous evidence of mRNA axonal transport and local translation in vivo, in the c

52 Sirt2, or administration of TSA rescues both axonal transport and locomotor behavior.

53 ncluding SNAP-25, Rab3A and PSD-95, and with axonal transport and microtubules, including KIF3A, dyne

54 ue) gE/gI extracellular (ET) domains in both axonal transport and neuron-to-epithelial cell spread ha

55 s of the neuronal cytoskeleton that regulate axonal transport and neuronal function.

56 ing to further deficits in the mitochondrial axonal transport and onset of disease.

57 In vivo fluorescent imaging of axonal transport and photobleaching of labeled axons dem

58 e role between Tip60 HAT activity and APP in axonal transport and provide insight into the importance

59 ant of Miro1 rescued defective mitochondrial axonal transport and restored the amounts of tubulin ass

60 sic cytosolic/soluble protein moving in slow axonal transport and reveal previously unknown links bet

61 ement of dynamic MTs for kinesin-1-dependent axonal transport and shed light on the role of the MT cy

62 Thus, alphaherpesviruses repurpose the axonal transport and sorting pathway to spread within th

63 tau ratio has an impact on the regulation of axonal transport and specifically in APP dynamics, which

64 ystem showed both a reduction in anterograde axonal transport and spread from axons to nonneuronal ce

65 ic domain of pUS9 contributes to anterograde axonal transport and spread of HSV-1 from neurons to the

66 how a key viral protein plays a role in both axonal transport and spread of the virus from nerve cell

67 Injury blocks axonal transport and the delivery of SCG10, leading to t

68 to constricted axons with signs of impaired axonal transport and to paranodal defects and abnormal o

69 al nerves into skeletal muscle as a model of axonal transport and transynaptic spread.

70 ), and subsequently reversible disruption of axonal transport, and are regulated by stable tubulin-on

71 coprotein gE/gI is important for anterograde axonal transport, and gE/gI cytoplasmic domains play imp

72 rotein expression and microtubule stability, axonal transport, and mitochondrial dysfunction were add

73 tions such as the regulation of MT dynamics, axonal transport, and neurite outgrowth.

74 ex that determines axonal diameter, supports axonal transport, and provides independent control of sy

75 f impaired mitochondrial function, disrupted axonal transport, and/or dysfunctional intracellular Ca(

76 Of interest, anterograde and retrograde axonal transport appear to be interdependent, as perturb

77 Defects in axonal transport are an early pathological feature in Al

78 e conclusion that anterograde and retrograde axonal transport are not necessarily interdependent.

79 spacing, is regulated and how it impinges on axonal transport are unclear.

80 These results further support defects in axonal transport as a common factor in models of ALS tha

81 the central mediator, and kinesin-3 mediated axonal transport as the key effector.

82 d in synaptic function, the cytoskeleton and axonal transport, at 1-16 months of age.

83 adaptor to link Nav channels to KIF5 during axonal transport before anchoring them to the AIS and no

84 the impact of a few pathogenic mutations on axonal transport but a broad survey across a range of mo

85 tabilize microtubules, inhibit kinesin-based axonal transport, but not dynein-based transport, wherea

86 Excess of active GSK-3beta perturbed axonal transport by causing axonal blockages, which were

87 VAPBP56S perturbs anterograde mitochondrial axonal transport by disrupting Ca(2+) homeostasis and ef

88 Impaired axonal transport can contribute to axon degeneration and

89 The amyloid precursor protein (APP) is a key axonal transport cargo in Alzheimer's disease since pert

90 oma to exclude somatodendritic proteins from axonal transport carriers.

91 le high-molecular-weight tau, the failure of axonal transport, clumping of mitochondria, disruption o

92 findings, betaCTFs have reduced anterograde axonal transport compared with full-length, wild-type AP

93 Axonal transport defects and axonopathy are prominent in

94 a clear correlation between the severity of axonal transport defects and motor ability.

95 bulin acetylation levels are associated with axonal transport defects and neurodegeneration.

96 Axonal transport defects are an early pathology occurrin

97 We found that axonal transport defects are common across all models te

98 Axonal transport defects are rescued by CRISPR/Cas9-medi

99 ore these hallmark features appear, signs of axonal transport defects develop, though the initiating

100 (ER)-mitochondrial overlay, and restore the axonal transport defects in patient-derived MNs.Amyotrop

101 Strikingly, GSK-3beta-activity-dependent axonal transport defects were enhanced by reduction of P

102 ormalities have been linked to mitochondrial axonal transport defects, but the temporal and spatial r

103 isruption of APP function is associated with axonal transport defects, raising the possibility that a

104 (HD) protein, was previously shown to cause axonal transport defects.

105 gy, hypoexcitability, as well as progressive axonal transport defects.

106 ablation of PINK1 rescued the mitochondrial axonal transport deficit in ALS mutant SOD1-expressing c

107 of tau prevents neuronal overexcitation and axonal transport deficits caused by recombinant Abeta ol

108 Protein aggregation and axonal transport deficits have been implicated in the di

109 Axonal transport deficits have been reported in many neu

110 dings suggest that Abeta trimers might cause axonal transport deficits in AD.

111 Axonal transport deficits in Alzheimer's disease (AD) ar

112 results from transcriptional inhibition and axonal transport deficits mediated by mutant huntingtin,

113 ed in mutant Hsp27 neurons, implicating that axonal transport deficits primarily affect mitochondria

114 FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cel

115 y characterised by microtubule breakdown and axonal transport deficits.

116 We also determined that fast axonal transport delivers Nrxns to the neuronal surface

117 eurons to measure anterograde and retrograde axonal transport, demonstrating the usefulness of this n

118 ase cleavage site mutations of APP alter APP axonal transport directly.

119 cked NAP's protective effects, by preventing axonal transport disruption and improving behavioural de

120 haracterised by microtubule destabilisation, axonal transport disruption, synaptic defects and behavi

121 n following a 'dying-back' pattern involving axonal transport disruption.

122 Bidirectional axonal transport driven by kinesin and dynein along micr

123 sm, impaired cytoskeletal integrity, altered axonal transport dynamics, and DNA damage accumulation d

124 rved only in the myogenic model, even though axonal transport dysfunction is characteristic of both m

125 ved adverse effects on microtubule dynamics, axonal transport, endoplasmic reticulum, and endosomal t

126 and US9 initiate the process of anterograde axonal transport, ensuring that virus particles are tran

127 we utilize a computational model and common axonal transport experimental metrics to reveal the axon

128 After initial axonal transport failure, retinal terminal densities did

129 kinetics consistent with slow component-b of axonal transport (fast axonal transport with saltatory m

130 Disruption of fast axonal transport (FAT) and intracellular Ca(2+) dysregul

131 Disruption of fast axonal transport (FAT) is an early pathological event in

132 ed variants (G230C, R521G and R495X) on fast axonal transport (FAT), a cellular process critical for

133 acellular trafficking events, including fast axonal transport (FAT), may contribute to HSP pathogenes

134 , Trpv1(-/-) accelerated both degradation of axonal transport from retinal ganglion cells to the supe

135 The well-documented localization of SMN in axonal transport granules and its interaction with numer

136 The underlying mechanism of slow axonal transport has been under debate during the past t

137 Defects in axonal transport have been linked to Alzheimer's and oth

138 Impairments in axonal transport have been linked to devastating and oft

139 SCL2), RNA metabolism (IGHMBP2, SETX, GARS), axonal transport (HSPB1, DYNC1H1, DCTN1) and cation-chan

140 transport experimental metrics to reveal the axonal transport impairment general characteristics or "

141 ssue, Sorbara et al. (2014) demonstrate that axonal transport impairment is an early feature of neuro

142 Axonal transport impairment types include a decrease in

143 ch are most likely to be responsible for the axonal transport impairments in the G93A SOD1 mouse mode

144 al method, can be used to help elucidate the axonal transport impairments observed in experimental an

145 in vivo evidence that this kinase regulates axonal transport in a Tau-dependent manner.

146 hes the zebrafish as a model system to study axonal transport in a whole developing vertebrate organi

147 tin-induced neurotoxicity affects retrograde axonal transport in an animal model.

148 of the microtubule cytoskeleton and loss of axonal transport in branches that will subsequently dism

149 Direct visualization of axonal transport in live neurons is essential for our un

150 cultured human neuronal SK-N-SH cells and on axonal transport in mouse sciatic nerves.

151 Long-range retrograde axonal transport in neurons is driven exclusively by the

152 The study of axonal transport in neurons of adult animals requires in

153 The small GTPase Ran coordinates retrograde axonal transport in neurons, spindle assembly during mit

154 with deacetylated microtubules, and inhibits axonal transport in primary neurons and in Drosophila, c

155 iro1) is a master regulator of mitochondrial axonal transport in response to cytosolic calcium (Ca2+)

156 Using dual-colour live-cell imaging of axonal transport in SCG primary culture neurons, we find

157 highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide no

158 8 phosphorylated Tau regulates inhibition of axonal transport in the disease state.

159 avioral analyses highlight the importance of axonal transport in the maintenance of synaptic structur

160 rmers of Abeta and tau cooperatively disrupt axonal transport independently from plaques and tangles.

161 corrects the synaptotoxicity and deficits of axonal transport induced by Abeta.

162 heral lesion and can explain the increase in axonal transport induced by conditioning.

163 ls in aged mice exhibiting varying levels of axonal transport integrity.

164 ive axon degeneration-whether, when, and how axonal transport is affected in this condition is unknow

165 Defective axonal transport is an early neuropathological feature o

166 Disruption to axonal transport is an early pathological feature in Alz

167 Axonal transport is an essential process in neurons, ana

168 Abnormal axonal transport is associated with neuronal disease.

169 Axonal transport is critical for maintaining synaptic tr

170 Axonal transport is essential for neuronal function, and

171 pposing kinesin and dynein motors that drive axonal transport is essential to maintain neuronal homeo

172 Defective axonal transport is hypothesized to be a key factor in t

173 Defective microtubule-based axonal transport is hypothesized to contribute to Parkin

174 Axonal transport is indispensable for the distribution o

175 nally, we demonstrate that Tip60 function in axonal transport is mediated by APP and that, remarkably

176 Long-distance intracellular axonal transport is predominantly microtubule-based, and

177 Axonal transport is seen as an early pathogenic event th

178 Microtubule-based axonal transport is tightly regulated by numerous pathwa

179 Axonal transport is typically divided into two component

180 sicle-motor complex that contains HTT during axonal transport is unknown.

181 been shown to be required for kinesin-driven axonal transport, is also critically required for the dy

182 Ps and directly activates UNC-104/KIF1A, the axonal-transport kinesin for SVPs in C. elegans.

183 ted with epigenetic misregulation of certain axonal transport-linked Tip60 target genes.

184 ficits primarily affect mitochondria and the axonal transport machinery itself is less affected.

185 rative diseases result from mutations in the axonal transport machinery.

186 ent alpha-Syn species act divergently on the axonal transport machinery.

187 r imaging technology based on the retrograde axonal transport mechanism (neurography), to determine i

188 ation was inhibited, suggesting a retrograde axonal transport mechanism for delivery into the CNS.

189 To evaluate axonal transport mechanisms, we developed a high-resolut

190 ndria without producing any defects in their axonal transport, morphology, or metabolic state.

191 sive (piggybacking upon MTs at rates of slow axonal transport) motion of bound tau.

192 a key feature associated with reductions of axonal transport motor proteins in Parkinson's disease a

193 There was a decline in axonal transport motor proteins in sporadic Parkinson's

194 body loss, we tested whether alterations of axonal transport motor proteins would be early features

195 Although we have a basic understanding of axonal transport, much less is known about transport in

196 c dynein, the major motor driving retrograde axonal transport, must be actively localized to axon ter

197 ty in motor neurons involves diminished fast axonal transport, observed both in transgenic mice and,

198 Here, we characterized and quantified the axonal transport of alpha-synuclein fibrils and showed t

199 g of APP can directly impair the anterograde axonal transport of APP and are sufficient to lead to ax

200 that disruption of calsyntenin-1-associated axonal transport of APP is a pathogenic mechanism in Alz

201 emains unknown if APP processing affects the axonal transport of APP itself, and whether increased AP

202 Thus, perturbation to axonal transport of APP on calsyntenin-1 containing carr

203 a-secretase cleavage reduces the anterograde axonal transport of APP, while inhibited beta-cleavage s

204 uced loss of calsyntenin-1 markedly disrupts axonal transport of APP.

205 Axonal transport of ATP-producing mitochondria along neu

206 D knock-in mice is sufficient to disrupt the axonal transport of autophagosomes.

207 ules, huntingtin dephosphorylation increases axonal transport of BDNF, a crucial factor for hippocamp

208 followed by a delayed increase in retrograde axonal transport of BoNT/A-Hc carriers.

209 Time-lapse imaging of the axonal transport of chimeric filaments demonstrated that

210 lead us to propose a new model for the slow axonal transport of cytosolic cargos, based on short-liv

211 Neurotransmission requires anterograde axonal transport of dense core vesicles (DCVs) containin

212 is, we provide evidence that CKA facilitates axonal transport of dense core vesicles and autophagosom

213 Here, we assessed the axonal transport of different cargos in multiple Drosoph

214 ts in envelopment can explain the defects in axonal transport of enveloped virions.

215 been shown to play a role in the anterograde axonal transport of herpes simplex virus 1 (HSV-1), yet

216 s cause a local impairment in the retrograde axonal transport of lysosome precursors, leading to thei

217 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synap

218 Kinesin-1 drives axonal transport of membrane cargoes to fulfill the meta

219 Axonal transport of mitochondria and mitochondrial fissi

220 asing mitochondrial fragmentation, enhancing axonal transport of mitochondria and protecting synapses

221 m BACHD mice, for the first time, we studied axonal transport of mitochondria and synaptic degenerati

222 ovide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parki

223 to mitochondrial fragmentation and defective axonal transport of mitochondria in HD neurons.

224 n Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor neurons isolat

225 o identify the mechanism underlying impaired axonal transport of mitochondria in mutant SOD1-related

226 Further, RanBP9 retards the anterograde axonal transport of mitochondria in primary neurons and

227 Here we demonstrate deficits in anterograde axonal transport of mitochondria in primary neurons from

228 Anterograde axonal transport of mitochondria is mediated by the micr

229 Axonal transport of mitochondria was also increased in t

230 functional electrophysiological profiles and axonal transport of mitochondria, suggestive of maturity

231 to the mitochondria, and via Parkin arrested axonal transport of mitochondria.

232 ysis of postmortem tissue suggested impaired axonal transport of neurturin from putamen to substantia

233 Here we investigate the mechanism of fast axonal transport of Nmnat2 and its site of action for ax

234 or stable membrane association and vesicular axonal transport of Nmnat2.

235 C3, dynactin, and AnkB that together promote axonal transport of organelles and are required for norm

236 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence a

237 , endosome swelling and selectively impaired axonal transport of rab5 endosomes.

238 Axonal transport of relevant proteins may underlie the s

239 l protein expression but is not required for axonal transport of ribosomes or its target mRNAs.

240 We simulate the motor-based axonal transport of short MTs to test the hypothesis tha

241 Thus alpha-syn pathology impairs axonal transport of signaling and degradative organelles

242 Caenorhabditis elegans causes defects in the axonal transport of Stx.

243 osphorylation-deficient FEZ1 (S58A) restored axonal transport of Stx.

244 en axonally connected areas results from the axonal transport of such aggregates.

245 spersin, and blos-9/MEF2BNB-cause defects in axonal transport of SVPs, leading to ectopic accumulatio

246 Here we show that slow axonal transport of synapsin, a prototypical member of t

247 Thus, BORC regulates the axonal transport of synaptic materials and synapse forma

248 Axonal transport of synaptic vesicle precursors (SVPs) i

249 -B (AnkB), and dynactin, which promotes fast axonal transport of synaptic vesicles, mitochondria, end

250 We report that rapid axonal transport of these integrins and their traffickin

251 tures of the auditory system by means of the axonal transport of two bidirectional tracers, which wer

252 neurons to epithelial cells: (i) anterograde axonal transport of virus particles from neuron bodies t

253 pathway during synapse growth but not during axonal transport or synapse stabilization.

254 rrence of dystrophic axon terminals, reduced axonal transport, organelle-filled axonal swellings, and

255 ila, this is a tractable system for studying axonal transport over the life span of an animal and thu

256 This review provides an overview of axonal transport pathways and discusses their role in ne

257 cerebrospinal fluid (CSF) flux and hijacking axonal transport pathways.

258 In turn, MT organization determines axonal transport progression: cargoes pause at polymer t

259 differs from other viral proteins regarding axonal transport properties.

260 c and progressive synaptic, cytoskeletal and axonal transport protein abnormalities that may accompan

261 lso observed, along with accumulation of the axonal transport proteins JNK-interacting protein 1 and

262 with exocytic vesicles and motion at a fast axonal transport rate.

263 However, it remains largely unknown whether axonal transport regulates synaptic APP processing.

264 genous relative content of tau isoforms over axonal transport regulation.

265 erstanding how HSV gE/gI and US9 function in axonal transport relates to observations that gE(-), gI(

266 constantly transported down the axon at slow axonal transport speeds; inhibition of the kinesin-1-dyn

267 Downregulating either Sac1 or DVAP disrupts axonal transport, synaptic growth, synaptic microtubule

268 ripheral injury induces a global increase in axonal transport that is not restricted to the periphera

269 wer overall velocities than vesicles in fast axonal transport, the fundamental basis for this slow mo

270 lations do not cause a generalized defect in axonal transport; the inclusions do not fill the axonal

271 7 and gE-348 did not function in anterograde axonal transport; there were markedly reduced numbers of

272 ugh Snapin-mediated dynein-driven retrograde axonal transport, thereby suggesting a potential approac

273 Thus, tau allows Abeta oligomers to inhibit axonal transport through activation of GSK3beta, possibl

274 alyses showed that psychosine inhibited fast axonal transport through the activation of axonal PP1 an

275 n of retromer trafficking through retrograde axonal transport to fulfil its function in promoting lys

276 s simplex virus 1 (HSV-1) virions travel via axonal transport to sensory ganglia and establish a life

277 in regions, indicating the virus can move by axonal transport to synaptically coupled brain loci.

278 from axonal guidance, synapse formation, or axonal transport to the development of 3D models of the

279 This is consistent with APP axonal transport to the synapse, where APP is involved i

280 ding pseudorabies virus (PRV)-use retrograde axonal transport to travel toward the neuronal cell body

281 t the axon tip and undergo robust retrograde axonal transport toward the cell body, but the factors r

282 mine whether Tip60 HAT activity functions in axonal transport using Drosophila CNS motor neurons as a

283 the initiation of dynein-mediated retrograde axonal transport using live-cell imaging of cargo motili

284 We recently reported that loss of axonal transport vesicle association through mutations i

285 ated and analyzed presumptive APP-containing axonal transport vesicles from mouse cortical synaptosom

286 t palmitoylation and stable association with axonal transport vesicles.

287 the functional consequences of impaired APP axonal transport, we isolated and analyzed presumptive A

288 The defects in axonal transport were manifest in neuronal cell bodies,

289 Changes in axonal transport were only elicited by a peripheral lesi

290 h motility and processivity of mitochondrial axonal transport were reduced by expression of either Wt

291 cating that paclitaxel inhibited anterograde axonal transport, whereas eribulin did not.

292 mage-induced APP processing might impair APP axonal transport, which could result in failure of synap

293 between tau isoform imbalance and defects in axonal transport, which induce an abnormal APP metabolis

294 reveal key dynamic and emergent features of axonal transport, which potentially underlie multiple im

295 hat rat hippocampal axons completely recover axonal transport with no detectable axonal loss when com

296 h slow component-b of axonal transport (fast axonal transport with saltatory movement).

297 directional transport and pausing stages of axonal transport, with a temporal resolution of 2 ms.

298 o display selective impairment of retrograde axonal transport, with reduced frequency and velocity of

299 , but whether it is also an effector of fast axonal transport within axons is unknown.

300 the threshold force required to 1), uncouple axonal transport without impairing axonal survival, and